New Insights in ATP Synthesis as Therapeutic Target in Cancer and Angiogenic Ocular Diseases
J Histochem Cytochem. 2024 May 11:221554241249515. doi: 10.1369/00221554241249515. Online ahead of print. ABSTRACT Lactate and ATP formation by aerobic glycolysis, the Warburg effect, is considered a hallmark of cancer. During angiogenesis in non-cancerous tissue, proliferating stalk endothelial cells (ECs) also produce lactate and ATP by aerobic glycolysis. In fact, all proliferating cells, both non-cancer and […]
Vitamin C alleviates hyperglycemic stress in retinal pigment epithelial cells
Mol Biol Rep. 2024 May 10;51(1):637. doi: 10.1007/s11033-024-09595-2. ABSTRACT BACKGROUND: Retinal pigment epithelial cells (RPECs) are a type of retinal cells that structurally and physiologically support photoreceptors. However, hyperglycemia has been shown to play a critical role in the progression of diabetic retinopathy (DR), which is one of the leading causes of vision impairment. In […]
Rod photoreceptor-specific deletion of cytosolic aspartate aminotransferase, GOT1, causes retinal degeneration
Front Ophthalmol (Lausanne). 2023;3:1306019. doi: 10.3389/fopht.2023.1306019. Epub 2023 Dec 5. ABSTRACT Photoreceptor cell death is the cause of vision loss in many forms of retinal disease. Metabolic dysfunction within the outer retina has been shown to be an underlying factor contributing to photoreceptor loss. Therefore, a comprehensive understanding of the metabolic pathways essential to photoreceptor […]
Comprehensive dry eye therapy: overcoming ocular surface barrier and combating inflammation, oxidation, and mitochondrial damage
J Nanobiotechnology. 2024 May 9;22(1):233. doi: 10.1186/s12951-024-02503-7. ABSTRACT BACKGROUND: Dry Eye Disease (DED) is a prevalent multifactorial ocular disease characterized by a vicious cycle of inflammation, oxidative stress, and mitochondrial dysfunction on the ocular surface, all of which lead to DED deterioration and impair the patients’ quality of life and social functioning. Currently, anti-inflammatory drugs […]
ADVANCES IN ALZHEIMER’S DISEASE: A MULTIFACETED REVIEW OF POTENTIAL THERAPIES AND DIAGNOSTIC TECHNIQUES FOR EARLY DETECTION
Neurochem Int. 2024 May 7:105761. doi: 10.1016/j.neuint.2024.105761. Online ahead of print. ABSTRACT Alzheimer’s disease (AD) remains one of the most formidable neurological disorders, affecting millions globally. This review provides a holistic overview of the therapeutic strategies, both conventional and novel, aimed at mitigating the impact of AD. Initially, we delve into the conventional approach, emphasizing […]
Inhibiting the SARM1-NAD+ axis reduces oxidative stress-induced damage to retinal and nerve cells
Int Immunopharmacol. 2024 May 8;134:112193. doi: 10.1016/j.intimp.2024.112193. Online ahead of print. ABSTRACT Retinal neurodegenerative diseases are a category of refractory blinding eye conditions closely associated with oxidative stress induced by mitochondrial dysfunction in retinal cells. SARM1, a core driver molecule leading to axonal degeneration, possesses NAD+ enzyme (NADase) activity. However, the role of the SARM1-NAD+ […]
Overexpression of TRPV1 activates autophagy in human lens epithelial cells under hyperosmotic stress through Ca2+-dependent AMPK/mTOR pathway
Int J Ophthalmol. 2024 Mar 18;17(3):420-434. doi: 10.18240/ijo.2024.03.03. eCollection 2024. ABSTRACT AIM: To explore whether autophagy functions as a cellular adaptation mechanism in lens epithelial cells (LECs) under hyperosmotic stress. METHODS: LECs were treated with hyperosmotic stress at the concentration of 270, 300, 400, 500, or 600 mOsm for 6, 12, 18, 24h in vitro. […]
The cGAS-STING pathway in cardiovascular diseases: from basic research to clinical perspectives
Cell Biosci. 2024 May 8;14(1):58. doi: 10.1186/s13578-024-01242-4. ABSTRACT The cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase-stimulator of interferon genes (cGAS-STING) signaling pathway, an important component of the innate immune system, is involved in the development of several diseases. Ectopic DNA-induced inflammatory responses are involved in several pathological processes. Repeated damage to tissues and metabolic organelles […]
Mitochondrial DNA-Associated Leigh Syndrome Spectrum
2003 Oct 30 [updated 2024 May 9]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. ABSTRACT CLINICAL CHARACTERISTICS: Mitochondrial DNA-associated Leigh syndrome spectrum (mtDNA-LSS) is part of a continuum of progressive neurodegenerative disorders caused by abnormalities […]
Mitochondria Energy Metabolism Depression as Novel Adjuvant to Sensitize Radiotherapy and Inhibit Radiation Induced-Pulmonary Fibrosis
Adv Sci (Weinh). 2024 May 7:e2401394. doi: 10.1002/advs.202401394. Online ahead of print. ABSTRACT Currently, the typical combination therapy of programmed death ligand-1 (PD-L1) antibodies with radiotherapy (RT) still exhibits impaired immunogenic antitumor response in clinical due to lessened DNA damage and acquired immune tolerance via the upregulation of some other immune checkpoint inhibitors. Apart from […]