Synergistic Anticancer Effects of Lenvatinib Combined with N-butylidenephthalide in Human Colorectal Cancer Cells
Int J Med Sci. 2026 Mar 4;23(4):1356-1368. doi: 10.7150/ijms.122381. eCollection 2026. ABSTRACT BACKGROUND: Colorectal cancer (CRC) is one of the most prevalent and deadly gastrointestinal malignancies worldwide. Lenvatinib, a multi-tyrosine kinase inhibitor, has shown limited clinical benefit as a monotherapy for CRC. Therefore, combining lenvatinib with N-butylidenephthalide (BP), a known anticancer and adjuvant agent, has […]
A dual-responsive CO-releasing nanogel ameliorates retinal ischemia-reperfusion injury by restoring mitochondrial homeostasis and attenuating cGAS-STING pathway activation
Mater Today Bio. 2026 Mar 5;38:102974. doi: 10.1016/j.mtbio.2026.102974. eCollection 2026 Jun. ABSTRACT Retinal ischemia-reperfusion injury (RIRI) represents a central pathological mechanism underlying neurodegeneration in multiple blinding ocular diseases, including glaucoma, diabetic retinopathy, and retinal vein occlusion. Ischemic stress triggers a surge of reactive oxygen species (ROS) within retinal ganglion cells, leading to mitochondrial dysfunction and […]
Using image classifiers to predict CMT2A disease-relevant mitochondrial motility phenotypes in iPSC motor neurons
bioRxiv [Preprint]. 2026 Mar 17:2026.03.16.712192. doi: 10.64898/2026.03.16.712192. ABSTRACT Charcot-Marie-Tooth disease type 2A (CMT2A) is a genetic disease characterized by autosomal dominant MFN2 mutations and dysregulated mitochondrial trafficking. While there is currently no FDA-approved CMT2A therapy, the recent development of iPSC motor neuron model systems, high-throughput imaging platforms, and CRISPR-based gene editing technologies holds promise for […]
Leber Hereditary Optic Neuropathy in the Elderly: A Case Report
Case Rep Ophthalmol. 2026 Feb 20;17(1):305-311. doi: 10.1159/000551146. eCollection 2026 Jan-Dec. ABSTRACT INTRODUCTION: Leber hereditary optic neuropathy (LHON) is a mitochondrial disorder typically affecting young males, with rare reports of late-onset disease. Among the three primary LHON mutations, m.14484T>C is generally associated with a relatively favorable visual prognosis. However, the disease in elderly patients carrying […]
Ophthalmic manifestations of mitochondrial disorders
Prog Retin Eye Res. 2026 Apr 3:101466. doi: 10.1016/j.preteyeres.2026.101466. Online ahead of print. ABSTRACT Mitochondrial diseases are the most common group of inherited neurometabolic disorders and frequently involve multiple organ systems with high energy demands. Ophthalmic manifestations are a common occurrence in affected individuals and may be the earliest or predominant clinical feature. However, the […]
Mitochondrial dynamics and their role in the pathogenesis of age-related macular degeneration: A comprehensive review
Redox Biol. 2025 Dec 20;93:103976. doi: 10.1016/j.redox.2025.103976. Online ahead of print. ABSTRACT Age-related macular degeneration (AMD) is a leading cause of irreversible blindness in the elderly and has a multifactorial etiology involving advanced age, genetic susceptibility, and environmental risk factors. Accumulating evidence suggests that mitochondrial dysfunction is a central pathogenic mechanism in AMD, particularly in […]
Metabolic and redox adaptations of the corneal endothelium: From metabolic plasticity to therapeutic opportunities
Redox Biol. 2026 Mar 30;93:104148. doi: 10.1016/j.redox.2026.104148. Online ahead of print. ABSTRACT The corneal endothelium, a monolayer of nonregenerating cells on the posterior cornea, maintains corneal transparency through active fluid pumping. This review examines how corneal endothelial cells (CEnCs) meet high energy demands and adapt metabolically from quiescence to stress, with particular emphasis on their […]
Leber hereditary optic neuropathy triggered by the AstraZeneca coronavirus disease 2019 vaccination
Oman J Ophthalmol. 2026 Feb 27;19(1):137-139. doi: 10.4103/ojo.ojo_431_24. eCollection 2026 Jan-Apr. ABSTRACT Leber hereditary optic neuropathy (LHON) is a rare mitochondrial disorder primarily affecting young males, characterized by progressive vision loss due to retinal ganglion cell degeneration. LHON is typically associated with specific mitochondrial mutations with potential triggers such as environmental factors and, more recently, […]
The 5-HT1A receptor antagonist WAY-100635 maleate promotes retinal ganglion cell differentiation and protects the retino-visual circuits
Commun Med (Lond). 2026 Apr 2. doi: 10.1038/s43856-026-01528-3. Online ahead of print. ABSTRACT BACKGROUND: Growing evidence implicates early metabolic dysfunctions in retinal ganglion cells (RGCs) as a contributor to both high- and normal-tension glaucoma, yet no approved therapy directly protects RGCs to preserve vision. We aimed at identifying a safe, druggable neuroprotective strategy that restores […]
Neuron-derived mitochondrial DNA (mtDNA) activates microglia via the Z-DNA binding protein 1 (ZBP1)-mediated pathway in mild traumatic brain injury
Proc Natl Acad Sci U S A. 2026 Apr 7;123(14):e2527009123. doi: 10.1073/pnas.2527009123. Epub 2026 Apr 2. ABSTRACT Traumatic brain injury (TBI) is a leading cause of morbidity and mortality, with closed-head mild TBI (mTBI) accounting for nearly 90% of all cases. Early pathological events include microglial activation and neuronal mitochondrial dysfunction; however, their interconnection in […]