SUCLG1 restricts POLRMT succinylation to enhance mitochondrial biogenesis and leukemia progression
EMBO J. 2024 Apr 22. doi: 10.1038/s44318-024-00101-9. Online ahead of print. ABSTRACT Mitochondria are cellular powerhouses that generate energy through the electron transport chain (ETC). The mitochondrial genome (mtDNA) encodes essential ETC proteins in a compartmentalized manner, however, the mechanism underlying metabolic regulation of mtDNA function remains unknown. Here, we report that expression of tricarboxylic […]
Mitochondrial DNA-Activated cGAS-STING Signaling in Environmental Dry Eye
Invest Ophthalmol Vis Sci. 2024 Apr 1;65(4):33. doi: 10.1167/iovs.65.4.33. ABSTRACT PURPOSE: The cGAS-STING pathway has been shown to be an important mediator of inflammation. There is emerging evidence of the importance of this signaling cascade in a variety of inflammatory diseases settings. Here, we present evidence that the mitochondrial DNA (mtDNA) damage-mediated cGAS-STING pathway plays […]
Leber’s hereditary optic neuropathy
Rinsho Shinkeigaku. 2024 Apr 20. doi: 10.5692/clinicalneurol.cn-001924. Online ahead of print. ABSTRACT Leber’s hereditary optic atrophy (LHON) is a genetic optic neuropathy that is more prevalent in young males but can occur from childhood to old age. The primary cause is mitochondrial genetic mutations, which are associated with dysfunction of mitochondrial electron transport chain complex […]
Targeting dysregulated lipid metabolism for the treatment of Alzheimer’s disease and Parkinson’s disease: Current advancements and future prospects
Neurobiol Dis. 2024 Apr 18:106505. doi: 10.1016/j.nbd.2024.106505. Online ahead of print. ABSTRACT Alzheimer’s and Parkinson’s diseases are two of the most frequent neurological diseases. The clinical features of AD are memory decline and cognitive dysfunction, while PD mainly manifests as motor dysfunction such as limb tremors, muscle rigidity abnormalities, and slow gait. Abnormalities in cholesterol, […]
Nanoceria-Mediated Cyclosporin A Delivery for Dry Eye Disease Management through Modulating Immune-Epithelial Crosstalk
ACS Nano. 2024 Apr 17. doi: 10.1021/acsnano.3c11514. Online ahead of print. ABSTRACT Dry eye disease (DED) affects a substantial worldwide population with increasing frequency. Current single-targeting DED management is severely hindered by the existence of an oxidative stress-inflammation vicious cycle and complicated intercellular crosstalk within the ocular microenvironment. Here, a nanozyme-based eye drop, namely nanoceria […]
Metabolic reprogramming of the retinal pigment epithelium by cytokines associated with age-related macular degeneration
Biosci Rep. 2024 Apr 24;44(4):BSR20231904. doi: 10.1042/BSR20231904. ABSTRACT The complex metabolic relationship between the retinal pigment epithelium (RPE) and photoreceptors is essential for maintaining retinal health. Recent evidence indicates the RPE acts as an adjacent lactate sink, suppressing glycolysis in the epithelium in order to maximize glycolysis in the photoreceptors. Dysregulated metabolism within the RPE […]
Retinoprotective Effect of SkQ1, Visomitin Eye Drops, Is Associated with Suppression of P38 MAPK and ERK1/2 Signaling Pathways Activity
Biochemistry (Mosc). 2024 Feb;89(2):201-211. doi: 10.1134/S0006297924020020. ABSTRACT Visomitin eye drops are the first and, so far, the only drug based on SkQ1 – the mitochondria-targeted antioxidant 10-(6′-plastoquinonyl) decyltriphenylphosphonium, developed in the laboratories of Moscow State University under the leadership of Academician V. P. Skulachev. SkQ1 is considered as a potential tool to combat the aging […]
Induction of Petite Colonies in Candida glabrate via Rose Bengal-Mediated Photodynamic Therapy
J Vis Exp. 2024 Mar 29;(205). doi: 10.3791/66549. ABSTRACT Facing a 40% mortality rate in candidemia patients, drug-resistant Candida and their petite mutants remain a major treatment challenge. Antimicrobial photodynamic therapy (aPDT) targets multiple fungal structures, unlike antibiotics/antifungals, potentially thwarting resistance. Traditional methods for inducing petite colonies rely on ethidium bromide or fluconazole, which can […]
Glutaminase deficiency in rod photoreceptors disrupts nonessential amino acid levels to activate the integrated stress response and induce rapid degeneration
bioRxiv [Preprint]. 2024 Mar 27:2024.03.26.582525. doi: 10.1101/2024.03.26.582525. ABSTRACT The bioenergetic demand of photoreceptors rivals that of cancer cells, and numerous metabolic similarities exist between these cells. Glutamine (Gln) anaplerosis via the tricarboxylic acid (TCA) cycle provides biosynthetic intermediates and is a hallmark of cancer metabolism. In this process, Gln is first converted to glutamate via […]
AIBP controls TLR4 inflammarafts and mitochondrial dysfunction in a mouse model of Alzheimer’s disease
bioRxiv [Preprint]. 2024 Mar 27:2024.02.16.580751. doi: 10.1101/2024.02.16.580751. ABSTRACT Microglia-driven neuroinflammation plays an important role in the development of Alzheimer’s disease (AD). Microglia activation is accompanied by the formation and chronic maintenance of TLR4 inflammarafts, defined as enlarged and cholesterol-rich lipid rafts serving as an assembly platform for TLR4 dimers and complexes of other inflammatory receptors. […]