Reprogramming patient-iPSC specific retinal organoids for deciphering epigenetic modifications of RNA methylation
J Chin Med Assoc. 2024 Dec 23. doi: 10.1097/JCMA.0000000000001198. Online ahead of print. ABSTRACT BACKGROUND: Induced pluripotent stem cell (iPSC) technology has emerged as a powerful tool for disease modeling, providing an innovative platform for investigating disease mechanisms. iPSC-derived organoids, including retinal organoids, offer patient-specific models that closely replicate in vivo cellular environments, making them […]
Taurine mechanism in preventing retinal cell damage from acute ocular hypertension through GTPBP3 regulation
Exp Eye Res. 2024 Dec 20:110222. doi: 10.1016/j.exer.2024.110222. Online ahead of print. ABSTRACT We aimed to explore the protective effects and underlying mechanisms of taurine on retinal cells during acute ocular hypertension (AOH)-induced damage. Retinal morphology, apoptosis, mitochondrial structure, electroretinography, expression of GTP binding protein 3 (GTPBP3), and molecules in the unfolded protein response (UPR) […]
PRDX4 mitigates diabetic retinopathy by inhibiting reactive gliosis, apoptosis, ER stress, oxidative stress, and mitochondrial dysfunction in Muller cells
J Biol Chem. 2024 Dec 18:108111. doi: 10.1016/j.jbc.2024.108111. Online ahead of print. ABSTRACT Diabetic retinopathy (DR) is a neurovascular complication of diabetes. As a crucial player in the retinal physiology, Müller cells are affected in DR, impairments of Müller cell function lead to retinal malfunctions. Therefore, searching for approaches to mitigate diabetes-induced injury in Müller […]
Clinical trials in Leber hereditary optic neuropathy: outcomes and opportunities
Curr Opin Neurol. 2024 Dec 23. doi: 10.1097/WCO.0000000000001343. Online ahead of print. ABSTRACT PURPOSE OF REVIEW: Leber hereditary optic neuropathy (LHON) is a mitochondrial DNA disease characterised by sequential bilateral vision loss due to loss of retinal ganglion cells. The purpose of this review is to provide an update on the results of recent clinical […]
Proteomic Alterations in Retinal Müller Glial Cells Lacking Interleukin-6 Receptor: A Comprehensive Analysis
Invest Ophthalmol Vis Sci. 2024 Dec 2;65(14):33. doi: 10.1167/iovs.65.14.33. ABSTRACT PURPOSE: Interleukin-6 (IL-6) is an inflammatory cytokine implicated in various retinal pathologies and functions primarily through two signaling pathways: cis-signaling via IL-6 binding to its membrane-bound receptor (IL-6Rα), and trans-signaling via IL-6 binding to soluble IL-6 receptor (sIL-6R). Because the differential effects of IL-6 signaling […]
Five-Year Outcomes of Lenadogene Nolparvovec Gene Therapy in Leber Hereditary Optic Neuropathy
JAMA Ophthalmol. 2024 Dec 19. doi: 10.1001/jamaophthalmol.2024.5375. Online ahead of print. ABSTRACT IMPORTANCE: Limited studies have assessed the long-term benefit/risk of gene therapy for Leber hereditary optic neuropathy (LHON). OBJECTIVE: To determine the safety and efficacy of lenadogene nolparvovec in patients with LHON due to the MT-ND4 gene variant for up to 5 years after […]
Transcriptomic analysis of plasma-derived small extracellular vesicles reveals the pathological characteristics of normal tension glaucoma
Extracell Vesicles Circ Nucl Acids. 2024 Aug 19;5(3):438-454. doi: 10.20517/evcna.2024.45. eCollection 2024. ABSTRACT AIM: Normal tension glaucoma (NTG) is a common optic neuropathy that can be challenging to diagnose due to the intraocular pressure remaining within the normal range. Early diagnosis and intervention are crucial for the effective lifelong management of patients. METHODS: This study […]
Role of PI3K/AKT/MAOA in glucocorticoid-induced oxidative stress and associated premature senescence of the trabecular meshwork
Aging Cell. 2024 Dec 17:e14452. doi: 10.1111/acel.14452. Online ahead of print. ABSTRACT The oxidative stress-induced premature senescence of trabecular meshwork (TM) represents a pivotal risk factor for the development of glucocorticoid-induced glaucoma (GIG). This study aimed to elucidate the pathogenesis of TM senescence in GIG. MethodsIntraocular pressure (IOP), transmission electron microscopy and senescence-associated protein expression […]
Mitochondrial Function and Oxidative Stress Biomarkers in Diabetic Retinopathy Development: An Analytical Cross-Sectional Study
Int J Mol Sci. 2024 Dec 5;25(23):13084. doi: 10.3390/ijms252313084. ABSTRACT DR is a complex complication of DM with multiple biochemical pathways implicated in its genesis and progression. Circulating OS and mitochondrial function biomarkers represent potential candidates in the DR staging system. We conducted a comparative cross-sectional study comparing the OS biomarkers: TAC, GR, NOS, CARB, […]
A Reduction in Mitophagy Is Associated with Glaucomatous Neurodegeneration in Rodent Models of Glaucoma
Int J Mol Sci. 2024 Dec 4;25(23):13040. doi: 10.3390/ijms252313040. ABSTRACT Glaucoma is a heterogenous group of optic neuropathies characterized by the degeneration of optic nerve axons and the progressive loss of retinal ganglion cells (RGCs), which could ultimately lead to vision loss. Elevated intraocular pressure (IOP) is a major risk factor in the development of […]