Zhuhuang granules inhibit HIF-1alpha signaling to regulate oxidative stress-mitochondrial function axis to improve psoriasis
Tissue Cell. 2026 Aug 13;104(Pt 1):103861. doi: 10.1016/j.tice.2026.103861. Online ahead of print. ABSTRACT Psoriasis is a chronic immune-mediated skin disorder characterized by keratinocyte hyperproliferation and persistent inflammation. This study evaluated the therapeutic effects of Zhuhuang granules and investigated their underlying mechanism. Ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS), network pharmacology, and molecular docking were combined with […]
Dual-Action Cationic Nanoparticle Eye Drops Synergistically Disrupt the Pathological Cycle of Dry Eye Disease via ROS-Scavenging and Inflammation Inhibition
ACS Appl Mater Interfaces. 2026 Aug 20. doi: 10.1021/acsami.6c13824. Online ahead of print. ABSTRACT Dry eye disease (DED) is an increasingly prevalent ocular surface disorder that causes discomfort and, in severe cases, visual impairment. A central feature of DED is a self-perpetuating oxidative stress-inflammation cycle, in which excessive reactive oxygen species (ROS) production initiates and […]
New mitogenomic evidence for the phylogeny of Siphonaptera: insights from Callopsylla dolabris and Oropsylla silantiewi
Front Vet Sci. 2026 Aug 4;13:1876060. doi: 10.3389/fvets.2026.1876060. eCollection 2026. ABSTRACT As important vectors of infectious diseases such as plague, fleas require accurate classification and phylogenetic analysis, which are essential for public health prevention and control. However, complete mitochondrial genome resources for Siphonaptera in public databases are still extremely scarce. In this study, the complete […]
Exploring the effect of red and near-infrared light on neurodegenerative disease: A focus on amyotrophic lateral sclerosis, Charcot’s devastating disease of the motor system
Int Rev Neurobiol. 2026;189:205-236. doi: 10.1016/bs.irn.2026.01.013. Epub 2026 Feb 9. ABSTRACT All neurodegenerative diseases, from Alzheimer’s disease to amyotrophic lateral sclerosis (ALS), are characterised by a relentless and progressive degeneration of neurones. The degenerating neurones suffer from mitochondrial dysfunction, glutamate excitotoxicity, metabolic disorder and atypical protein aggregations; there is also widespread neuroinflammation and damage to […]
Late-onset Leber Hereditary Optic Neuropathy: disease triggers and prognostic factors in a large Italian cohort
Ophthalmology. 2026 Aug 18:S0161-6420(26)00586-5. doi: 10.1016/j.ophtha.2026.08.017. Online ahead of print. ABSTRACT PURPOSE: To characterize the clinical and genetic features, investigate disease triggers, and explore factors associated with visual recovery in late-onset Leber Hereditary Optic Neuropathy (LHON). DESIGN: Retrospective cohort study. SUBJECTS, PARTICIPANTS, AND/OR CONTROLS: Seventy-seven patients with late-onset LHON (onset ≥ 40 years of age) […]
Hierarchical ROS-scavenging hydrogel system for coordinating the modulation of RGC necroptosis and oxidative stress in an acute glaucoma model
Bioact Mater. 2026 Aug 7;66:1252-1271. doi: 10.1016/j.bioactmat.2026.07.012. eCollection 2026 Dec. ABSTRACT Glaucoma, a leading cause of irreversible blindness, is characterized by the progressive loss of retinal ganglion cells (RGCs). Beyond intraocular pressure (IOP)-dependent injury, IOP-independent pathways, specifically the self-amplifying axis between oxidative stress and the necroptotic cascade, are key drivers of disease progression. Mediated by […]
The role of mitochondrial energy metabolism in drug resistance and prognosis of lung adenocarcinoma: a multi-omics and machine learning strategy for predictive and personalized therapy
Front Med (Lausanne). 2026 Jul 31;13:1892773. doi: 10.3389/fmed.2026.1892773. eCollection 2026. ABSTRACT BACKGROUND: As the leading histological form of lung cancer, lung adenocarcinoma (LUAD) displays considerable intratumoral heterogeneity, frequent therapeutic resistance, and an unfavorable clinical outcome. Although rewiring of mitochondrial energy metabolism is known to drive tumor progression and treatment failure, a comprehensive understanding of its […]
Musculoskeletal degeneration in space: translational parallels with spaceflight-associated ocular pathology and surgical implications
Life Sci Space Res (Amst). 2026 Sep;52:237-243. doi: 10.1016/j.lssr.2026.03.006. Epub 2026 Mar 20. ABSTRACT Prolonged exposure to microgravity leads to rapid and widespread physiological changes, most notably musculoskeletal degeneration and spaceflight-associated neuro-ocular syndrome (SANS), which are often considered separate clinical challenges. This opinion piece suggests that these conditions may share overlapping upstream mechanisms – particularly […]
Reframing spaceflight-associated neuro-ocular syndrome as spaceflight-associated optic neuropathy (SAON): Transcriptomic in-vivo analysis reveals mitochondrial retinal ganglion cell injury during spaceflight
Life Sci Space Res (Amst). 2026 Sep;52:55-64. doi: 10.1016/j.lssr.2026.07.004. Epub 2026 Jul 9. ABSTRACT Spaceflight-Associated Neuro-Ocular Syndrome (SANS) has remained poorly understood throughout the history of human spaceflight despite being classified as the largest physiologic barrier that astronauts face. Existing mechanistic explanations of SANS are limited in accounting for its tissue specificity, interindividual heterogeneity, and […]
N-acetylcysteine suppresses retinal defects in Drosophila models of SNRNP200-associated retinitis pigmentosa
Hum Mol Genet. 2026 Aug 10;35(17):ddag077. doi: 10.1093/hmg/ddag077. ABSTRACT Retinitis Pigmentosa (RP) is an inherited retinal degenerative disease that affects 1 in 4000 individuals worldwide and can lead to complete blindness. Early stages of RP involve death of rod photoreceptors via apoptosis, causing loss of peripheral and night vision, which is followed by death of […]