The role of mitochondrial dysfunction in the stabilization of the glaucomatous process
Vestn Oftalmol. 2024;140(4):49-58. doi: 10.17116/oftalma202414004149. ABSTRACT Many key aspects of retinal ganglion cell (RGC) neurodegeneration in glaucoma are associated with mitochondrial dysfunction. Understanding the mechanisms and relationships between structural and functional changes in mitochondria would be beneficial for developing mitochondria-targeted therapeutic strategies to protect RGCs from glaucomatous neurodegeneration. PURPOSE: This study determines the extent of […]
Comparative single-cell transcriptomic analysis across tissues of aging primates reveals specific autologous activation of ZNF281 to mitigate oxidative stress in cornea
Aging Cell. 2024 Sep 10:e14319. doi: 10.1111/acel.14319. Online ahead of print. ABSTRACT Reactive oxygen species (ROS) and oxidative stress accelerate cellular aging, but their impact on different tissues varies. The cornea, known for its robust antioxidant defense systems, is relatively resistant to age-related diseases like cancer. However, the precise mechanisms by which the cornea maintains […]
N-ACETYLCYSTEINE AMIDE AND DI- N-ACETYLCYSTEINE AMIDE PROTECT RETINAL CELLS IN CULTURE VIA AN ANTIOXIDANT ACTION
Exp Eye Res. 2024 Sep 7:110074. doi: 10.1016/j.exer.2024.110074. Online ahead of print. ABSTRACT Reactive oxygen species (ROS) play a significant role in toxicity to the retina in a variety of diseases. N-acetylcysteine (NAC), N-acetylcysteine amide (NACA) and the dimeric di-N-acetylcysteine amide (diNACA) were evaluated in terms of protecting retinal cells, in vitro, in a variety […]
Y and Mitochondrial Chromosomes in the Heterogeneous Stock Rat Population
G3 (Bethesda). 2024 Sep 9:jkae213. doi: 10.1093/g3journal/jkae213. Online ahead of print. ABSTRACT Genome-wide association studies typically evaluate the autosomes and sometimes the X Chromosome, but seldom consider the Y or mitochondrial Chromosomes. We genotyped the Y and mitochondrial Chromosomes in heterogeneous stock rats (Rattus norvegicus), an outbred population created from eight inbred strains. We identified […]
Elevated concentrations of amyloid-β oligomers and their proapoptotic effects on age-related cataract
FASEB J. 2024 Sep;38(17):e23861. doi: 10.1096/fj.202301281RR. ABSTRACT Recently, amyloid-β oligomers (AβOs) have been studied as the primary pathogenic substances in Alzheimer’s disease (AD). Our previous study revealed that the Aβ expression level is closely related to ARC progression. Here, we demonstrated that the accumulation of AβOs in the lens epithelium of age-related cataract (ARC) patients […]
Multifaceted mitochondrial as a novel therapeutic target in dry eye: insights and interventions
Cell Death Discov. 2024 Sep 6;10(1):398. doi: 10.1038/s41420-024-02159-0. ABSTRACT Dry eye, recognized as the most prevalent ocular surface disorder, has risen to prominence as a significant public health issue, adversely impacting the quality of life for individuals across the globe. Despite decades of extensive research into the chronic inflammation that characterizes dry eye, the intricate […]
Self-Assembly Hypoxic and ROS Dual Response Nano Prodrug as a New Therapeutic Approach for Glaucoma Treatments
Adv Sci (Weinh). 2024 Sep 4:e2407043. doi: 10.1002/advs.202407043. Online ahead of print. ABSTRACT Glaucoma is an irreversible blinding eye disease characterized by retinal ganglion cell (RGC) death.Previous studies have demonstrated that protecting mitochondria and activating the CaMKII/CREB signaling pathway can effectively protect RGC and axon. However, currently treatments are often unsatisfactory, and the pathogenesis of […]
Bi-allelic variants in COQ8B, a gene involved in the biosynthesis of coenzyme Q10, lead to non-syndromic retinitis pigmentosa
Am J Hum Genet. 2024 Aug 28:S0002-9297(24)00291-X. doi: 10.1016/j.ajhg.2024.08.005. Online ahead of print. ABSTRACT Retinitis pigmentosa (RP) is a Mendelian disease characterized by gradual loss of vision, due to the progressive degeneration of retinal cells. Genetically, it is highly heterogeneous, with pathogenic variants identified in more than 100 genes so far. Following a large-scale sequencing […]
Astaxanthin activated the SLC7A11/GPX4 pathway to inhibit ferroptosis and enhance autophagy, ameliorating dry eye disease
Front Pharmacol. 2024 Aug 19;15:1407659. doi: 10.3389/fphar.2024.1407659. eCollection 2024. ABSTRACT Dry eye disease (DED) is a common eye disease in clinical practice. The crucial pathogenesis of DED is that hyperosmolarity activates oxidative stress signaling pathways in corneal epithelial and immune cells and, thus, produces inflammatory molecules. The complex pathological changes in the dry eye still […]
Long-term Monitoring of Oxygen Consumption Rates in Highly Differentiated and Polarized Retinal Pigment Epithelial Cultures
J Vis Exp. 2024 Aug 16;(210). doi: 10.3791/67038. ABSTRACT Mitochondrial metabolism is critical for the normal function of the retinal pigment epithelium (RPE), a monolayer of cells in the retina important for photoreceptor survival. RPE mitochondrial dysfunction is a hallmark of age-related macular degeneration (AMD), the leading cause of irreversible blindness in the developed world, […]