Glial Cell Activation and Immune Responses in Glaucoma: A Systematic Review of Human Postmortem Studies of the Retina and Optic Nerve
Aging Dis. 2024 Mar 2. doi: 10.14336/AD.2024.0103. Online ahead of print. ABSTRACT Although researched extensively the understanding regarding mechanisms underlying glaucoma pathogenesis remains limited. Further, the exact mechanism behind neuronal death remains elusive. The role of neuroinflammation in retinal ganglion cell (RGC) death has been prominently theorised. This review provides a comprehensive summary of neuroinflammatory […]
Quantifying nanoscopic alterations associated with mitochondrial dysfunction using three-dimensional single-molecule localization microscopy
Biomed Opt Express. 2024 Feb 12;15(3):1571-1584. doi: 10.1364/BOE.510351. eCollection 2024 Mar 1. ABSTRACT Mitochondrial morphology provides unique insights into their integrity and function. Among fluorescence microscopy techniques, 3D super-resolution microscopy uniquely enables the analysis of mitochondrial morphological features individually. However, there is a lack of tools to extract morphological parameters from super-resolution images of mitochondria. […]
p38 MAPK inhibitor SB202190 suppresses ferroptosis in the glutamate-induced retinal excitotoxicity glaucoma model
Neural Regen Res. 2024 Oct 1;19(10):2299-2309. doi: 10.4103/1673-5374.391193. Epub 2023 Dec 21. ABSTRACT JOURNAL/nrgr/04.03/01300535-202410000-00031/figure1/v/2024-02-06T055622Z/r/image-tiff Glutamate excitotoxicity has been shown to play an important role in glaucoma, and glutamate can induce ferroptosis. The p38 mitogen-activated protein kinase (MAPK) pathway inhibitor SB202190 has a potential ability to suppress ferroptosis, and its downstream targets, such as p53, have […]
Acetazolamide Challenge Changes Outer Retina Bioenergy-Linked and Anatomical OCT Biomarkers Depending on Mouse Strain
Invest Ophthalmol Vis Sci. 2024 Mar 5;65(3):21. doi: 10.1167/iovs.65.3.21. ABSTRACT PURPOSE: The purpose of this study was to test the hypothesis that optical coherence tomography (OCT) bioenergy-linked and anatomical biomarkers are responsive to an acetazolamide (ACZ) provocation. METHODS: C57BL/6J mice (B6J, a strain with relatively inefficient mitochondria) and 129S6/ev mice (S6, a strain with relatively […]
Curcumin relieves oxaliplatin-induced neuropathic pain via reducing inflammation and activating antioxidant response
Cell Biol Int. 2024 Mar 13. doi: 10.1002/cbin.12153. Online ahead of print. ABSTRACT Oxaliplatin (OXA) has shown high effectiveness in the treatment of cancers, but its anticancer clinical effects often induce neurotoxicity leading to neuropathic pain. Oxidative damage and NLRP3 inflammasome play important roles in neuropathic pain development. Here, neuropathic pain mouse model was constructed […]
Digenic Leigh syndrome on the background of the m.11778G>A Leber hereditary optic neuropathy variant
Brain. 2024 Mar 13:awae057. doi: 10.1093/brain/awae057. Online ahead of print. ABSTRACT Leigh syndrome spectrum (LSS) is a primary mitochondrial disorder defined neuropathologically by a subacute necrotizing encephalomyelopathy and characterised by bilateral basal ganglia and/or brainstem lesions. LSS is associated with variants in several mitochondrial DNA (mtDNA) genes and more than 100 nuclear genes, most often […]
Chlorine-Induced Toxicity on Murine Cornea: Exploring the Potential Therapeutic Role of Antioxidants
Cells. 2024 Mar 5;13(5):458. doi: 10.3390/cells13050458. ABSTRACT Chlorine (Cl2) exposure poses a significant risk to ocular health, with the cornea being particularly susceptible to its corrosive effects. Antioxidants, known for their ability to neutralize reactive oxygen species (ROS) and alleviate oxidative stress, were explored as potential therapeutic agents to counteract chlorine-induced damage. In vitro experiments […]
Peripapillary retinal nerve fibre layer thinning, perfusion changes and optic neuropathy in carriers of Leber hereditary optic neuropathy-associated mitochondrial variants
BMJ Open Ophthalmol. 2024 Mar 11;9(1):e001295. doi: 10.1136/bmjophth-2023-001295. ABSTRACT BACKGROUND: We investigated Leber hereditary optic neuropathy (LHON) families for variation in peripapillary retinal nerve fibre layer thickness and perfusion, and associated optic nerve dysfunction. METHOD: A group of LHON-affected patients (n=12) and their asymptomatic maternal relatives (n=16) underwent examination including visual acuity (VA), visual-evoked-potential and […]
Drp1-dependent mitochondrial fragmentation mediates photoreceptor abnormalities in type 1 diabetic retina
Exp Eye Res. 2024 Mar 9:109860. doi: 10.1016/j.exer.2024.109860. Online ahead of print. ABSTRACT Recent studies have highlighted that retinal neurodegeneration precedes microvascular changes in diabetic retinopathy (DR), but the specific mechanisms remain unclear. Given the pivotal role of dysfunctional mitochondria and oxidative stress in early DR, our objective was to observe mitochondria-related alterations in the […]
A recurrent missense variant in the E3 ubiquitin ligase substrate recognition subunit FEM1B causes a rare syndromic neurodevelopmental disorder
Genet Med. 2024 Mar 7:101119. doi: 10.1016/j.gim.2024.101119. Online ahead of print. ABSTRACT PURPOSE: FEM1B acts as a substrate recognition subunit for ubiquitin ligase complexes belonging to the CRL2 E3 family. Several biological functions have been proposed for FEM1B, including a structurally resolved function as a sensor for redox cell status by controlling mitochondrial activity, but […]