Hierarchical ROS-scavenging hydrogel system for coordinating the modulation of RGC necroptosis and oxidative stress in an acute glaucoma model
Bioact Mater. 2026 Aug 7;66:1252-1271. doi: 10.1016/j.bioactmat.2026.07.012. eCollection 2026 Dec. ABSTRACT Glaucoma, a leading cause of irreversible blindness, is characterized by the progressive loss of retinal ganglion cells (RGCs). Beyond intraocular pressure (IOP)-dependent injury, IOP-independent pathways, specifically the self-amplifying axis between oxidative stress and the necroptotic cascade, are key drivers of disease progression. Mediated by […]
The role of mitochondrial energy metabolism in drug resistance and prognosis of lung adenocarcinoma: a multi-omics and machine learning strategy for predictive and personalized therapy
Front Med (Lausanne). 2026 Jul 31;13:1892773. doi: 10.3389/fmed.2026.1892773. eCollection 2026. ABSTRACT BACKGROUND: As the leading histological form of lung cancer, lung adenocarcinoma (LUAD) displays considerable intratumoral heterogeneity, frequent therapeutic resistance, and an unfavorable clinical outcome. Although rewiring of mitochondrial energy metabolism is known to drive tumor progression and treatment failure, a comprehensive understanding of its […]
Musculoskeletal degeneration in space: translational parallels with spaceflight-associated ocular pathology and surgical implications
Life Sci Space Res (Amst). 2026 Sep;52:237-243. doi: 10.1016/j.lssr.2026.03.006. Epub 2026 Mar 20. ABSTRACT Prolonged exposure to microgravity leads to rapid and widespread physiological changes, most notably musculoskeletal degeneration and spaceflight-associated neuro-ocular syndrome (SANS), which are often considered separate clinical challenges. This opinion piece suggests that these conditions may share overlapping upstream mechanisms – particularly […]
Reframing spaceflight-associated neuro-ocular syndrome as spaceflight-associated optic neuropathy (SAON): Transcriptomic in-vivo analysis reveals mitochondrial retinal ganglion cell injury during spaceflight
Life Sci Space Res (Amst). 2026 Sep;52:55-64. doi: 10.1016/j.lssr.2026.07.004. Epub 2026 Jul 9. ABSTRACT Spaceflight-Associated Neuro-Ocular Syndrome (SANS) has remained poorly understood throughout the history of human spaceflight despite being classified as the largest physiologic barrier that astronauts face. Existing mechanistic explanations of SANS are limited in accounting for its tissue specificity, interindividual heterogeneity, and […]
N-acetylcysteine suppresses retinal defects in Drosophila models of SNRNP200-associated retinitis pigmentosa
Hum Mol Genet. 2026 Aug 10;35(17):ddag077. doi: 10.1093/hmg/ddag077. ABSTRACT Retinitis Pigmentosa (RP) is an inherited retinal degenerative disease that affects 1 in 4000 individuals worldwide and can lead to complete blindness. Early stages of RP involve death of rod photoreceptors via apoptosis, causing loss of peripheral and night vision, which is followed by death of […]
Clinical Efficacy of Ultrasound Cycloplasty for Glaucoma Patients and Pathological Observation on the Ciliary Body in Rabbit Models
J Ophthalmol. 2026 Mar 30;2026:1279697. doi: 10.1155/joph/1279697. eCollection 2026. ABSTRACT PURPOSE: To evaluate the efficacy and safety of ultrasound cycloplasty (UCP) for glaucoma patients and the ciliary body in rabbit models. METHODS: A prospective case series clinical trial and a animal experiment were carried out separately. For human subjects, 55 patients (55 eyes) with refractory […]
Redox Homeostasis, Metabolic Pathways and Plasticity in Uveal Melanoma Compared to Other Cancers
Cancers (Basel). 2026 Jul 25;18(15):2402. doi: 10.3390/cancers18152402. ABSTRACT Background/Objectives: To date there is a lack of an integrative review literature on redox homeostasis, oxidative stress and the influence on metabolic pathways and plasticity in uveal melanoma (UM), since most literature findings are from cutaneous melanoma (CM), a genetically and behaviorally distinct cancer. Furthermore, UM metabolic […]
Bioactive Properties of Carotenoids in Ocular Diseases: Antioxidant, Anti-Inflammatory, and Neuroprotective Effects
Nutrients. 2026 Jul 29;18(15):2467. doi: 10.3390/nu18152467. ABSTRACT Ocular diseases are a significant public health problem worldwide and represent one of the leading causes of disability. The prevalence of visual impairment is steadily increasing, largely driven by the ageing population. Oxidative stress, chronic inflammation and neurodegenerative processes underlie the pathogenesis of many eye diseases, including age-related […]
Expression and mechanistic roles of long non-coding RNAs in diabetic cataract: a systematic review and meta-analysis
Biol Direct. 2026 Aug 12;21(1):142. doi: 10.1186/s13062-026-00888-z. ABSTRACT INTRODUCTION: Diabetic cataract (DC) is a lens-opacity complication of diabetes driven by hyperglycemia-related oxidative, apoptotic, metabolic, and epithelial-mesenchymal transition (EMT) pathways. This review evaluated the expression and mechanistic roles of long non-coding RNAs (lncRNAs) and lncRNA-related epitranscriptomic regulators in DC. METHODS: PubMed, Embase, Cochrane Library, Scopus, Web […]
System-level disruption of cortical temporal integration after stroke: linking intrinsic neural timescales to molecular and neurochemical architecture
Brain Res. 2026 Aug 9:150483. doi: 10.1016/j.brainres.2026.150483. Online ahead of print. ABSTRACT Stroke disrupts the brain’s ability to process and integrate information over time, yet the underlying molecular mechanisms remain unclear. This study investigates post-stroke alterations in intrinsic neural timescales (INTs)-a measure of regional temporal integration-by combining resting-state fMRI, spatial transcriptomics, and PET-based neurochemical mapping. […]