Perfluorooctanoic acid exposure induces visual impairment via microglia-mediated neuroinflammation and retinal ganglion cell apoptosis
Environ Int. 2026 Jul 22;214:110432. doi: 10.1016/j.envint.2026.110432. Online ahead of print. ABSTRACT Perfluoroalkyl and polyfluoroalkyl substances are closely associated with visual impairment; however, the pathogenic mechanisms through which they cause optic nerve damage and their relationships with the onset of ocular diseases remain poorly defined. In this study, a mouse model of perfluorooctanoic acid (PFOA) […]
GSH-Responsive Co-Delivery of Chrysin and 3‑Methyladenine Disrupts Tumor Adaptive Stress for Synergistic Antitumor Therapy
ACS Omega. 2026 Jul 9;11(28):42728-42741. doi: 10.1021/acsomega.6c04046. eCollection 2026 Jul 21. ABSTRACT Cancer remains a major global health challenge, and conventional therapies are still limited by poor tumor specificity, therapeutic resistance, and systemic side effects. Herein, we developed a glutathione (GSH)-responsive FFSSFF coacervate system for the codelivery of chrysin (CH) and the autophagy inhibitor 3-methyladenine […]
FZD7 Inhibitor SRI Attenuates High Glucose-Induced Retinal Pigment Epithelial Cell Injury Accompanied by Ferroptosis-Associated Changes via Suppression of the Wnt/β-Catenin Pathway
Endocrinol Diabetes Metab. 2026 Jul;9(4):e70290. doi: 10.1002/edm2.70290. ABSTRACT PURPOSE: This study investigated the protective effects of the Frizzled-7 (FZD7) inhibitor SRI against high glucose-induced injury in human retinal pigment epithelial (ARPE-19) cells. It also explored the underlying mechanism, focusing on whether SRI attenuates ferroptosis and apoptosis by inhibiting the Wnt/β-catenin signalling pathway. METHODS: ARPE-19 cells […]
6-Gingerol alleviates hepatic fibrosis via inhibiting glycolytic reprogramming by targeting IGF2BP2
Chin Herb Med. 2026 May 13;18(3):585-603. doi: 10.1016/j.chmed.2026.05.012. eCollection 2026 Jul. ABSTRACT OBJECTIVE: Hepatic fibrosis remains a major global health burden, often progressing to cirrhosis and hepatocellular carcinoma. Despite extensive research, no effective antifibrotic drugs are clinically approved due to the complexity of hepatic stellate cells (HSCs) activation and metabolic remodeling. Enhanced glycolysis is increasingly […]
ACSL1 orchestrates ferroptosis and degranulation in low-density neutrophils: a novel pathogenic mechanism and therapeutic target in systemic lupus erythematosus
Mol Cell Biochem. 2026 Jul 22. doi: 10.1007/s11010-026-05645-4. Online ahead of print. ABSTRACT Systemic lupus erythematosus (SLE) is a complex autoimmune disease in which neutrophils, especially the pro-inflammatory low-density neutrophil (LDN) subset, play a central pathogenic role. Yet, the molecular mechanisms that link neutrophil ferroptosis, degranulation, and interferon amplification remain incompletely understood. Through integrative bioinformatics […]
Macular Metabolism in Young and Older Adults: A Preliminary Optical Coherence Tomography Biomarker Study
Invest Ophthalmol Vis Sci. 2026 Jul 1;67(8):41. doi: 10.1167/iovs.67.8.41. ABSTRACT PURPOSE: To begin to test whether optical coherence tomography (OCT) metabolic biomarkers-established in mouse studies-change with age in ways consistent with published ex vivo findings on macular metabolism in healthy young vs. older adults. METHODS: In this cross-sectional study, light-adapted subjects-25 light-adapted participants aged 20-30 […]
Neuroprotective effect of intraperitoneal Humanin-G in retinal degeneration of Royal College of Surgeons rats
Sci Rep. 2026 Jul 18. doi: 10.1038/s41598-026-62834-3. Online ahead of print. ABSTRACT This study aimed to examine whether Humanin-G (HNG), a mitochondrial derived peptide with cytoprotective properties, could improve the retinal function and gene expression in Royal College of Surgeons (RCS) rats with retinal pigment epithelium (RPE) dysfunction and retinal degeneration. Starting at postnatal day […]
DNA Sensing and Neuroinflammation: Mechanistic Insights into cGAS-STING Biology and Therapeutic Translation in Age-Related Neurodegenerative Diseases
Mol Neurobiol. 2026 Jul 18;63(1):779. doi: 10.1007/s12035-026-06061-x. ABSTRACT Emerging evidence suggests that some of the earliest events contributing to neurodegeneration may occur upstream of classical proteinopathies, underscoring the urgency of identifying molecular pathways that link age-associated genomic instability to chronic neuroinflammation. Among these, DNA sensing through the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) […]
How past European Board of Ophthalmology (EBO) candidates acquired theoretical knowledge: an EBO survey
BMC Med Educ. 2026 Jul 17. doi: 10.1186/s12909-026-09913-1. Online ahead of print. ABSTRACT BACKGROUND: The European Board of Ophthalmology (EBO), whose mission is to guarantee high standards of care in ophthalmology, has assessed residency training quality for over 30 years through the EBO Diploma (EBOD) examination, undertaken by residents and certified ophthalmologists from the 27 […]
Retinal connections to migraine
Front Neurol. 2026 Jul 2;17:1835914. doi: 10.3389/fneur.2026.1835914. eCollection 2026. ABSTRACT OBJECTIVE: This narrative review aims to examine potential associations between migraine and retinal disorders, with particular attention to retinal migraine, age-related macular degeneration (AMD), retinal vascular occlusions, and photophobia. BACKGROUND: The role of retinal pathways in migraine pathophysiology remains poorly understood. As a component of […]