Genotype-phenotype correlations in retinitis pigmentosa: structural and vascular insights using OCT and OCTA
Int J Retina Vitreous. 2026 Jun 24. doi: 10.1186/s40942-026-00882-7. Online ahead of print. ABSTRACT BACKGROUND: This study aimed to identify disease-related genetic variants in 41 patients with retinitis pigmentosa (RP) and to evaluate their phenotypic effects on the retina and choroid. METHODS: Patients diagnosed with RP underwent targeted next-generation sequencing of RP-related genes and mitochondrial […]
Label-Free Detection of Cellular Abeta Accumulation and Mitochondrial Dysfunction in AD Cell Models via Raman Microscopy
Anal Chem. 2026 Jun 23. doi: 10.1021/acs.analchem.5c06200. Online ahead of print. ABSTRACT Alzheimer’s disease (AD) is a neurocognitive disorder characterized by the accumulation of amyloid beta (Aβ) in senile plaques in the brain. Aβ accumulates in nerve cells, causing cellular dysfunction through various mechanisms, including mitochondrial dysfunction, leading to apoptosis. AD cell models are being […]
Autophagy in thyroid cancer: Immune suppression and drug resistance
Drug Resist Updat. 2026 Jun 19;88:101437. doi: 10.1016/j.drup.2026.101437. Online ahead of print. ABSTRACT Thyroid cancer exhibits a broad spectrum of clinical behaviors, ranging from indolent differentiated tumors to highly aggressive, dedifferentiated malignancies that are refractory to radioactive iodine (RAI), targeted therapy, and immunotherapy. Autophagy, a highly conserved lysosome-mediated degradation pathway, has been identified as a […]
Generation and characterization of a human induced pluripotent stem cell line (SNUi001-A) harboring the MT-ND4 m.11778G>A mutation
Stem Cell Res. 2026 Jun 20;95:104043. doi: 10.1016/j.scr.2026.104043. Online ahead of print. ABSTRACT Leber hereditary optic neuropathy (LHON) is a maternally inherited optic neuropathy caused by mutations in mitochondrial DNA. To facilitate disease modeling and the investigation of pathogenetic mechanisms, we generated an induced pluripotent stem cell (iPSC) line, SNUi001-A, derived from the peripheral blood […]
Senp1 O-GlcNAcylation Promotes Mitochondrial Fragmentation by Regulating Fis1 SUMO1-ylation Underlying Diabetic Cataract
Invest Ophthalmol Vis Sci. 2026 Jun 1;67(6):44. doi: 10.1167/iovs.67.6.44. ABSTRACT PURPOSE: Cataract is a major cause of blindness among patients with diabetes mellitus. The pathology underlying diabetic cataract (DC) is complex because of changes in biological processes caused by chronic hyperglycemia. O-GlcNAcylation is highly dependent on glucose availability and regulates mitochondrial functions. Dysregulation of O-GlcNAcylation […]
Humanin Mitigates Aβ-Induced Retinal Pigment Epithelium Injury via AMPK-Beclin1-Dependent Mitophagy
Aging Cell. 2026 Jul;25(7):e70601. doi: 10.1111/acel.70601. ABSTRACT Amyloid beta (Aβ), a key component of drusen in age-related macular degeneration (AMD), induces oxidative stress, mitochondrial dysfunction, and degeneration in the retinal pigment epithelium (RPE), contributing to progressive vision loss in the elderly. We investigated the protective role of Humanin (HN), a mitochondria-derived peptide with known neuroprotective […]
Prospects for Neuroprotective Therapies in Glaucoma: Drug Targets and Emerging Clinical Strategies
Drug Des Devel Ther. 2026 Jun 16;20:612176. doi: 10.2147/DDDT.S612176. eCollection 2026. ABSTRACT Management of glaucoma is now at an inflection point with a new generation of therapeutic candidates, whilst targeting intraocular pressure-independent strategies is challenged by the landmark Phase III failure of memantine regarding trial design and endpoint sensitivity. Preclinical research has identified promising targets […]
Malnutrition as a Risk Factor for Cerebral and Glaucomatous Neurodegeneration – Mechanisms and Therapeutic Strategies
Klin Monbl Augenheilkd. 2026 Jun 22. doi: 10.1055/a-2841-0517. Online ahead of print. ABSTRACT ABSTRACT: BACKGROUND: Neurodegenerative diseases are an increasing challenge for healthcare systems in the context of demographic change. They affect the central nervous system, including the brain-manifesting, for example, as dementia-as well as the retina, as seen in glaucoma or age-related macular degeneration. […]
MGST1 drives lymph node metastasis in papillary thyroid carcinoma via mitochondrial metabolic reprogramming and immune suppression
Front Immunol. 2026 Jun 4;17:1848083. doi: 10.3389/fimmu.2026.1848083. eCollection 2026. ABSTRACT BACKGROUND: While papillary thyroid carcinoma (PTC) generally exhibits a favorable prognosis, a subset of patients experiences poorer outcomes, with lymph node metastasis (LNM) significantly increasing the risk of recurrence and correlating with a worse prognosis. Mitochondrial metabolic reprogramming and immune evasion play pivotal roles in […]
Stage- and compartment-specific remodeling of autophagy and selective mitophagy in glaucoma: from aqueous outflow dysfunction to retinal ganglion cell neurodegeneration
Front Cell Dev Biol. 2026 Jun 4;14:1842496. doi: 10.3389/fcell.2026.1842496. eCollection 2026. ABSTRACT BACKGROUND: Glaucoma is a leading cause of irreversible blindness and is increasingly understood as a chronic neurodegenerative disorder rather than a disease explained solely by elevated intraocular pressure (IOP). Although IOP lowering remains the cornerstone of treatment, many patients continue to progress despite […]