Review on the Role of Mitochondrial Dysfunction in Septic Encephalopathy
Cell Biochem Biophys. 2024 Aug 30. doi: 10.1007/s12013-024-01493-5. Online ahead of print. ABSTRACT Septic Encephalopathy (SE) is a frequent and severe complication of sepsis, characterized by a range of neurocognitive impairments from mild confusion to deep coma. The underlying pathophysiology of SE involves systemic inflammation, neuroinflammation, blood-brain barrier (BBB) disruption, and mitochondrial dysfunction. Among these […]
Modeling aging and retinal degeneration with mitochondrial DNA mutation burden
Aging Cell. 2024 Aug 29:e14282. doi: 10.1111/acel.14282. Online ahead of print. ABSTRACT Somatic mitochondrial DNA (mtDNA) mutation accumulation has been observed in individuals with retinal degenerative disorders. To study the effects of aging and mtDNA mutation accumulation in the retina, a polymerase gamma (POLG) exonuclease-deficient model, the PolgD257A mutator mice (D257A), was used. POLG is […]
Allicin Mitigates Diabetic Retinopathy in Rats by Activating Phosphatase and Tensin Homolog-induced Kinase 1/Parkin-mitophagy and Inhibiting Oxidative Stress-mediated NOD-like Receptor Family Pyrin Domain Containing 3 Inflammasome
J Physiol Investig. 2024 Jul 1;67(4):215-224. doi: 10.4103/ejpi.EJPI-D-24-00039. Epub 2024 Aug 29. ABSTRACT Diabetic retinopathy (DR) is one of the significant disabling outcomes of diabetes mellitus characterized by retinal microvascular damage, inflammation, and neuronal dysfunction. Allicin (Alc), a natural compound found in garlic, has garnered attention for its antioxidant and anti-inflammatory properties, positioning it as […]
NAD+ and Niacin Supplementation as Possible Treatments for Glaucoma and Age-Related Macular Degeneration: A Narrative Review
Nutrients. 2024 Aug 21;16(16):2795. doi: 10.3390/nu16162795. ABSTRACT Glaucoma and age-related macular degeneration (AMD) are progressive retinal diseases characterized by increased oxidative stress, inflammation, and mitochondrial dysfunction. This review investigates the potential therapeutic benefits of NAD+ and niacin supplementation in managing glaucoma and AMD. A literature search was conducted encompassing keywords such as “niacin”, “NAD”, “glaucoma”, […]
The benzoylphenylurea derivative BPU17 acts as an inhibitor of prohibitin and exhibits antifibrotic activity
Exp Cell Res. 2024 Aug 23:114221. doi: 10.1016/j.yexcr.2024.114221. Online ahead of print. ABSTRACT Inflammation-induced choroidal neovascularization followed by the epithelial-mesenchymal transition (EMT) of retinal pigment epithelial cells (RPEs) is a cause of neovascular age-related macular degeneration (nAMD). RPE-derived myofibroblasts overproduce extracellular matrix, leading to subretinal fibrosis. We already have demonstrated that benzylphenylurea (BPU) derivatives inhibit […]
The novel secretome ST266 activates Akt and protects against oxidative stress-mediated injury in human RPE and Müller cells
Exp Eye Res. 2024 Aug 23:110060. doi: 10.1016/j.exer.2024.110060. Online ahead of print. ABSTRACT Oxidative stress-mediated retinal pigment epithelial (RPE) cell damage is associated with age-related macular degeneration (AMD). ST266 is the biological secretome produced by a novel population of amnion-derived multipotent progenitor cells. Herein, we investigated the effect of ST266 on RPE cell injury induced […]
MitoQ relieves mitochondrial dysfunction in UVA and cigarette smoke-induced Fuchs endothelial corneal dystrophy
Exp Eye Res. 2024 Aug 21:110056. doi: 10.1016/j.exer.2024.110056. Online ahead of print. ABSTRACT Fuchs endothelial corneal dystrophy (FECD), a degenerative corneal condition, is characterized by the droplet-like accumulation of the extracellular matrix, known as guttae and progressive loss of corneal endothelial cells ultimately leading to visual distortion and glare. FECD can be influenced by environmental […]
Drosophila model to clarify the pathological significance of OPA1 in autosomal dominant optic atrophy
Elife. 2024 Aug 23;12:RP87880. doi: 10.7554/eLife.87880. ABSTRACT Autosomal dominant optic atrophy (DOA) is a progressive form of blindness caused by degeneration of retinal ganglion cells and their axons, mainly caused by mutations in the OPA1 mitochondrial dynamin like GTPase (OPA1) gene. OPA1 encodes a dynamin-like GTPase present in the mitochondrial inner membrane. When associated with […]
Gastrodin ameliorates oxidative stress-induced RPE damage by facilitating autophagy and phagocytosis through PPARα-TFEB/CD36 signal pathway
Free Radic Biol Med. 2024 Aug 20:S0891-5849(24)00616-6. doi: 10.1016/j.freeradbiomed.2024.08.023. Online ahead of print. ABSTRACT Age-related macular degeneration (AMD), the leading cause of irreversible blindness in the elderly, is primarily characterized by the degeneration of the retinal pigment epithelium (RPE). However, effective therapeutic options for dry AMD are currently lacking, necessitating further exploration into preventive and […]
Restoration of defective oxidative phosphorylation to a subset of neurons prevents mitochondrial encephalopathy
EMBO Mol Med. 2024 Aug 21. doi: 10.1038/s44321-024-00111-4. Online ahead of print. ABSTRACT Oxidative Phosphorylation (OXPHOS) defects can cause severe encephalopathies and no effective treatment exists for these disorders. To assess the ability of gene replacement to prevent disease progression, we subjected two different CNS-deficient mouse models (Ndufs3/complex I or Cox10/complex IV conditional knockouts) to […]