Mitochondrial hyperoxidation contributes to warm ischemia-reperfusion injury in rat and pig livers
Commun Med (Lond). 2026 Apr 1. doi: 10.1038/s43856-026-01551-4. Online ahead of print. ABSTRACT BACKGROUND: Mitochondrial dysfunction is a critical factor in several diseases, but current in situ assessment methods are severely limited. Non-invasive monitoring of mitochondrial redox state using resonance Raman Spectroscopy (RRS) offers a promising solution. This study aims to demonstrate RRS utility with […]
Hepatocyte Growth Factor Confers Trabecular Meshwork Stem Cell Resilience and Paracrine Protection of Trabecular Meshwork Cells in Glaucoma
Invest Ophthalmol Vis Sci. 2026 Apr 1;67(4):1. doi: 10.1167/iovs.67.4.1. ABSTRACT PURPOSE: We have reported that trabecular meshwork stem cells (TMSCs) are effective for trabecular meshwork (TM) regeneration. This study aims to investigate different responses of TMSCs and TM cells to TGF-β2 and protective factors in TMSCs. METHODS: Human TMSCs and TM cells were exposed to […]
Mitochondrial kinase CMPK2 in immune homeostasis and disease: from metabolic regulation to inflammatory signaling
Int Immunopharmacol. 2026 Mar 30;178:116582. doi: 10.1016/j.intimp.2026.116582. Online ahead of print. ABSTRACT Cytidine monophosphate kinase 2 (CMPK2) is a pivotal mitochondrial enzyme that plays a multifaceted role in cellular nucleotide metabolism, immune regulation, and disease pathogenesis. This review comprehensively examines the structural characteristics, enzymatic functions, and regulatory mechanisms of CMPK2, emphasizing its significance in maintaining […]
NAD+ subcellular partitioning mediated by miR-183 and miR-96 regulates muscle stem cell differentiation
J Mol Cell Biol. 2026 Mar 31:mjag015. doi: 10.1093/jmcb/mjag015. Online ahead of print. ABSTRACT The intracellular abundance of NAD+, a vital metabolic cofactor, critically influences muscle stem cell (MuSC) function. However, the spatial regulation of NAD+ and its impact on MuSC function remain unclear. In this study, we demonstrated that the loss of miR-183 and […]
Phosphatase and tensin homolog: A potential target for therapeutic intervention in optic nerve regeneration
Neural Regen Res. 2026 Jul 1;21(7):2752-2760. doi: 10.4103/NRR.NRR-D-24-01599. Epub 2025 Sep 19. ABSTRACT Recent studies have found that the suppression of phosphatase and tensin homolog is one of the most effective single-gene approaches for promoting optic nerve regeneration. This effect is primarily mediated through the activation of the protein kinase B/phosphoinositide 3-kinase/mammalian target of rapamycin […]
Comparison of Optic Nerve Head Parameters in Alcoholic Liver Disease Patients With Age-Matched Controls
Cureus. 2026 Feb 27;18(2):e104366. doi: 10.7759/cureus.104366. eCollection 2026 Feb. ABSTRACT Alcoholic liver disease (ALD) is associated with systemic neurodegeneration mediated by oxidative stress, mitochondrial dysfunction, and chronic inflammation. As the retina and optic nerve head represent extensions of the central nervous system, they may provide a non-invasive window for detecting alcohol-related neuroretinal damage. This retrospective […]
Endoplasmic reticulum stress-based ATF6 signaling pathway: evaluation of 4-PBA improving retinal state in myopic guinea pigs
Naunyn Schmiedebergs Arch Pharmacol. 2026 Mar 30. doi: 10.1007/s00210-026-05232-w. Online ahead of print. ABSTRACT This study aims to evaluate whether 4-phenylbutyric acid (4-PBA) ameliorates retinal damage in myopic Cavia porcellus by inhibiting endoplasmic reticulum stress (ERS)-mediated activating transcription factor 6 (ATF6) signaling pathway activation and suppressing downstream apoptotic cascades. Lens-induced myopia (LIM) was established in […]
The P23H Rhodopsin Mouse Model Reveals a Novel Interaction Between the Endoplasmic Reticulum and Connecting Cilium Rootlet Within Photoreceptors
Invest Ophthalmol Vis Sci. 2026 Mar 2;67(3):57. doi: 10.1167/iovs.67.3.57. ABSTRACT PURPOSE: Photoreceptors are highly polarized sensory neurons containing a modified cilium known as the outer segment. This cilium has a rootlet that spans the length of the metabolically active inner segment and anchors the outer segment to the remainder of the photoreceptor. The full function […]
Procyanidin capsules attenuate PI3K/AKT-mediated mitochondrial dysfunction and accelerate skin wound healing in diabetic mice
Mater Today Bio. 2026 Mar 14;38:103029. doi: 10.1016/j.mtbio.2026.103029. eCollection 2026 Jun. ABSTRACT Hyperglycemia-induced oxidative stress considerably hinders healing of diabetic wounds, primarily due to mitochondrial dysfunction. This pathology leads to an excessive production of reactive oxygen species (ROS), disrupts respiratory chain function, and impairs energy metabolism. This study introduces procyanidin (PC) capsules designed to target […]
Everolimus suppresses glucose transporter 3 membrane trafficking to improve therapeutic efficacy of umbilical cord blood-derived mesenchymal stem cell transplantation in diabetic retinopathy
Cell Death Dis. 2026 Mar 28. doi: 10.1038/s41419-026-08673-6. Online ahead of print. ABSTRACT Diabetic retinopathy (DR) is a microvascular and retinal neurologic disorder that occurs in patients with long-term diabetes. Umbilical cord blood-derived mesenchymal stem cell (UCB-MSC) therapy has emerged as a promising treatment because of its regenerative potential; however, its effectiveness is limited under […]