Fructus Lycii and Salvia miltiorrhiza Bunge extract attenuate oxidative stress-induced photoreceptor ferroptosis in retinitis pigmentosa

Biomed Pharmacother. 2023 Sep 21;167:115547. doi: 10.1016/j.biopha.2023.115547. Online ahead of print. ABSTRACT AIM OF THE STUDY: To assess the impact of Fructus Lycii and Salvia miltiorrhiza Bunge extract (FSE) on retinitis pigmentosa (RP) and to explore the mechanisms by which FSE can prevent oxidative stress-induced photoreceptor ferroptosis in RP. METHODS: Hydrogen peroxide(H2O2) was used to […]

Retinal ferroptosis as a critical mechanism for the induction of retinochoroiditis during ocular toxoplasmosis

Redox Biol. 2023 Sep 17;67:102890. doi: 10.1016/j.redox.2023.102890. Online ahead of print. ABSTRACT Toxoplasmosis is a major infectious disease, affecting approximately one-third of the world’s population; its main clinical manifestation, ocular toxoplasmosis (OT), is a severe sight-threatening disease. Nevertheless, the diagnosis of OT is based on clinical findings, which needs improvement, even with biochemical tests, such […]

The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation

Signal Transduct Target Ther. 2023 Sep 21;8(1):371. doi: 10.1038/s41392-023-01624-z. ABSTRACT The innate immune response is the main pathophysiological process of ocular surface diseases exposed to multiple environmental stresses. The epithelium is central to the innate immune response, but whether and how innate immunity is initiated by ocular epithelial cells in response to various environmental stresses […]

Recessive MECR pathogenic variants cause an LHON-like optic neuropathy

J Med Genet. 2023 Sep 21:jmg-2023-109340. doi: 10.1136/jmg-2023-109340. Online ahead of print. ABSTRACT BACKGROUND: Leber’s hereditary optic neuropathy (LHON) is a mitochondrial disorder characterised by complex I defect leading to sudden degeneration of retinal ganglion cells. Although typically associated with pathogenic variants in mitochondrial DNA, LHON was recently described in patients carrying biallelic variants in […]

Coenzyme Q10 trapping in mitochondrial complex I underlies Leber’s hereditary optic neuropathy

Proc Natl Acad Sci U S A. 2023 Sep 26;120(39):e2304884120. doi: 10.1073/pnas.2304884120. Epub 2023 Sep 21. ABSTRACT How does a single amino acid mutation occurring in the blinding disease, Leber’s hereditary optic neuropathy (LHON), impair electron shuttling in mitochondria? We investigated changes induced by the m.3460 G>A mutation in mitochondrial protein ND1 using the tools […]

Mitochondrial disease in New Zealand: a nationwide prevalence study

Intern Med J. 2023 Sep 21. doi: 10.1111/imj.16211. Online ahead of print. ABSTRACT BACKGROUND: The complexities of mitochondrial disease make epidemiological studies challenging, yet this information is important in understanding the healthcare burden and addressing service and educational needs. Existing studies are limited to quaternary centres or focus on a single genotype or phenotype and […]

MG132, Attenuates the Retinal Vascular Injury Through the Upregulation of Nrf2 Expression

J Ocul Pharmacol Ther. 2023 Sep 20. doi: 10.1089/jop.2023.0053. Online ahead of print. ABSTRACT Purpose: This study clarifies the beneficial effects of MG132, a proteasomal inhibitor, on retinal vascular injury mediated by diabetes-induced oxidative stress through nuclear factor erythroid 2-related factor 2 (Nrf2). Methods: Diabetic rats and control animals were randomly assigned to receive MG132 […]

Aging, Cellular Senescence, and Glaucoma

Aging Dis. 2023 Jul 16. doi: 10.14336/AD.2023.0630-1. Online ahead of print. ABSTRACT Aging is one of the most serious risk factors for glaucoma, and according to age-standardized prevalence, glaucoma is the second leading cause of legal blindness worldwide. Cellular senescence is a hallmark of aging that is defined by a stable exit from the cell […]

Unleashing the potential of CRISPR multiplexing: Harnessing Cas12 and Cas13 for precise gene modulation in eye diseases

Vision Res. 2023 Sep 16;213:108317. doi: 10.1016/j.visres.2023.108317. Online ahead of print. ABSTRACT Gene therapy is a flourishing field with the potential to revolutionize the treatment of genetic diseases. The emergence of CRISPR-Cas9 has significantly advanced targeted and efficient genome editing. Although CRISPR-Cas9 has demonstrated promising potential applications in various genetic disorders, it faces limitations in […]