Ultrastructural characteristics of the trabecular meshwork in primary open-angle glaucoma versus chronic angle-closure glaucoma: a comparative study
BMC Ophthalmol. 2026 Jul 16. doi: 10.1186/s12886-026-05112-0. Online ahead of print. ABSTRACT BACKGROUND: The trabecular meshwork (TM), the principal site of aqueous humor outflow resistance, plays a pivotal role in the regulation of intraocular pressure (IOP), the key modifiable risk factor for glaucoma. This study aimed to compare the ultrastructural characteristics of the TM in […]
10-HDA attenuates inflammatory responses in LPS-activated RAW264.7 cells in vitro via the NUR77/NF-kappaB pathways and improving mitochondrial functions
Front Pharmacol. 2026 Jul 1;17:1833265. doi: 10.3389/fphar.2026.1833265. eCollection 2026. ABSTRACT BACKGROUND: Inflammation is implicated in the pathogenesis of various diseases, including cancer, diabetes, and diseases caused by bacterial infections. Macrophages, as key regulators of inflammatory responses, can polarize into distinct phenotypes such as pro-inflammatory M1 and anti-inflammatory M2 macrophages. Trans-10-hydroxy-2-decenoic acid (10-HDA), a bioactive component […]
Quantification of Mitochondrial Stress in Nonarteritic Anterior Ischemic Optic Neuropathy Using Flavoprotein Fluorescence Imaging
J Neuroophthalmol. 2026 Jul 15. doi: 10.1097/WNO.0000000000002478. Online ahead of print. ABSTRACT BACKGROUND: Nonarteritic anterior ischemic optic neuropathy (NAION) or optic nerve stroke is the most common acute optic neuropathy in patients older than 50 years and results in severe vision loss. Endogenous flavoprotein fluorescence (FPF) imaging is a novel imaging modality to quantify axonal […]
Quantification of Mitochondrial Stress in Nonarteritic Anterior Ischemic Optic Neuropathy Using Flavoprotein Fluorescence Imaging
J Neuroophthalmol. 2026 Jul 15. doi: 10.1097/WNO.0000000000002478. Online ahead of print. ABSTRACT BACKGROUND: Nonarteritic anterior ischemic optic neuropathy (NAION) or optic nerve stroke is the most common acute optic neuropathy in patients older than 50 years and results in severe vision loss. Endogenous flavoprotein fluorescence (FPF) imaging is a novel imaging modality to quantify axonal […]
Quantification of Mitochondrial Stress in Nonarteritic Anterior Ischemic Optic Neuropathy Using Flavoprotein Fluorescence Imaging
J Neuroophthalmol. 2026 Jul 15. doi: 10.1097/WNO.0000000000002478. Online ahead of print. ABSTRACT BACKGROUND: Nonarteritic anterior ischemic optic neuropathy (NAION) or optic nerve stroke is the most common acute optic neuropathy in patients older than 50 years and results in severe vision loss. Endogenous flavoprotein fluorescence (FPF) imaging is a novel imaging modality to quantify axonal […]
Bilateral Ischemic Optic Neuropathy in a Patient With 3243 A > G Mutation
J Neuroophthalmol. 2026 Jul 15. doi: 10.1097/WNO.0000000000002500. Online ahead of print. NO ABSTRACT PMID:42455652 | DOI:10.1097/WNO.0000000000002500
Beyond Acute Cytotoxicity: A Repair-Exhaustion Framework for Chronic Sublethal Benzalkonium Chloride Toxicity in Repeated Ophthalmic Exposure
J Ocul Pharmacol Ther. 2026 Jul 15:10807683261466785. doi: 10.1177/10807683261466785. Online ahead of print. ABSTRACT Benzalkonium chloride (BAK), a common preservative in multi-dose ophthalmic products, is often studied under acute high-dose exposure, which highlights overt damage to corneal epithelial cells. These studies tend to exaggerate the maximum cytotoxic effects and do not accurately reflect the gradual, […]
When LHON Mimics Demyelination: Area Postrema Syndrome in Biallelic DNAJC30 Variants
J Clin Med. 2026 Jul 7;15(13):5289. doi: 10.3390/jcm15135289. ABSTRACT Introduction: Biallelic pathogenic variants in DNAJC30 cause an autosomal recessive form of Leber hereditary optic neuropathy (LHONAR1), traditionally considered a mitochondrially transmitted disorder. The phenotypic spectrum of diseases linked to DNAJC30 includes isolated optic neuropathy, Leigh syndrome spectrum (LSS), and atypical LHON-plus. Case description: Here, we […]
Mitochondrial transfer and mesenchymal stem cells in ophthalmology: current evidence and therapeutic implications
Exp Biol Med (Maywood). 2026 Jun 30;251:11128. doi: 10.3389/ebm.2026.11128. eCollection 2026. ABSTRACT Mitochondrial dysfunction, driven by genetic mutations or oxidative stress, is a central contributor to the onset and progression of ophthalmic diseases. In recent years, intercellular mitochondrial transfer (MT) has emerged as a novel mechanism of cellular communication and repair in ocular tissues. MT […]
Consensus Recommendations for the Clinical Management of Wolfram syndrome Using a Delphi Method
medRxiv [Preprint]. 2026 Jul 2:2026.07.02.26357130. doi: 10.64898/2026.07.02.26357130. ABSTRACT BACKGROUND: Wolfram syndrome is a rare neurodegenerative disorder, most commonly caused by pathogenic variants in WFS1, while cases due to CISD2 are exceedingly rare. The estimated prevalence is 1 in 160,000 to 770,000 individuals worldwide. In these clinical guidelines, disorders caused by WFS1 are referred to as […]