Severe Optic Neuropathy Induced by Very Prolonged Tedizolid as Suppressive Therapy: Description of a Case Report and Implication for Better Assessment
Open Forum Infect Dis. 2024 Sep 24;11(9):ofae517. doi: 10.1093/ofid/ofae517. eCollection 2024 Sep. ABSTRACT The long-term tolerability of linezolid is low because of mitochondrial toxicity, whereas tedizolid may represent a better option for suppressive therapy. We report a first presumed case of tedizolid-associated optic neuropathy after a very prolonged (18-month) intake and believe that screening for […]
Current Insights on Mitochondria-Associated Endoplasmic Reticulum Membranes (MAMs) and their significance in the pathophysiology of ocular disorders
Exp Eye Res. 2024 Sep 24:110110. doi: 10.1016/j.exer.2024.110110. Online ahead of print. ABSTRACT The intricate interaction network necessary for essential physiological functions underscores the interdependence among eukaryotic cells. Mitochondria-Associated Endoplasmic Reticulum Membranes (MAMs), specialized junctions between mitochondria and the ER, were recently discovered. These junctions participate in various cellular processes, including calcium level regulation, lipid […]
ER Stress and Mitochondrial Perturbations Regulate Cell Death in Retinal Detachment: Exploring the Role of HIF1alpha
Invest Ophthalmol Vis Sci. 2024 Sep 3;65(11):39. doi: 10.1167/iovs.65.11.39. ABSTRACT PURPOSE: Retinal detachment (RD) leads to photoreceptor (PR) hypoxia due to separation from the retinal pigment epithelium (RPE). Hypoxia stabilizes retinal hypoxia-inducible factor 1-alpha (HIF1α), crucial for PR survival during RD. This study explores the regulatory role of HIF1α in PR cell survival pathways during […]
DJ-1 regulates mitochondrial function and promotes retinal ganglion cell survival under high glucose-induced oxidative stress
Front Pharmacol. 2024 Sep 11;15:1455439. doi: 10.3389/fphar.2024.1455439. eCollection 2024. ABSTRACT PURPOSE: This study aimed to investigate the antioxidative and neuroprotective effects of DJ-1 in mitigating retinal ganglion cell (RGC) damage induced by high glucose (HG). METHODS: A diabetic mouse model and an HG-induced R28 cell model were employed for loss- and gain-of-function experiments. The expression […]
Mitochondrial ferritin upregulation by deferiprone reduced neuronal ferroptosis and improved neurological deficits via NDRG1/Yap pathway in a neonatal rat model of germinal matrix hemorrhage
J Cereb Blood Flow Metab. 2024 Sep 24:271678X241252110. doi: 10.1177/0271678X241252110. Online ahead of print. ABSTRACT Ferroptosis contributes to brain injury after germinal matrix hemorrhage (GMH). Mitochondrial ferritin (FTMT), a novel mitochondrial outer membrane protein, reduces oxidative stress in neurodegenerative diseases. In vitro, Deferiprone has been shown to upregulate FTMT. However, the effects of FTMT upregulation […]
Overexpression of PRDM16 attenuates acute kidney injury progression: genetic and pharmacological approaches
MedComm (2020). 2024 Sep 21;5(10):e737. doi: 10.1002/mco2.737. eCollection 2024 Oct. ABSTRACT Acute kidney injury (AKI) presents as a condition marked by a sudden and rapid decrease in kidney function over a short timeframe, resulting from diverse causes. As a transcription factor, PR domain-containing 16 (PRDM16), has recently been implicated in brown fat biogenesis and heart […]
Mitochondrial metabolism blockade nanoadjuvant reversed immune-resistance microenvironment to sensitize albumin-bound paclitaxel-based chemo-immunotherapy
Acta Pharm Sin B. 2024 Sep;14(9):4087-4101. doi: 10.1016/j.apsb.2024.05.028. Epub 2024 Jun 3. ABSTRACT Currently, the efficacy of albumin-bound paclitaxel (PTX@Alb) is still limited due to the impaired PTX@Alb accumulation in tumors partly mediated by the dense collagen distribution. Meanwhile, acquired immune resistance always occurs due to the enhanced programmed cell death-ligand 1 (PD-L1) expression after […]
A novel frameshift variant in LAMP2 gene mimicking choroideremia carrier retinopathy
Ophthalmic Genet. 2024 Sep 19:1-8. doi: 10.1080/13816810.2024.2404148. Online ahead of print. ABSTRACT BACKGROUND: Danon disease is a rare, multisystemic X-linked dominant disorder caused by variants in the LAMP2 gene. It can be associated with retinal degeneration, but this is not well characterized. Here we describe a late presentation of a mild retinal phenotype, initially diagnosed […]
Zotarolimus alleviates post-trabeculectomy fibrosis via dual functions of anti-inflammation and regulating AMPK/mTOR axis
Int Immunopharmacol. 2024 Sep 19;142(Pt B):113176. doi: 10.1016/j.intimp.2024.113176. Online ahead of print. ABSTRACT OBJECTIVE: Postoperative scar formation is the primary cause of uncontrolled intraocular pressure following trabeculectomy failure. This study aimed to evaluate the efficacy of zotarolimus as an adjuvant anti-scarring agent in the experimental trabeculectomy. METHODS: We performed differential gene and Gene Ontology enrichment […]
Morphological multiparameter filtration and persistent homology in mitochondrial image analysis
PLoS One. 2024 Sep 20;19(9):e0310157. doi: 10.1371/journal.pone.0310157. eCollection 2024. ABSTRACT The complexity of branching and curvilinear morphology of a complete mitochondrial network within each cell is challenging to analyze and quantify. To address this challenge, we developed an image analysis technique using persistent homology with a multiparameter filtration framework, combining image processing techniques in mathematical […]