Near-Infrared and Red-Light Photobiomodulation for Ocular Aging and Diseases: A Narrative Review
Ophthalmol Ther. 2026 Jun 21. doi: 10.1007/s40123-026-01427-9. Online ahead of print. ABSTRACT Near-infrared (NIR) and red light photobiomodulation (PBM) has gained increasing interest as a non-invasive therapeutic approach for a variety of medical conditions including ocular diseases. The eye represents a particularly suitable target for light-based therapies owing to its optical accessibility and the high […]
Mitochondrial peptide MOTS-c suppresses systemic and cardiac inflammasome activation in a diabetic rat model
Exp Physiol. 2026 Jun 19. doi: 10.1113/EP093714. Online ahead of print. ABSTRACT Type 2 diabetes mellitus (T2DM) is associated with chronic systemic and cardiac inflammation, contributing to the development of diabetic cardiomyopathy. The mitochondrial-derived peptide mitochondrial open reading frame of the 12S rRNA type-C (MOTS-c) has emerged as a promising regulator of metabolic and inflammatory […]
The role of short-chain fatty acids as key mediators of gut microbiota – host crosstalk in athyroid diseases
Autoimmun Rev. 2026 Jun 19:104123. doi: 10.1016/j.autrev.2026.104123. Online ahead of print. ABSTRACT The gut-thyroid axis has emerged as a pivotal area of research in endocrinology. Growing evidence suggests that gut microbiota (GM) dysbiosis is implicated in the pathogenesis of thyroid diseases. Short-chain fatty acids (SCFAs), key microbial metabolites, are proposed as critical mediators in this […]
Redox imbalance dictates dependence on GOT1 versus GOT2 for rod photoreceptor health during aging and stress
Redox Biol. 2026 Jun 18;95:104266. doi: 10.1016/j.redox.2026.104266. Online ahead of print. ABSTRACT Photoreceptor (PR) loss causes vision loss in many blinding diseases and effective therapies to prevent this cell loss are lacking. Aspartate aminotransferases (GOTs), located in the cytosol (GOT1) and mitochondria (GOT2), are key components of the malate-aspartate shuttle, which transfers reducing equivalents from […]
Minocycline as a therapeutic candidate in diabetic retinopathy: insights into pathophysiology and translational potential
Exp Eye Res. 2026 Jun 19;270:111134. doi: 10.1016/j.exer.2026.111134. Online ahead of print. ABSTRACT Diabetic retinopathy (DR) is a leading cause of vision loss worldwide and is increasingly recognized as a complex neurovascular disease characterized by early neuroinflammation, neurodegeneration, and microvascular dysfunction. Current therapies primarily target late-stage vascular complications and do not adequately address the upstream […]
Mitofusins are required for specialized mitochondrial morphology and function of rod photoreceptor cells
Front Cell Dev Biol. 2026 Jun 3;14:1724328. doi: 10.3389/fcell.2026.1724328. eCollection 2026. ABSTRACT Mitochondria are dynamic organelles that undergo continuous morphological changes, yet exhibit unique, cell-type-specific structures. In rod photoreceptor cells of the retina, these include elongated mitochondria in the inner segments and a distinct, large, circular mitochondrion within each presynaptic terminal. The mechanisms underlying the […]
Dual regulation of metabolic reprogramming and protein competitive modifications: the core role and mechanism of MRPL36 in glioblastoma malignant progression
J Exp Clin Cancer Res. 2026 Jun 18. doi: 10.1186/s13046-026-03764-w. Online ahead of print. ABSTRACT BACKGROUND: Glioblastoma (GBM) has an extremely poor prognosis. Abnormal mitochondrial function, metabolic disorders, and dysregulated ferroptosis all drive its malignant progression, and the underlying molecular regulatory mechanisms still need further clarification. This study focuses on the regulatory mechanisms linking mitochondrial […]
Therapeutic Potential of miR-196a in Protecting Corneal Endothelial Cells From Senescence Through Mitochondrial and TGF-beta Signaling Modulation
Transl Vis Sci Technol. 2026 Jun 1;15(6):23. doi: 10.1167/tvst.15.6.23. ABSTRACT PURPOSE: Corneal endothelial cells (CECs) play a vital role in maintaining corneal transparency and function, with their hexagonal morphology being a hallmark of proper cellular packing and barrier integrity. This study investigates the functional role of miR-196a in regulating key cellular processes, including viability, cell […]
Spatially resolved in vivo ratiometric imaging of mitochondrial quality control using co-registered confocal-OCT
Biomed Opt Express. 2026 May 8;17(6):2852-2864. doi: 10.1364/BOE.597380. eCollection 2026 Jun 1. ABSTRACT Mitochondrial quality control is essential for maintaining cellular bioenergetic homeostasis, but in vivo monitoring of its spatial dynamics remains difficult to quantify. Here we present a multimodal retinal imaging approach that enables spatially resolved ratiometric assessment of mitochondrial turnover using a hybrid […]
Targeting lysosomal pH restores mitochondrial quality control in GBA1-mutant Parkinson’s disease
Transl Neurodegener. 2026 Jun 17;15(1):27. doi: 10.1186/s40035-026-00559-z. ABSTRACT BACKGROUND: Heterozygous mutations in the glucocerebrosidase gene (GBA1), which encodes the lysosomal enzyme β-glucocerebrosidase (GCase), are a genetic risk factor for Parkinson’s disease (PD). The pathophysiological consequences of GBA1 mutations on dopaminergic neuronal function, especially their impact on lysosomal function, mitophagy, and mitochondrial bioenergetics, remain unclear. METHODS: […]