The Role of NLRP3 Inflammasome in the Pathogenesis of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis

Med Res Arch. 2024 Jan;12(1). doi: 10.18103/mra.v12i1.4939. Epub 2024 Jan 30. ABSTRACT Stevens Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN) are mainly drug-induced severe cutaneous adverse reactions with increased mortality. It also involves the eyes causing ocular surface disease leading to visual impairment and blindness. The role of NLRP3 Inflammasome in causing ocular surface disease and keratinocyte […]

Regulatory factors of Nrf2 in age-related macular degeneration pathogenesis

Int J Ophthalmol. 2024 Jul 18;17(7):1344-1362. doi: 10.18240/ijo.2024.07.21. eCollection 2024. ABSTRACT Age-related macular degeneration (AMD) is a complicated disease that causes irreversible visual impairment. Increasing evidences pointed retinal pigment epithelia (RPE) cells as the decisive cell involved in the progress of AMD, and the function of anti-oxidant capacity of PRE plays a fundamental physiological role. […]

SIRT4 Protects Muller Glial Cells Against Apoptosis by Mediating Mitochondrial Dynamics and Oxidative Stress

Mol Neurobiol. 2024 Jul 18. doi: 10.1007/s12035-024-04349-4. Online ahead of print. ABSTRACT SIRT4 is a member of the sirtuin family, which is related to mitochondrial function and possesses antioxidant and regulatory redox effects. Currently, the roles of SIRT4 in retinal Müller glial cells, oxidative stress, and mitochondrial function are still unclear. We confirmed, by immunofluorescence […]

Minocycline prevents photoreceptor degeneration in Retinitis pigmentosa through modulating mitochondrial homeostasis

Int Immunopharmacol. 2024 Jul 16;139:112703. doi: 10.1016/j.intimp.2024.112703. Online ahead of print. ABSTRACT Minocycline, a broad-spectrum tetracycline antibiotic, has been shown to possess anti-inflammatory and antioxidative effects in various neurodegenerative diseases. However, its specific effects on retinitis pigmentosa (RP) have not been thoroughly investigated. Therefore, the objective of this study was to explore the potential role […]

Leber Hereditary Optic Neuropathy Case Report: Clinical Presentation and Treatment with Idebenone Reinforce the Evidence for m.3866T>C as a Causative Variant

Case Rep Ophthalmol. 2024 Jun 20;15(1):513-517. doi: 10.1159/000539445. eCollection 2024 Jan-Dec. ABSTRACT INTRODUCTION: Leber hereditary optic neuropathy (LHON) is a mitochondrial disorder that typically presents with painless, central visual loss, hyperaemia of the optic nerve head, and peripapillary telangiectasias. Most LHON cases are due to one of three variants, but several less common variants also […]

Single-cell transcriptomic analysis reveals the antiangiogenic role of Mgarp in diabetic retinopathy

BMJ Open Diabetes Res Care. 2024 Jul 16;12(4):e004189. doi: 10.1136/bmjdrc-2024-004189. ABSTRACT INTRODUCTION: Diabetic retinopathy (DR) is a common vascular complication of diabetes mellitus and a leading cause of vision loss worldwide. Endothelial cell (EC) heterogeneity has been observed in the pathogenesis of DR. Elucidating the underlying mechanisms governing EC heterogeneity may provide novel insights into […]

Organic photovoltaic biomaterial with fullerene derivatives for near-infrared light sensing in neural cells

Biointerphases. 2024 Jul 1;19(4):041001. doi: 10.1116/6.0003279. ABSTRACT Retinal degenerative diseases, which can lead to photoreceptor cell apoptosis, have now become the leading irreversible cause of blindness worldwide. In this study, we developed an organic photovoltaic biomaterial for artificial retinas, enabling neural cells to detect photoelectric stimulation. The biomaterial was prepared using a conjugated polymer donor, […]

Protocol for real-time measurement of mitochondrial respiration in the mouse ocular posterior pole using a Seahorse XFe24 analyzer

STAR Protoc. 2024 Jul 11;5(3):103150. doi: 10.1016/j.xpro.2024.103150. Online ahead of print. ABSTRACT During aging and in retinal degenerative diseases, vulnerable retinal pigment epithelial (RPE) cells are subject to mitochondrial dysfunction, creating a need for accessibility to tools which can facilitate assessment of the ocular posterior pole bioenergetics. Here, we present a protocol for quantifying mitochondrial […]

Daily Light Onset and Plasma Membrane Tethers Regulate Mitochondria Redistribution within the Retinal Pigment Epithelium

Cells. 2024 Jun 25;13(13):1100. doi: 10.3390/cells13131100. ABSTRACT The retinal pigment epithelium (RPE) is an essential component of the retina that plays multiple roles required to support visual function. These include light onset- and circadian rhythm-dependent tasks, such as daily phagocytosis of photoreceptor outer segments. Mitochondria provide energy to the highly specialized and energy-dependent RPE. In […]

Biomechanic, proteomic and miRNA transcriptional changes in the trabecular meshwork of primates injected with intravitreal triamcinolone

Vision Res. 2024 Jul 10;222:108456. doi: 10.1016/j.visres.2024.108456. Online ahead of print. ABSTRACT Although biomechanical changes of the trabecular meshwork (TM) are important to the pathogenesis of glucocorticoids-induced ocular hypertension (GC-OHT), there is a knowledge gap in the underlying molecular mechanisms of the development of it. In this study, we performed intravitreal triamcinolone injection (IVTA) in […]