Molecular mechanisms of mitochondrial dysfunction mediated by the MAPK axis in diabetic cataract
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2026 Apr;42(4):316-324. ABSTRACT Objective To explore molecular mechanisms of mitochondrial dysfunction mediated by p38 mitogen-activated protein kinase (p38 MAPK) in diabetic cataract (DC). Methods Lens epithelial cells (LECs) from cell line SRA01/04 were divided into the following six treatment groups: blank group (Con), osmotic control […]
Branch retinal vein occlusion in Leber hereditary optic neuropathy with onset at age 50 years or older: frequency and clinical characteristics
Jpn J Ophthalmol. 2026 Apr 22. doi: 10.1007/s10384-026-01364-x. Online ahead of print. ABSTRACT PURPOSE: To describe branch retinal vein occlusion (BRVO) observed in patients with Leber hereditary optic neuropathy (LHON) with onset at age ≥50 years and to explore whether BRVO prevalence may be higher than age- and sex-matched general population estimates. STUDY DESIGN: Retrospective […]
Lipid stress evolved, microbiome-based probiotics reduce lipid uptake in mice
Bioeng Transl Med. 2026 Feb 1;11(2):e70122. doi: 10.1002/btm2.70122. eCollection 2026 Mar. ABSTRACT Controlling the molecular transport of nutrients through the gut is an attractive strategy to modulate host metabolism. Herein, a technique of stress-based evolution of an individual’s own microbiota to enhance lipid metabolism is presented, which is based on sequential culture of these bacteria […]
CIDEC impairs mitochondrial fitness and blocks protective autophagy via the inhibition of cGMP/PKG pathway to exert tumor-suppressive effects in breast cancer
Cell Oncol (Dordr). 2026 Apr 20;49(3):78. doi: 10.1007/s13402-026-01211-8. NO ABSTRACT PMID:42010152 | DOI:10.1007/s13402-026-01211-8
Submandibular gland oncocytoma: Imaging features and histopathological correlation of a rare benign salivary gland tumor
Radiol Case Rep. 2026 Apr 8;21(7):2680-2684. doi: 10.1016/j.radcr.2026.02.014. eCollection 2026 Jul. ABSTRACT Submandibular gland oncocytoma is a rare benign epithelial tumor accounting for less than 1% of all salivary gland neoplasms. It is composed of oncocytes-large polygonal epithelial cells with abundant eosinophilic granular cytoplasm resulting from mitochondrial accumulation-and typically affects adults between the fifth and […]
DHCR24 Deficiency Drives Age-Related Meibomian Gland Dysfunction by Regulating Lipid Metabolic Imbalance and Cytosolic mtDNA-Induced cGAS-STING Activation
Int J Biol Sci. 2026 Mar 28;22(7):3886-3908. doi: 10.7150/ijbs.129636. eCollection 2026. ABSTRACT Dysregulated lipid metabolism and chronic inflammation are hallmarks of aging, yet their interplay in age-related tissue disorders remains poorly defined. In the ocular surface, age-related meibomian gland dysfunction (ARMGD) is highly prevalent but mechanistically unclear, leading to significant visual impairment without targeted therapies. […]
Glutathione-Depleting Mitochondria-targeting Nanodrugs for Stress Amplification and Immune Activation via Synergistic Photodynamic Therapy and Cuproptosis
Acta Biomater. 2026 Apr 17:S1742-7061(26)00243-6. doi: 10.1016/j.actbio.2026.04.024. Online ahead of print. ABSTRACT Multiple mitochondrial stress dysregulation represents an emergent mechanism for inducing tumor cell death. While photodynamic (PDT) and cuproptosis therapies can generate oxidative and proteotoxic stress respectively, their cooperativity and effects are hampered by the uncontrolled spatiotemporal interaction with glutathione (GSH) overexpressed in the […]
Neuroprotective Effect of Intraperitoneal Humanin-G in Retinal Degeneration of Royal College of Surgeons Rats
bioRxiv [Preprint]. 2026 Mar 24:2026.03.20.713049. doi: 10.64898/2026.03.20.713049. ABSTRACT This study aimed to examine whether Humanin-G (HNG), a mitochondrial derived peptide with cytoprotective properties, could improve the retinal function and gene expression profiles after intraperitoneal injections to Royal College of Surgeons (RCS) rats with Retinal Pigment Epithelium (RPE) dysfunction and retinal degeneration. Starting at postnatal day […]
Blood mtDNA markers of mitochondrial subtype and early-onset Parkinson’s disease biology
Brain. 2026 Apr 16:awag135. doi: 10.1093/brain/awag135. Online ahead of print. ABSTRACT Mitochondrial dysfunction is central to the pathogenesis of Parkinson’s disease (PD), integrating both genetic and environmental factors. Therefore, reliable blood-based biomarkers reflecting mitochondrial alterations are needed. Emerging evidence suggests that somatic changes to mitochondrial DNA (mtDNA) may reflect early disease-associated processes relevant to PD […]
Cross-species transcriptomics identify mineralocorticoid receptor pathway overactivation as a central driver of ocular rosacea
Nat Commun. 2026 Apr 16. doi: 10.1038/s41467-026-71945-4. Online ahead of print. ABSTRACT Ocular rosacea (OR) is a chronic inflammatory disease of the ocular surface frequently associated with meibomian gland dysfunction (MGD), with limited therapeutic options and an underexplored pathophysiology. Here, we uncover the pivotal role of mineralocorticoid receptor (MR) pathway overactivation in driving MGD and […]