Spleen Tyrosine Kinase (SYK) is Necessary for cGAS-STING Signaling in Müller Glia and Visual Function Deficits in Diabetic Mice
Glia. 2026 Jun;74(6):e70155. doi: 10.1002/glia.70155. ABSTRACT It is well established that inflammation contributes to the ocular complications caused by diabetes; however, the specific molecular events that drive diabetes-induced pro-inflammatory signaling in the retina remain to be fully elucidated. This study investigated the role of Müller glial spleen tyrosine kinase (SYK) in diabetes-induced retinal complications. Hyperglycemic […]
Chronic psychological stress disrupts liver homeostasis by dysregulating oxidative phosphorylation via the PI3K/AKT/FoxO3a axis
iScience. 2026 Mar 18;29(4):115389. doi: 10.1016/j.isci.2026.115389. eCollection 2026 Apr 17. ABSTRACT Epidemiological evidence indicates that chronic psychological stress correlates with the morbidity and mortality of chronic liver disease. However, the underlying mechanisms remain unclear. We established a chronic restraint stress (CRS) mouse model to simulate emotional stress. Histological and biochemical analyses showed marked hepatocyte vacuolization, […]
Multi-omics liquid biopsy identifies mitochondrial dysfunction in geographic atrophy and supports the longevity-associated metabolite alpha-ketoglutarate as a therapeutic strategy
medRxiv [Preprint]. 2026 Mar 19:2026.03.12.26347263. doi: 10.64898/2026.03.12.26347263. ABSTRACT BACKGROUND: Mitochondrial dysfunction is an emerging metabolic hallmark of age-related diseases, yet tools to directly profile mitochondrial pathways and test metabolic interventions in the living human eye remain limited. Multi-omics ocular liquid biopsy enables real-time proteomic and metabolomic profiling of the intraocular microenvironment, complementing systemic biomarkers and […]
The human cytomegalovirus vMIA protein inhibits apoptosis and innate immune signaling in human Mueller cells
Exp Eye Res. 2026 Apr 10:111009. doi: 10.1016/j.exer.2026.111009. Online ahead of print. ABSTRACT Human cytomegalovirus (HCMV) encodes the viral mitochondria-localized inhibitor of apoptosis (vMIA) protein which blocks host cell apoptosis. vMIA also inhibits innate immune signaling through the DNA sensing cGAS-STING pathway and the RNA sensing RLR pathway which interacts with the mitochondrial adapter protein […]
Repeated low-level red light modulates retinal metabolic alterations in lens-induced myopic chicks
J Photochem Photobiol B. 2026 Mar 21;278:113432. doi: 10.1016/j.jphotobiol.2026.113432. Online ahead of print. ABSTRACT BACKGROUND: Repeated low-level red-light (RLRL) therapy effectively controls myopia, yet its retinal metabolic mechanisms remain elusive. This study aimed to elucidate RLRL-induced metabolic alterations in a lens-induced myopia (LIM) chick model. METHODS: Seven-day-old chicks were randomized into three groups (n = […]
Clinical and Genetic Spectrum of ACO2-Linked Dominant Optic Atrophy
JAMA Ophthalmol. 2026 Apr 9. doi: 10.1001/jamaophthalmol.2026.0634. Online ahead of print. ABSTRACT IMPORTANCE: Aconitase 2 (ACO2) gene variants are one of the most frequent causes of dominant optic atrophy (DOA). However, the associated phenotypes and genotypes still lack proper characterization. OBJECTIVE: To characterize the clinical and genetic spectrum of ACO2-related DOA and evaluate genotype-phenotype correlations. […]
Targeting of ibrutinib resistance-driving pathways by miR-28 in ABC-DLBCL
Leukemia. 2026 Apr 8. doi: 10.1038/s41375-026-02948-9. Online ahead of print. ABSTRACT Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive B-cell lymphoma. Although many patients respond well to R-CHOP immunochemotherapy, those with the activated B-cell (ABC) subtype are often refractory or relapse. Bruton tyrosine kinase (BTK) inhibitors such as ibrutinib have improved outcomes, but […]
Hypoxia-Induced Ferroptosis Resistance Drives Orbital Fibrosis in Thyroid Eye Disease
Invest Ophthalmol Vis Sci. 2026 Apr 1;67(4):15. doi: 10.1167/iovs.67.4.15. ABSTRACT PURPOSE: To determine whether hypoxia promotes a ferroptosis-resistant phenotype in patient-derived thyroid eye disease (TED) orbital fibroblasts (OFs), and whether hypoxia-associated metabolic changes (lactate) relate to profibrotic activation readouts, as well as to test whether modulating ferroptosis alters these readouts. METHODS: Primary OFs from TED […]
Histologic Photoreceptor and Retinal Pigment Epithelium Degeneration in an Eye With Clinically Documented Geographic Atrophy of AMD
Invest Ophthalmol Vis Sci. 2026 Apr 1;67(4):12. doi: 10.1167/iovs.67.4.12. ABSTRACT PURPOSE: In geographic atrophy (GA) of AMD, comparing photoreceptor disintegrity and RPE loss in optical coherence tomography (OCT) and microscopy may elucidate atrophy expansion and suggest imaging biomarkers. METHODS: One eye of a 93-year-old woman with bilateral drusen-driven GA of AMD was analyzed. RPE loss […]
FTO mediated m6A demethylation of LncRNA RMRP drives mitochondrial dysfunction in diabetic cataract
Exp Eye Res. 2026 Apr 4:110991. doi: 10.1016/j.exer.2026.110991. Online ahead of print. ABSTRACT Diabetic cataract is characterized by early lens opacification. This study identifies a pathogenic axis that involves the N6-methyladenosine (m6A) demethylase fat mass and obesity-associated protein (FTO) and the mitochondria-enriched long non-coding RNA (lncRNA) RMRP. Transcriptomic analysis of lens epithelial cells (LECs) under […]