Dual-restricted AAV gene delivery via suprachoroidal administration mediates precision RPE SOCS3 restoration for dry age-related macular degeneration
J Control Release. 2026 Aug 24:115289. doi: 10.1016/j.jconrel.2026.115289. Online ahead of print. ABSTRACT Dry age-related macular degeneration (dAMD) is a leading cause of irreversible vision loss, driven by chronic oxidative stress and inflammation in the retinal pigment epithelium (RPE). Disruption of key negative regulators of the JAK-STAT pathway, particularly SOCS3, contributes to this oxidative-inflammatory cascade. […]
Core-shell lycopene-loaded nanoparticle-modified intraocular lens for posterior capsule opacification prevention via mitochondrial homeostasis
J Control Release. 2026 Aug 23:115292. doi: 10.1016/j.jconrel.2026.115292. Online ahead of print. ABSTRACT Posterior capsule opacification (PCO) develops when residual lens epithelial cells (LECs) proliferate, migrate, and undergo epithelial-mesenchymal transition (EMT) after cataract surgery. Because mitochondrial dysfunction may promote EMT-associated cellular remodeling, modulation of mitochondrial quality control could provide a complementary strategy for PCO prevention. […]
Genetic architecture and inheritance patterns of Leber hereditary optic neuropathy among 419 Chinese pedigrees carrying the ND4 11778G>A mutation
J Genet Genomics. 2026 Aug 22:S1673-8527(26)00272-9. doi: 10.1016/j.jgg.2026.08.007. Online ahead of print. ABSTRACT Leber’s hereditary optic neuropathy (LHON) is a mitochondrial disease mainly driven by the m.11778G>A mutation, and its incomplete penetrance and diverse inheritance patterns remain unclear. This study integrates clinical and genetic analyses of 419 Han Chinese pedigrees carrying this mutation, covering 5262 […]
FZD7 drives retinal ferroptosis in diabetic retinopathy via β-catenin-dependent suppression of the DHODH/FSP1 axis
J Pharmacol Sci. 2026 Oct;162(2):130-142. doi: 10.1016/j.jphs.2026.07.006. Epub 2026 Aug 3. ABSTRACT PURPOSE: To investigate the role of Frizzled-7 (FZD7) in diabetic retinopathy (DR) and elucidate the molecular mechanism by which FZD7 regulates ferroptosis during disease progression. METHODS: Core DR-associated genes were identified through integrated bioinformatic analyses and validated by RT-qPCR. Gain- and loss-of-function experiments […]
Cytoprotective Potential of N-Acetylcysteine in an In Vitro Model of Retinal Oxidative Injury
J Ocul Pharmacol Ther. 2026 Aug 21:10807683261480480. doi: 10.1177/10807683261480480. Online ahead of print. ABSTRACT PURPOSE: Sodium iodate (NaIO3) is a well-established oxidizing agent that induces oxidative stress (OS) in ARPE-19 cells, while antioxidants such as N-acetylcysteine (NAC) have demonstrated cytoprotective effects in retinal degeneration models. This study establishes an in vitro NaIO3-induced OS disease model […]
UCHL1 attenuates diabetic retinopathy by deubiquitinating and stabilizing NRF2 to suppress oxidative stress-induced retinal vascular endothelial ferroptosis
Biochem Pharmacol. 2026 Aug 21:118389. doi: 10.1016/j.bcp.2026.118389. Online ahead of print. ABSTRACT Diabetic retinopathy (DR) is characterized by progressive retinal microvascular injury, with oxidative stress and ferroptosis increasingly recognized as key pathogenic contributors. This study investigated whether ubiquitin C-terminal hydrolase L1 (UCHL1) regulates retinal endothelial ferroptosis through stabilization of nuclear factor erythroid 2-related factor 2 […]
RETHINKING AEROBIC METABOLISM IN RETINAL ROD OUTER SEGMENTS: TRIPLE METABOLIC HYPOTHESIS AND CLINICAL IMPLICATIONS
Prog Retin Eye Res. 2026 Aug 21:101513. doi: 10.1016/j.preteyeres.2026.101513. Online ahead of print. ABSTRACT The vertebrate retina is among the most energy-demanding tissues in the body, with photoreceptors accounting for most of its metabolic activity. The photoreceptor outer segment, devoid of mitochondria, carries out visual transduction. Oxidative phosphorylation in the rod inner segment has been […]
Dysfunction of the Neurovascular Unit in Diabetic Retinopathy: Advances from Molecular Mechanisms to Targeted Interventions
Stem Cell Rev Rep. 2026 Aug 20. doi: 10.1007/s12015-026-11213-6. Online ahead of print. ABSTRACT Diabetic retinopathy (DR) is a leading cause of vision loss and is now increasingly understood as a neurovascular disease rather than a purely microvascular complication of diabetes. The retinal neurovascular unit (NVU), composed of neurons, Müller cells, microglia, astrocytes, endothelial cells, […]
Novel Variants in Mitochondrial Ribosomal RNA Genes MT-RNR1 and MT-RNR2 Identified in Hereditary Optic Neuropathy Initially Presenting as Normal Tension Glaucoma: A Case Report
Case Rep Ophthalmol. 2026 Jul 15;17(1):853-859. doi: 10.1159/000553606. eCollection 2026 Jan-Dec. ABSTRACT INTRODUCTION: Hereditary optic neuropathy may be caused by various mitochondrial or nuclear DNA mutations affecting the mitochondrial function. A growing body of evidence shows that mutations in non-classical mitochondrial genes, including the ribosomal RNA genes MT-RNR1 and MT-RNR2, have been reported in patients […]
Advancing Treatment of Degenerative Eye Diseases at the Nanoscale
Smart Med. 2026 Aug 12;5(4):e70050. doi: 10.1002/smmd.70050. eCollection 2026 Aug. ABSTRACT Degenerative ocular diseases are characterized by a convergence of molecular perturbations, including oxidative stress, chronic inflammation, failure of proteostasis, mitochondrial dysfunction, abnormal angiogenic signaling, and biomechanical remodeling. The eye’s unique architecture, sealed by the blood-retina barrier, presents formidable anatomical and cellular topological challenges to […]