Sirt6 protects retinal ganglion cells and optic nerve from degeneration during aging and glaucoma
Mol Ther. 2024 Apr 23:S1525-0016(24)00253-3. doi: 10.1016/j.ymthe.2024.04.030. Online ahead of print. ABSTRACT Glaucoma is characterized by the progressive degeneration of retinal ganglion cells (RGCs) and their axons, and its risk increases with aging. Yet comprehensive insights into the complex mechanisms are largely unknown. Here, we found that anti-aging molecule Sirt6 was highly expressed in RGCs. […]
TIN2-mediated reduction of mitophagy induces RPE senescence under high glucose
Cell Signal. 2024 Apr 22:111188. doi: 10.1016/j.cellsig.2024.111188. Online ahead of print. ABSTRACT The telomere-associated protein TIN2 localizes to both telomeres and mitochondria. Nevertheless, the impact of TIN2 on retinal pigment epithelial (RPE) cells in diabetic retinopathy (DR) remains unclear. This research aims to examine the role of TIN2 in the senescence of RPE and its […]
Optineurin-facilitated axonal mitochondria delivery promotes neuroprotection and axon regeneration
bioRxiv [Preprint]. 2024 Apr 3:2024.04.02.587832. doi: 10.1101/2024.04.02.587832. ABSTRACT Optineurin (OPTN) mutations are linked to amyotrophic lateral sclerosis (ALS) and normal tension glaucoma (NTG), but a relevant animal model is lacking, and the molecular mechanisms underlying neurodegeneration are unknown. We found that OPTN C-terminus truncation (OPTN∆C) causes late-onset neurodegeneration of retinal ganglion cells (RGCs), optic nerve […]
Molecular mechanism of high glucose-induced mitochondrial DNA damage in retinal ganglion cells
Cell Mol Biol (Noisy-le-grand). 2024 Mar 31;70(3):219-224. doi: 10.14715/cmb/2024.70.3.33. ABSTRACT Mitochondrial DNA damage in retinal ganglion cells (RGCs) may be closely related to lesions of glaucoma. RGCs were cultured with different concentrations of glucose and grouped into 3 groups, namely normal control (NC) group, Low-Glu group, and High-Glu group. Cell viability was measured with cell […]
Extracellular vesicle encapsulated nicotinamide delivered via a trans-scleral route provides retinal ganglion cell neuroprotection
Acta Neuropathol Commun. 2024 Apr 22;12(1):65. doi: 10.1186/s40478-024-01777-0. ABSTRACT The progressive and irreversible degeneration of retinal ganglion cells (RGCs) and their axons is the major characteristic of glaucoma, a leading cause of irreversible blindness worldwide. Nicotinamide adenine dinucleotide (NAD) is a cofactor and metabolite of redox reaction critical for neuronal survival. Supplementation with nicotinamide (NAM), […]
SUCLG1 restricts POLRMT succinylation to enhance mitochondrial biogenesis and leukemia progression
EMBO J. 2024 Apr 22. doi: 10.1038/s44318-024-00101-9. Online ahead of print. ABSTRACT Mitochondria are cellular powerhouses that generate energy through the electron transport chain (ETC). The mitochondrial genome (mtDNA) encodes essential ETC proteins in a compartmentalized manner, however, the mechanism underlying metabolic regulation of mtDNA function remains unknown. Here, we report that expression of tricarboxylic […]
Mitochondrial DNA-Activated cGAS-STING Signaling in Environmental Dry Eye
Invest Ophthalmol Vis Sci. 2024 Apr 1;65(4):33. doi: 10.1167/iovs.65.4.33. ABSTRACT PURPOSE: The cGAS-STING pathway has been shown to be an important mediator of inflammation. There is emerging evidence of the importance of this signaling cascade in a variety of inflammatory diseases settings. Here, we present evidence that the mitochondrial DNA (mtDNA) damage-mediated cGAS-STING pathway plays […]
Leber’s hereditary optic neuropathy
Rinsho Shinkeigaku. 2024 Apr 20. doi: 10.5692/clinicalneurol.cn-001924. Online ahead of print. ABSTRACT Leber’s hereditary optic atrophy (LHON) is a genetic optic neuropathy that is more prevalent in young males but can occur from childhood to old age. The primary cause is mitochondrial genetic mutations, which are associated with dysfunction of mitochondrial electron transport chain complex […]
Targeting dysregulated lipid metabolism for the treatment of Alzheimer’s disease and Parkinson’s disease: Current advancements and future prospects
Neurobiol Dis. 2024 Apr 18:106505. doi: 10.1016/j.nbd.2024.106505. Online ahead of print. ABSTRACT Alzheimer’s and Parkinson’s diseases are two of the most frequent neurological diseases. The clinical features of AD are memory decline and cognitive dysfunction, while PD mainly manifests as motor dysfunction such as limb tremors, muscle rigidity abnormalities, and slow gait. Abnormalities in cholesterol, […]
Nanoceria-Mediated Cyclosporin A Delivery for Dry Eye Disease Management through Modulating Immune-Epithelial Crosstalk
ACS Nano. 2024 Apr 17. doi: 10.1021/acsnano.3c11514. Online ahead of print. ABSTRACT Dry eye disease (DED) affects a substantial worldwide population with increasing frequency. Current single-targeting DED management is severely hindered by the existence of an oxidative stress-inflammation vicious cycle and complicated intercellular crosstalk within the ocular microenvironment. Here, a nanozyme-based eye drop, namely nanoceria […]