Clinical Efficacy of Ultrasound Cycloplasty for Glaucoma Patients and Pathological Observation on the Ciliary Body in Rabbit Models
J Ophthalmol. 2026 Mar 30;2026:1279697. doi: 10.1155/joph/1279697. eCollection 2026. ABSTRACT PURPOSE: To evaluate the efficacy and safety of ultrasound cycloplasty (UCP) for glaucoma patients and the ciliary body in rabbit models. METHODS: A prospective case series clinical trial and a animal experiment were carried out separately. For human subjects, 55 patients (55 eyes) with refractory […]
Redox Homeostasis, Metabolic Pathways and Plasticity in Uveal Melanoma Compared to Other Cancers
Cancers (Basel). 2026 Jul 25;18(15):2402. doi: 10.3390/cancers18152402. ABSTRACT Background/Objectives: To date there is a lack of an integrative review literature on redox homeostasis, oxidative stress and the influence on metabolic pathways and plasticity in uveal melanoma (UM), since most literature findings are from cutaneous melanoma (CM), a genetically and behaviorally distinct cancer. Furthermore, UM metabolic […]
Bioactive Properties of Carotenoids in Ocular Diseases: Antioxidant, Anti-Inflammatory, and Neuroprotective Effects
Nutrients. 2026 Jul 29;18(15):2467. doi: 10.3390/nu18152467. ABSTRACT Ocular diseases are a significant public health problem worldwide and represent one of the leading causes of disability. The prevalence of visual impairment is steadily increasing, largely driven by the ageing population. Oxidative stress, chronic inflammation and neurodegenerative processes underlie the pathogenesis of many eye diseases, including age-related […]
Expression and mechanistic roles of long non-coding RNAs in diabetic cataract: a systematic review and meta-analysis
Biol Direct. 2026 Aug 12;21(1):142. doi: 10.1186/s13062-026-00888-z. ABSTRACT INTRODUCTION: Diabetic cataract (DC) is a lens-opacity complication of diabetes driven by hyperglycemia-related oxidative, apoptotic, metabolic, and epithelial-mesenchymal transition (EMT) pathways. This review evaluated the expression and mechanistic roles of long non-coding RNAs (lncRNAs) and lncRNA-related epitranscriptomic regulators in DC. METHODS: PubMed, Embase, Cochrane Library, Scopus, Web […]
System-level disruption of cortical temporal integration after stroke: linking intrinsic neural timescales to molecular and neurochemical architecture
Brain Res. 2026 Aug 9:150483. doi: 10.1016/j.brainres.2026.150483. Online ahead of print. ABSTRACT Stroke disrupts the brain’s ability to process and integrate information over time, yet the underlying molecular mechanisms remain unclear. This study investigates post-stroke alterations in intrinsic neural timescales (INTs)-a measure of regional temporal integration-by combining resting-state fMRI, spatial transcriptomics, and PET-based neurochemical mapping. […]
Microglial immunometabolism in Alzheimer’s disease: A stage-resolved trajectory from adaptive remodeling to the metabolic paradox
Biomed Pharmacother. 2026 Aug 8;202:119841. doi: 10.1016/j.biopha.2026.119841. Online ahead of print. ABSTRACT Microglia are central regulators of the cellular phase of Alzheimer’s disease (AD). Under chronic exposure to amyloid-β, pathological tau, and aging-associated bioenergetic decline, these cells undergo immunometabolic remodeling that may initially be adaptive. As stress persists, this remodeling can become maladaptive, marked by […]
Retinal ganglion cell autophagy: a housekeeper essential for neuronal homeostasis and survival
Autophagy Rep. 2026 Aug 5;5(1):2710457. doi: 10.1080/27694127.2026.2710457. eCollection 2026. ABSTRACT Retinal ganglion cells (RGCs) are the sole projection neurons of the retina and the only direct link between retinal circuitry and the brain. Maintaining this lifelong connection requires constitutive autophagy to preserve organelle quality control and neuronal homeostasis. Although autophagy has been widely studied following […]
Engineering cuproptosis with nanomedicine: Design, combination therapy, and translation in cancer
Mater Today Bio. 2026 Jul 15;39:103466. doi: 10.1016/j.mtbio.2026.103466. eCollection 2026 Aug. ABSTRACT Cuproptosis is a distinct form of regulated cell death triggered by copper and characterized by the aggregation of lipoylated mitochondrial proteins, destabilization of iron-sulfur cluster proteins, and proteotoxic stress. Unlike nonspecific copper toxicity, cuproptosis depends on a defined biochemical context shaped by FDX1-associated […]
Immunological drivers of oxidative stress in glaucoma: implications for antioxidant therapy
Graefes Arch Clin Exp Ophthalmol. 2026 Aug 8. doi: 10.1007/s00417-026-07445-4. Online ahead of print. ABSTRACT Glaucoma is a progressive neurodegenerative disorder characterized by RGC loss and irreversible visual impairment, representing the second leading cause of global blindness. Immune-inflammatory responses and oxidative stress are core pathological drivers of glaucomatous optic nerve degeneration, forming a vicious cycle […]
Ginkgolide B protects retinal pigment epithelial cells from H2O2-induced oxidative stress and apoptosis by activating the AMPK/Nrf2 pathway
Front Med (Lausanne). 2026 Jul 24;13:1755596. doi: 10.3389/fmed.2026.1755596. eCollection 2026. ABSTRACT OBJECTIVE: To investigate whether Ginkgolide B (GB) protects retinal pigment epithelial cells (RPEs) from hydrogen peroxide (H2O2)-induced oxidative stress and apoptosis, and to explore the potential involvement of the adenosine monophosphate-activated protein kinase α (AMPKα)/nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. METHODS: Human […]