T Cell-Derived IFN-γ Activates Ferroptosis in Lacrimal Luminal Ductal Cells via JAK-STAT Signaling in Sjögren’s Disease-Related Dry Eye
Invest Ophthalmol Vis Sci. 2026 Sep 1;67(11):43. doi: 10.1167/iovs.67.11.43. ABSTRACT PURPOSE: Sjögren’s disease (SjD) leads to severe dry eye disease (DED) via lacrimal gland inflammation and dysfunction, yet the specific pathogenic mechanisms remain unclear. In this study, we aimed to deeply identify the vulnerable lacrimal epithelial subclusters and elucidate the immune-epithelial cross-talk. METHODS: We used […]
SS31 protects damaged retinal cells through the AMPK/DRP1 signaling pathway
Mol Vis. 2026 Jul 5;32:265-279. doi: 10.63500/mv_v32_265. eCollection 2026. ABSTRACT PURPOSE: Glaucoma is a group of neurodegenerative diseases characterized by progressive loss of retinal ganglion cells (RGCs) and optic nerve fibers. Mitochondrial dynamics contribute to the maintenance of neuronal homeostasis, and abnormalities can lead to the development of glaucoma. SS31 is a mitochondria-targeting short peptide […]
Assessing mitochondrial phenotypes in a cybrid model of dry age-related macular degeneration
Mol Vis. 2026 Jun 12;32:196-208. doi: 10.63500/mv_v32_196. eCollection 2026. ABSTRACT PURPOSE: Dry age-related macular degeneration (DAMD) is the leading cause of vision loss in developed countries, yet there are no FDA-approved treatments currently available. Mitochondria play a significant role in the pathology of DAMD; the retinal pigment epithelium cells of patients with DAMD exhibit mitochondrial […]
A mutation in Bicdl1 (BICD family-like cargo adaptor 1) leads to mild outer retina thinning and late retinal dysfunction in a mouse model
Mol Vis. 2026 Jul 10;32:281-306. doi: 10.63500/mv_v32_281. eCollection 2026. ABSTRACT PURPOSE: Both photoreceptors and the retinal pigment epithelium (RPE) are highly metabolically active cell types that require extensive molecular transport and adequate energy production to maintain their function. We tested the hypothesis that cargo adaptor protein Bicdl1 has a non-redundant role in retinal health. METHODS: […]
Self-Propelled HPB@Lip@AB Nanomotors Ameliorate Dry Eye Disease
Adv Sci (Weinh). 2026 Sep 22:e77681. doi: 10.1002/advs.77681. Online ahead of print. ABSTRACT Dry eye disease (DED) is a common ocular surface disorder closely associated with mitochondrial dysfunction and excessive accumulation of reactive oxygen species (ROS). However, existing treatments are limited by ocular surface barriers. This study developed an integrated nanomotor-based eye drop system (HPB@Lip@AB) […]
The MTRNR2L gene family and age-related macular degeneration
Front Immunol. 2026 Sep 7;17:1925795. doi: 10.3389/fimmu.2026.1925795. eCollection 2026. ABSTRACT Age-related macular degeneration (AMD) is the leading cause of blindness in aging adults, yet no FDA-approved therapies exist for early and intermediate disease. Multiple interconnected pathways, including mitochondrial dysfunction, oxidative stress, and inflammation, contribute to retinal pigment epithelium (RPE) degeneration in AMD, highlighting the need […]
Dendrimer-mediated co-delivery of curcumin and miR-146a attenuates dry eye disease
J Control Release. 2026 Sep 21:115385. doi: 10.1016/j.jconrel.2026.115385. Online ahead of print. ABSTRACT Dry eye disease (DED) is a highly prevalent ocular disorder affecting an estimated 5-50% of the global population. Despite its substantial clinical burden, effective therapeutic options remain limited owing to the multifactorial nature and complex pathophysiology of the disease. To simultaneously address […]
Hierarchical Fe3O4-DOX-TPP@HA Superparticles for Mitochondria-Targeted Photothermo-Chemotherapy of Breast Tumors
ACS Appl Mater Interfaces. 2026 Sep 21. doi: 10.1021/acsami.6c15499. Online ahead of print. ABSTRACT Nanodrug delivery systems have shown great potential for tumor therapy but still meet the challenge of precise and efficient targeting. In this work, we demonstrate a hierarchical approach for mitochondria-targeted photothermo-chemotherapy of a breast tumor by fabricating hyaluronic acid (HA)-coated Fe3O4 […]
Inhibition of EphA2 triggers ferroptosis by disrupting USP38mediated SLC7A11 stabilization in chemoresistant gastric cancer
Cell Mol Life Sci. 2026 Jul 30;83(1):341. doi: 10.1007/s00018-026-06345-4. ABSTRACT Aberrant expression of EphA2 (Ephrin receptor A2) in gastric cancer (GC) promotes chemoresistance by suppressing ferroptosis, yet the underlying mechanism remains poorly defined. In this study, we show that EphA2 confers resistance to platinum-based chemotherapy by suppressing ferroptosis through redox homeostasis regulation. Mechanistically, EphA2 directly […]
Correlation of Mitochondrial Flavoprotein Fluorescence and Sectoral OCT in Patients with Glaucoma, Suspects, and Ocular Hypertension
Clin Ophthalmol. 2026 Sep 16;20:613398. doi: 10.2147/OPTH.S613398. eCollection 2026. ABSTRACT PURPOSE: Flavoprotein fluorescence (FPF) can be measured using a noninvasive investigational device, the OcuMet Beacon (OcuSciences). The Beacon uses blue light to stimulate oxidized mitochondrial flavoproteins, which subsequently emit green autofluorescence. As mitochondrial metabolic stress may reflect axonal damage in glaucomatous eyes, this cross-sectional, exploratory […]