Macular Metabolism in Young and Older Adults: A Preliminary Optical Coherence Tomography Biomarker Study
Invest Ophthalmol Vis Sci. 2026 Jul 1;67(8):41. doi: 10.1167/iovs.67.8.41. ABSTRACT PURPOSE: To begin to test whether optical coherence tomography (OCT) metabolic biomarkers-established in mouse studies-change with age in ways consistent with published ex vivo findings on macular metabolism in healthy young vs. older adults. METHODS: In this cross-sectional study, light-adapted subjects-25 light-adapted participants aged 20-30 […]
Neuroprotective effect of intraperitoneal Humanin-G in retinal degeneration of Royal College of Surgeons rats
Sci Rep. 2026 Jul 18. doi: 10.1038/s41598-026-62834-3. Online ahead of print. ABSTRACT This study aimed to examine whether Humanin-G (HNG), a mitochondrial derived peptide with cytoprotective properties, could improve the retinal function and gene expression in Royal College of Surgeons (RCS) rats with retinal pigment epithelium (RPE) dysfunction and retinal degeneration. Starting at postnatal day […]
DNA Sensing and Neuroinflammation: Mechanistic Insights into cGAS-STING Biology and Therapeutic Translation in Age-Related Neurodegenerative Diseases
Mol Neurobiol. 2026 Jul 18;63(1):779. doi: 10.1007/s12035-026-06061-x. ABSTRACT Emerging evidence suggests that some of the earliest events contributing to neurodegeneration may occur upstream of classical proteinopathies, underscoring the urgency of identifying molecular pathways that link age-associated genomic instability to chronic neuroinflammation. Among these, DNA sensing through the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) […]
How past European Board of Ophthalmology (EBO) candidates acquired theoretical knowledge: an EBO survey
BMC Med Educ. 2026 Jul 17. doi: 10.1186/s12909-026-09913-1. Online ahead of print. ABSTRACT BACKGROUND: The European Board of Ophthalmology (EBO), whose mission is to guarantee high standards of care in ophthalmology, has assessed residency training quality for over 30 years through the EBO Diploma (EBOD) examination, undertaken by residents and certified ophthalmologists from the 27 […]
Retinal connections to migraine
Front Neurol. 2026 Jul 2;17:1835914. doi: 10.3389/fneur.2026.1835914. eCollection 2026. ABSTRACT OBJECTIVE: This narrative review aims to examine potential associations between migraine and retinal disorders, with particular attention to retinal migraine, age-related macular degeneration (AMD), retinal vascular occlusions, and photophobia. BACKGROUND: The role of retinal pathways in migraine pathophysiology remains poorly understood. As a component of […]
Ultrastructural characteristics of the trabecular meshwork in primary open-angle glaucoma versus chronic angle-closure glaucoma: a comparative study
BMC Ophthalmol. 2026 Jul 16. doi: 10.1186/s12886-026-05112-0. Online ahead of print. ABSTRACT BACKGROUND: The trabecular meshwork (TM), the principal site of aqueous humor outflow resistance, plays a pivotal role in the regulation of intraocular pressure (IOP), the key modifiable risk factor for glaucoma. This study aimed to compare the ultrastructural characteristics of the TM in […]
10-HDA attenuates inflammatory responses in LPS-activated RAW264.7 cells in vitro via the NUR77/NF-kappaB pathways and improving mitochondrial functions
Front Pharmacol. 2026 Jul 1;17:1833265. doi: 10.3389/fphar.2026.1833265. eCollection 2026. ABSTRACT BACKGROUND: Inflammation is implicated in the pathogenesis of various diseases, including cancer, diabetes, and diseases caused by bacterial infections. Macrophages, as key regulators of inflammatory responses, can polarize into distinct phenotypes such as pro-inflammatory M1 and anti-inflammatory M2 macrophages. Trans-10-hydroxy-2-decenoic acid (10-HDA), a bioactive component […]
Quantification of Mitochondrial Stress in Nonarteritic Anterior Ischemic Optic Neuropathy Using Flavoprotein Fluorescence Imaging
J Neuroophthalmol. 2026 Jul 15. doi: 10.1097/WNO.0000000000002478. Online ahead of print. ABSTRACT BACKGROUND: Nonarteritic anterior ischemic optic neuropathy (NAION) or optic nerve stroke is the most common acute optic neuropathy in patients older than 50 years and results in severe vision loss. Endogenous flavoprotein fluorescence (FPF) imaging is a novel imaging modality to quantify axonal […]
Quantification of Mitochondrial Stress in Nonarteritic Anterior Ischemic Optic Neuropathy Using Flavoprotein Fluorescence Imaging
J Neuroophthalmol. 2026 Jul 15. doi: 10.1097/WNO.0000000000002478. Online ahead of print. ABSTRACT BACKGROUND: Nonarteritic anterior ischemic optic neuropathy (NAION) or optic nerve stroke is the most common acute optic neuropathy in patients older than 50 years and results in severe vision loss. Endogenous flavoprotein fluorescence (FPF) imaging is a novel imaging modality to quantify axonal […]
Quantification of Mitochondrial Stress in Nonarteritic Anterior Ischemic Optic Neuropathy Using Flavoprotein Fluorescence Imaging
J Neuroophthalmol. 2026 Jul 15. doi: 10.1097/WNO.0000000000002478. Online ahead of print. ABSTRACT BACKGROUND: Nonarteritic anterior ischemic optic neuropathy (NAION) or optic nerve stroke is the most common acute optic neuropathy in patients older than 50 years and results in severe vision loss. Endogenous flavoprotein fluorescence (FPF) imaging is a novel imaging modality to quantify axonal […]