NFAT5 Restricts Bovine Herpesvirus 1 Productive Infection in MDBK Cell Cultures

Microbiol Spectr. 2023 May 25:e0011723. doi: 10.1128/spectrum.00117-23. Online ahead of print. ABSTRACT Bovine herpesvirus 1 (BoHV-1), an important bovine viral pathogen, causes severe disease in the upper respiratory tract and reproductive system. Tonicity-responsive enhancer-binding protein (TonEBP), also known as nuclear factor of activated T cells 5 (NFAT5), is a pleiotropic stress protein involved in a […]

Klotho prevents transforming growth factor-β2-induced senescent-like morphological changes in the retinal pigment epithelium

Cell Death Dis. 2023 May 20;14(5):334. doi: 10.1038/s41419-023-05851-8. ABSTRACT Degenerative changes of the retinal pigment epithelium (RPE) triggered by transforming growth factor-β2 (TGF-β2) and oxidative stress play a critical role in the progression of age-related macular degeneration (AMD). The expression of α-klotho, an antiaging protein, declines with age, increasing the risk factors for age-related diseases. […]

Reactive oxygen species-responsive mitochondria-targeted liposomal quercetin attenuates retinal ischemia-reperfusion injury via regulating SIRT1/FOXO3A and p38 MAPK signaling pathways

Bioeng Transl Med. 2022 Dec 1;8(3):e10460. doi: 10.1002/btm2.10460. eCollection 2023 May. ABSTRACT Retinal ischemia-reperfusion (RIR) injury is involved in the pathogenesis of various vision-threatening diseases. The overproduction of reactive oxygen species (ROS) is thought to be the main cause of RIR injury. A variety of natural products, including quercetin (Que), exhibit potent antioxidant activity. However, […]

Non-invasive treatment of ischemia/reperfusion injury: Effective transmission of therapeutic near-infrared light into the human brain through soft skin-conforming silicone waveguides

Bioeng Transl Med. 2023 Feb 7;8(3):e10496. doi: 10.1002/btm2.10496. eCollection 2023 May. ABSTRACT Noninvasive delivery of near-infrared light (IRL) to human tissues has been researched as a treatment for several acute and chronic disease conditions. We recently showed that use of specific IRL wavelengths, which inhibit the mitochondrial enzyme cytochrome c oxidase (COX), leads to robust […]

Mitochondrial dysfunction in glaucomatous degeneration

Int J Ophthalmol. 2023 May 18;16(5):811-823. doi: 10.18240/ijo.2023.05.20. eCollection 2023. ABSTRACT Glaucoma is a kind of optic neuropathy mainly manifested in the permanent death of retinal ganglion cells (RGCs), atrophy of the optic nerve, and loss of visual ability. The main risk factors for glaucoma consist of the pathological elevation of intraocular pressure (IOP) and […]

The Presence of Guttae in Fuchs Endothelial Corneal Dystrophy Explants Correlates With Cellular Markers of Disease Progression

Invest Ophthalmol Vis Sci. 2023 May 1;64(5):13. doi: 10.1167/iovs.64.5.13. ABSTRACT PURPOSE: Fuchs endothelial corneal dystrophy (FECD) is characterized by an accelerated depletion of corneal endothelial cells. There is growing evidence that mitochondrial exhaustion is central in the pathology. Indeed, endothelial cells loss in FECD forces the remaining cells to increase their mitochondrial activity, leading to […]

Remote ischemic preconditioning-induced late cardioprotection: possible role of melatonin-mitoKATP-H2S signaling pathway

Acta Cir Bras. 2023 May 15;38:e380423. doi: 10.1590/acb380423. eCollection 2023. ABSTRACT PURPOSE: Remote ischemic preconditioning (RIPC) confers cardioprotection against ischemia reperfusion (IR) injury. However, the precise mechanisms involved in RIPC-induced cardioprotection are not fully explored. The present study was aimed to identify the role of melatonin in RIPC-induced late cardioprotective effects in rats and to […]

Suppression of NLRP3/Caspase-1/GSDMD Mediated Corneal Epithelium Pyroptosis Using Melatonin-Loaded Liposomes to Inhibit Benzalkonium Chloride-Induced Dry Eye Disease

Int J Nanomedicine. 2023 May 9;18:2447-2463. doi: 10.2147/IJN.S403337. eCollection 2023. ABSTRACT INTRODUCTION: Benzalkonium chloride (BAC) is widely employed as a preservative in eye drops, which will cause the death of corneal epithelial cells due to ROS production, DNA strand breakage, and mitochondrial dysfunction, resulting in dry eye disease (DED)-like changes in ocular surface tissues. In […]

JP1 normalizes tumor vasculature to suppress metastasis and facilitate drug delivery by inhibiting IL8

JCI Insight. 2023 May 16:e161675. doi: 10.1172/jci.insight.161675. Online ahead of print. ABSTRACT Tumor vascular normalization prevents tumor cells from breaking through the basement membrane and entering the vasculature, and then inhibiting metastasis initiation. In this study, we reported that the anti-tumor peptide JP1 regulates the mitochondria metabolic reprogramming through AMPK/FOXO3a/UQCRC2 signaling, which improves the tumor […]

Biallelic variants in Ribonuclease Inhibitor (RNH1), an inflammasome modulator, are associated with a distinctive subtype of acute necrotizing encephalopathy

Genet Med. 2023 May 13:100897. doi: 10.1016/j.gim.2023.100897. Online ahead of print. ABSTRACT PURPOSE: Mendelian etiologies for acute encephalopathies in previously healthy children are poorly understood, with the exception of RAN Binding Protein 2 (RANBP2) associated Acute Necrotizing Encephalopathy sub-type 1 (ANE1). We provide clinical, genetic and neuroradiological evidence that biallelic variants in ribonuclease inhibitor (RNH1) […]