Integrative omics identify NID2 as a therapeutic target linking depression and colorectal cancer in humans
iScience. 2026 May 26;29(6):116003. doi: 10.1016/j.isci.2026.116003. eCollection 2026 Jun 19. ABSTRACT Depression is frequently comorbid with gastrointestinal malignancies, yet the biological links governing this relationship require precise characterization. Analysis of a prospective colonoscopy cohort (n = 2,857) and National Health and Nutrition Examination Survey data (n = 37,597) shows that major depression is associated with […]
α-Viniferin Induces Intrinsic Apoptosis in Triple-Negative Breast Cancer Cells and Synergizes With SB203580 Independently of p38 Mitogen-Activated Protein Kinase
J Breast Cancer. 2026 Jun 4. doi: 10.4048/jbc.2026.0016. Online ahead of print. ABSTRACT PURPOSE: Triple-negative breast cancer (TNBC) is recognized as the most aggressive subtype of breast cancer. Due to the absence of established molecular targets, treatment options remain limited. In this study, we investigated the anticancer effects of α-viniferin in TNBC cells. METHODS: The […]
Ndufa4l2 drives the pathological activation of Müller cells in ischemic retinopathy via the PI3K/AKT signaling pathway
Pathol Res Pract. 2026 May 30;286:156567. doi: 10.1016/j.prp.2026.156567. Online ahead of print. ABSTRACT Ischemic retinopathies are major causes of irreversible blindness such as proliferative diabetic retinopathy (PDR). Müller cells, essential for retinal homeostasis, undergo profound pathological activation (reactive gliosis, aberrant proliferation, and migration) under ischemic stress, exacerbating retinal structural disruption and disease progression; however, the […]
The Role of lncRNA GAS5 in Oxidative Stress and Mitochondrial Dysfunction in Age-Related Cataracts: Insights From Transcriptome Profiling
Invest Ophthalmol Vis Sci. 2026 Jun 1;67(6):7. doi: 10.1167/iovs.67.6.7. ABSTRACT PURPOSE: This study aimed to investigate the role of lncRNA GAS5 and GADD45a in H₂O₂-induced oxidative stress and mitochondrial dysfunction in human lens epithelial cells (LECs), and to explore the underlying ceRNA mechanism involving miR-3666. METHODS: Human LECs were exposed to H₂O₂ to induce oxidative […]
Early proteomic signatures of Alzheimer’s disease in the retina and brain of 3xTg-AD mice
Front Cell Dev Biol. 2026 May 18;14:1827348. doi: 10.3389/fcell.2026.1827348. eCollection 2026. ABSTRACT INTRODUCTION: Visual dysfunction and retinal structural changes can occur early in Alzheimer’s disease (AD), but the molecular basis of these early alterations remains unclear. METHODS: We performed quantitative proteomic profiling of the retina and brain from 4-week-old triple-transgenic AD (3xTg-AD) mice carrying human […]
First Revision of the Guidelines for the Diagnosis and Management of Remethylation Disorders
J Inherit Metab Dis. 2026 Jul;49(4):e70177. doi: 10.1002/jimd.70177. ABSTRACT This guideline summarizes diagnostic and therapeutic approaches based on a systematic literature review and evidence evaluation using the GRADE methodology. Given the limited high-quality data, expert consensus was additionally obtained through a modified Delphi process. Remethylation disorders are rare inherited conditions that disrupt the methionine-homocysteine cycle […]
Deficient autophagy in retinal ganglion cells impairs the degradation of intracellular organelles, leading to neurodegeneration
Cell Death Dis. 2026 May 30. doi: 10.1038/s41419-026-08927-3. Online ahead of print. ABSTRACT Autophagy is a fundamental catabolic process that facilitates the degradation and recycling of cellular components like protein aggregates and defective organelles. However, the precise role of constitutive autophagy in regulating retinal ganglion cell (RGC) function and survival remains largely undefined. Here, we […]
PKM2-driven glycolysis mediates rotenone neurotoxicity via MG-Hs in Parkinson’s disease
Sci Rep. 2026 May 30. doi: 10.1038/s41598-026-54865-7. Online ahead of print. ABSTRACT Parkinson’s disease (PD) is a progressive neurodegenerative disorder lacking disease-modifying therapies. Rotenone (Rot) is widely used to model PD, but its neurotoxicity is not fully understood beyond mitochondrial complex I inhibition. Here, we identify a glycolytic mechanism that contributes to Rot-induced neuronal damage […]
Immune-Metabolic Interactions in the Degenerative Retina: A Systems Biology Approach Based on Diabetic Retinopathy
Front Biosci (Landmark Ed). 2026 May 22;31(5):49588. doi: 10.31083/FBL49588. ABSTRACT Diabetic retinopathy (DR) is increasingly recognized as a complex neurovascular degenerative disorder driven by intertwined immune and metabolic disturbances within the retinal microenvironment. Chronic hyperglycemia induces metabolic stress, mitochondrial dysfunction, and oxidative imbalance, which, in turn, activate innate and adaptive immune pathways. Key mechanisms-including complement […]
Autophagy impairs the sensitivity of Ewing sarcoma cells to PARP inhibitors
Cancer Chemother Pharmacol. 2026 May 30;96(1):60. doi: 10.1007/s00280-026-04907-8. ABSTRACT PURPOSE: PARP inhibitors (PARPi) proved effective in Ewing sarcoma cells in preclinical studies. In clinical evaluation, however, the PARPi olaparib failed to elicit substantial responses, suggesting an unknown mechanism of resistance to PARPi in Ewing sarcoma. Since autophagy has been identified as a PARPi resistance mechanism […]