Category: Ophthalmology AND mitochondrial

Protective effect of apelin-13 in lens epithelial cells via inhibiting oxidative stress-induced apoptosis

BMC Ophthalmol. 2024 Nov 4;24(1):479. doi: 10.1186/s12886-024-03746-6. ABSTRACT BACKGROUND: It is widely accepted that glaucoma-induced oxidative stress expedites cataracts’ process. Therefore, we examined the effects of apelin-13 against oxidative stress-induced damage in human lens epithelial cells (HLECs) and investigated the potential pathogenic mechanism of acute primary angle-closure glaucoma. METHODS: This experiment included five groups: control, […]

N6-methyladenosine and its epitranscriptomic effects on hematopoietic stem cell regulation and leukemogenesis

Mol Med. 2024 Nov 4;30(1):196. doi: 10.1186/s10020-024-00965-x. ABSTRACT N6-methyladenosine (m6A) RNA modification orchestrates cellular epitranscriptome through tuning the homeostasis of transcript stability, translation efficiency, and the transcript affinity toward RNA-binding proteins (RBPs). An aberrant m6A deposition on RNA can lead toward oncogenic expression profile (mRNA), impaired mitochondrial metabolism (mtRNA), and translational suppression (rRNA) of tumor […]

Treatment of Conjunctival Melanoma Cell Lines With a Light-Activated Virus-Like Drug Conjugate Induces Immunogenic Cell Death

Invest Ophthalmol Vis Sci. 2024 Nov 4;65(13):3. doi: 10.1167/iovs.65.13.3. ABSTRACT PURPOSE: Conjunctival melanoma (CJM) is a rare malignant ocular surface tumor, which often leads to local recurrences and metastases. In murine models of subcutaneous tumors, treatment with a novel virus-like drug conjugate (VDC; Bel-sar) showed a dual mechanism of action with direct tumor cell killing […]

The Complement Factor H (Y402H) risk polymorphism for age-related macular degeneration affects metabolism and response to oxidative stress in the retinal pigment epithelium

Free Radic Biol Med. 2024 Nov 2:S0891-5849(24)01015-3. doi: 10.1016/j.freeradbiomed.2024.10.307. Online ahead of print. ABSTRACT Age-related macular degeneration (AMD), the leading cause of central vision loss in the elderly, involves death of the retinal pigment epithelium (RPE) and light-sensing photoreceptors. This multifactorial disease includes contributions from both genetic and environmental risk factors. The current study examined […]

SIRT3 mitigates high glucose-induced damage in retinal microvascular endothelial cells via OPA1-mediated mitochondrial dynamics

Exp Cell Res. 2024 Nov 2:114320. doi: 10.1016/j.yexcr.2024.114320. Online ahead of print. ABSTRACT Oxidative stress in endothelial cells is pivotal in diabetic retinopathy (DR), with mitochondrial homeostasis being crucial to mitigate this stress. This study explored the roles of mitochondrial sirtuins (SIRTs) in high glucose (HG)-induced oxidative stress, related endothelial impairment, and mitochondrial homeostasis damage […]

Integrative multiomic analysis unveils the molecular nexus of mitochondrial dysfunction in the pathogenesis of age-related macular degeneration

Exp Eye Res. 2024 Oct 26:110141. doi: 10.1016/j.exer.2024.110141. Online ahead of print. ABSTRACT Mitochondrial dysfunction is linked to age-related macular degeneration (AMD), but its mechanisms and related molecular networks remain unclear. We explored the association between mitochondrial-related genes and AMD by integrating multiomic data. We acquired summary-level data on mitochondrial-related protein abundance, gene expression, and […]

Association of optic disc drusen and small scleral canals – A systematic review and meta-analysis

Eye (Lond). 2024 Nov 2. doi: 10.1038/s41433-024-03451-0. Online ahead of print. ABSTRACT The pathophysiology of optic disc drusen (ODD) has long been discussed. According to one leading theory, they develop from calcified mitochondria extruded from axons compressed by an unusually small scleral canal. To examine this hypothesis, we conducted a systematic review and meta-analysis evaluating […]

AARS2-Related Disorder

2024 Oct 31. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. ABSTRACT CLINICAL CHARACTERISTICS: AARS2-related disorder includes two distinct phenotypes, infantile-onset cardiomyopathy and neurodegeneration with or without leukoencephalopathy. AARS2-related infantile-onset cardiomyopathy is characterized by hypertrophic cardiomyopathy, hypotonia, skeletal myopathy, and […]

Hexokinase 2 senses fructose in tumor-associated macrophages to promote colorectal cancer growth

Cell Metab. 2024 Oct 24:S1550-4131(24)00398-X. doi: 10.1016/j.cmet.2024.10.002. Online ahead of print. ABSTRACT Fructose is associated with colorectal cancer tumorigenesis and metastasis through ketohexokinase-mediated metabolism in the colorectal epithelium, yet its role in the tumor immune microenvironment remains largely unknown. Here, we show that a modest amount of fructose, without affecting obesity and associated complications, promotes […]