The benzoylphenylurea derivative BPU17 acts as an inhibitor of prohibitin and exhibits antifibrotic activity
Exp Cell Res. 2024 Aug 23:114221. doi: 10.1016/j.yexcr.2024.114221. Online ahead of print. ABSTRACT Inflammation-induced choroidal neovascularization followed by the epithelial-mesenchymal transition (EMT) of retinal pigment epithelial cells (RPEs) is a cause of neovascular age-related macular degeneration (nAMD). RPE-derived myofibroblasts overproduce extracellular matrix, leading to subretinal fibrosis. We already have demonstrated that benzylphenylurea (BPU) derivatives inhibit […]
The novel secretome ST266 activates Akt and protects against oxidative stress-mediated injury in human RPE and Müller cells
Exp Eye Res. 2024 Aug 23:110060. doi: 10.1016/j.exer.2024.110060. Online ahead of print. ABSTRACT Oxidative stress-mediated retinal pigment epithelial (RPE) cell damage is associated with age-related macular degeneration (AMD). ST266 is the biological secretome produced by a novel population of amnion-derived multipotent progenitor cells. Herein, we investigated the effect of ST266 on RPE cell injury induced […]
MitoQ relieves mitochondrial dysfunction in UVA and cigarette smoke-induced Fuchs endothelial corneal dystrophy
Exp Eye Res. 2024 Aug 21:110056. doi: 10.1016/j.exer.2024.110056. Online ahead of print. ABSTRACT Fuchs endothelial corneal dystrophy (FECD), a degenerative corneal condition, is characterized by the droplet-like accumulation of the extracellular matrix, known as guttae and progressive loss of corneal endothelial cells ultimately leading to visual distortion and glare. FECD can be influenced by environmental […]
Drosophila model to clarify the pathological significance of OPA1 in autosomal dominant optic atrophy
Elife. 2024 Aug 23;12:RP87880. doi: 10.7554/eLife.87880. ABSTRACT Autosomal dominant optic atrophy (DOA) is a progressive form of blindness caused by degeneration of retinal ganglion cells and their axons, mainly caused by mutations in the OPA1 mitochondrial dynamin like GTPase (OPA1) gene. OPA1 encodes a dynamin-like GTPase present in the mitochondrial inner membrane. When associated with […]
Gastrodin ameliorates oxidative stress-induced RPE damage by facilitating autophagy and phagocytosis through PPARα-TFEB/CD36 signal pathway
Free Radic Biol Med. 2024 Aug 20:S0891-5849(24)00616-6. doi: 10.1016/j.freeradbiomed.2024.08.023. Online ahead of print. ABSTRACT Age-related macular degeneration (AMD), the leading cause of irreversible blindness in the elderly, is primarily characterized by the degeneration of the retinal pigment epithelium (RPE). However, effective therapeutic options for dry AMD are currently lacking, necessitating further exploration into preventive and […]
Restoration of defective oxidative phosphorylation to a subset of neurons prevents mitochondrial encephalopathy
EMBO Mol Med. 2024 Aug 21. doi: 10.1038/s44321-024-00111-4. Online ahead of print. ABSTRACT Oxidative Phosphorylation (OXPHOS) defects can cause severe encephalopathies and no effective treatment exists for these disorders. To assess the ability of gene replacement to prevent disease progression, we subjected two different CNS-deficient mouse models (Ndufs3/complex I or Cox10/complex IV conditional knockouts) to […]
Human rod photoreceptor outer segments are supported by accessory inner segment structures
bioRxiv [Preprint]. 2024 Aug 10:2024.08.09.607370. doi: 10.1101/2024.08.09.607370. ABSTRACT The first steps in vision take place in photoreceptor cells, which are highly compartmentalized neurons exhibiting significant structural variation across species. The light-sensitive ciliary compartment, called the outer segment, is located atop of the cell soma, called the inner segment. In this study, we present an ultrastructural […]
Sodium-Iodate Injection Can Replicate Retinal and Choroid Degeneration in Pigmented Mice: Using Multimodal Imaging and Label-free Quantitative Proteomics analysis
Exp Eye Res. 2024 Aug 14:110050. doi: 10.1016/j.exer.2024.110050. Online ahead of print. ABSTRACT Age-related macular degeneration (AMD) is the leading cause of irreversible visual loss in the elderly population. Sodium iodate (NaIO3), a stable oxidizing agent, has been injected to establish a reproducible model of oxidative stress-induced RPE and photoreceptor death. The aim of our […]
Artesunate induces HO-1-mediated cell cycle arrest and senescence to protect against ocular fibrosis
Int Immunopharmacol. 2024 Aug 15;141:112882. doi: 10.1016/j.intimp.2024.112882. Online ahead of print. ABSTRACT Recent research found artesunate could inhibit ocular fibrosis; however, the underlying mechanisms are not fully known. Since the ocular fibroblast is the main effector cell in fibrosis, we hypothesized that artesunate may exert its protective effects by inhibiting the fibroblasts proliferation. TGF-β1-induced ocular […]
Clinical outcomes of radial optic neurotomy versus pars plana vitrectomy in recent onset non-arteritic anterior ischemic optic neuropathy
Eur J Ophthalmol. 2024 Aug 16:11206721241272194. doi: 10.1177/11206721241272194. Online ahead of print. ABSTRACT INTRODUCTION: This study investigated the effect of pars plana vitrectomy (VIT) versus pars plana vitrectomy combined with radial optic neurotomy (RON) on recent onset non-arteritic anterior ischemic optic neuropathy (NAION). METHODS: In this prospective interventional case series, individuals with recent-onset NAION, lower […]