Correlation of Mitochondrial Flavoprotein Fluorescence and Sectoral OCT in Patients with Glaucoma, Suspects, and Ocular Hypertension
Clin Ophthalmol. 2026 Sep 16;20:613398. doi: 10.2147/OPTH.S613398. eCollection 2026. ABSTRACT PURPOSE: Flavoprotein fluorescence (FPF) can be measured using a noninvasive investigational device, the OcuMet Beacon (OcuSciences). The Beacon uses blue light to stimulate oxidized mitochondrial flavoproteins, which subsequently emit green autofluorescence. As mitochondrial metabolic stress may reflect axonal damage in glaucomatous eyes, this cross-sectional, exploratory […]
Elesclomol-mediated cuproptosis overcomes cisplatin resistance by restricting epigenetically activated mitochondrial respiration: Novel therapeutic insights into cisplatin-elesclomol combination therapy
Acta Pharm Sin B. 2026 Sep;16(9):6030-6044. doi: 10.1016/j.apsb.2026.07.027. Epub 2026 Jul 18. ABSTRACT Chemoresistance remains a significant challenge in cancer treatment, substantially limiting therapeutic efficacy. Cuproptosis is copper-induced cell death driven by mitochondrial protein aggregation and metabolic dysfunction. However, the involvement of cuproptosis in chemoresistance remains enigmatic. This study reveals that epigenetic remodeling augments mitochondrial […]
A New Omics View of Retinal Aging: Cell-Type Vulnerability, Spatial Niches, and Disease Susceptibility
Exp Eye Res. 2026 Sep 19:111243. doi: 10.1016/j.exer.2026.111243. Online ahead of print. ABSTRACT Classical accounts of retinal aging emphasize oxidative, mitochondrial, inflammatory, vascular, proteostatic, and retinal pigment epithelium (RPE)-centered mechanisms. Omics studies now confirm and refine this non-uniformity, showing that aging-associated signals vary by cell type, anatomical niche, molecular layer, and functional reserve. Direct evidence […]
Defective neuronal differentiation in Lowe syndrome is associated with mitochondrial dysfunction and impaired cilia-related Sonic Hedgehog signaling
Elife. 2026 Sep 18;13:RP104055. doi: 10.7554/eLife.104055. ABSTRACT Human brain development requires tight coordination of metabolic and signaling pathways. Lowe syndrome (LS) is a recessive X-linked disorder characterized by proximal tubular renal disease, congenital cataracts, glaucoma, and neurodevelopmental delays. While LS results from mutations in the OCRL gene, which encodes an inositol polyphosphate 5-phosphatase, the cellular […]
Assessing oxidative stress in retinal tissue using multispectral autofluorescence imaging
Free Radic Biol Med. 2026 Sep 17:S0891-5849(26)01168-8. doi: 10.1016/j.freeradbiomed.2026.09.017. Online ahead of print. ABSTRACT PURPOSE: Oxidative stress plays a central role in retinal degeneration, yet in-vivo assessment remains challenging due to the reliance on invasive or exogenous techniques. Here, we investigate the use of multispectral autofluorescence imaging as a label-free approach to detect stress-induced metabolic […]
Regeneration and Replacement of the Corneal Endothelium: Advances in Cell Therapy, Tissue Engineering, Molecular and Pharmacologic Strategies
Am J Ophthalmol. 2026 Sep 17:S0002-9394(26)00533-7. doi: 10.1016/j.ajo.2026.09.019. Online ahead of print. ABSTRACT Endothelial keratoplasty remains the current gold standard for treating corneal endothelial dysfunction, relying on transplantation of cadaveric donor-derived Descemet’s membrane with functional corneal endothelial cells (CECs) to restore corneal clarity. However, global shortages of suitable cadaveric donor tissue have accelerated interest in […]
Targeting prostaglandin catabolism via topical nanotherapy rescues vision in ischemic optic neuropathy
Neurotherapeutics. 2026 Sep 16;23(6):e01065. doi: 10.1016/j.neurot.2026.e01065. Online ahead of print. ABSTRACT Ischemic optic neuropathy is a leading cause of acute vision loss and currently lacks effective therapy. Here, we identify 15-hydroxyprostaglandin dehydrogenase (15-PGDH), the key enzyme responsible for prostaglandin degradation, as a metabolic checkpoint in ischemic optic neurodegeneration. Analysis of human ischemic optic nerve tissue […]
Homocysteine and mitophagy in diabetic retinopathy: unraveling the underlying molecular crosstalk
Endocrine. 2026 Sep 16;91(1):297. doi: 10.1007/s12020-026-04787-1. ABSTRACT PURPOSE: Diabetic retinopathy (DR), the leading cause of blindness among microvascular complications of diabetes, remains poorly understood regarding its pathogenesis, with effective clinical interventions remaining limited. Emerging evidence indicates that hyperhomocysteinemia (HHcy) and mitochondrial autophagy dysfunction act synergistically as key pathogenic drivers in DR progression, where their interactive […]
Bushen Mingmu Wan attenuates excitotoxic retinal injury and ferroptosis-associated pathology with involvement of CYP1B1-related PI3K/AKT signaling
Pathol Res Pract. 2026 Sep 11;288:156691. doi: 10.1016/j.prp.2026.156691. Online ahead of print. ABSTRACT OBJECTIVE: This study investigated whether Bushen Mingmu Wan (BSMMW) attenuates excitotoxic retinal injury and explored the involvement of CYP1B1-related PI3K/AKT signaling in ferroptosis-associated pathological changes. METHODS: The chemical profile of the tested BSMMW batch was characterized by UPLC-Q-TOF-MS. Candidate glaucoma-related targets were […]
Fifteen-year follow-up of implantable collamer lens surgery in high myopia: Complications, cataract surgery outcomes, and ultrastructural analysis
Adv Ophthalmol Pract Res. 2026 Mar 13;6(3):308-318. doi: 10.1016/j.aopr.2026.02.001. eCollection 2026 Aug-Sep. ABSTRACT PURPOSES: This study reports 15-year outcomes of implantable collamer lens (ICL) surgery in patients with high myopia, analyzing complications, efficacy of cataract surgical, and ultrastructural mechanisms of anterior subcapsular cataract (ASC). METHODS: This retrospective study included 1208 eyes (ICL V4) and 6258 […]