LEBER HEREDITARY OPTIC NEUROPATHY: A CASE REPORT OF CONCURRENT RARE MITOCHONDRIAL MUTATIONS AND ABCA4 NUCLEAR GENE MUTATION
Retin Cases Brief Rep. 2025 Sep;19(5):647-651. doi: 10.1097/ICB.0000000000001618. ABSTRACT PURPOSE: This case report aimed to describe the clinical presentation of a 21-year-old male patient with subacute bilateral painless vision loss, clinically consistent with Leber hereditary optic neuropathy (LHON), a mitochondrially inherited disorder and to investigate the genetic mutations associated with this condition. METHODS: Genetic testing […]
Synthesis and evaluation of mitochondrion-targeted tetraphenylethylene-based photosensitizer
Bioorg Chem. 2026 Apr 11;176:109862. doi: 10.1016/j.bioorg.2026.109862. Online ahead of print. ABSTRACT As typical compounds with aggregation induced emission (AIE) property, tetraphenylethylene-based photosensitizers with unique molecular structures and excellent photophysical properties have been widely applied in the bio-specific imaging, diagnosis, photodynamic therapy (PDT) and other related fields. In this work, we have developed a concise […]
Therapeutic Exploitation of Ferroptosis Pathways in Dry Eye Disease: Opportunities and Challenges
Exp Eye Res. 2026 Apr 13:111022. doi: 10.1016/j.exer.2026.111022. Online ahead of print. ABSTRACT Conventional management of dry eye disease (DED) often fails to arrest the progressive loss of corneal epithelial cells, making therapeutic management challenging. Emerging evidence points to ferroptosis, an iron-dependent form of regulated cell death, as a central driver of this ocular surface […]
Cell-type-targeted mitochondrial transplantation rescues cell degeneration
Nature. 2026 Apr 15. doi: 10.1038/s41586-026-10391-0. Online ahead of print. ABSTRACT A number of currently untreatable diseases, including neurodegenerative disorders, optic nerve atrophy and heart failure, are associated with mitochondrial dysfunction. Transplantation of healthy mitochondria has been proposed as a potential therapeutic strategy1-3. However, the lack of methods to target donor mitochondria to disease-affected cell […]
NSUN4-mediated m5C RNA methylation protects retinal cells against excitotoxic injury via the SHH signaling pathway
PLoS One. 2026 Apr 15;21(4):e0347414. doi: 10.1371/journal.pone.0347414. eCollection 2026. ABSTRACT Glaucoma, a leading global cause of blindness, is characterized by progressive retinal neuronal loss. NOP2/Sun RNA methyltransferase 4 (NSUN4), a writer of 5-methylcytosine (m5C) RNA modifications, has established roles in methylation and mitoribosome assembly, yet its function in retinal cell survival remains unexplored. In this […]
Rhesus macaques with an OPA1 mutation demonstrate features of autosomal dominant optic atrophy
Proc Natl Acad Sci U S A. 2026 Apr 21;123(16):e2509165123. doi: 10.1073/pnas.2509165123. Epub 2026 Apr 15. ABSTRACT Autosomal dominant optic atrophy (ADOA) is an inherited optic neuropathy primarily caused by mutations in OPA1. We identified and defined a spontaneous nonhuman primate (NHP) model of ADOA using rhesus macaques heterozygous for a missense mutation (OPA1A8S). With […]
Comparative Proteomic Profiling of Microdissected Spindle and Epithelioid Uveal Melanoma Subtypes
Invest Ophthalmol Vis Sci. 2026 Apr 1;67(4):32. doi: 10.1167/iovs.67.4.32. ABSTRACT PURPOSE: Uveal melanoma (UM), the most prevalent primary intraocular cancer in adults, is defined by salient histopathological diversity. Spindle and epithelioid cells constitute its two dominant pathological lineages, yet the latter foreshadows aggressive behavior and shortened survival. This study aimed to explore the molecular and […]
Quercetin improves retinal glycolysis to slow myopia progression through orchestrating the AKT/FOXO/HK2 axis
Redox Biol. 2026 Mar 31;93:104139. doi: 10.1016/j.redox.2026.104139. Online ahead of print. ABSTRACT OBJECTIVES: Myopia is a major global public health issue. The retina relies on glycolysis to maintain its normal physiological functions and is vulnerable to oxidative damage. However, the effects of altered glycolysis on myopia progression remain poorly understood. This study aimed to explore […]
Modulation of Iron-Induced Glucose Metabolic Reprogramming Alleviates Retinal Pigment Epithelial Cell Senescence
Invest Ophthalmol Vis Sci. 2026 Apr 1;67(4):30. doi: 10.1167/iovs.67.4.30. ABSTRACT PURPOSE: This study aimed to investigate whether iron overload induces retinal pigment epithelial (RPE) cell senescence through glucose metabolic reprogramming and to evaluate the therapeutic potential of targeting this metabolic pathway. METHODS: We utilized human-induced pluripotent stem cell-derived RPE cells and induced RPE cells, along […]
Dihydroartemisinin Induces Ferroptosis in Uveal Melanoma Cells Through the HO-1 and xCT/GPX4 Signaling Pathways
Int J Mol Sci. 2026 Mar 26;27(7):3027. doi: 10.3390/ijms27073027. ABSTRACT Uveal melanoma (UM) represents an uncommon intraocular malignancy with high aggressiveness. Dysregulation of ferroptosis has been associated with UM progression. Dihydroartemisinin (DHA), a natural derivative of Artemisia annua, exhibits potent antitumor activity with a favorable safety profile, yet its role in ferroptosis regulation in UM […]