Gastrodin ameliorates oxidative stress-induced RPE damage by facilitating autophagy and phagocytosis through PPARα-TFEB/CD36 signal pathway
Free Radic Biol Med. 2024 Aug 20:S0891-5849(24)00616-6. doi: 10.1016/j.freeradbiomed.2024.08.023. Online ahead of print. ABSTRACT Age-related macular degeneration (AMD), the leading cause of irreversible blindness in the elderly, is primarily characterized by the degeneration of the retinal pigment epithelium (RPE). However, effective therapeutic options for dry AMD are currently lacking, necessitating further exploration into preventive and […]
Restoration of defective oxidative phosphorylation to a subset of neurons prevents mitochondrial encephalopathy
EMBO Mol Med. 2024 Aug 21. doi: 10.1038/s44321-024-00111-4. Online ahead of print. ABSTRACT Oxidative Phosphorylation (OXPHOS) defects can cause severe encephalopathies and no effective treatment exists for these disorders. To assess the ability of gene replacement to prevent disease progression, we subjected two different CNS-deficient mouse models (Ndufs3/complex I or Cox10/complex IV conditional knockouts) to […]
Human rod photoreceptor outer segments are supported by accessory inner segment structures
bioRxiv [Preprint]. 2024 Aug 10:2024.08.09.607370. doi: 10.1101/2024.08.09.607370. ABSTRACT The first steps in vision take place in photoreceptor cells, which are highly compartmentalized neurons exhibiting significant structural variation across species. The light-sensitive ciliary compartment, called the outer segment, is located atop of the cell soma, called the inner segment. In this study, we present an ultrastructural […]
Sodium-Iodate Injection Can Replicate Retinal and Choroid Degeneration in Pigmented Mice: Using Multimodal Imaging and Label-free Quantitative Proteomics analysis
Exp Eye Res. 2024 Aug 14:110050. doi: 10.1016/j.exer.2024.110050. Online ahead of print. ABSTRACT Age-related macular degeneration (AMD) is the leading cause of irreversible visual loss in the elderly population. Sodium iodate (NaIO3), a stable oxidizing agent, has been injected to establish a reproducible model of oxidative stress-induced RPE and photoreceptor death. The aim of our […]
Artesunate induces HO-1-mediated cell cycle arrest and senescence to protect against ocular fibrosis
Int Immunopharmacol. 2024 Aug 15;141:112882. doi: 10.1016/j.intimp.2024.112882. Online ahead of print. ABSTRACT Recent research found artesunate could inhibit ocular fibrosis; however, the underlying mechanisms are not fully known. Since the ocular fibroblast is the main effector cell in fibrosis, we hypothesized that artesunate may exert its protective effects by inhibiting the fibroblasts proliferation. TGF-β1-induced ocular […]
Clinical outcomes of radial optic neurotomy versus pars plana vitrectomy in recent onset non-arteritic anterior ischemic optic neuropathy
Eur J Ophthalmol. 2024 Aug 16:11206721241272194. doi: 10.1177/11206721241272194. Online ahead of print. ABSTRACT INTRODUCTION: This study investigated the effect of pars plana vitrectomy (VIT) versus pars plana vitrectomy combined with radial optic neurotomy (RON) on recent onset non-arteritic anterior ischemic optic neuropathy (NAION). METHODS: In this prospective interventional case series, individuals with recent-onset NAION, lower […]
Accumulation of branched-chain amino acids deteriorates the neuroinflammatory response of Müller cells in diabetic retinopathy via leucine/Sestrin2-mediated sensing of mTOR signaling
Acta Diabetol. 2024 Aug 16. doi: 10.1007/s00592-024-02349-3. Online ahead of print. ABSTRACT AIMS: This study aimed to investigate branched-chain amino acid (BCAA) catabolism in diabetic retinopathy (DR). METHODS: Wild-type and db/db mice were fed BCAAs (5 or 10 mg/kg/day) for 12 weeks, and hyperglycemia-exposed Müller cells were treated with BCAAs (2 or 5 mmol/L) for […]
The genomic mosaic of mitochondrial dysfunction: Decoding nuclear and mitochondrial epigenetic contributions to maternally inherited diabetes and deafness pathogenesis
Heliyon. 2024 Jul 17;10(14):e34756. doi: 10.1016/j.heliyon.2024.e34756. eCollection 2024 Jul 30. ABSTRACT AIMS: Maternally inherited diabetes and deafness (MIDD) is a complex disorder characterized by multiorgan clinical manifestations, including diabetes, hearing loss, and ophthalmic complications. This pilot study aimed to elucidate the intricate interplay between nuclear and mitochondrial genetics, epigenetic modifications, and their potential implications in […]
Photobiomodulation efficacy in age-related macular degeneration: a systematic review and meta-analysis of randomized clinical trials
Int J Retina Vitreous. 2024 Aug 15;10(1):54. doi: 10.1186/s40942-024-00569-x. ABSTRACT BACKGROUND: Age-related macular degeneration (AMD) is a leading cause of vision loss. Photobiomodulation (PBM) offers a controversial approach for managing dry AMD, aiming to halt or reverse progression through mitochondrial activity modulation. However, the efficacy and clinical relevance of PBM as a potential approach for […]
Dysregulation of mitochondria, apoptosis and mitophagy in Leber’s hereditary optic neuropathy with MT-ND1 3635G>A mutation
Gene. 2024 Aug 13:148853. doi: 10.1016/j.gene.2024.148853. Online ahead of print. ABSTRACT Leber’s hereditary optic neuropathy (LHON) is a maternal inherited disorder, primarily due to mitochondrial DNA (mtDNA) mutations. This investigation aimed to assess the pathogenicity of m.3635G>A alteration known to confer susceptibility to LHON. The disruption of electrostatic interactions among S110 of the MT-ND1 and […]