Mitochondrial ribosomal proteins in metastasis and their potential use as prognostic and therapeutic targets
Cancer Metastasis Rev. 2024 Oct 1. doi: 10.1007/s10555-024-10216-4. Online ahead of print. ABSTRACT The mitochondrion is an essential cell organelle known as the powerhouse of the cell. Mitochondrial ribosomal proteins (MRPs) are nuclear encoded, synthesised in the cytoplasm but perform their main functions in the mitochondria, which includes translation, transcription, cell death and maintenance. However, […]
Exposure to aircraft noise exacerbates cardiovascular and oxidative damage in three mouse models of diabetes
Eur J Prev Cardiol. 2024 Oct 1:zwae320. doi: 10.1093/eurjpc/zwae320. Online ahead of print. ABSTRACT BACKGROUND: Epidemiology links noise to increased risk of metabolic diseases like diabetes and obesity. Translational studies in humans and experimental animals showed that noise causes reactive oxygen species (ROS)-mediated cardiovascular damage. The interaction between noise and diabetes, specifically potential additive adverse […]
ROCK inhibitor enhances mitochondrial transfer via tunneling nanotubes in retinal pigment epithelium
Theranostics. 2024 Sep 9;14(15):5762-5777. doi: 10.7150/thno.96508. eCollection 2024. ABSTRACT Rationale: Tunnel nanotube (TNT)-mediated mitochondrial transport is crucial for the development and maintenance of multicellular organisms. Despite numerous studies highlighting the significance of this process in both physiological and pathological contexts, knowledge of the underlying mechanisms is still limited. This research focused on the role of […]
Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration
bioRxiv [Preprint]. 2024 Sep 12:2024.09.09.612106. doi: 10.1101/2024.09.09.612106. ABSTRACT Rare inherited diseases caused by mutations in the copper transporters SLC31A1 (CTR1) or ATP7A induce copper deficiency in the brain and throughout the body, causing seizures and neurodegeneration in infancy. The mechanistic underpinnings of such neuropathology remains unclear. Here, we characterized the molecular mechanisms by which neuronal […]
Effects of 5G radiofrequency electromagnetic radiation on indicators of vitality and DNA integrity of in vitro exposed boar semen
Theriogenology. 2024 Sep 25;230:243-249. doi: 10.1016/j.theriogenology.2024.09.025. Online ahead of print. ABSTRACT The effects of radiofrequency electromagnetic radiation (RF-EMR) on semen quality have been in the spotlight in recent years, though research results to date have been contradictory. The effects of RF-EMR amongst others depend upon frequency, and there is currently no literature concerning the influence […]
AIBP controls TLR4 inflammarafts and mitochondrial dysfunction in a mouse model of Alzheimer’s disease
J Neuroinflammation. 2024 Sep 28;21(1):245. doi: 10.1186/s12974-024-03214-4. ABSTRACT Microglia-driven neuroinflammation plays an important role in the development of Alzheimer’s disease. Microglia activation is accompanied by the formation and chronic expression of TLR4 inflammarafts, defined as enlarged and cholesterol-rich lipid rafts serving as an assembly platform for TLR4 dimers and complexes of other inflammatory receptors. The […]
Melatonin protects RPE cells from necroptosis and NLRP3 activation via promoting SERCA2-related intracellular Ca2+ homeostasis
Phytomedicine. 2024 Sep 22;135:156088. doi: 10.1016/j.phymed.2024.156088. Online ahead of print. ABSTRACT BACKGROUND: Melatonin is an antioxidant that also has anti-inflammatory effects. It has been reported to delay the progression of age-related macular degeneration (AMD), however, the mechanism has not been fully recognized. PURPOSE: The aim of the present study was to investigate the effects of […]
Crocin Protects the 661W Murine Photoreceptor Cell Line against the Toxic Effects of All-Trans-Retinal
Int J Mol Sci. 2024 Sep 20;25(18):10124. doi: 10.3390/ijms251810124. ABSTRACT Age-related macular degeneration (AMD) is a common disease contributing to vision loss in the elderly. All-trans-retinal (atRAL) is a retinoid in the retina, and its abnormal accumulation exhibits toxicity to the retina and promotes oxidative stress-induced photoreceptor degeneration, which plays a crucial role in AMD […]
Rotenone-Induced Optic Nerve Damage and Retinal Ganglion Cell Loss in Rats
Biomolecules. 2024 Aug 23;14(9):1047. doi: 10.3390/biom14091047. ABSTRACT Rotenone is a mitochondrial complex I inhibitor that causes retinal degeneration. A study of a rat model of rotenone-induced retinal degeneration suggested that this model is caused by indirect postsynaptic N-methyl-D-aspartate (NMDA) stimulation triggered by oxidative stress-mediated presynaptic intracellular calcium signaling. To elucidate the mechanisms by which rotenone […]
Clustered ARPE-19 cells distinct in mitochondrial membrane potential may play a pivotal role in cell differentiation
Sci Rep. 2024 Sep 27;14(1):22391. doi: 10.1038/s41598-024-73145-w. ABSTRACT Age-related macular degeneration (AMD) is associated with the dysfunction and degeneration of retinal pigment epithelium (RPE) cells. Here, we examined how the formation and expansions of cell clusters are regulated by the differentiation of the RPE cells. In this study, ARPE-19 cells were cultivated in standard or […]