Polycatechol-based iron predators disrupt fungal iron homeostasis to drive selective antifungal action
Proc Natl Acad Sci U S A. 2026 Jun 23;123(25):e2537796123. doi: 10.1073/pnas.2537796123. Epub 2026 Jun 15. ABSTRACT Fungal infections pose a growing global health challenge, exacerbated by a scarcity of effective treatments and rising drug resistance. Although cationic polymers emerge as promising antifungal candidates owing to structural tunability, design flexibility, and resistance to proteolytic degradation, […]
Age-Related Dry Eye Disease: Redefining a Distinct Subtype Driven by Aging
Ocul Surf. 2026 Jun 11:S1542-0124(26)00077-7. doi: 10.1016/j.jtos.2026.06.011. Online ahead of print. ABSTRACT Dry eye disease (DED) is highly prevalent in older adults and represents a growing public health burden in aging societies. Although age is a well-recognized risk factor for DED, it is still often treated as a background variable rather than an active biological […]
ZONAB Regulates DNA Methylation, Mitochondrial Function, and Entry into Cell Senescence of Endothelial Cells
Cells. 2026 May 31;15(11):1015. doi: 10.3390/cells15111015. ABSTRACT Regulation of the endothelial stress response is important for blood vessel homeostasis and angiogenesis, processes disrupted in common vascular diseases and ageing. Here, we discovered that the Y-box factor ZONAB (ZO-1-associated nucleic acid binding protein; YBX3), a gene associated with risk loci for severe vascular disorders, regulates endothelial […]
New Insights into Parthanatos as Programmed Cell Death During Murine Cytomegalovirus or Herpes Simplex Virus Type 1 Productive Replication in Diverse Cell Types
Cells. 2026 May 30;15(11):1009. doi: 10.3390/cells15111009. ABSTRACT Programmed cell death (PCD) pathways of innate immunity serve to protect host cells from invading viruses. Parthanatos is a novel form of PCD triggered by excessive host cell DNA damage that leads to overactivation of poly(ADP-ribose) polymerase-1 (PARP-1) which in turn stimulates poly(ADP-ribose) (PAR) polymer formation. PAR translocates […]
ScRNA-seq Data Reveal Gene Upregulation and Downregulation in Oxygen-Induced Retinopathy
Med Sci Monit. 2026 Jun 11;32:e951911. doi: 10.12659/MSM.951911. ABSTRACT BACKGROUND Retinopathy of prematurity is characterized by retinal vascular ischemia and hypoxia that lead to neovascularization, potentially causing retinal detachment and blindness. This study aimed to explore target genes involved in oxygen-induced retinopathy (OIR) through comprehensive single-cell RNA sequencing (scRNA-seq) data analysis. MATERIAL AND METHODS ScRNA-seq […]
Dysregulated Lipid Metabolism in Dry Eye Disease: Pathophysiological Mechanisms and Emerging Treatments
Ocul Surf. 2026 Jun 10:S1542-0124(26)00069-8. doi: 10.1016/j.jtos.2026.06.003. Online ahead of print. ABSTRACT Dry eye disease (DED) is increasingly recognized as a metabolic disorder characterized by the disruption of lipid homeostasis rather than solely an inflammatory condition. This review synthesizes current evidence regarding the dysregulation of lipid metabolism in the pathogenesis of DED. Furthermore, this review […]
Drp1-driven fragmentation of scleral mitochondria promotes myopia development
Proc Natl Acad Sci U S A. 2026 Jun 16;123(24):e2511427123. doi: 10.1073/pnas.2511427123. Epub 2026 Jun 10. ABSTRACT The global epidemic of myopia constitutes a growing public health concern worldwide. Myopia development is characterized by pathological scleral remodeling through fibroblast-myofibroblast transdifferentiation (FMT) and extracellular matrix (ECM) degradation. Since myopia is progressive, the development of sustainable and […]
Chrysin Attenuates Dry Eye Progression by Suppressing NOX2-Dependent Ferroptosis and STING/NLRP3-Mediated Inflammatory Responses
Invest Ophthalmol Vis Sci. 2026 Jun 1;67(6):15. doi: 10.1167/iovs.67.6.15. ABSTRACT PURPOSE: This study aimed to evaluate the effects of chrysin on dry eye and to elucidate its underlying mechanisms. METHODS: Public transcriptomic datasets were analyzed to identify ferroptosis-associated hub genes and to predict potential modulatory compounds. Ocular surface signs were evaluated using phenol red thread […]
Quantitative models of photoreceptor metabolisms: implications for rod outer segment length, retinal glycolysis and choroidal blood flow
Phys Biol. 2026 Jun 9. doi: 10.1088/1478-3975/ae7ad6. Online ahead of print. ABSTRACT The outer retina exhibits several distinctive physiological features, including continuous turnover of rod photoreceptor outer segments (OS), a strong reliance on aerobic glycolysis despite oxygen availability, and an unusually high rate of choroidal blood flow. The mechanistic links between these phenomena remain incompletely […]
Salvianolic acid a attenuates sodium iodate-induced ferroptosis in age-related macular degeneration models via the SLC7A11/GPX4 axis
Front Pharmacol. 2026 May 25;17:1803187. doi: 10.3389/fphar.2026.1803187. eCollection 2026. ABSTRACT INTRODUCTION: Oxidative stress-mediated retinal pigment epithelial (RPE) cell injury is a key pathological feature of age-related macular degeneration (AMD). Ferroptosis-an iron-dependent form of regulated cell death driven by lipid peroxidation-has been increasingly identified as a critical executor of RPE degeneration and a key pathogenic mechanism […]