Fifteen-year follow-up of implantable collamer lens surgery in high myopia: Complications, cataract surgery outcomes, and ultrastructural analysis
Adv Ophthalmol Pract Res. 2026 Mar 13;6(3):308-318. doi: 10.1016/j.aopr.2026.02.001. eCollection 2026 Aug-Sep. ABSTRACT PURPOSES: This study reports 15-year outcomes of implantable collamer lens (ICL) surgery in patients with high myopia, analyzing complications, efficacy of cataract surgical, and ultrastructural mechanisms of anterior subcapsular cataract (ASC). METHODS: This retrospective study included 1208 eyes (ICL V4) and 6258 […]
Nicotinamide Supplementation in Glaucoma: A Systematic Review of Human Studies
Nutrients. 2026 Sep 3;18(17):2885. doi: 10.3390/nu18172885. ABSTRACT Background/Objectives: Nicotinamide (NAM), a form of vitamin B3 and precursor of nicotinamide adenine dinucleotide (NAD), has emerged as a potential metabolic and neuroprotective strategy in glaucoma. This systematic review aimed to evaluate the available human evidence on NAM-containing and NAD-targeted strategies in glaucoma, integrating interventional, observational, and mechanistic […]
Clinical Use of Melatonin as a Cross-Sectional Modulator of Oxidative Stress Across the Perinatal Continuum: From Placental Dysfunction to Neonatal Disease
Nutrients. 2026 Aug 28;18(17):2817. doi: 10.3390/nu18172817. ABSTRACT Oxidative stress is a central mechanism linking placental dysfunction, fetal injury, and neonatal disease, supporting the concept of a perinatal oxidative stress continuum that begins during abnormal placentation and may persist after birth. This narrative review explores the biological rationale and current experimental and clinical evidence for melatonin […]
Loss of Ca(2+) Signaling Fidelity During Aging: Mitochondrial Dysfunction, Senescence, and Cognitive-Motor Decline
Mech Ageing Dev. 2026 Sep 14:112242. doi: 10.1016/j.mad.2026.112242. Online ahead of print. ABSTRACT Aging is characterized by a progressive decline in cellular homeostasis that ultimately compromises tissue integrity, regenerative capacity, and organismal function. Among the molecular processes increasingly recognized as central regulators of aging, intracellular Ca2+ signaling has emerged as a major determinant of metabolic […]
ZhuJing Pill retards lens-induced myopia progression by improving ciliary muscle mitochondrial function via KEAP1/NRF2-TGF-beta axis
Naunyn Schmiedebergs Arch Pharmacol. 2026 Sep 11. doi: 10.1007/s00210-026-05899-1. Online ahead of print. ABSTRACT To evaluate the anti-myopic effect of ZhuJing Pill (ZJP) in a guinea pig model of lens-induced myopia (LIM) and investigate whether ZJP attenuates ciliary muscle fibrosis by improving mitochondrial function, regulating KEAP1/NRF2 antioxidant defense, and inhibiting TGF-β-related fibrotic signaling. One hundred […]
Biallelic Pathogenic Variants in PYGM Impair Retinal Glycogenolysis Causing a Range of Phenotypes
Invest Ophthalmol Vis Sci. 2026 Sep 1;67(11):18. doi: 10.1167/iovs.67.11.18. ABSTRACT PURPOSE: Biallelic pathogenic variants in PYGM (glycogen myophosphorylase) cause glycogen storage disease V (GSDV), a skeletal muscle disorder with reported association with hereditary macular dystrophy (HMD). This study investigated the role of PYGM in HMD and broader retinal disease through clinical and functional analyses. METHODS: […]
Mechanisms underlying the reversal of hypoxia-induced energy metabolic reprogramming in cardiomyocytes by Poria cocos triterpenoids: integrated regulation of mitochondrial dynamics and the autophagy-lysosomal pathway
Front Cardiovasc Med. 2026 Aug 27;13:1891480. doi: 10.3389/fcvm.2026.1891480. eCollection 2026. ABSTRACT OBJECTIVE: To elucidate the mechanisms by which Poria cocos triterpenoids reverse hypoxia-induced energy metabolic reprogramming in cardiomyocytes through integrated regulation of mitochondrial dynamics and the autophagy-lysosomal pathway. METHODS: A hypoxic injury model was established in H9c2 rat cardiomyoblasts. Cells were randomized into five groups: […]
Regulation of hepatic mitochondrial function by AIBP mitigates MASLD development
Metabolism. 2026 Sep 10:156769. doi: 10.1016/j.metabol.2026.156769. Online ahead of print. ABSTRACT BACKGROUND AND AIMS: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a multifactorial disorder characterized by dysregulated lipid metabolism, hepatic inflammation, oxidative stress, and mitochondrial dysfunction. Emerging evidence suggests that apolipoprotein A-I binding protein (AIBP) regulates mitochondrial quality control and protects against oxidative stress in […]
Integrative transcriptomic- neuroimaging analysis reveals polygenic correlates of interhemispheric functional decoupling in ischemic stroke
Front Cell Neurosci. 2026 Aug 26;20:1908231. doi: 10.3389/fncel.2026.1908231. eCollection 2026. ABSTRACT BACKGROUND: Functional magnetic resonance imaging (fMRI) has revealed abnormal brain activity patterns in stroke patients, yet the genetic correlates underlying functional homotopy – defined as synchronized spontaneous activity between bilateral homologous brain regions – remain poorly characterized. This study investigates the genetic basis of […]
Single-Cell Profiling Identifies Glial Transcriptional Remodeling in the Trigeminal Ganglion After Corneal Injury
Glia. 2026 Nov;74(11):e70226. doi: 10.1002/glia.70226. ABSTRACT The cornea depends on trigeminal sensory innervation for sensation and epithelial homeostasis, yet cell type-specific transcriptional responses in the trigeminal ganglion following corneal injury remain incompletely defined. To address this gap, we combined bulk and single-cell RNA sequencing to profile the mouse trigeminal ganglion after a moderate corneal alkali […]