A Modified Polydopamine Nanoparticle Loaded with Melatonin for Synergistic ROS Scavenging and Anti-Inflammatory Effects in the Treatment of Dry Eye Disease
Adv Healthc Mater. 2025 Jan 19:e2404372. doi: 10.1002/adhm.202404372. Online ahead of print. ABSTRACT Dry eye disease (DED) is a multifaceted ocular surface disorder that significantly impacts patients’ daily lives and imposes a substantial economic burden on society. Oxidative stress, induced by the overproduction of reactive oxygen species (ROS), is a critical factor perpetuating the inflammatory […]
Voltage-dependent anion channel 1 oligomerization regulates PANoptosis in retinal ischemia-reperfusion injury
Neural Regen Res. 2025 Jan 13. doi: 10.4103/NRR.NRR-D-24-00674. Online ahead of print. ABSTRACT Ischemia-reperfusion injury is a common pathophysiological mechanism in retinal degeneration. PANoptosis is a newly defined integral form of regulated cell death that combines the key features of pyroptosis, apoptosis, and necroptosis. Oligomerization of mitochondrial voltage-dependent anion channel 1 is an important pathological […]
Targeting the glymphatic system to promote α-synuclein clearance: a novel therapeutic strategy for Parkinson’s disease
Neural Regen Res. 2025 Jan 13. doi: 10.4103/NRR.NRR-D-24-00764. Online ahead of print. ABSTRACT The excessive buildup of neurotoxic α-synuclein plays a pivotal role in the pathogenesis of Parkinson’s disease, highlighting the urgent need for innovative therapeutic strategies to promote α-synuclein clearance, particularly given the current lack of disease-modifying treatments. The glymphatic system, a recently identified […]
Mitochondria-Targeted Antioxidant (MitoQ) and Nontargeted Antioxidant (Idebenone) Mitigate Mitochondrial Dysfunction in Corneal Endothelial Cells
Cornea. 2025 Jan 17. doi: 10.1097/ICO.0000000000003801. Online ahead of print. ABSTRACT PURPOSE: To investigate the effectiveness of mitochondrial-targeted antioxidant mitoquinone (MitoQ) and nontargeted antioxidant idebenone (Idb) in alleviating mitochondrial dysfunction in corneal endothelial cells (CEnCs). METHODS: In vitro experiments were conducted using immortalized normal human corneal endothelial cells (HCEnC-21T; SVN1-67F) and Fuchs endothelial corneal dystrophy […]
Adrenomedullin 2/Intermedin Exerts Cardioprotective Effects by Regulating Cardiomyocyte Mitochondrial Function
Hypertension. 2025 Jan 16. doi: 10.1161/HYPERTENSIONAHA.124.23666. Online ahead of print. ABSTRACT BACKGROUND: Adrenomedullin 2 (AM2) plays critical roles in regulating blood pressure and fluid balance. However, the specific involvement of AM2 in cardiac hypertrophy has not been comprehensively elucidated, warranting further investigation into its molecular mechanisms and therapeutic implications. METHODS: Cardiac hypertrophy was induced in […]
Understanding cataract development in axial myopia: The contribution of oxidative stress and related pathways
Redox Biol. 2025 Jan 10;80:103495. doi: 10.1016/j.redox.2025.103495. Online ahead of print. ABSTRACT Myopia is an evolving global health challenge, with estimates suggesting that by 2050 it will affect half of the world’s population, becoming the leading cause of irreversible vision loss. Moreover, myopia can lead to various complications, including the earlier onset of cataracts. Given […]
Epithelial OPA1 links mitochondrial fusion to inflammatory bowel disease
Sci Transl Med. 2025 Jan 15;17(781):eadn8699. doi: 10.1126/scitranslmed.adn8699. Epub 2025 Jan 15. ABSTRACT Dysregulation at the intestinal epithelial barrier is a driver of inflammatory bowel disease (IBD). However, the molecular mechanisms of barrier failure are not well understood. Here, we demonstrate dysregulated mitochondrial fusion in intestinal epithelial cells (IECs) of patients with IBD and show […]
In vivo imaging of mitochondrial function in normal, glaucoma suspect, and glaucoma eyes
PLoS One. 2025 Jan 14;20(1):e0317354. doi: 10.1371/journal.pone.0317354. eCollection 2025. ABSTRACT To investigate macula and optic nerve head (ONH) mitochondrial metabolic activity using flavoprotein fluorescence (FPF) in normal, glaucoma suspect (GS), and open-angle glaucoma (OAG) eyes we performed a cross-sectional, observational study of FPF in normal, GS, and OAG eyes. The macula and ONH of each […]
Unraveling the genetic spectrum of inherited deaf-blindness in Portugal
Orphanet J Rare Dis. 2025 Jan 14;20(1):22. doi: 10.1186/s13023-025-03542-5. ABSTRACT BACKGROUND: Syndromic genetic disorders affecting vision can also cause hearing loss, and Usher syndrome is by far the most common etiology. However, many other conditions can present dual sensory impairment. Accurate diagnosis is essential for providing patients with genetic counseling, prognostic information, and appropriate resources. […]
From Cellular to Metabolic: Advances in Imaging of Inherited Retinal Diseases
Diagnostics (Basel). 2024 Dec 26;15(1):28. doi: 10.3390/diagnostics15010028. ABSTRACT Background: Inherited retinal diseases (IRDs) are a genetically complex group of disorders, usually resulting in progressive vision loss due to retinal degeneration. Traditional imaging methods help in structural assessments, but limitations exist in early functional cellular-level detection that are crucial for guiding new therapies. Methods: This review […]