Archetypal Visual Field Analysis of Patients With Chronic Leber Hereditary Optic Neuropathy in Relation to Visual Recovery
Invest Ophthalmol Vis Sci. 2026 Jul 1;67(8):8. doi: 10.1167/iovs.67.8.8. ABSTRACT PURPOSE: To use the machine learning algorithm archetypal analysis (AA) to characterize visual field (VF) loss patterns in patients with chronic Leber hereditary optic neuropathy (LHON) and to determine whether these VF patterns differentiate for patients who recovered visual acuity (VA). METHODS: For patients with […]
Multi-targeted biomimetic CeO2-based nanoplatform for sepsis therapy via mitochondrial homeostasis
Int J Pharm X. 2026 Jun 15;12:100585. doi: 10.1016/j.ijpx.2026.100585. eCollection 2026 Dec. ABSTRACT Sepsis is a life – threatening systemic inflammatory response syndrome triggered by pathogenic infections, which is characterized by severe oxidative stress, immune dysregulation, and multiple organ dysfunction, accompanied by a high mortality rate. Its primary pathogenesis encompasses pathogen – induced immune overactivation, […]
AMPK orchestrates mitochondrial homeostasis via dynamics and mitophagy to combat hypoxia-induced energetic crisis in keratocytes
Cell Biol Toxicol. 2026 Jul 1. doi: 10.1007/s10565-026-10222-y. Online ahead of print. ABSTRACT BACKGROUND: Hypoxia disrupts corneal stromal physiology and alters cellular energy metabolism. This study aimed to elucidate the molecular role of the cellular energy sensor AMP-activated protein kinase (AMPK) in modulating the energy metabolism of human keratocytes (HKs) under hypoxic conditions and to […]
A Critical Role for Mitochondrial Dynamics in Cigarette Smoke Condensate-induced RPE Senescence
Free Radic Biol Med. 2026 Jul 1:S0891-5849(26)00915-9. doi: 10.1016/j.freeradbiomed.2026.06.060. Online ahead of print. ABSTRACT Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly. Its pathogenesis remains incompletely understood, partly due to the complex interplay of genetic risk, aging, and environmental stressors. Cigarette smoking (CS) is a major modifiable risk factor for […]
Concurrence of Inherited Nuclear and Mitochondrial DNA Optic Neuropathies
J Neuroophthalmol. 2026 Jul 2. doi: 10.1097/WNO.0000000000002466. Online ahead of print. NO ABSTRACT PMID:42384543 | DOI:10.1097/WNO.0000000000002466
Regulation of SARM1 on SNPH expression and its participation in glaucomatous optic neuropathy
Zhonghua Yan Ke Za Zhi. 2026 Jul 11;62(7):520-527. doi: 10.3760/cma.j.cn112142-20251106-00463. ABSTRACT Objective: To investigate the molecular mechanism of toll-like receptor adaptor protein SARM1 in glaucomatous optic neuropathy. Methods: The experimental study was conducted from February 2024 to October 2025. A chronic ocular hypertension glaucoma model was established by injecting micro-magnetic beads into the anterior chamber […]
Early Proteomic and Metabolic Signatures of Liver and Eye in OAT-Deficient Mice
Exp Eye Res. 2026 Jun 29:111140. doi: 10.1016/j.exer.2026.111140. Online ahead of print. ABSTRACT Ornithine aminotransferase (OAT) deficiency causes hyperornithinemia and gyrate atrophy (GA) of the choroid and retina, a rare inherited retinal degeneration. To understand the early molecular changes that make the eye susceptible to damage, we performed quantitative proteomic and metabolomic profiling of liver, […]
Lipocalin-2 Restores Mitochondrial and Antioxidant Adaptation in a Strain-Specific Manner During LPS Induced Sepsis
J Cell Physiol. 2026 Jun;241(6):e70205. doi: 10.1002/jcp.70205. ABSTRACT Sepsis induces profound metabolic and mitochondrial dysfunction, contributing to multiple organ injury and mortality. Lipocalin-2 (Lcn2), an acute-phase protein, regulates iron homeostasis and oxidative stress, but its impact on mitochondrial resilience remains poorly understood. Here, we investigated the role of Lcn2 in modulating mitochondrial function and hepatic […]
Retraction notice to ‘Mitochondrial ferritin upregulation reduced oxidative stress and blood-brain-barrier disruption by maintaining cellular iron homeostasis in a neonatal rat model of germinal matrix hemorrhage’ [Experimental Neurology 374 (2024) 114703]
Exp Neurol. 2026 Jun 28:115735. doi: 10.1016/j.expneurol.2026.115735. Online ahead of print. NO ABSTRACT PMID:42366134 | DOI:10.1016/j.expneurol.2026.115735
NAD+ modulates mitochondrial vulnerability in MERTK-associated models of retinitis pigmentosa
Nat Commun. 2026 Jun 27. doi: 10.1038/s41467-026-74400-6. Online ahead of print. ABSTRACT Retinitis pigmentosa (RP) is the most common inherited retinal degenerative disease leading to blindness. RP is characterized by progressive loss of photoreceptors and retinal pigment epithelium (RPE), leading to retinal degeneration. The mechanisms that initiate RP and drive retinal vulnerability are poorly understood, […]