Category: Ophthalmology AND mitochondrial

Machine learning-based 3D segmentation of mitochondria in polarized epithelial cells

Mitochondrion. 2024 Apr 8:101882. doi: 10.1016/j.mito.2024.101882. Online ahead of print. ABSTRACT Mitochondria are dynamic organelles that alter their morphological characteristics in response to functional needs. Therefore, mitochondrial morphology is an important indicator of mitochondrial function and cellular health. Reliable segmentation of mitochondrial networks in microscopy images is a crucial initial step for further quantitative evaluation […]

Management of Ptosis in Kearns-Sayre Syndrome: A Case Report and Literature Review

Arch Plast Surg. 2024 Apr 8;51(2):182-186. doi: 10.1055/a-2207-7587. eCollection 2024 Mar. ABSTRACT Kearns-Sayre syndrome (KSS) is a rare mitochondrial disease that affects young adults, due to a deletion of mitochondrial DNA and characterized by the triad: age of onset lower than 20 years, chronic progressive external ophthalmoplegia, and an atypical pigmentary retinopathy. It is also […]

The antioxidant effect of tetrahedral framework nucleic acid-based delivery of small activating RNA targeting DJ-1 on retinal oxidative stress injury

Cell Prolif. 2024 Apr 9:e13635. doi: 10.1111/cpr.13635. Online ahead of print. ABSTRACT Age-related macular degeneration (AMD) and diabetic retinopathy (DR) are the world’s leading causes of blindness. The retinal pigment epithelium (RPE) and vascular endothelial cell exposed to oxidative stress is the major cause of AMD and DR. DJ-1, an important endogenous antioxidant, its overexpression […]

Poor visual prognosis of Asian patients with 3460 mitochondrial DNA mutation in Leber’s hereditary optic neuropathy

Can J Ophthalmol. 2024 Apr 6:S0008-4182(24)00095-4. doi: 10.1016/j.jcjo.2024.03.013. Online ahead of print. ABSTRACT BACKGROUND: Among the 3 primary mutations of Leber’s hereditary optic neuropathy (LHON), the incidence of LHON with a mutation at nucleotide position 3460 is the lowest in Asians. Therefore, information about the clinical manifestations of LHON mutations in Asians with the 3460 […]

Mitochondria-associated endoplasmic reticulum membranes tethering protein VAPB-PTPIP51 protects against ischemic stroke through inhibiting the activation of autophagy

CNS Neurosci Ther. 2024 Apr;30(4):e14707. doi: 10.1111/cns.14707. ABSTRACT AIMS: Mitochondria-associated endoplasmic reticulum membranes (MAMs) serve as a crucial bridge connecting the endoplasmic reticulum (ER) and mitochondria within cells. Vesicle-associated membrane protein-associated protein B (VAPB) and protein tyrosine phosphatase interacting protein 51 (PTPIP51) are responsible for the formation and stability of MAMs, which have been implicated […]

Idebenone ameliorates statin-induced myotoxicity in atherosclerotic ApoE-/- mice by reducing oxidative stress and improving mitochondrial function

Biochim Biophys Acta Mol Basis Dis. 2024 Apr 4:167157. doi: 10.1016/j.bbadis.2024.167157. Online ahead of print. ABSTRACT Statins are the first line of choice for the treatment for atherosclerosis, but their use can cause myotoxicity, a common side effect that may require dosage reduction or discontinuation. The exact mechanism of statin-induced myotoxicity is unknown. Previous research […]

Mitochondrial quality control in non-exudative age-related macular degeneration: From molecular mechanisms to structural and functional recovery

Free Radic Biol Med. 2024 Apr 3:S0891-5849(24)00161-8. doi: 10.1016/j.freeradbiomed.2024.03.024. Online ahead of print. ABSTRACT Non-exudative age-related macular degeneration (NE-AMD) is the leading blindness cause in the elderly. Clinical and experimental evidence supports that early alterations in macular retinal pigment epithelium (RPE) mitochondria play a key role in NE-AMD-induced damage. Mitochondrial dynamics (biogenesis, fusion, fission, and […]