Chrysin Attenuates Dry Eye Progression by Suppressing NOX2-Dependent Ferroptosis and STING/NLRP3-Mediated Inflammatory Responses
Invest Ophthalmol Vis Sci. 2026 Jun 1;67(6):15. doi: 10.1167/iovs.67.6.15. ABSTRACT PURPOSE: This study aimed to evaluate the effects of chrysin on dry eye and to elucidate its underlying mechanisms. METHODS: Public transcriptomic datasets were analyzed to identify ferroptosis-associated hub genes and to predict potential modulatory compounds. Ocular surface signs were evaluated using phenol red thread […]
Salvianolic acid a attenuates sodium iodate-induced ferroptosis in age-related macular degeneration models via the SLC7A11/GPX4 axis
Front Pharmacol. 2026 May 25;17:1803187. doi: 10.3389/fphar.2026.1803187. eCollection 2026. ABSTRACT INTRODUCTION: Oxidative stress-mediated retinal pigment epithelial (RPE) cell injury is a key pathological feature of age-related macular degeneration (AMD). Ferroptosis-an iron-dependent form of regulated cell death driven by lipid peroxidation-has been increasingly identified as a critical executor of RPE degeneration and a key pathogenic mechanism […]
Programmable delivery of mitochondria to specific cell types
Nat Rev Mol Cell Biol. 2026 Jun 9. doi: 10.1038/s41580-026-00986-w. Online ahead of print. NO ABSTRACT PMID:42265201 | DOI:10.1038/s41580-026-00986-w
Quantitative models of photoreceptor metabolisms: implications for rod outer segment length, retinal glycolysis and choroidal blood flow
Phys Biol. 2026 Jun 9. doi: 10.1088/1478-3975/ae7ad6. Online ahead of print. ABSTRACT The outer retina exhibits several distinctive physiological features, including continuous turnover of rod photoreceptor outer segments (OS), a strong reliance on aerobic glycolysis despite oxygen availability, and an unusually high rate of choroidal blood flow. The mechanistic links between these phenomena remain incompletely […]
Arsenic exposure promotes retinal pigment epithelium dysfunction and oxidative stress via NF-κB pathway
Sci Rep. 2026 Jun 8. doi: 10.1038/s41598-026-55608-4. Online ahead of print. ABSTRACT Age-related macular degeneration (AMD) is a leading cause of blindness in older adults and is closely linked to dysfunction of the retinal pigment epithelium (RPE). Arsenic (As), a ubiquitous environmental toxicant present in drinking water and food, has been implicated in multiple chronic […]
12-month outcomes of photobiomodulation in dry age-related macular degeneration: a prospective multicentre randomised double-masked controlled clinical trial
Br J Ophthalmol. 2026 Jun 8:bjo-2025-328389. doi: 10.1136/bjo-2025-328389. Online ahead of print. ABSTRACT BACKGROUND: Dry age-related macular degeneration (dAMD) is the leading cause of irreversible vision loss in older adults, with no approved treatment to modify progression in early and intermediate stages. Photobiomodulation (PBM), which targets mitochondrial dysfunction and retinal inflammation, has shown promise in […]
SIRT1: Protean roles at the nexus of health, disease, and therapeutics
J Cell Commun Signal. 2026 Jun 2;20(2):e70086. doi: 10.1002/ccs3.70086. eCollection 2026 Jun. ABSTRACT Silent mating type information regulators (sirtuins and SIRTs) have emerged as central nodes linking cellular metabolism to stress adaptation and diseases. SIRT1 stands out as a ubiquitously expressed, NAD+-dependent deacetylase with remarkably broad and sometimes paradoxical functions. Beyond its canonical roles in […]
A Novel LMX1A Frameshift Variant Underlies Familial Phenotypic Heterogeneity in DFNA7
Hum Mutat. 2026 May 30;2026:9930672. doi: 10.1155/humu/9930672. eCollection 2026. ABSTRACT Pathogenic variants in the LIM-homeodomain transcription factor LMX1A represent a rare yet critical etiology for autosomal dominant nonsyndromic hearing loss 7 (DFNA7) and less frequently, its autosomal recessive counterpart (ARNSHL). Here, we describe a novel heterozygous frameshift variant, LMX1A c.405delT (p.Phe135LeufsTer3), identified in a three-generation […]
MicroRNA-SIRT1 crosstalk in liver diseases: molecular regulation of metabolism, inflammation, and cell survival
Mol Biol Rep. 2026 Jun 6;53(1):899. doi: 10.1007/s11033-026-12062-9. ABSTRACT MicroRNAs (miRNAs) and the NAD+-dependent deacetylase SIRT1 are critical regulators of hepatic metabolism, inflammation, and stress responses. Growing evidence suggests that miRNA-SIRT1 interactions are frequently disrupted during the pathogenesis of liver diseases, including Metabolism-Associated Steatotic Liver Disease (MASLD), Alcohol-Associated Liver Disease, Drug-Induced Liver Injury (DILI), fibrosis, […]
Spotlight on cGAS-STING: role in disease pathogenesis and therapeutic potential
Mol Biomed. 2026 Jun 5;7(1):83. doi: 10.1186/s43556-026-00478-5. ABSTRACT The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway represents a cornerstone of innate immunity, functioning as the primary cytosolic DNA sensor in mammalian cells. Upon detecting pathogenic DNA or mislocalized self-DNA (such as leaked mitochondrial or micronuclear DNA), cGAS synthesizes the second messenger cGAMP, […]