Mitochondrial Protection and Neural Repair via ROS-Responsive Biomimetic Nanoparticles in Intracerebral Hemorrhage
Adv Sci (Weinh). 2026 Oct 11:e78075. doi: 10.1002/advs.78075. Online ahead of print. ABSTRACT Intracerebral hemorrhage (ICH)-induced secondary brain injury is driven in part by oxidative stress, blood-brain barrier disruption, mitochondrial dysfunction, and neuronal loss. Here, we developed a brain endothelial cell membrane-coated ROS-responsive biomimetic nanoplatform (NP@D+M) for co-delivery of the VDAC1 inhibitor DIDS and the […]
SIRT1 alleviates hypoxia-induced mitochondrial dysfunction and scleral remodeling in scleral fibroblasts by regulating AMPK via FOXO1
Cell Signal. 2026 Oct 9:112941. doi: 10.1016/j.cellsig.2026.112941. Online ahead of print. ABSTRACT BACKGROUND AND PURPOSE: Myopia is a globally prevalent refractive error. Sirtuin 1 (SIRT1) may be involved in myopia progression, but the specific underlying mechanisms remain to be elucidated. This study aimed to investigate the role of SIRT1 in myopia and elucidate its underlying […]
Multi‑target mechanisms of paeoniflorin in inflammatory regulation: A network pharmacology (Review)
Int J Mol Med. 2026 Dec;58(6):339. doi: 10.3892/ijmm.2026.6010. Epub 2026 Oct 9. ABSTRACT Paeoniflorin (PF), a monoterpene glycoside from Paeonia roots, shows low toxicity and broad anti‑inflammatory activity. A systematic review (PubMed, through 2025) with network pharmacology indicates that PF restores mitochondrial function, raises anti‑inflammatory mediators (IL‑10 and arginase‑1), reduces TNF‑α, IL‑1β and IL‑6, and […]
Nrf2/HO-1 signaling in retinal neurodegenerative diseases: redox homeostasis, cytoprotection, and therapeutic perspectives
Front Med (Lausanne). 2026 Sep 21;13:1910230. doi: 10.3389/fmed.2026.1910230. eCollection 2026. ABSTRACT Retinal neurodegenerative diseases (RNDs) represent a major group of disorders leading to irreversible visual impairment. Persistent oxidative stress, mitochondrial dysfunction, inflammatory responses, lipid peroxidation, and disruption of neurovascular unit homeostasis are closely implicated in retinal neuronal and vascular injury. Nuclear factor erythroid 2-related factor […]
Applications of single-cell transcriptomics in glaucoma research: from the aqueous humor outflow pathway to retinal ganglion cell neurodegeneration
Front Physiol. 2026 Sep 24;17:1953962. doi: 10.3389/fphys.2026.1953962. eCollection 2026. ABSTRACT Glaucoma is the leading cause of irreversible blindness worldwide, driven by progressive retinal ganglion cell (RGC) degeneration. While genetic and environmental risk factors have been identified, the cell-type-specific mechanisms underlying pathogenesis remain incompletely understood. Single-cell RNA sequencing (scRNA-seq) enables high-resolution analysis of cellular heterogeneity, developmental […]
Human ocular thelaziasis due to Thelazia callipaeda in a child from Türkiye: a case report and One Health perspective
Parasitol Int. 2026 Oct 8:103404. doi: 10.1016/j.parint.2026.103404. Online ahead of print. ABSTRACT Thelazia callipaeda is an emerging zoonotic eyeworm that infects the ocular tissues of domestic and wild mammals, including humans. This study describes the first molecularly confirmed pediatric case of human ocular thelaziasis caused by T. callipaeda in Türkiye and discusses its epidemiological significance […]
Targeting C3aR/STAT3 signaling attenuates neuroinflammation and reverses neurological impairment in Neuromyelitis optica
Fundam Res. 2025 Nov 7;6(5):3491-3506. doi: 10.1016/j.fmre.2025.11.001. eCollection 2026 Sep. ABSTRACT Abundant evidence indicates that the interaction between astrocytes and microglia through the C3-C3a receptor (C3aR) pathway is a crucial contributor to the pathogenesis of neurodegenerative and autoimmune disorders, such as neuromyelitis optica (NMO). However, the role of C3aR in microglia in modulating inflammation related […]
A ROS-Responsive and Mucoadhesive Thermosensitive Hydrogel Encapsulated with Mizoribine for Synergistic Dry Eye Therapy
Adv Sci (Weinh). 2026 Oct 6:e78106. doi: 10.1002/advs.78106. Online ahead of print. ABSTRACT Dry eye disease (DED) is a multifactorial disorder characterized by intricate pathogenesis, necessitating a multi-target synergistic intervention strategy. Current anti-inflammatory drugs for DED are limited by low bioavailability, ocular irritation, and inadequate relief. Herein, we propose a multifunctional hydrogel encapsulating Mizoribine, a […]
Intranasal Artesunate Ameliorates Hippocampal LFP Abnormalities and Cellular Apoptosis in APP/PS1 Mice via a Mechanism Involving GHRH/PI3K/AKT Signaling
Mol Neurobiol. 2026 Oct 6;63(1):948. doi: 10.1007/s12035-026-06250-8. ABSTRACT Alzheimer’s disease (AD) is characterized by progressive neurodegeneration and aberrant neural network activity. Artesunate (ART) has shown neuroprotective potential, but its effects on macroscopic hippocampal network dynamics and the underlying molecular mechanisms remain unclear. This study investigated the therapeutic efficacy and mechanisms of intranasal ART in APP/PS1 […]
Genotype-Phenotype Relationships in Patients Carrying Biallelic FDXR Pathogenic Variants-New Cases and Systematic Review
Hum Mutat. 2026 Oct 2;2026:5928629. doi: 10.1155/humu/5928629. eCollection 2026. ABSTRACT Biallelic pathogenic FDXR variations were identified in 2017 as being responsible for sensorial neuropathies. The first reported patients suffered from auditory and optic sensorineural impairments (ANOA, MIM #617717). Since then, many publications have described various phenotypes including peripheral and central nervous systems impairments (MMDS9B, MIM […]