Astrocytopathy in Wernicke Encephalopathy and Neuromyelitis Optica Spectrum Disorder. Pathogenic Differences With Occasional Clinical and Neuroimaging Overlap. A Review
Curr Neurol Neurosci Rep. 2026 Apr 25;26(1):27. doi: 10.1007/s11910-026-01497-z. ABSTRACT PURPOSE OF THE REVIEW: There is an increasing number of single case reports describing patients with findings compatible with thiamine deficiency, in whom rapid replacement of thiamine fails to induce improvement. Further work-up identifies positive aquaporin-4 antibodies (AQP-4) leading to a final diagnosis of neuromyelitis […]
Retinal Pigment Epithelium Ageing: Cellular and Molecular Mechanisms of Long-Term Homeostasis and Age-Related Dysfunction
Cells. 2026 Apr 19;15(8):725. doi: 10.3390/cells15080725. ABSTRACT The retinal pigment epithelium (RPE) is a long-lived, highly polarised epithelial monolayer that performs essential functions in retinal homeostasis, including outer blood-retina barrier maintenance, visual cycle activity, metabolic exchange, phagocytic clearance of photoreceptor outer segments, and regulation of oxidative and immune balance. Because RPE cells persist for decades […]
The impact of near-infrared photobiomodulation therapy on human oocyte rescue in vitro maturation
J Photochem Photobiol B. 2026 Apr 21;279:113452. doi: 10.1016/j.jphotobiol.2026.113452. Online ahead of print. ABSTRACT This prospective study investigated the effects of photobiomodulation therapy (PBMT) at 810 nm on rescue in vitro maturation (rescue-IVM) of human immature oocytes following controlled ovarian stimulation (COS). A total of 260 immature oocytes (germinal vesicles (GV): 143; metaphase I (MI): […]
Nr2e3-Deficient Mice Show Evidence for Elevated Photoreceptor Bioenergetics and Retinal Visual Cycle Activity Based on OCT Metabolic Biomarkers
Invest Ophthalmol Vis Sci. 2026 Apr 1;67(4):57. doi: 10.1167/iovs.67.4.57. ABSTRACT PURPOSE: Ex vivo studies show that photoreceptors of Nr2e3-deficient (rd7) mice display (1) cone-like juxtanuclear mitochondria suggesting higher bioenergetics than in wild-type (WT) mice, and (2) reliance on a cone-only “retinal” visual cycle-two hypotheses examined in vivo herein. METHODS: We measured two optical coherence tomography […]
TARGETING DRP1 ATTENUATES FERROPTOSIS AND DELAYS THE PROGRESSION OF DIABETIC RETINOPATHY
Exp Eye Res. 2026 Apr 21:111035. doi: 10.1016/j.exer.2026.111035. Online ahead of print. ABSTRACT Diabetic retinopathy (DR), the leading cause of blindness among working-age adults, is driven by largely undefined modes of retinal microvascular cell death. We asked whether the mitochondrial fission GTPase dynamin-related protein 1 (DRP1) governs ferroptotic injury in this setting. In cultured human […]
The N6-methyladenosine (m6A) reader YTHDF3 increases PINK1/Parkin-mediated mitophagy by facilitating prohibitin 2 (PHB2) translation to promote retinal ganglion cell damage in diabetic retinopathy
J Neuropathol Exp Neurol. 2026 Apr 23:nlag027. doi: 10.1093/jnen/nlag027. Online ahead of print. ABSTRACT Retinal ganglion cells (RGCs) are particularly vulnerable to damage during the early stages of diabetic retinopathy (DR). Emerging evidence indicates that dysregulated expression of N6-methyladenosine (m6A) methylation regulators contributes to DR pathogenesis. In particular, the m6A reader protein YTHDF3 has been […]
Exploring the mechanism of baicalein on choroid melanoma based on network pharmacology, transcriptomics and experimental verification
Front Pharmacol. 2026 Apr 8;17:1787798. doi: 10.3389/fphar.2026.1787798. eCollection 2026. ABSTRACT OBJECTIVE: Baicalein (BAI), a flavonoid from Scutellaria baicalensis, exhibits therapeutic potential across inflammation, viral infections, and cancers. Yet, its role in choroidal melanoma (CM), the most common intraocular malignancy, remains poorly understood. The aim of this study was to investigate BAI’s anti-CM effects and underlying […]
Nanobacterial detection in aqueous humor and its effect on postphacoemulsification visual acuity among highly myopic patients
Mol Vis. 2026 Feb 17;32:84-100. eCollection 2026. ABSTRACT This study aimed to investigate factors affecting visual outcomes after phacoemulsification in highly myopic patients with cataracts, based on the detection of nanobacteria (NB) in aqueous humor. Fifty highly myopic patients with cataracts who underwent phacoemulsification surgery at The First People’s Hospital of Ziyang from December 2022 […]
Efficacy of lenadogene nolparvovec gene therapy versus idebenone in Leber hereditary optic neuropathy due to the m.11778G>A MT-ND4 variant: two matching adjusted indirect comparisons
Br J Ophthalmol. 2026 Apr 22:bjo-2025-329206. doi: 10.1136/bjo-2025-329206. Online ahead of print. ABSTRACT BACKGROUND: Lenadogene nolparvovec is an intravitreal gene therapy for patients with Leber hereditary optic neuropathy (LHON) carrying the m.11778G>A MT-ND4 variant. Idebenone, a synthetic coenzyme Q10 analogue, is the only approved treatment for LHON. To estimate the relative effects of both treatments, […]
Amino Acid Metabolism in Retinal Diseases: Mechanisms, Diagnostics, and Therapeutic Opportunities
Exp Eye Res. 2026 Apr 20:111033. doi: 10.1016/j.exer.2026.111033. Online ahead of print. ABSTRACT Amino acid metabolism serves as a central hub linking retinal energy supply, neurotransmission, and cell signaling, which is critical for maintaining retinal structure and function. This review summarizes the molecular mechanisms by which abnormal amino acid metabolism contributes to retinal diseases. The […]