Category: Ophthalmology AND mitochondrial

Atomoxetine Hydrochloride impairs human sperm quality and function via disruption of calcium homeostasis and PKC signaling: A combined network pharmacology and in vitro study

Reprod Toxicol. 2026 May 14:109263. doi: 10.1016/j.reprotox.2026.109263. Online ahead of print. ABSTRACT Atomoxetine Hydrochloride (ATX) is a widely prescribed first-line pharmacotherapy for adult attention deficit hyperactivity disorder (ADHD). Despite its chronic use among men of reproductive age, the potential impact of ATX on male fertility remains largely unknown. This study aimed to elucidate the toxicological […]

KEAP1-mediated mitochondrial remodeling on stiffness-graded collagen substrates drives hepatocellular carcinoma adaptation

Biomaterials. 2026 May 12;334:124302. doi: 10.1016/j.biomaterials.2026.124302. Online ahead of print. ABSTRACT Mechanical and structural cues of the extracellular matrix (ECM) regulate tumor cell metabolism and drug response, yet the molecular mediators that link these biophysical signals are unclear. We present an elastically supported surface platform bioengineered with varying stiffness and collagen fiber anisotropy to replicate […]

Single-Cell Sequencing Analysis Reveals Dysregulated Energy Metabolism and Altered Synaptic Connectivity in the Mouse Retina Following Dark Rearing

Invest Ophthalmol Vis Sci. 2026 May 1;67(5):35. doi: 10.1167/iovs.67.5.35. ABSTRACT PURPOSE: In this study, single-cell RNA sequencing (scRNA-seq) was applied to retinas from dark-reared and normally reared mice to resolve how each cell type contributes to retinal alterations under visual deprivation. METHODS: C57BL/6J mice were reared in complete darkness from birth to postnatal day 36 […]

Disrupting VE-cadherin Y685 phosphorylation inhibits development of experimental diabetic and prediabetic retinopathy

J Clin Invest. 2026 May 15;136(10):e195048. doi: 10.1172/JCI195048. eCollection 2026 May 15. ABSTRACT Diabetic retinopathy involves early retinal vascular barrier breakdown and pericyte loss, yet the initiating molecular events remain poorly defined. Vascular endothelial cadherin (VE-cadherin), a key regulator of endothelial integrity, is notably reduced in diabetic and prediabetic nucleoside diphosphate kinase B-deficient (NDPKB-deficient) mouse […]

Environmental Stress-Induced Mitochondrial Metabolic Reprogramming as a Central Driver of Endocrine Dysfunction: A Food and Chemical Toxicology Perspective

Food Chem Toxicol. 2026 May 13:116154. doi: 10.1016/j.fct.2026.116154. Online ahead of print. ABSTRACT Dietary and environmental chemical exposures including food contact materials, pesticide residues, heavy metals, mycotoxins, and synthetic food additives are increasingly recognized as contributors to endocrine and metabolic disease via mitochondrial mechanisms not captured by classical receptor-based screening. Mitochondria function as central integrators […]

Maternal-Derived Polystyrene Nanoplastics Impair Early Retinal Development in Zebrafish (Danio rerio)

ACS Nano. 2026 May 14. doi: 10.1021/acsnano.6c00114. Online ahead of print. ABSTRACT The ubiquitous presence of nanoplastics (NPs) has drawn widespread attention for their accumulation in reproductive tissues, posing latent threats to the delicate retina. Nevertheless, the transgenerational effects of maternally transferred NPs on embryonic retinal morphogenesis and functional development remain largely uncharacterized. Here, we […]

Gene Therapy for Leber Hereditary Optic Neuropathy (LHON): A Systematic Review and Meta-Analysis

Neuroophthalmology. 2026 Feb 17;50(3):215-221. doi: 10.1080/01658107.2026.2624440. eCollection 2026. ABSTRACT BACKGROUND: LHON is a rare mitochondrial disease causing bilateral vision loss, most commonly due to the m.11778G>A mutation. rAAV2/2-ND4 gene therapy is a potential disease-modifying treatment. METHODS: Systematic review and meta-analysis of three RCTs (RESCUE, REVERSE, REFLECT) including 175 patients. RESULTS: Gene therapy significantly improved best-corrected […]

An X-linked long non-coding RNA, PTCHD1-AS, and the core features of autism

Nature. 2026 May 13. doi: 10.1038/s41586-026-10515-6. Online ahead of print. ABSTRACT There are around 100 genes or copy-number variations used in genetic testing for autism spectrum disorder (ASD)1,2. The established genes are protein coding, and the associated phenotypes usually extend beyond sociobehavioural traits seen in autism, including cognitive/medical complexities and attention deficit hyperactivity disorder (ADHD)3,4. […]