Hallmarks of aging in age-related macular degeneration and age-related neurological disorders: novel insights into common mechanisms and clinical relevance
Eye (Lond). 2024 Sep 17. doi: 10.1038/s41433-024-03341-5. Online ahead of print. ABSTRACT Age-related macular degeneration (AMD) and age-related neurological diseases (ANDs), such as Alzheimer’s and Parkinson’s Diseases, are increasingly prevalent conditions that significantly contribute to global morbidity, disability, and mortality. The retina, as an accessible part of the central nervous system (CNS), provides a unique […]
Timed topical dexamethasone eye drops improve mitochondrial function to prevent severe retinopathy of prematurity
Angiogenesis. 2024 Sep 17. doi: 10.1007/s10456-024-09948-2. Online ahead of print. ABSTRACT Pathological neovascularization in retinopathy of prematurity (ROP) can cause visual impairment in preterm infants. Current ROP treatments which are not preventative and only address late neovascular ROP, are costly and can lead to severe complications. We showed that topical 0.1% dexamethasone eye drops administered […]
Sex-dependent regulation of retinal pigment epithelium and retinal function by Pgc-1α
Front Cell Neurosci. 2024 Sep 2;18:1442079. doi: 10.3389/fncel.2024.1442079. eCollection 2024. ABSTRACT Age-related macular degeneration (AMD) is a major cause of blindness that affects people over 60. While aging is the prominent factor in AMD, studies have reported a higher prevalence of AMD in women compared to age-matched men. Higher levels of the innate immune response’s […]
Licochalcone A Ameliorates Aspergillus fumigatus Keratitis by Reducing Fungal Load and Activating the Nrf2/HO-1 Signaling Pathway
ACS Infect Dis. 2024 Sep 16. doi: 10.1021/acsinfecdis.4c00123. Online ahead of print. ABSTRACT Fungal keratitis (FK) is a blinding corneal infectious disease. The prognosis is frequently unfavorable due to fungal invasion and an excessive host inflammatory response. Licochalcone A (Lico A) exhibits a broad spectrum of pharmacological activities, encompassing antifungal, anti-inflammatory, antioxidation, and antitumor properties. […]
Diagnostic dilemma: Leber’s hereditary optic neuropathy in a 70-year-Old woman
Am J Ophthalmol Case Rep. 2024 Aug 22;36:102143. doi: 10.1016/j.ajoc.2024.102143. eCollection 2024 Dec. ABSTRACT PURPOSE: Reports of atypical cases have increased awareness that Leber’s hereditary optic neuropathy (LHON) is not solely a disease of young men. Here, we present a case of a 70-year-old woman who presented with bilateral sequential loss of vision, and, after […]
The S341P mutant MYOC renders the trabecular meshwork sensitive to cyclic mechanical stretch
Heliyon. 2024 Aug 29;10(17):e37137. doi: 10.1016/j.heliyon.2024.e37137. eCollection 2024 Sep 15. ABSTRACT The trabecular meshwork (TM) plays an essential role in the circulation of aqueous humor by sensing mechanical stretch. The balance between the outflow and inflow of aqueous humor is critical in regulating intraocular pressure (IOP). A dysfunctional TM leads to resistance to the outflow […]
PPARgamma drives mitochondrial stress signaling and the loss of atrial cardiomyocytes in newborn mice exposed to hyperoxia
Redox Biol. 2024 Sep 12;76:103351. doi: 10.1016/j.redox.2024.103351. Online ahead of print. ABSTRACT Diastolic dysfunction is increasingly common in preterm infants exposed to supplemental oxygen (hyperoxia). Previous studies in neonatal mice showed hyperoxia suppresses fatty acid synthesis genes required for proliferation and survival of atrial cardiomyocytes. The loss of atrial cardiomyocytes creates a hypoplastic left atrium […]
Unveiling the Therapeutic Potential and Mechanisms of Stanniocalcin-1 in Retinal Degeneration
Surv Ophthalmol. 2024 Sep 11:S0039-6257(24)00085-7. doi: 10.1016/j.survophthal.2024.08.001. Online ahead of print. ABSTRACT Retinal degeneration (RD) is a group of ocular diseases characterized by progressive photoreceptor apoptosis and visual impairment. Mitochondrial malfunction, excessive oxidative stress, and chronic activation of neuroglia collectively contribute to the development of RD. Currently, there is a lack of efficacious therapeutic interventions […]
Metformin Alleviates Inflammation and Induces Mitophagy in Human Retinal Pigment Epithelium Cells Suffering from Mitochondrial Damage
Cells. 2024 Aug 27;13(17):1433. doi: 10.3390/cells13171433. ABSTRACT Mitochondrial malfunction, excessive production of reactive oxygen species (ROS), deficient autophagy/mitophagy, and chronic inflammation are hallmarks of age-related macular degeneration (AMD). Metformin has been shown to activate mitophagy, alleviate inflammation, and lower the odds of developing AMD. Here, we explored the ability of metformin to activate mitophagy and […]
Uncovering a novel SERPING1 pathogenic variant: insights into the aggregation of C1-INH in hereditary angioedema
Orphanet J Rare Dis. 2024 Sep 13;19(1):341. doi: 10.1186/s13023-024-03306-7. ABSTRACT BACKGROUND: Hereditary angioedema (HAE) is a rare autosomal dominant genetic disease characterized by recurrent edema and a potentially fatal risk. Despite its severity, there is a notable lack of effective methods for predicting and preventing HAE attacks. This study aims to thoroughly investigate the underlying […]