Mechanisms Underlying Myopia Progression from Visual Signaling to Metabolic Remodeling in Retina
JMA J. 2025 Oct 15;8(4):1031-1038. doi: 10.31662/jmaj.2025-0268. Epub 2025 Aug 1. ABSTRACT Myopia has emerged as a major global health concern due to its rising prevalence and the associated risk of irreversible visual impairment. Although scleral and choroidal changes have traditionally received emphasis, recent studies highlight the retina as a key contributor to the onset […]
Fluorescence lifetime imaging ophthalmoscopy adds the retina to cortical pathology for visual dysfunction in neurodegenerative diseases
Front Neurol. 2025 Oct 23;16:1659264. doi: 10.3389/fneur.2025.1659264. eCollection 2025. ABSTRACT Because neurodegenerative diseases such as Parkinson’s and Alzheimer’s Diseases [AD and PD] as well as the progressive forms of multiple sclerosis [MS] are invariably associated with clinically significant cortical symptoms such as language difficulties, motor skill deficits and cognitive impairments, especially memory, a tacit assumption […]
Molecular hydrogen mitigates acetaminophen-induced liver injury and enhances the effects of N-acetylcysteine in diabetic mice
J Nutr Biochem. 2025 Nov 7:110176. doi: 10.1016/j.jnutbio.2025.110176. Online ahead of print. ABSTRACT Acetaminophen (APAP) overdose induces severe liver injury, especially in diabetic patients. N-acetylcysteine (NAC) is commonly used as an approved antidote for APAP toxicity; however, its narrow therapeutic window limits its clinical utility. This study investigated the protective effects of molecular hydrogen (H₂) […]
Piperine alleviates retinal ischemic injury by mediating the APE1 signaling
Neurotherapeutics. 2025 Nov 7:e00781. doi: 10.1016/j.neurot.2025.e00781. Online ahead of print. ABSTRACT Ischemic retinal damage is the most common cause of severe vision impairment and blindness. Anti-vascular endothelial growth factor (anti-VEGF) agents have transformed the treatment of retinal ischemic disorders and have become the cornerstone therapy for these conditions. Nonetheless, the risk for systemic and ocular […]
Transketolase regulates endoplasmic reticulum stress independent of enzymatic activity in human retinal Müller cells
Exp Eye Res. 2025 Nov 6:110732. doi: 10.1016/j.exer.2025.110732. Online ahead of print. ABSTRACT Transketolase (TKT) expression in the nucleus of the retina has been reported, but its function beyond metabolism remains unclear. In this study, we investigated the role of TKT in the regulation of endoplasmic reticulum (ER) stress in the retina. Using a VEGF-overexpressing […]
Dihydroartemisinin: A Targeting Agent of CCT3-Mediated Oxidative Stress to Enhance the Antitumor Activity of Doxorubicin in Hepatocellular Carcinoma
Dig Dis Sci. 2025 Nov 8. doi: 10.1007/s10620-025-09503-z. Online ahead of print. ABSTRACT BACKGROUND: Liver cancer is the third most common cause of cancer-related death after lung and colorectal cancers. Hepatocellular carcinoma (LIHC) is the predominant subtype. Doxorubicin (DOX), an anthracycline chemotherapy drug, is extensively employed in the clinical treatment of early-stage and mid-stage liver […]
Nanoparticles-mediated mitochondrial relocation of lipid-lowering drugs shape energy metabolism to conquer acquired immune resistance
Drug Resist Updat. 2025 Nov 4;84:101323. doi: 10.1016/j.drup.2025.101323. Online ahead of print. ABSTRACT CD276, is a fatal recently discovered immune checkpoint proteins of B7 family. Due to the not clearly uncovered signal pathways that involved in the expression of CD276 in tumors, few strategies were discovered to regulate CD276. Here, we newly discovered that abnormal […]
Biological aging phenotypes mediate gut microbiota effects on age-related macular degeneration subtype progression: genetic causality by mendelian randomization and mediation analysis
AMB Express. 2025 Nov 7;15(1):167. doi: 10.1186/s13568-025-01972-9. ABSTRACT The mechanisms driving age-related macular degeneration (AMD) progression into two major but distinct vision-threatening subtypes, geographic atrophy (GA) and choroidal neovascularization (CNV), are unclear. This study identifies causal gut microbiota (GM) taxa involved in AMD and their connections to biological aging phenotypes, including epigenetic clock acceleration, telomere […]
Non-invasive bioelectrical therapy suppresses retinal neovascularization by modulating cellular metabolism and inflammation
Cell Commun Signal. 2025 Nov 6;23(1):479. doi: 10.1186/s12964-025-02451-1. ABSTRACT BACKGROUND: Pathological retinal neovascularization, a major cause of blindness, occurs in conditions such as age-related macular degeneration (AMD) and diabetic retinopathy (DR). Microglial activation and chronic neuroinflammation play critical roles in disease progression by promoting vascular permeability and angiogenesis. While anti-VEGF therapies are the current standard […]
From Castro to Quantum Mechanics: Marching Through Tunnels With Reactive Oxygen Species
J Neuroophthalmol. 2025 Oct 16. doi: 10.1097/WNO.0000000000002400. Online ahead of print. ABSTRACT The 2025 Jacobson Lecture revealed a scientific journey that began with the Cuban epidemic of blindness to recent studies of the quantum mechanical underpinnings of Leber’s Hereditary Optic Neuropathy (LHON). A sudden outbreak of bilaterally symmetrical optic neuropathy and peripheral neuropathy in more […]