Genomic Medicine Among Ophthalmologists: Knowledge, Current Practice, and Barriers
J Pers Med. 2026 May 16;16(5):267. doi: 10.3390/jpm16050267. ABSTRACT Background/Objectives: To assess the knowledge, attitudes, and practices of ophthalmologists in Saudi Arabia towards genomic medicine and genetic testing, in light of the growing significance of genomics in ophthalmology and the national transition towards precision medicine. Methods: A cross-sectional, questionnaire-based survey was conducted among ophthalmologists, including […]
Quercetin attenuates neutrophil extracellular trap formation in uveitis through orchestrating the cGAS-STING signaling pathway
Food Funct. 2026 May 26. doi: 10.1039/d6fo00799f. Online ahead of print. ABSTRACT Uveitis is an autoimmune disease with a high rate of blindness. Clinically, treatments of uveitis mainly rely on corticosteroids and immunosuppressants, which are prone to recurrence and carry significant side effects. Quercetin, a natural flavonoid compound, exhibits anti-inflammatory, antioxidant, and immunomodulatory effects. However, […]
Mitochondrial genetic variation across tissues of the human body
Nucleic Acids Res. 2026 May 20;54(10):gkag513. doi: 10.1093/nar/gkag513. ABSTRACT Each mitochondrion contains 2-10 copies of the mitochondrial genome. Multiple mitochondria in a cell allow for mitochondrial genomes carrying different variants to co-exist within a cell or tissue, termed heteroplasmy. The extent to which mitochondrial genetic variation differs across tissues of the human body and the […]
A sequentially targeted and pathology-responsive nanoplatform for synergistic treatment of dry eye disease via concurrent anti-inflammation and mitochondrial ROS scavenging
J Nanobiotechnology. 2026 May 22. doi: 10.1186/s12951-026-04365-7. Online ahead of print. ABSTRACT The treatment of complex inflammatory diseases like dry eye disease (DED) is hampered by the intertwined pathologies of inflammation and oxidative stress, which form a self-amplifying vicious cycle. Here, we report an intelligent nanoplatform (CFMPDA) designed to actively navigate and disrupt this cycle […]
Mitoredox Shifts in Mitochondrial Dysfunction
Free Radic Biol Med. 2026 May 21:S0891-5849(26)00787-2. doi: 10.1016/j.freeradbiomed.2026.05.307. Online ahead of print. ABSTRACT Mitochondrial dysfunction underlies a broad spectrum of primary and secondary disorders, yet current frameworks do not fully capture how diverse genetic, metabolic, and environmental stressors converge on shared pathological outcomes. Here, we propose that mitoredox shifts – bidirectional disruptions in mitochondrial […]
Mitochondrial complex I activity promotes antigen cross-presentation in dendritic cells
Sci Immunol. 2026 May 29;11(119):eaef0098. doi: 10.1126/sciimmunol.aef0098. Epub 2026 May 22. ABSTRACT Mitochondrial metabolism modulates immune cell signaling, yet how individual electron transport chain complexes fine-tune dendritic cell (DC) function remains unclear. Here, we identify mitochondrial complex I (CI) as a critical metabolic checkpoint controlling antigen cross-presentation by DCs in mice. Deficiency of the CI […]
Blue Light Induces Retinal Ganglion Cell Damage by Stimulating Drp1-Dependent Mitochondrial Fission and Activating NF-kappaB/NOX4 Axis
Invest Ophthalmol Vis Sci. 2026 May 1;67(5):62. doi: 10.1167/iovs.67.5.62. ABSTRACT PURPOSE: This study aimed to investigate the mechanisms of blue light-induced neurotoxicity in retinal ganglion cells (RGCs), focusing on the roles of mitochondrial dynamics and oxidative stress. METHODS: The impact of blue light exposure was assessed in vitro and in vivo. Key molecular changes were […]
Targeting metabolic dysregulation in postmenopausal breast cancer: Synergistic effects of nutrition-based interventions and exercise on molecular and cellular pathways
Cancer Cell Int. 2026 May 21. doi: 10.1186/s12935-026-04321-3. Online ahead of print. ABSTRACT Postmenopausal females diagnosed with breast cancer who are undergoing aromatase inhibitor (AI) therapy often exhibit metabolic disturbances, which may manifest as insulin resistance, dyslipidemia, increased adiposity, and an elevated risk of cardiovascular events. Such metabolic disruptions have the potential to undermine the […]
Mechanosensitive ion channel TRPV4 inhibition alleviates glaucomatous inflammation by regulating microglial ferroptosis
Int Immunopharmacol. 2026 May 20;183:116863. doi: 10.1016/j.intimp.2026.116863. Online ahead of print. ABSTRACT Glaucoma is a neurodegenerative disease characterized by the progressive and irreversible loss of retinal ganglion cells (RGCs). Elevated intraocular pressure (IOP) is a key factor in initiating pathological processes in acute glaucoma. This study aims to investigate the role of TRPV4 in mediating […]
SERAC1 Deficiency
2014 Apr 17 [updated 2026 May 21]. In: Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2026. ABSTRACT CLINICAL CHARACTERISTICS: The phenotypic spectrum of SERAC1 deficiency comprises infantile, severe MEGD(H)EL syndrome (3-methylglutaconic aciduria with deafness-dystonia, [hepatopathy], encephalopathy, and Leigh-like syndrome), juvenile-onset complicated […]