Therapeutic Effects of Glycyrrhizic Acid on Dry Eye Disease: Targeting Pyroptosis, Oxidative Stress, and Epithelial Barrier Dysfunction
Int J Mol Sci. 2026 May 6;27(9):4153. doi: 10.3390/ijms27094153. ABSTRACT Dry eye disease (DED) is a common ocular surface disorder characterized by instability of the tear film, inflammatory responses, and epithelial damage, and therapeutic interventions directed at these fundamental pathogenetic processes are still insufficient. This research aimed to evaluate the medicinal efficacy of glycyrrhizic acid […]
Targeting Neuroinflammation and Oxidative Stress to Slow Neurodegeneration in the Visual System
J Clin Med. 2026 Apr 24;15(9):3254. doi: 10.3390/jcm15093254. ABSTRACT PURPOSE: Neuroinflammation and oxidative stress are increasingly recognized as central, interconnected drivers of neurodegeneration in the visual system. This review examines the pathogenic mechanisms shared across glaucoma, age-related macular degeneration (AMD), diabetic retinopathy (DR), and Alzheimer’s disease (AD), and evaluates the therapeutic rationale for targeting both […]
Emerin is necessary for microtubule-organizing center translocation to the nuclear envelope of muscle cells
Cell Death Dis. 2026 May 12. doi: 10.1038/s41419-026-08819-6. Online ahead of print. ABSTRACT During myogenic differentiation, the Microtubule-Organizing Center (MTOC) is relocated to the nuclear envelope by a molecular platform including Linker of Nucleoskeleton and Cytoskeleton (LINC) complex proteins, A Kinase Anchoring Proteins (AKAP9 and AKAP6) and Pericentriolar Material 1 (PCM-1). Here, we show that […]
Metformin Attenuates Ciliary Muscle Aging by Downregulating GSK-3β to Modulate Cell-Cycle Progression and Autophagy
FASEB J. 2026 May 31;40(10):e71835. doi: 10.1096/fj.202600364R. ABSTRACT Presbyopia is linked to age-related decline in ciliary muscle (CM) function, yet pharmacologic strategies that target CM senescence remain limited. We investigated whether metformin (MET) mitigates CM aging in guinea pigs and explored the underlying mechanism. A D-galactose-induced CM aging model was established in vivo in guinea […]
Mitophagy in ophthalmic pathologies: Molecular mechanisms and therapeutic implications
Medicine (Baltimore). 2026 May 8;105(19):e47600. doi: 10.1097/MD.0000000000047600. ABSTRACT Mitophagy, a selective autophagic process responsible for the degradation of dysfunctional mitochondria, serves as a critical regulator of cellular homeostasis. Despite its emerging significance in ocular pathophysiology, comprehensive analyses bridging molecular mechanisms to clinical translation remain scarce. The retina, with its high metabolic demands and reliance on […]
Effects of coenzyme Q10 on retinal inflammation in streptozotocin-induced diabetic rats
BMC Ophthalmol. 2026 May 11. doi: 10.1186/s12886-026-04863-0. Online ahead of print. ABSTRACT BACKGROUND: Inflammation, oxidative stress, and apoptosis play important roles in diabetes-induced retinal injury. Coenzyme Q10 (CoQ10) is an endogenous antioxidant involved in mitochondrial energy metabolism and cellular protection. This study aimed to investigate the effects of CoQ10 on diabetes-induced retinal injury in a […]
Piezo-metastructured arrays enhance osteoblast mitochondrial quality control to promote osseointegration under osteoporotic conditions
Biomaterials. 2026 Apr 27;334:124248. doi: 10.1016/j.biomaterials.2026.124248. Online ahead of print. ABSTRACT Titanium (Ti)-based implants often exhibit poor osseointegration in osteoporotic bone defects, primarily due to osteoporosis frequently accompanied by excessive reactive oxygen species (ROS), which induce mitochondrial oxidative stress within osteoblasts, leading to dysfunctional mitochondria. To address this challenge, a piezo-metastructured array composed of BaTiO3 […]
Correction: Impaired mitochondrial dynamics and removal of the damaged mitochondria in diabetic retinopathy
Front Endocrinol (Lausanne). 2026 Apr 24;17:1793182. doi: 10.3389/fendo.2026.1793182. eCollection 2026. ABSTRACT [This corrects the article DOI: 10.3389/fendo.2023.1160155.]. PMID:42109714 | PMC:PMC13154154 | DOI:10.3389/fendo.2026.1793182
Regional and Systemic Metabolic Remodeling Promotes Longevity by Bioengineered Yeast-Derived Lipids
bioRxiv [Preprint]. 2026 Apr 13:2026.04.10.717033. doi: 10.64898/2026.04.10.717033. ABSTRACT Aging is marked by a progressive breakdown of intestinal integrity and metabolic homeostasis, which together drives systemic decline in physiology and reduces lifespan. Here, we found that dietary lipids extracted from a genetically engineered long-lived yeast strain robustly extend lifespan in Drosophila and further uncovered the mechanisms […]
A regenerative cerium oxide nanozyme for cataract treatment via oxidative stress regulation
Biomater Sci. 2026 May 8. doi: 10.1039/d6bm00331a. Online ahead of print. ABSTRACT As the world’s leading blinding eye disease, cataract pathogenesis is closely related to reactive oxygen species (ROS)-mediated oxidative damage to the lens. Surgical intervention has limitations, necessitating non-invasive antioxidant treatment strategies. This study used branched-chain polyethylenimine grafted polyethylene glycol (bPEI-g-PEG) to obtain cerium […]