FABP5 Is a Possible Factor for the Maintenance of Functions of Human Non-Pigmented Ciliary Epithelium Cells
Int J Mol Sci. 2024 Aug 27;25(17):9285. doi: 10.3390/ijms25179285. ABSTRACT To elucidate the possible biological roles of fatty acid-binding protein 5 (FABP5) in the intraocular environment, the cells from which FABP5 originates were determined by using four different intraocular tissue-derived cell types including human non-pigmented ciliary epithelium (HNPCE) cells, retinoblastoma (RB) cells, adult retinal pigment […]
Hypoxia-induced BNIP3 facilitates the progression and metastasis of uveal melanoma by driving metabolic reprogramming
Autophagy. 2024 Sep 12:1-19. doi: 10.1080/15548627.2024.2395142. Online ahead of print. ABSTRACT Uveal melanoma (UM) is an aggressive intraocular malignancy derived from melanocytes in the uvea tract of the eye. Up to 50% of patients with UM develop distant metastases which is usually fatal within one year; preventing metastases is therefore essential. Metabolic reprogramming plays a […]
Heme: A link between hemorrhage and retinopathy of prematurity progression
Redox Biol. 2024 Aug 16;76:103316. doi: 10.1016/j.redox.2024.103316. Online ahead of print. ABSTRACT Neovascularization is implicated in the pathology of retinopathy of prematurity (ROP), diabetic retinopathy (DR), and age-related macular degeneration (AMD), which are the leading causes of blindness worldwide. In our work, we analyzed how heme released during hemorrhage affects hypoxic response and neovascularization. Our […]
Pregnancy in women with mitochondrial disease-A literature review and suggested guidance for preconception and pregnancy care
Aust N Z J Obstet Gynaecol. 2024 Sep 11. doi: 10.1111/ajo.13874. Online ahead of print. ABSTRACT Mitochondrial donation to reduce the risk of primary mitochondrial disease transmission from mother to child is now permitted under Australian law as part of a clinical trial. The energy demands of pregnancy have the potential to worsen mitochondrial disease […]
The role of mitochondrial dysfunction in the stabilization of the glaucomatous process
Vestn Oftalmol. 2024;140(4):49-58. doi: 10.17116/oftalma202414004149. ABSTRACT Many key aspects of retinal ganglion cell (RGC) neurodegeneration in glaucoma are associated with mitochondrial dysfunction. Understanding the mechanisms and relationships between structural and functional changes in mitochondria would be beneficial for developing mitochondria-targeted therapeutic strategies to protect RGCs from glaucomatous neurodegeneration. PURPOSE: This study determines the extent of […]
Comparative single-cell transcriptomic analysis across tissues of aging primates reveals specific autologous activation of ZNF281 to mitigate oxidative stress in cornea
Aging Cell. 2024 Sep 10:e14319. doi: 10.1111/acel.14319. Online ahead of print. ABSTRACT Reactive oxygen species (ROS) and oxidative stress accelerate cellular aging, but their impact on different tissues varies. The cornea, known for its robust antioxidant defense systems, is relatively resistant to age-related diseases like cancer. However, the precise mechanisms by which the cornea maintains […]
N-ACETYLCYSTEINE AMIDE AND DI- N-ACETYLCYSTEINE AMIDE PROTECT RETINAL CELLS IN CULTURE VIA AN ANTIOXIDANT ACTION
Exp Eye Res. 2024 Sep 7:110074. doi: 10.1016/j.exer.2024.110074. Online ahead of print. ABSTRACT Reactive oxygen species (ROS) play a significant role in toxicity to the retina in a variety of diseases. N-acetylcysteine (NAC), N-acetylcysteine amide (NACA) and the dimeric di-N-acetylcysteine amide (diNACA) were evaluated in terms of protecting retinal cells, in vitro, in a variety […]
Y and Mitochondrial Chromosomes in the Heterogeneous Stock Rat Population
G3 (Bethesda). 2024 Sep 9:jkae213. doi: 10.1093/g3journal/jkae213. Online ahead of print. ABSTRACT Genome-wide association studies typically evaluate the autosomes and sometimes the X Chromosome, but seldom consider the Y or mitochondrial Chromosomes. We genotyped the Y and mitochondrial Chromosomes in heterogeneous stock rats (Rattus norvegicus), an outbred population created from eight inbred strains. We identified […]
Elevated concentrations of amyloid-β oligomers and their proapoptotic effects on age-related cataract
FASEB J. 2024 Sep;38(17):e23861. doi: 10.1096/fj.202301281RR. ABSTRACT Recently, amyloid-β oligomers (AβOs) have been studied as the primary pathogenic substances in Alzheimer’s disease (AD). Our previous study revealed that the Aβ expression level is closely related to ARC progression. Here, we demonstrated that the accumulation of AβOs in the lens epithelium of age-related cataract (ARC) patients […]
Multifaceted mitochondrial as a novel therapeutic target in dry eye: insights and interventions
Cell Death Discov. 2024 Sep 6;10(1):398. doi: 10.1038/s41420-024-02159-0. ABSTRACT Dry eye, recognized as the most prevalent ocular surface disorder, has risen to prominence as a significant public health issue, adversely impacting the quality of life for individuals across the globe. Despite decades of extensive research into the chronic inflammation that characterizes dry eye, the intricate […]