4-Octyl Itaconate Attenuates Age-Induced Parotid Gland Dysfunction Through the Suppression of Fibrosis and Lipid Deposition by AMPKα/PPARα and the Inhibition of Oxidative Stress via the AMPKα/Nrf2 Signaling Pathway
FASEB J. 2026 Oct 15;40(19):e72335. doi: 10.1096/fj.202602956RR. ABSTRACT Parotid gland aging is a key factor for reduced salivary production in older individuals. The role of 4-Octyl itaconate (4-OI) in age-related parotid gland dysfunction remains unclear. Thirteen-month-old male mice were administered 4-OI (25 mg/kg) or vehicle once daily for 4 weeks. The salivary flow rate was […]
Lactylation and oxidative stress in diabetic retinopathy: Emerging links among metabolic reprogramming, epigenetic regulation and therapeutic potential
Life Sci. 2026 Sep 29:124712. doi: 10.1016/j.lfs.2026.124712. Online ahead of print. ABSTRACT Diabetic retinopathy (DR) is a leading cause of visual impairment and is characterized by progressive microvascular injury, neurovascular dysfunction, and sustained oxidative stress. Lactylation, a lactate-derived post-translational modification, may represent a mechanistic link between hyperglycemia-induced metabolic reprogramming and epigenetic regulation. In the diabetic […]
Alpha-Ketoglutarate Dehydrogenase and Citric Acid Cycle Flexibility in Heart Disease and Failure
Am J Physiol Heart Circ Physiol. 2026 Sep 29. doi: 10.1152/ajpheart.00428.2026. Online ahead of print. ABSTRACT Tricarboxylic acid cycle (TCA) enzymes, mitochondrial isocitrate dehydrogenase (IDH2), α-ketoglutarate dehydrogenase (AKGDH), and succinyl-CoA synthetase (SCS) catalyse the conversion of isocitrate to succinate generating reducing equivalents for mitochondrial complex I and ATP by substrate level phosphorylation. Because of their […]
Targeting osteoblast fatty acid metabolism attenuates skeletal and cardiovascular complications in chronic kidney disease models
J Clin Invest. 2026 Sep 29:e207322. doi: 10.1172/JCI207322. Online ahead of print. ABSTRACT Chronic kidney disease (CKD) disrupts mineral homeostasis, leading to impaired skeletal mineralization and cardiovascular pathology, yet the mechanism linking these processes remains undefined. Here we identify glycerol-3-phosphate acyltransferase 2 (GPAT2) as a regulator that couples free fatty acid (FFA) partitioning in osteoblasts […]
Mitochondrial migraine: A multicenter study based on mitochondrial diseases presenting as encephalopathy and/or myopathy
Headache. 2026 Sep 29. doi: 10.1111/head.70225. Online ahead of print. ABSTRACT OBJECTIVE: This study aimed to investigate the clinical features of migraine in a cohort of patients with mitochondrial disease (MD) presenting as encephalopathy and/or myopathy, and to explore the potential association between migraine and mitochondrial dysfunction. BACKGROUND: MDs comprise a heterogeneous group of disorders […]
Honokiol Alleviates Dry Eye-Related Corneal Epithelial Damage by Activating SIRT3/PINK1-Mediated Mitophagy
Drug Des Devel Ther. 2026 Sep 22;20:622482. doi: 10.2147/DDDT.S622482. eCollection 2026. ABSTRACT BACKGROUND: Dry eye is a common ocular surface disease characterized by corneal epithelial damage, yet effective therapies targeting mitochondrial dysfunction remain limited. PURPOSE: To investigate the protective effects of honokiol (HKL) against dry eye-related corneal epithelial injury and elucidate the underlying mechanisms focusing […]
Beyond Anti-VEGF: Toward Integrated Precision Care in Diabetic Retinal Disease
Pharmaceutics. 2026 Sep 17;18(9):1178. doi: 10.3390/pharmaceutics18091178. ABSTRACT Diabetic retinal disease (DRD) remains one of the leading causes of preventable vision loss worldwide and continues to represent a major global public health challenge despite remarkable therapeutic advances over the past two decades. Intravitreal anti-vascular endothelial growth factor (VEGF) therapy has revolutionized the management of diabetic macular […]
Correction: Macin et al. Synergistic Anticancer Effects of Resveratrol and Carboplatin in Y79 Retinoblastoma Cells: Mechanistic Insights into Apoptosis, G2/M Arrest, and ROS-Dependent Mitochondrial Dysfunction. Int. J. Mol. Sci. 2026, 27, 3473
Int J Mol Sci. 2026 Sep 21;27(18):8402. doi: 10.3390/ijms27188402. ABSTRACT In the original publication […]. PMID:42794863 | DOI:10.3390/ijms27188402
Oxidative Stress and Uveitis: Molecular Mechanisms and Pathogenetic Role
Curr Issues Mol Biol. 2026 Sep 3;48(9):903. doi: 10.3390/cimb48090903. ABSTRACT Uveitis comprises a heterogeneous group of intraocular inflammatory diseases that differ in anatomical location, etiology, clinical course, and immune mechanisms. Despite this diversity, evidence derived predominantly from experimental autoimmune uveitis (EAU) suggests that oxidative stress may act as a context-dependent amplifier linking immune activation, ocular […]
Unveiling Disulfidptosis and Cuproptosis Vulnerabilities in Pterygium: A Transcriptomic Analysis and In-Silico Drug Repurposing Strategy
Genes (Basel). 2026 Sep 12;17(9):1105. doi: 10.3390/genes17091105. ABSTRACT OBJECTIVES: Pterygium is an invasive, hyperproliferative fibrovascular disorder of the ocular surface characterized by frequent postoperative recurrence and resistance to apoptosis. This study investigated transcriptional alterations in genes related to the regulated cell death pathways disulfidptosis and cuproptosis in pterygium and explored potential pharmacological candidates through in-silico […]