Generation of an Armcx1 Conditional Knockout Mouse
Genesis. 2024 Aug;62(4):e23615. doi: 10.1002/dvg.23615. ABSTRACT Armadillo repeat-containing X-linked protein-1 (Armcx1) is a poorly characterized transmembrane protein that regulates mitochondrial transport in neurons. Its overexpression has been shown to induce neurite outgrowth in embryonic neurons and to promote retinal ganglion cell (RGC) survival and axonal regrowth in a mouse optic nerve crush model. In order […]
High-throughput ultrastructural analysis of macular telangiectasia type 2
Front Ophthalmol (Lausanne). 2024 Jul 30;4:1428777. doi: 10.3389/fopht.2024.1428777. eCollection 2024. ABSTRACT INTRODUCTION: Macular Telangiectasia type 2 (MacTel), is an uncommon form of late-onset, slowly-progressive macular degeneration. Associated with regional Müller glial cell loss in the retina and the amino acid serine synthesized by Müller cells, the disease is functionally confined to a central retinal region […]
Inherited mitochondrial dysfunction triggered by OPA1 mutation impacts the sensory innervation fibre identity, functionality and regenerative potential in the cornea
Sci Rep. 2024 Aug 13;14(1):18794. doi: 10.1038/s41598-024-68994-4. ABSTRACT Mitochondrial dysfunctions are detrimental to organ metabolism. The cornea, transparent outmost layer of the eye, is prone to environmental aggressions, such as UV light, and therefore dependent on adequate mitochondrial function. While several reports have linked corneal defects to mitochondrial dysfunction, the impact of OPA1 mutation, known […]
MSC-mediated mitochondrial transfer restores mitochondrial DNA and function in neural progenitor cells of Leber’s hereditary optic neuropathy
Sci China Life Sci. 2024 Aug 8. doi: 10.1007/s11427-024-2647-8. Online ahead of print. ABSTRACT Leber’s hereditary optic neuropathy (LHON) is a debilitating mitochondrial disease associated with mutations in mitochondrial DNA (mtDNA). Unfortunately, the available treatment options for LHON patients are limited due to challenges in mitochondrial replacement. In our study, we reprogramming LHON urine cells […]
Effects of Acute High-Altitude Exposure on Morphology and Function of Retinal Ganglion Cell in Mice
Invest Ophthalmol Vis Sci. 2024 Aug 1;65(10):19. doi: 10.1167/iovs.65.10.19. ABSTRACT PURPOSE: High altitude retinopathy (HAR) is a retinal functional disorder caused by inadequate adaptation after exposure to high altitude. However, the cellular and molecular mechanisms underlying retinal dysfunction remain elusive. Retinal ganglion cell (RGC) injury is the most important pathological basis for most retinal and […]
Melanin-Like Nanomedicine Functions as a Novel RPE Ferroptosis Inhibitor to Ameliorate Retinal Degeneration and Visual Impairment in Dry Age-Related Macular Degeneration
Adv Healthc Mater. 2024 Aug 11:e2401613. doi: 10.1002/adhm.202401613. Online ahead of print. ABSTRACT Ferrous ion accumulation and lethal oxidative stress mediate irreversible retinal pigment epithelial (RPE) cell ferroptosis and subsequent photoreceptor degeneration, a potential key pathogenic factor in the onset of dry age-related macular degeneration (dAMD), causing irreversible vision loss in the global elderly population. […]
Inducible RPE-specific GPX4 knockout causes oxidative stress and retinal degeneration with features of age-related macular degeneration
Exp Eye Res. 2024 Aug 9:110028. doi: 10.1016/j.exer.2024.110028. Online ahead of print. ABSTRACT Age-related macular degeneration (AMD) is one of the leading causes of vision loss in the elderly. This disease involves oxidative stress burden in the retina leading to death of retinal pigment epithelial (RPE) cells and photoreceptors. The retina is susceptible to oxidative […]
Intraocular fatty acids induce reinforcement of barrier functions on the outer blood-retinal barrier
Prostaglandins Leukot Essent Fatty Acids. 2024 Aug 8;202:102637. doi: 10.1016/j.plefa.2024.102637. Online ahead of print. ABSTRACT The aim of the present study was to elucidate unknown effects of intraocular fatty acids (ioFAs) including palmitic acid (C16:0), stearic acid (C18:0), oleic acid (C18:1), linoleic acid (C18:2), arachidonic acid (C20:4), eicosapentaenoic acid (EPA, C20:5) and docosahexaenoic acid (DHA, […]
Dynasore Modulates Store-Operated Calcium Entry and Mitochondrial Calcium Release in Corneal Epithelial Cells
Exp Eye Res. 2024 Aug 8:110029. doi: 10.1016/j.exer.2024.110029. Online ahead of print. ABSTRACT Dysregulation of calcium homeostasis can precipitate a cascade of pathological events that lead to tissue damage and cell death. Dynasore is a small molecule that inhibits endocytosis by targeting classic dynamins. In a previous study, we showed that dynasore can protect human […]
Inhibition of angiogenesis by the secretome from iPSC-derived retinal ganglion cells with Leber’s hereditary optic neuropathy-like phenotypes
Biomed Pharmacother. 2024 Aug 9;178:117270. doi: 10.1016/j.biopha.2024.117270. Online ahead of print. ABSTRACT The blood supply in the retina ensures photoreceptor function and maintains regular vision. Leber’s hereditary optic neuropathy (LHON), caused by the mitochondrial DNA mutations that deteriorate complex I activity, is characterized by progressive vision loss. Although some reports indicated retinal vasculature abnormalities as […]