The Role of lncRNA GAS5 in Oxidative Stress and Mitochondrial Dysfunction in Age-Related Cataracts: Insights From Transcriptome Profiling
Invest Ophthalmol Vis Sci. 2026 Jun 1;67(6):7. doi: 10.1167/iovs.67.6.7. ABSTRACT PURPOSE: This study aimed to investigate the role of lncRNA GAS5 and GADD45a in H₂O₂-induced oxidative stress and mitochondrial dysfunction in human lens epithelial cells (LECs), and to explore the underlying ceRNA mechanism involving miR-3666. METHODS: Human LECs were exposed to H₂O₂ to induce oxidative […]
Early proteomic signatures of Alzheimer’s disease in the retina and brain of 3xTg-AD mice
Front Cell Dev Biol. 2026 May 18;14:1827348. doi: 10.3389/fcell.2026.1827348. eCollection 2026. ABSTRACT INTRODUCTION: Visual dysfunction and retinal structural changes can occur early in Alzheimer’s disease (AD), but the molecular basis of these early alterations remains unclear. METHODS: We performed quantitative proteomic profiling of the retina and brain from 4-week-old triple-transgenic AD (3xTg-AD) mice carrying human […]
First Revision of the Guidelines for the Diagnosis and Management of Remethylation Disorders
J Inherit Metab Dis. 2026 Jul;49(4):e70177. doi: 10.1002/jimd.70177. ABSTRACT This guideline summarizes diagnostic and therapeutic approaches based on a systematic literature review and evidence evaluation using the GRADE methodology. Given the limited high-quality data, expert consensus was additionally obtained through a modified Delphi process. Remethylation disorders are rare inherited conditions that disrupt the methionine-homocysteine cycle […]
Deficient autophagy in retinal ganglion cells impairs the degradation of intracellular organelles, leading to neurodegeneration
Cell Death Dis. 2026 May 30. doi: 10.1038/s41419-026-08927-3. Online ahead of print. ABSTRACT Autophagy is a fundamental catabolic process that facilitates the degradation and recycling of cellular components like protein aggregates and defective organelles. However, the precise role of constitutive autophagy in regulating retinal ganglion cell (RGC) function and survival remains largely undefined. Here, we […]
PKM2-driven glycolysis mediates rotenone neurotoxicity via MG-Hs in Parkinson’s disease
Sci Rep. 2026 May 30. doi: 10.1038/s41598-026-54865-7. Online ahead of print. ABSTRACT Parkinson’s disease (PD) is a progressive neurodegenerative disorder lacking disease-modifying therapies. Rotenone (Rot) is widely used to model PD, but its neurotoxicity is not fully understood beyond mitochondrial complex I inhibition. Here, we identify a glycolytic mechanism that contributes to Rot-induced neuronal damage […]
Immune-Metabolic Interactions in the Degenerative Retina: A Systems Biology Approach Based on Diabetic Retinopathy
Front Biosci (Landmark Ed). 2026 May 22;31(5):49588. doi: 10.31083/FBL49588. ABSTRACT Diabetic retinopathy (DR) is increasingly recognized as a complex neurovascular degenerative disorder driven by intertwined immune and metabolic disturbances within the retinal microenvironment. Chronic hyperglycemia induces metabolic stress, mitochondrial dysfunction, and oxidative imbalance, which, in turn, activate innate and adaptive immune pathways. Key mechanisms-including complement […]
Autophagy impairs the sensitivity of Ewing sarcoma cells to PARP inhibitors
Cancer Chemother Pharmacol. 2026 May 30;96(1):60. doi: 10.1007/s00280-026-04907-8. ABSTRACT PURPOSE: PARP inhibitors (PARPi) proved effective in Ewing sarcoma cells in preclinical studies. In clinical evaluation, however, the PARPi olaparib failed to elicit substantial responses, suggesting an unknown mechanism of resistance to PARPi in Ewing sarcoma. Since autophagy has been identified as a PARPi resistance mechanism […]
SGLT2 inhibition with empagliflozin attenuates retinal oxidative stress and damage in diabetic mice
Sci Rep. 2026 May 29. doi: 10.1038/s41598-026-53536-x. Online ahead of print. ABSTRACT To investigate the effects of empagliflozin (EMPA), an SGLT2 inhibitor, on retinal damage in diabetic mice, exploring its potential as a therapeutic strategy for diabetic retinopathy (DR). DR was induced by a high-fat diet and streptozotocin injections, followed by EMPA treatment. The study […]
Feasibility of In Vivo Retinal Flavoprotein Autofluorescence Imaging in a Magnetic-Bead-Induced Rodent Glaucoma Model
J Biophotonics. 2026 Jun;19(6):e70297. doi: 10.1002/jbio.70297. ABSTRACT Mitochondrial dysfunction and oxidative stress in retinal ganglion cells (RGCs) are critical events in the pathogenesis of glaucoma that occur prior to structural degeneration and visual field loss. Flavoprotein fluorescence (FPF) produced by oxidized mitochondrial flavoproteins offers a potential biomarker for early detection of cellular dysfunction. This study […]
Mitochondrial transplantation protects the retinal pigment epithelial cells from the oxidative stress induced by NaIO(3)
Exp Eye Res. 2026 May 27:111090. doi: 10.1016/j.exer.2026.111090. Online ahead of print. ABSTRACT The retinal pigment epithelium (RPE) is the outermost part of the retina, and it is essential for the photoreceptor survival and function. Oxidative stress, aging, accumulation of lipofuscin, and drusen can lead to retinal degenerative diseases such as age-related macular degeneration (AMD). […]