CIDEC impairs mitochondrial fitness and blocks protective autophagy via the inhibition of cGMP/PKG pathway to exert tumor-suppressive effects in breast cancer
Cell Oncol (Dordr). 2026 Apr 20;49(3):78. doi: 10.1007/s13402-026-01211-8. NO ABSTRACT PMID:42010152 | DOI:10.1007/s13402-026-01211-8
Submandibular gland oncocytoma: Imaging features and histopathological correlation of a rare benign salivary gland tumor
Radiol Case Rep. 2026 Apr 8;21(7):2680-2684. doi: 10.1016/j.radcr.2026.02.014. eCollection 2026 Jul. ABSTRACT Submandibular gland oncocytoma is a rare benign epithelial tumor accounting for less than 1% of all salivary gland neoplasms. It is composed of oncocytes-large polygonal epithelial cells with abundant eosinophilic granular cytoplasm resulting from mitochondrial accumulation-and typically affects adults between the fifth and […]
DHCR24 Deficiency Drives Age-Related Meibomian Gland Dysfunction by Regulating Lipid Metabolic Imbalance and Cytosolic mtDNA-Induced cGAS-STING Activation
Int J Biol Sci. 2026 Mar 28;22(7):3886-3908. doi: 10.7150/ijbs.129636. eCollection 2026. ABSTRACT Dysregulated lipid metabolism and chronic inflammation are hallmarks of aging, yet their interplay in age-related tissue disorders remains poorly defined. In the ocular surface, age-related meibomian gland dysfunction (ARMGD) is highly prevalent but mechanistically unclear, leading to significant visual impairment without targeted therapies. […]
Glutathione-Depleting Mitochondria-targeting Nanodrugs for Stress Amplification and Immune Activation via Synergistic Photodynamic Therapy and Cuproptosis
Acta Biomater. 2026 Apr 17:S1742-7061(26)00243-6. doi: 10.1016/j.actbio.2026.04.024. Online ahead of print. ABSTRACT Multiple mitochondrial stress dysregulation represents an emergent mechanism for inducing tumor cell death. While photodynamic (PDT) and cuproptosis therapies can generate oxidative and proteotoxic stress respectively, their cooperativity and effects are hampered by the uncontrolled spatiotemporal interaction with glutathione (GSH) overexpressed in the […]
Neuroprotective Effect of Intraperitoneal Humanin-G in Retinal Degeneration of Royal College of Surgeons Rats
bioRxiv [Preprint]. 2026 Mar 24:2026.03.20.713049. doi: 10.64898/2026.03.20.713049. ABSTRACT This study aimed to examine whether Humanin-G (HNG), a mitochondrial derived peptide with cytoprotective properties, could improve the retinal function and gene expression profiles after intraperitoneal injections to Royal College of Surgeons (RCS) rats with Retinal Pigment Epithelium (RPE) dysfunction and retinal degeneration. Starting at postnatal day […]
Blood mtDNA markers of mitochondrial subtype and early-onset Parkinson’s disease biology
Brain. 2026 Apr 16:awag135. doi: 10.1093/brain/awag135. Online ahead of print. ABSTRACT Mitochondrial dysfunction is central to the pathogenesis of Parkinson’s disease (PD), integrating both genetic and environmental factors. Therefore, reliable blood-based biomarkers reflecting mitochondrial alterations are needed. Emerging evidence suggests that somatic changes to mitochondrial DNA (mtDNA) may reflect early disease-associated processes relevant to PD […]
Cross-species transcriptomics identify mineralocorticoid receptor pathway overactivation as a central driver of ocular rosacea
Nat Commun. 2026 Apr 16. doi: 10.1038/s41467-026-71945-4. Online ahead of print. ABSTRACT Ocular rosacea (OR) is a chronic inflammatory disease of the ocular surface frequently associated with meibomian gland dysfunction (MGD), with limited therapeutic options and an underexplored pathophysiology. Here, we uncover the pivotal role of mineralocorticoid receptor (MR) pathway overactivation in driving MGD and […]
LEBER HEREDITARY OPTIC NEUROPATHY: A CASE REPORT OF CONCURRENT RARE MITOCHONDRIAL MUTATIONS AND ABCA4 NUCLEAR GENE MUTATION
Retin Cases Brief Rep. 2025 Sep;19(5):647-651. doi: 10.1097/ICB.0000000000001618. ABSTRACT PURPOSE: This case report aimed to describe the clinical presentation of a 21-year-old male patient with subacute bilateral painless vision loss, clinically consistent with Leber hereditary optic neuropathy (LHON), a mitochondrially inherited disorder and to investigate the genetic mutations associated with this condition. METHODS: Genetic testing […]
Synthesis and evaluation of mitochondrion-targeted tetraphenylethylene-based photosensitizer
Bioorg Chem. 2026 Apr 11;176:109862. doi: 10.1016/j.bioorg.2026.109862. Online ahead of print. ABSTRACT As typical compounds with aggregation induced emission (AIE) property, tetraphenylethylene-based photosensitizers with unique molecular structures and excellent photophysical properties have been widely applied in the bio-specific imaging, diagnosis, photodynamic therapy (PDT) and other related fields. In this work, we have developed a concise […]
Therapeutic Exploitation of Ferroptosis Pathways in Dry Eye Disease: Opportunities and Challenges
Exp Eye Res. 2026 Apr 13:111022. doi: 10.1016/j.exer.2026.111022. Online ahead of print. ABSTRACT Conventional management of dry eye disease (DED) often fails to arrest the progressive loss of corneal epithelial cells, making therapeutic management challenging. Emerging evidence points to ferroptosis, an iron-dependent form of regulated cell death, as a central driver of this ocular surface […]