A Systems View of Posterior Capsule Opacification: TGF-beta/ROS Signaling, Mitochondrial Homeostasis, and Injury/Aging Cues-Therapeutic Opportunities
Invest Ophthalmol Vis Sci. 2026 Sep 1;67(11):14. doi: 10.1167/iovs.67.11.14. ABSTRACT Posterior capsule opacification is a common long-term complication of cataract surgery that can cause persistent visual impairment in some patients despite advances in surgical techniques and IOL design. Most current studies focus on single signaling pathways or isolated time windows, showing benefits in some models […]
When rare diseases do not appear as a single entity
Adv Lab Med. 2026 Jul 16;7(3):234-237. doi: 10.1515/almed-2025-0193. eCollection 2026 Sep. ABSTRACT OBJECTIVES: The coexistence of multisystemic involvement in a young adult raises the need to consider rare metabolic and mitochondrial disorders. We report a case of late-onset propionic acidemia (PPA) that may have contributed to unmasking Leber hereditary optic neuropathy (LHON), an extremely infrequent […]
Fenofibrate in ophthalmology: therapeutic efficacy and mechanisms
J Pharm Pharm Sci. 2026 Sep 3;29:16995. doi: 10.3389/jpps.2026.16995. eCollection 2026. ABSTRACT Ophthalmic diseases are a growing global cause of visual impairment, driven by population aging and the rising prevalence of diabetes mellitus. Fenofibrate, a peroxisome proliferator-activated receptor alpha (PPARα) agonist widely used for dyslipidemia, has emerged as a candidate for therapeutic repurposing in ophthalmology. […]
Can continuous glucose monitoring-derived glycemic variability predict retinal neurodegeneration earlier than HbA1c in patients without clinically apparent retinopathy?
Front Endocrinol (Lausanne). 2026 Aug 25;17:1925994. doi: 10.3389/fendo.2026.1925994. eCollection 2026. ABSTRACT Early screening for diabetic retinopathy (DR) has long relied on the detection of fundus vascular lesions. However, accumulating evidence indicates that retinal neurodegeneration may occur before overt microvascular abnormalities become clinically visible. At the stage of no clinically apparent diabetic retinopathy (NDR), glycated hemoglobin […]
3D Culture Reverses Limbal Niche Cell Replicative Aging via FOSL1 Upregulation
Aging Cell. 2026 Sep;25(9):e70705. doi: 10.1111/acel.70705. ABSTRACT Limbal niche cells (LNCs) serve as essential regulators of limbal microenvironmental homeostasis and corneal epithelial wound repair, representing a promising therapeutic resource for limbal stem cell deficiency (LSCD). However, their clinical application is constrained by replicative aging during in vitro expansion. In this study, we investigated whether a […]
Iron-Deprivation Liposomes for Cancer Therapy
Angew Chem Int Ed Engl. 2026 Sep 8:e5926794. doi: 10.1002/anie.5926794. Online ahead of print. ABSTRACT Targeting iron homeostasis in tumor cells represents a promising anticancer strategy, as iron plays essential roles in tumor growth, invasion, and metastasis. Although deferoxamine can effectively chelate iron, its clinical application is limited by poor membrane permeability, short half-life, and […]
Allotopic Expression of ND6 Restores Vision in a Mitochondrial Disease Model
JCI Insight. 2026 Sep 8:e209108. doi: 10.1172/jci.insight.209108. Online ahead of print. ABSTRACT Mutations in mitochondrial DNA (mtDNA) cause various mitochondrial diseases that are currently incurable. Allotopic expression of nuclear-recoded mitochondrial genes represents a promising therapeutic strategy, given its demonstrated capacity to restore mitochondrial function in human cell models harboring mtDNA mutations. However, the in vivo […]
LAPTM5 correlates with RPE senescence and subretinal fibrosis through the LAPTM5-WWP2-OPTN mitophagy cascade and cGAS/STING activation in a D-galactose-induced aging model
Geroscience. 2026 Sep 8. doi: 10.1007/s11357-026-02506-2. Online ahead of print. ABSTRACT Retinal pigment epithelium (RPE) senescence acts as a core driver of subretinal fibrosis, a major irreversible pathological feature that exacerbates age-related macular degeneration (AMD). Mitophagy is essential for maintaining RPE homeostasis during aging. However, the upstream molecular mechanisms underlying mitophagy impairment in senescent RPE […]
Intrinsically Photosensitive Retinal Ganglion Cell Dysfunction and Suprachiasmatic Nucleus -Mediated Circadian Disruption in Humans: A Systematic Review
Exp Eye Res. 2026 Sep 3:111229. doi: 10.1016/j.exer.2026.111229. Online ahead of print. ABSTRACT Circadian entraining input to the suprachiasmatic nucleus (SCN) is primarily from intrinsically photosensitive retinal ganglion cells (ipRGCs). While several retinal and optic nerve diseases are associated with ipRGC dysfunction, the role of ipRGC dysfunction in the context of SCN-mediated circadian disruption remains […]
Pseudomonas aeruginosa Impairs Mitochondrial Function During Infection of Corneal Epithelial Cells
Invest Ophthalmol Vis Sci. 2026 Sep 1;67(11):9. doi: 10.1167/iovs.67.11.9. ABSTRACT PURPOSE: Pseudomonas aeruginosa (PA) is a Gram-negative opportunistic bacterial pathogen that can infect the cornea as a result of trauma or contact lens wear. Mitochondria, originally derived from bacteria, play important roles in host defense. This study investigated the effect of PA on mitochondrial structure […]