Human ocular thelaziasis due to Thelazia callipaeda in a child from Türkiye: a case report and One Health perspective
Parasitol Int. 2026 Oct 8:103404. doi: 10.1016/j.parint.2026.103404. Online ahead of print. ABSTRACT Thelazia callipaeda is an emerging zoonotic eyeworm that infects the ocular tissues of domestic and wild mammals, including humans. This study describes the first molecularly confirmed pediatric case of human ocular thelaziasis caused by T. callipaeda in Türkiye and discusses its epidemiological significance […]
Targeting C3aR/STAT3 signaling attenuates neuroinflammation and reverses neurological impairment in Neuromyelitis optica
Fundam Res. 2025 Nov 7;6(5):3491-3506. doi: 10.1016/j.fmre.2025.11.001. eCollection 2026 Sep. ABSTRACT Abundant evidence indicates that the interaction between astrocytes and microglia through the C3-C3a receptor (C3aR) pathway is a crucial contributor to the pathogenesis of neurodegenerative and autoimmune disorders, such as neuromyelitis optica (NMO). However, the role of C3aR in microglia in modulating inflammation related […]
A ROS-Responsive and Mucoadhesive Thermosensitive Hydrogel Encapsulated with Mizoribine for Synergistic Dry Eye Therapy
Adv Sci (Weinh). 2026 Oct 6:e78106. doi: 10.1002/advs.78106. Online ahead of print. ABSTRACT Dry eye disease (DED) is a multifactorial disorder characterized by intricate pathogenesis, necessitating a multi-target synergistic intervention strategy. Current anti-inflammatory drugs for DED are limited by low bioavailability, ocular irritation, and inadequate relief. Herein, we propose a multifunctional hydrogel encapsulating Mizoribine, a […]
Intranasal Artesunate Ameliorates Hippocampal LFP Abnormalities and Cellular Apoptosis in APP/PS1 Mice via a Mechanism Involving GHRH/PI3K/AKT Signaling
Mol Neurobiol. 2026 Oct 6;63(1):948. doi: 10.1007/s12035-026-06250-8. ABSTRACT Alzheimer’s disease (AD) is characterized by progressive neurodegeneration and aberrant neural network activity. Artesunate (ART) has shown neuroprotective potential, but its effects on macroscopic hippocampal network dynamics and the underlying molecular mechanisms remain unclear. This study investigated the therapeutic efficacy and mechanisms of intranasal ART in APP/PS1 […]
Genotype-Phenotype Relationships in Patients Carrying Biallelic FDXR Pathogenic Variants-New Cases and Systematic Review
Hum Mutat. 2026 Oct 2;2026:5928629. doi: 10.1155/humu/5928629. eCollection 2026. ABSTRACT Biallelic pathogenic FDXR variations were identified in 2017 as being responsible for sensorial neuropathies. The first reported patients suffered from auditory and optic sensorineural impairments (ANOA, MIM #617717). Since then, many publications have described various phenotypes including peripheral and central nervous systems impairments (MMDS9B, MIM […]
Coordinated Retinal Metabolic Remodeling Reveals Mitochondrial Stress and Redox Vulnerability in Experimental Myopia
Free Radic Biol Med. 2026 Oct 3:S0891-5849(26)01175-5. doi: 10.1016/j.freeradbiomed.2026.09.024. Online ahead of print. ABSTRACT Form-deprivation myopia (FDM) was initiated by retinal responses to abnormal visual input, but how retinal metabolism was coordinated with mitochondrial and redox homeostasis remains incompletely understood. We integrated transcriptomics, proteomics, untargeted and targeted metabolomics, U-13C6-glucose tracing, extracellular flux analysis, molecular validation, […]
Sterile inflammation in LHON: mitochondrial stress, innate immune signaling, and implications for AAV gene therapy
Front Immunol. 2026 Sep 18;17:1935135. doi: 10.3389/fimmu.2026.1935135. eCollection 2026. ABSTRACT Leber hereditary optic neuropathy (LHON) is a mitochondrial disease caused primarily by pathogenic mitochondrial DNA (mtDNA) variants that impair respiratory chain complex I function. Although bioenergetic failure, oxidative stress, and retinal ganglion cell degeneration are central features of disease pathogenesis, these mechanisms do not fully […]
Mapping human visual contrast sensitivity and vision loss across the visual field with model-based fMRI
Elife. 2026 Oct 2;14:RP105930. doi: 10.7554/eLife.105930. ABSTRACT Peripheral vision is crucial for daily activities and quality of life, yet traditional measures of visual function like visual acuity primarily assess central vision. Visual field tests can evaluate peripheral vision but require extended focus and precise fixation, often challenging for patients with severe sight loss. Functional MRI […]
The key mechanisms and intervention strategies of cell-type-specific mitochondrial metabolism in ophthalmic diseases
Front Cell Dev Biol. 2026 Sep 16;14:1961856. doi: 10.3389/fcell.2026.1961856. eCollection 2026. ABSTRACT The eye is one of the most metabolically active organs, and mitochondria serve as the central hub for cellular energy metabolism by providing adenosine triphosphate through oxidative phosphorylation. Disruption of mitochondrial metabolism-including insufficient adenosine triphosphate synthesis, excessive production of reactive oxygen species, and […]
Yingmu San ameliorates pathological myopia by protecting retinal pigment epithelium and enhancing mitophagy-associated responses
Phytomedicine. 2026 Jul 31;162:158663. doi: 10.1016/j.phymed.2026.158663. Online ahead of print. ABSTRACT BACKGROUND: Pathological myopia is associated with progressive axial elongation and retinal pigment epithelium (RPE) injury, in which oxidative stress, inflammation, and mitochondrial dysfunction are important pathological contributors. Yingmu San (YMS) is a defined multi-component formulation composed of peony seed oil (PSO), lutein, and zeaxanthin […]