Mastering the Eye: Clinical Paradigm Shifts from Optical Restoration to Genomic Correction
Prog Retin Eye Res. 2026 Oct 20:101537. doi: 10.1016/j.preteyeres.2026.101537. Online ahead of print. ABSTRACT Historically, the main operation for cataract was couching, and the interior of the living eye could not be examined until Hermann von Helmholtz introduced the ophthalmoscope in 1851. Since the mid-twentieth century, seven advances have reshaped ophthalmic care. Harold Ridley implanted […]
Beyond Ocular Symptoms: Chronic Progressive External Ophthalmoplegia With Coexisting Facial Palsy and T-wave Inversion
Cureus. 2026 Sep 18;18(9):e116467. doi: 10.7759/cureus.116467. eCollection 2026 Sep. ABSTRACT Chronic progressive external ophthalmoplegia (CPEO) exists on a wide phenotypic continuum. The systemic propagation of cellular metabolic impairment frequently precipitates a heterogeneous spectrum of neurogenic, myopathic, and cardiovascular manifestations, clinically designated as CPEO-plus. Beyond the highly susceptible extraocular muscles, other metabolically intensive muscular tissues remain […]
AKAP1 Protects Retinal Ganglion Cells and Preserves Vision by Improving Mitochondrial and Synaptic Health in Glaucomatous Neurodegeneration
Adv Sci (Weinh). 2026 Oct 18:e78349. doi: 10.1002/advs.78349. Online ahead of print. ABSTRACT Glaucoma, a leading cause of irreversible blindness, is characterized by progressive loss of retinal ganglion cells (RGCs) and lacks effective neuroprotective therapies. Despite evidence implicating mitochondrial dysfunction in glaucoma, the mechanisms linking elevated intraocular pressure, synaptic dysfunction, mitochondrial failure, and RGC death […]
Biofluid Proteomic Biomarker Discovery in a Large Animal Model of CLN2 Neuronal Ceroid Lipofuscinosis
Biology (Basel). 2026 Oct 2;15(19):1761. doi: 10.3390/biology15191761. ABSTRACT CLN2 disease is a fatal lysosomal storage disorder caused by deficiency of the lysosomal enzyme tripeptidyl peptidase 1 (TPP1), resulting in progressive neurodegeneration and non-neuronal pathology. While enzyme replacement therapy has improved disease management, there remains a critical need for objective molecular biomarkers capable of monitoring disease […]
Metabolic and Immunometabolic Neuroprotection in Glaucoma: Mitochondrial Dysfunction, Neuroinflammation, and Emerging Therapeutic Strategies
Molecules. 2026 Sep 22;31(19):3367. doi: 10.3390/molecules31193367. ABSTRACT Glaucoma is increasingly recognized as a multifactorial neurodegenerative optic neuropathy in which intraocular pressure (IOP) is one of several stress amplifiers rather than a sufficient etiological explanation. Vascular dysregulation, mitochondrial and metabolic vulnerability, oxidative stress, excitotoxicity, glial dysregulation, and persistent neuroimmune activation can converge on retinal ganglion cell […]
Mitochondrial Myopathy in the Oculoplastic Practice
J Clin Med. 2026 Oct 2;15(19):7646. doi: 10.3390/jcm15197646. ABSTRACT Ptosis is a common ocular complaint in the elderly population. While most cases are often due to involutional changes in the eyelid, neurogenic, mechanical or myogenic diseases should remain as important differential diagnoses. We report a case of a 75-year-old Chinese man who presented with chronic […]
The mtROS-Stat1 Axis Defines an Acinar Dysfunctional State Linking Metabolic Stress to Immune Activation in Cigarette Smoking-Associated Dry Eye Disease
Ocul Surf. 2026 Oct 15:S1542-0124(26)00126-6. doi: 10.1016/j.jtos.2026.10.002. Online ahead of print. ABSTRACT PURPOSE: Dry eye disease (DED) is a prevalent ocular disorder in which environmental factors, particularly cigarette smoking (CS), are increasingly implicated. However, the underlying mechanisms remain poorly defined. METHODS: We integrated cross-sectional data from the UK Biobank with a chronic CS-exposure mouse model […]
The A53T Parkinson’s Disease Mouse Model Shows Abnormal Outer Retinal OCT Metabolic Biomarker Patterns
Invest Ophthalmol Vis Sci. 2026 Oct 1;67(12):28. doi: 10.1167/iovs.67.12.28. ABSTRACT PURPOSE: The purpose of this study was to test for abnormal optical coherence tomography (OCT) metabolic biomarker patterns in the A53T Parkinson’s disease model, which accumulates α-synuclein in photoreceptor inner segments before overt motor symptoms. METHODS: Four-to-6-month-old transgenic A53T homozygous mice and B6C3H wild-type (WT) […]
Optic disc drusen: Recent developments on a slow-moving condition
Taiwan J Ophthalmol. 2026 Sep 23;16(3):380-391. doi: 10.4103/tjo.TJO-D-26-00001. eCollection 2026 Jul-Sep. ABSTRACT Optic disc drusen (ODD) are benign acellular calcified deposits that typically form early in life. They do not normally cause symptoms, so ODD are often detected incidentally as an abnormal or potentially swollen optic disc appearance. Distinguishing ODD from true optic disc edema […]
Sirtuin 1-microRNA regulatory networks in liver diseases: Mechanistic convergence, cellular senescence, and translational implications
J Pharmacol Exp Ther. 2026 Sep 22;393(11):105031. doi: 10.1016/j.jpet.2026.105031. Online ahead of print. ABSTRACT Metabolic dysfunction-associated steatotic liver disease, hepatotoxicity, liver fibrosis, and hepatocellular carcinoma are stages of chronic liver injury that occur in the setting of complex interactions of the various factors, including metabolic dysregulation, inflammation, oxidative stress, and cellular senescence. Recent studies propose […]