TRPM7-mediated calcium signaling contributes to Hyperglycemia-induced mitochondrial dysfunction and apoptosis in retinal Muller cells
Cell Signal. 2026 Jul 7:112728. doi: 10.1016/j.cellsig.2026.112728. Online ahead of print. ABSTRACT Calcium signaling dysregulation is a critical trigger of mitochondrial dysfunction in metabolic disorders, yet the upstream mechanisms linking hyperglycemic stress to organellar Ca2+ overload remain poorly defined. The transient receptor potential melastatin 7 (TRPM7) channel functions as a Ca2+-permeable signaling node with unique […]
Endosymbiotic theory of aging revisited: Age-related leakage of mitochondrial dsDNA/RNA stimulates cytosolic nucleic acid sensors which remodel the immune network and promote the aging process
Biogerontology. 2026 Jul 7;27(4):124. doi: 10.1007/s10522-026-10470-9. ABSTRACT About 1.5-2 billion years ago, an endosymbiosis between aerobic α-proteobacteria and anaerobic archaeal cells generated mitochondria, i.e., organelles capable of producing oxidative energy. The bacterial genome was fundamentally reduced and a circular mitochondrial genome evolved containing mainly the genes coding for the subunits of the electron transport chain. […]
Enhanced Endocytosis and Mitochondrial Stress Underlie Severe Retinitis Pigmentosa With RHO P347L Mutant
Invest Ophthalmol Vis Sci. 2026 Jul 1;67(8):23. doi: 10.1167/iovs.67.8.23. ABSTRACT PURPOSE: RHO mutations are the primary cause of autosomal dominant retinitis pigmentosa (adRP), with Class 1 mutations typically exhibiting more severe phenotypes than Class 2. This study aims to clarify the mechanistic basis for this clinical disparity by systematically comparing protein degradation pathways, mitochondrial stress, […]
TRPM7 Channel-Mediated Mitochondrial Oxidative Stress Induces Dysfunction of Muller Cells Under High Glucose and Low Mg(2+) Stress
Front Biosci (Landmark Ed). 2026 Jun 8;31(6):50306. doi: 10.31083/FBL50306. ABSTRACT BACKGROUND: Clinical epidemiological data have shown that hypomagnesemia, defined as a serum Mg2+ concentration of <0.7 mmol/L, independently increases the risk of diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM). The molecular and cellular mechanisms through which hypomagnesemia accelerates the onset and […]
Dual-Hit Myopia Mechanism Unveiled by Multi-Omics: Opn1mw Deficiency Primed the Retina for Exaggerated Response to Environmental Defocus
Invest Ophthalmol Vis Sci. 2026 Jul 1;67(8):11. doi: 10.1167/iovs.67.8.11. ABSTRACT PURPOSE: Chromatic cues have long been implicated in refractive development, and OPN1MW variants are strongly associated with high myopia in humans. This study aimed to elucidate how cone opsin dysfunction translates into molecular and functional susceptibility to myopia. METHODS: Retinal transcriptome and metabolome sequencing were […]
The Molecular Basis of Ocular Aging: Mechanisms, Pathologies, and Emerging Therapeutics
Invest Ophthalmol Vis Sci. 2026 Jul 1;67(8):13. doi: 10.1167/iovs.67.8.13. ABSTRACT Age-related eye diseases (AREDs)-including age-related macular degeneration (AMD), glaucoma, and diabetic retinopathy-are leading causes of permanent blindness. Current treatments manage clinical manifestations but do not halt the molecular processes that drive disease progression. This limitation has shifted attention toward “geroscience,” a strategy that targets the […]
Mitochondrial Dysfunction and Diabetic Retinopathy: Research Progress from Pathogenic Mechanisms to Therapeutic Targets
Exp Eye Res. 2026 Jul 3:111157. doi: 10.1016/j.exer.2026.111157. Online ahead of print. ABSTRACT Diabetic retinopathy (DR) is one of the most common microvascular complications of diabetes mellitus (DM) and remains a major cause of visual impairment and blindness in adults. Accumulating evidence indicates that DR is not merely a microvascular disorder, but a complex neurovascular […]
High glucose-induced mitochondrial fission promotes Muller cell activation via suppression of the Hippo pathway
Mol Cell Biochem. 2026 Jul 3. doi: 10.1007/s11010-026-05625-8. Online ahead of print. ABSTRACT Diabetic retinopathy (DR) is the leading cause of blindness in diabetic patients, in which high glucose (HG)-induced Müller cell activation constitutes a central pathological event. This study aimed to untangle the critical role and mechanism of mitochondrial fission in this process. We […]
6PPD-quinone induces systemic and transgenerational effects in Caenorhabditis elegans
J Hazard Mater. 2026 Jun 25;514:142781. doi: 10.1016/j.jhazmat.2026.142781. Online ahead of print. ABSTRACT N-(1,3-dimethylbutyl)-N’-phenyl-p-phenylenediamine quinone (6PPD-Q), a redox-active transformation product of the tire antioxidant 6PPD, has emerged as a pervasive urban contaminant. Although acute lethality (LC50 ≥ 100 μg/L) occurs above most environmental concentrations, growing evidence indicates that environmentally relevant levels (0.1-10 μg/L), which overlap […]
AMPK Activation by AICAR Mitigates Hypoxic Corneal Damage Through Rebuilding Energy and Metabolic Homeostasis
Chem Biol Interact. 2026 Jul 2:112229. doi: 10.1016/j.cbi.2026.112229. Online ahead of print. ABSTRACT Hypoxia disrupts corneal physiological function by impairing energy metabolism. We identify AMP-activated protein kinase (AMPK) as a central regulator of coordinated metabolic adaptation in the hypoxic cornea. Using human corneal epithelial cells and an alkali burn-induced mouse model of corneal hypoxia, we […]