Identification of IDH3G, encoding the gamma subunit of mitochondrial isocitrate dehydrogenase, as a novel candidate gene for X-linked retinitis pigmentosa
Genet Med. 2025 Mar 19:101418. doi: 10.1016/j.gim.2025.101418. Online ahead of print. ABSTRACT PURPOSE: Retinitis pigmentosa (RP) is a genetically heterogeneous group of retinal degenerative disorders characterized by the loss rod and cone photoreceptors, leading to visual impairment and blindness. To date, X-linked RP has been associated with variants in three genes (RPGR, RP2, OFD1), while […]
AMPK-dependent Parkin activation suppresses macrophage antigen presentation to promote tumor progression
Sci Adv. 2025 Mar 21;11(12):eadn8402. doi: 10.1126/sciadv.adn8402. Epub 2025 Mar 21. ABSTRACT The constrained cross-talk between myeloid cells and T cells in the tumor immune microenvironment (TIME) restricts cancer immunotherapy efficacy, whereas the underlying mechanism remains elusive. Parkin, an E3 ubiquitin ligase renowned for mitochondrial quality control, has emerged as a regulator of immune response. […]
Identifying microglia-derived NFKBIA as a potential contributor to the pathogenesis of Alzheimer’s disease and age-related macular degeneration
J Alzheimers Dis. 2025 Mar 19:13872877251326267. doi: 10.1177/13872877251326267. Online ahead of print. ABSTRACT BackgroundAlzheimer’s disease (AD) and age-related macular degeneration (AMD) place considerable health burden on affected individuals and significant economic burden on society.ObjectiveThis study aims to explore the shared cellular and molecular mechanisms underlying the pathogenesis of AD and AMD.MethodsThe investigation in this study […]
Retinal Pigment Epithelium and Monocytes’ Mitochondrial Control of Ferroptosis and its Relevance to Age-Related Macular Degeneration
Mol Neurobiol. 2025 Mar 18. doi: 10.1007/s12035-025-04832-6. Online ahead of print. ABSTRACT Age-related macular degeneration (AMD) is the leading cause of vision impairment among older aged people. Recent studies have indicated that focusing on the underlying mechanism of ferroptosis (a form of iron-dependent cell death) could be crucial in understanding the progression of AMD, as […]
Potential Risks of Ocular Molecular and Cellular Changes in Spaceflight
Semin Ophthalmol. 2025 Mar 17:1-11. doi: 10.1080/08820538.2025.2471443. Online ahead of print. ABSTRACT PURPOSE: Many fundamental cellular and molecular changes are known to occur in biological systems during spaceflight, including oxidative stress, DNA damage, mitochondrial damage, epigenetic factors, telomere lengthening, and microbial shifts. We can apply the consequences of these molecular changes in ocular cells, such […]
Is Multiwavelength Photobiomodulation Effective and Safe for Age-Related Macular Degeneration? A Systematic Review and Meta-Analysis
Ophthalmol Ther. 2025 Mar 16. doi: 10.1007/s40123-025-01119-w. Online ahead of print. ABSTRACT INTRODUCTION: This systematic review and meta-analysis compares the complications and effects of photobiomodulation (PBM) therapy with sham treatment in patients with age-related macular degeneration (AMD). AMD is a leading cause of visual impairment in older adults, with current treatments primarily focusing on symptom […]
Dual targeting of the mitochondrial Lon peptidase 1 and the chymotrypsin-like proteasome activity as a potential therapeutic strategy in malignant astrocytoma models
Pharmacol Res. 2025 Mar 13:107697. doi: 10.1016/j.phrs.2025.107697. Online ahead of print. ABSTRACT Malignant astrocytomas are aggressive primary brain tumors characterized by extensive hypoxia-induced, mitochondria-dependent changes such as altered respiration, increased chymotrypsin-like (CT-L) proteasome activity, decreased apoptosis, drug resistance, stemness, and increased invasiveness. Mitochondrial Lon Peptidase 1 (LonP1) overexpression and increased CT-L proteasome activity are biomarkers […]
Whole-exome sequencing reveals sex difference in the genetic architecture of high myopia
J Med Genet. 2025 Mar 12:jmg-2024-110467. doi: 10.1136/jmg-2024-110467. Online ahead of print. ABSTRACT BACKGROUND: High myopia (HM) is one of the leading causes of visual impairment and blindness worldwide. To understand the sex difference in the genetic architecture of HM, which may contribute to understanding HM aetiology and help further the realisation of precision medicine […]
Ocular Surface Changes Differ Significantly Between Oxaliplatin- and Diabetes-Induced Polyneuropathy
Int J Mol Sci. 2025 Feb 22;26(5):1884. doi: 10.3390/ijms26051884. ABSTRACT Dry eye disease (DED) is often seen in patients with polyneuropathies (PNs), but the relationship between the different forms of PNs and DED is not known. In oxaliplatin (Ox-)-treated mice with PNs, morphological changes in the sciatic nerve (SN), dorsal root ganglia (DRG), trigeminal ganglia […]
Spectral and color temperature dependence of LED exposure on retinal damage and the protective effects of neohesperidin
J Photochem Photobiol B. 2025 Mar 8;266:113148. doi: 10.1016/j.jphotobiol.2025.113148. Online ahead of print. ABSTRACT PURPOSE: To investigate the effects of LEDs with different spectra and correlated color temperatures on the retina, as well as the protective role of neohesperidin(NHP). METHODS: Sprague-Dawley (SD) rats and 661W cells were divided into four groups: 2700K conventional LED group […]