Experimental models to study oxidative stress in glaucoma: integrating in vitro, in vivo, and clinical studies
Front Pharmacol. 2026 Aug 18;17:1893993. doi: 10.3389/fphar.2026.1893993. eCollection 2026. ABSTRACT Glaucoma is a complex optic neuropathy and the leading cause of permanent blindness worldwide. Elevated intraocular pressure (IOP) is the major modifiable risk factor for this disease. Growing evidence suggests that oxidative stress and reactive oxygen species (ROS) are key mediators of retinal ganglion cell […]
Tear proteomic atlas of local host-response states in herpes simplex keratitis
Ocul Surf. 2026 Sep 1:S1542-0124(26)00117-5. doi: 10.1016/j.jtos.2026.08.009. Online ahead of print. ABSTRACT PURPOSE: Herpes simplex keratitis (HSK) is a leading cause of infectious corneal blindness, yet local host-response programs underlying active disease, recurrence, and stromal involvement remain incompletely understood. This study aimed to establish a deep tear proteomic atlas of HSK and characterize phenotype-associated local […]
Retinal neurovascular and mitochondrial function signatures related to cognition improvement following yoga exercise in older adults
PLoS One. 2026 Sep 1;21(9):e0357464. doi: 10.1371/journal.pone.0357464. eCollection 2026. ABSTRACT PURPOSE: To investigate the associations between retinal neurovascular and mitochondrial function signatures and cognitive performances following a 24-week yoga intervention in healthy older adults. METHODS: Thirty healthy older adults (mean age 72 ± 6 years; 25 females) participated in three 60-minute sessions per week of […]
Microemulsion Eyedrop for Delivery of a PPARα Agonist To Improve Diabetic Keratopathy Corneal Wound Healing
ACS Appl Mater Interfaces. 2026 Aug 27. doi: 10.1021/acsami.6c16373. Online ahead of print. ABSTRACT Diabetic keratopathy (DK) is characterized by delayed corneal wound healing in diabetes, and recent studies have linked this defect to impaired mitochondrial respiration and reduced peroxisome proliferator-activated receptor-α (PPARα) signaling in the corneal epithelium. The PPARα agonist fenofibrate (Feno) has shown […]
OCT Biomarker Testing for Early Dysregulated Photoreceptor Metabolism in Dark-Reared Pde6brd10 Mice
Invest Ophthalmol Vis Sci. 2026 Sep 1;67(11):2. doi: 10.1167/iovs.67.11.2. ABSTRACT PURPOSE: The purpose of this study was to noninvasively test the hypothesis that dysregulated photoreceptor metabolism occurs with early retinal degeneration in dark-reared Pde6brd10 mice. METHODS: Postnatal day 23 (P23) phosphodiesterase (PDE) mutant (Pde6brd10) mice, P23 wild-type (WT) mice were continuously dark-reared, and 2-month-old dark-adapted […]
Polarized Secretion of Mitochondrial DNA by Retinal Pigment Epithelial cells
Exp Eye Res. 2026 Aug 31:111225. doi: 10.1016/j.exer.2026.111225. Online ahead of print. ABSTRACT Mitochondrial DNA (mtDNA) damage is strongly implicated in age-related macular degeneration (AMD), the most frequent cause of age-mediated visual impairment in developed countries. Here, we investigated and compared the fate of acutely induced oxidation damage in primary retinal pigment epithelial (RPE) cells. […]
Mesenchymal drift in ciliopathy iPSC-derived RPE reveals a convergent pathogenic cell state
Cell Rep. 2026 Aug 28;45(9):117906. doi: 10.1016/j.celrep.2026.117906. Online ahead of print. ABSTRACT Ciliopathies comprise a spectrum of disorders involving mutations in over 150 genes affecting the primary cilium, with retinal degeneration as a prominent feature driven by concomitant developmental and maturation defects in photoreceptors and the retinal pigment epithelium (RPE). Current single-gene-targeted therapeutic approaches are […]
Oxidative Stress and Redox Imbalance in Acanthamoeba Keratitis: Host-Parasite Crosstalk and Therapeutic Perspectives
Int J Mol Sci. 2026 Aug 15;27(16):7293. doi: 10.3390/ijms27167293. ABSTRACT Acanthamoeba keratitis is a severe, sight-threatening corneal infection caused by free-living amoebae widely distributed in soil, natural waters, and domestic or recreational water systems. Following entry into the corneal microenvironment, disease develops within a redox conflict in which host-derived reactive oxygen species (ROS) and reactive […]
Traffic Jams in the Brain: How Kinesin Dysfunction Shapes Neurodevelopmental Disorders
Curr Issues Mol Biol. 2026 Aug 18;48(8):837. doi: 10.3390/cimb48080837. ABSTRACT The development and maintenance of the nervous system depend on a tightly regulated intracellular transport network in which kinesin superfamily (KIF) motor proteins drive microtubule-based delivery of synaptic vesicle precursors, organelles, mRNAs, and signaling components along axons and dendrites. Disruption of this machinery underlies a […]
Mitochondrial Complex V Dysfunction in Neurodegeneration: Secondary Bystander or Primary Driver?
Brain Sci. 2026 Aug 20;16(8):890. doi: 10.3390/brainsci16080890. ABSTRACT BACKGROUND/OBJECTIVES: Mitochondrial Complex V (Complex V [CX-V], or ATP synthase) is the terminal enzyme of oxidative phosphorylation and is responsible for the majority of cellular ATP production. An increasing body of evidence suggests that CX-V dysfunction may contribute to mitochondrial impairment observed in neurodegenerative disease. This review […]