The Scavenging Activity of Coenzyme Q10 Plus a Nutritional Complex on Human Retinal Pigment Epithelial Cells
Int J Mol Sci. 2024 Jul 24;25(15):8070. doi: 10.3390/ijms25158070. ABSTRACT Age-related macular degeneration (AMD) and diabetic retinopathy (DR) are common retinal diseases responsible for most blindness in working-age and elderly populations. Oxidative stress and mitochondrial dysfunction play roles in these pathogenesis, and new therapies counteracting these contributors could be of great interest. Some molecules, like […]
PDK4-mediated metabolic reprogramming is a potential therapeutic target for neovascular age-related macular degeneration
Cell Death Dis. 2024 Aug 9;15(8):582. doi: 10.1038/s41419-024-06968-0. ABSTRACT Age-related macular degeneration (AMD) causes severe blindness in the elderly due to choroidal neovascularization (CNV), which results from the dysfunction of the retinal pigment epithelium (RPE). While normal RPE depends exclusively on mitochondrial oxidative phosphorylation for energy production, the inflammatory conditions associated with metabolic reprogramming of […]
Pericyte loss via glutaredoxin2 downregulation aggravates diabetes-induced microvascular dysfunction
Exp Eye Res. 2024 Aug 6:110025. doi: 10.1016/j.exer.2024.110025. Online ahead of print. ABSTRACT Diabetic retinopathy (DR) is the leading cause of vision loss and blindness among working-age adults. Pericyte loss is an early pathological feature of DR. Under hyperglycemic conditions, reactive oxygen species (ROS) production increases, leading to oxidative stress and subsequent mitochondrial dysfunction and […]
TRB3 Promotes Cataract Progression through Endoplasmic Reticulum Stress-mediated Mitochondrial Dysfunction and Cell Apoptosis
Cell Biochem Biophys. 2024 Aug 8. doi: 10.1007/s12013-024-01470-y. Online ahead of print. ABSTRACT Cataracts are characterized as a disease affecting lens opacity. Endoplasmic reticulum (ER) stress can cause lens epithelial cell (LEC) dysfunction, affecting normal lens transparency and function, but the role of Tribbles 3 (TRB3), an inducible gene of ER stress, in cataracts is […]
Cytosolic protein translation regulates cell asymmetry and function in early TCR activation of human CD8+ T lymphocytes
Front Immunol. 2024 Jul 24;15:1411957. doi: 10.3389/fimmu.2024.1411957. eCollection 2024. ABSTRACT INTRODUCTION: CD8+ cytotoxic T lymphocytes (CTLs) are highly effective in defending against viral infections and tumours. They are activated through the recognition of peptide-MHC-I complex by the T-cell receptor (TCR) and co-stimulation. This cognate interaction promotes the organisation of intimate cell-cell connections that involve cytoskeleton […]
Glutamine is the only amino acid that can adequately support the generation of NADPH in rod photoreceptors
Exp Eye Res. 2024 Aug 5:110018. doi: 10.1016/j.exer.2024.110018. Online ahead of print. ABSTRACT NADPH, the primary source of reducing equivalents in the cytosol, is used in vertebrate rod photoreceptor outer segments to reduce the all-trans retinal released from photoactivated visual pigment to all-trans retinol. Light activation of the visual pigment isomerizes the 11-cis retinal chromophore […]
Minocycline alleviates microglia ferroptosis by inhibiting HO-1 during cerebral ischemia-reperfusion injury
Inflamm Res. 2024 Aug 7. doi: 10.1007/s00011-024-01927-z. Online ahead of print. ABSTRACT OBJECTIVE: Ischemic stroke is a leading cause of death and disability in individuals worldwide. Cerebral ischemia-reperfusion injury (CIRI) typically results in severe secondary injury and complications following reperfusion therapy. Microglia play critical roles in the inflammatory reaction of CIRI. However, less attention has […]
Evolution of therapeutic strategy based on oxidant-antioxidant balance for Fuchs endothelial corneal dystrophy
Ocul Surf. 2024 Aug 5:S1542-0124(24)00083-1. doi: 10.1016/j.jtos.2024.08.003. Online ahead of print. ABSTRACT Fuchs endothelial corneal dystrophy (FECD) stands as the most prevalent primary corneal endothelial dystrophy worldwide, posing a significant risk to corneal homeostasis and clarity. Corneal endothelial cells exhibit susceptibility to oxidative stress, suggesting a nuanced relationship between oxidant-antioxidant imbalance and FECD pathogenesis, irrespective […]
Integrated Histological and Molecular Analysis of Filarial Species and Associated Wolbachia Endosymbionts in Human Filariasis Cases Presenting Atypically in Thailand
Am J Trop Med Hyg. 2024 Aug 6:tpmd240147. doi: 10.4269/ajtmh.24-0147. Online ahead of print. ABSTRACT Atypical presentations of filariasis have posed diagnostic challenges due to the complexity of identifying the causative species and the difficulties in both diagnosis and treatment. In this study, we present the integrative histological and molecular analysis of seven atypical filariasis […]
Novel Variant of FDXR as a Molecular Etiology of Postlingual Post-Synaptic Auditory Neuropathy Spectrum Disorder via Mitochondrial Dysfunction: Reiteration of the Correlation between Genotype and Cochlear Implantation Outcomes
Clin Exp Otorhinolaryngol. 2024 Aug 6. doi: 10.21053/ceo.2024.00184. Online ahead of print. ABSTRACT OBJECTIVES: FDXR encodes the mitochondrial ferredoxin reductase, which is associated with auditory neuropathy spectrum disorder (ANSD) and optic atrophy. Only two studies have described FDXRrelated hearing loss. The auditory rehabilitation outcomes of this disease entity have not been investigated, and the pathophysiologic […]