Iron-Deprivation Liposomes for Cancer Therapy
Angew Chem Int Ed Engl. 2026 Sep 8:e5926794. doi: 10.1002/anie.5926794. Online ahead of print. ABSTRACT Targeting iron homeostasis in tumor cells represents a promising anticancer strategy, as iron plays essential roles in tumor growth, invasion, and metastasis. Although deferoxamine can effectively chelate iron, its clinical application is limited by poor membrane permeability, short half-life, and […]
Allotopic Expression of ND6 Restores Vision in a Mitochondrial Disease Model
JCI Insight. 2026 Sep 8:e209108. doi: 10.1172/jci.insight.209108. Online ahead of print. ABSTRACT Mutations in mitochondrial DNA (mtDNA) cause various mitochondrial diseases that are currently incurable. Allotopic expression of nuclear-recoded mitochondrial genes represents a promising therapeutic strategy, given its demonstrated capacity to restore mitochondrial function in human cell models harboring mtDNA mutations. However, the in vivo […]
LAPTM5 correlates with RPE senescence and subretinal fibrosis through the LAPTM5-WWP2-OPTN mitophagy cascade and cGAS/STING activation in a D-galactose-induced aging model
Geroscience. 2026 Sep 8. doi: 10.1007/s11357-026-02506-2. Online ahead of print. ABSTRACT Retinal pigment epithelium (RPE) senescence acts as a core driver of subretinal fibrosis, a major irreversible pathological feature that exacerbates age-related macular degeneration (AMD). Mitophagy is essential for maintaining RPE homeostasis during aging. However, the upstream molecular mechanisms underlying mitophagy impairment in senescent RPE […]
Intrinsically Photosensitive Retinal Ganglion Cell Dysfunction and Suprachiasmatic Nucleus -Mediated Circadian Disruption in Humans: A Systematic Review
Exp Eye Res. 2026 Sep 3:111229. doi: 10.1016/j.exer.2026.111229. Online ahead of print. ABSTRACT Circadian entraining input to the suprachiasmatic nucleus (SCN) is primarily from intrinsically photosensitive retinal ganglion cells (ipRGCs). While several retinal and optic nerve diseases are associated with ipRGC dysfunction, the role of ipRGC dysfunction in the context of SCN-mediated circadian disruption remains […]
Pseudomonas aeruginosa Impairs Mitochondrial Function During Infection of Corneal Epithelial Cells
Invest Ophthalmol Vis Sci. 2026 Sep 1;67(11):9. doi: 10.1167/iovs.67.11.9. ABSTRACT PURPOSE: Pseudomonas aeruginosa (PA) is a Gram-negative opportunistic bacterial pathogen that can infect the cornea as a result of trauma or contact lens wear. Mitochondria, originally derived from bacteria, play important roles in host defense. This study investigated the effect of PA on mitochondrial structure […]
Experimental models to study oxidative stress in glaucoma: integrating in vitro, in vivo, and clinical studies
Front Pharmacol. 2026 Aug 18;17:1893993. doi: 10.3389/fphar.2026.1893993. eCollection 2026. ABSTRACT Glaucoma is a complex optic neuropathy and the leading cause of permanent blindness worldwide. Elevated intraocular pressure (IOP) is the major modifiable risk factor for this disease. Growing evidence suggests that oxidative stress and reactive oxygen species (ROS) are key mediators of retinal ganglion cell […]
Tear proteomic atlas of local host-response states in herpes simplex keratitis
Ocul Surf. 2026 Sep 1:S1542-0124(26)00117-5. doi: 10.1016/j.jtos.2026.08.009. Online ahead of print. ABSTRACT PURPOSE: Herpes simplex keratitis (HSK) is a leading cause of infectious corneal blindness, yet local host-response programs underlying active disease, recurrence, and stromal involvement remain incompletely understood. This study aimed to establish a deep tear proteomic atlas of HSK and characterize phenotype-associated local […]
Retinal neurovascular and mitochondrial function signatures related to cognition improvement following yoga exercise in older adults
PLoS One. 2026 Sep 1;21(9):e0357464. doi: 10.1371/journal.pone.0357464. eCollection 2026. ABSTRACT PURPOSE: To investigate the associations between retinal neurovascular and mitochondrial function signatures and cognitive performances following a 24-week yoga intervention in healthy older adults. METHODS: Thirty healthy older adults (mean age 72 ± 6 years; 25 females) participated in three 60-minute sessions per week of […]
Microemulsion Eyedrop for Delivery of a PPARα Agonist To Improve Diabetic Keratopathy Corneal Wound Healing
ACS Appl Mater Interfaces. 2026 Aug 27. doi: 10.1021/acsami.6c16373. Online ahead of print. ABSTRACT Diabetic keratopathy (DK) is characterized by delayed corneal wound healing in diabetes, and recent studies have linked this defect to impaired mitochondrial respiration and reduced peroxisome proliferator-activated receptor-α (PPARα) signaling in the corneal epithelium. The PPARα agonist fenofibrate (Feno) has shown […]
OCT Biomarker Testing for Early Dysregulated Photoreceptor Metabolism in Dark-Reared Pde6brd10 Mice
Invest Ophthalmol Vis Sci. 2026 Sep 1;67(11):2. doi: 10.1167/iovs.67.11.2. ABSTRACT PURPOSE: The purpose of this study was to noninvasively test the hypothesis that dysregulated photoreceptor metabolism occurs with early retinal degeneration in dark-reared Pde6brd10 mice. METHODS: Postnatal day 23 (P23) phosphodiesterase (PDE) mutant (Pde6brd10) mice, P23 wild-type (WT) mice were continuously dark-reared, and 2-month-old dark-adapted […]