Syndromic Retinitis Pigmentosa
Prog Retin Eye Res. 2024 Dec 27:101324. doi: 10.1016/j.preteyeres.2024.101324. Online ahead of print. ABSTRACT Retinitis pigmentosa (RP) is a progressive inherited retinal dystrophy, characterized by the degeneration of photoreceptors, presenting as a rod-cone dystrophy. Approximately 20-30% of patients with RP also exhibit extra-ocular manifestations in the context of a syndrome. This manuscript discusses the broad […]
Norepinephrine Attenuates Benzalkonium Chloride-Induced Dry Eye Disease by Regulating the PINK1/Parkin Mitophagy Pathway
Ocul Immunol Inflamm. 2024 Dec 27:1-15. doi: 10.1080/09273948.2024.2447816. Online ahead of print. ABSTRACT BACKGROUND: Increased reactive oxygen species (ROS) are involved in the pathological process of dry eye disease. Our previous results suggested that norepinephrine (NE) has a protective effect on dry eye. PURPOSE: This study explored the potential therapeutic role and underlying mechanisms of […]
Predictive biosignatures for hospitalization in patients with virologically confirmed COVID-19
J Chin Med Assoc. 2024 Dec 30. doi: 10.1097/JCMA.0000000000001203. Online ahead of print. ABSTRACT BACKGROUND: COVID-19, caused by the SARS-CoV-2 virus, presents with varying severity among individuals. Both viral and host factors can influence the severity of acute and chronic COVID-19, with chronic COVID-19 commonly referred to as long COVID. SARS-CoV-2 infection can be properly […]
Ptosis in human immunodeficiency virus-infected patients under long-term antiretroviral treatment
Clin Neurol Neurosurg. 2024 Dec 13;249:108690. doi: 10.1016/j.clineuro.2024.108690. Online ahead of print. ABSTRACT OBJECTIVE: To present cases of ptosis in HIV-1 patients on long-term antiretroviral therapy (ART) and review the existing literature. METHODS: Five HIV-1-positive patients with slowly progressive bilateral ptosis underwent a comprehensive diagnostic evaluation, including imaging studies, neurophysiological testing, muscle biopsy, and genetic […]
How crosstalk between mitochondria, lysosomes, and other organelles can prevent or promote dry age-related macular degeneration
Exp Eye Res. 2024 Dec 21:110219. doi: 10.1016/j.exer.2024.110219. Online ahead of print. ABSTRACT Organelles such as mitochondria, lysosomes, peroxisomes, and the endoplasmic reticulum form highly dynamic cellular networks and exchange information through sites of physical contact. While each organelle performs unique functions, this inter-organelle crosstalk helps maintain cell homeostasis. Age-related macular degeneration (AMD) is a […]
Extracellular Mitochondria Exacerbate Retinal Pigment Epithelium Degeneration in Diabetic Retinopathy
Diabetes. 2024 Dec 23:db240040. doi: 10.2337/db24-0040. Online ahead of print. ABSTRACT Advances in fundus imaging are revealing disruptions in the neurovascular unit in diabetic retinopathy (DR). In the era of anti-VEGF treatment, a thorough characterization of neurodegeneration is imperative until DR patients are sufficiently cured. Here we demonstrate that extracellular mitochondria exacerbate retinal pigment epithelium […]
Photobiomodulation Therapy for Non-exudative Age-related Macular Degeneration
Int Ophthalmol Clin. 2025 Jan 1;65(1):47-52. doi: 10.1097/IIO.0000000000000543. Epub 2024 Dec 23. ABSTRACT Age-related macular degeneration (AMD) is a chronic condition that causes gradual central vision loss, most commonly in patients 50 years or older. This disease is commonly classified as either dry (non-exudative) or wet (exudative). Most patients with AMD have the non-exudative form, […]
Reprogramming patient-iPSC specific retinal organoids for deciphering epigenetic modifications of RNA methylation
J Chin Med Assoc. 2024 Dec 23. doi: 10.1097/JCMA.0000000000001198. Online ahead of print. ABSTRACT BACKGROUND: Induced pluripotent stem cell (iPSC) technology has emerged as a powerful tool for disease modeling, providing an innovative platform for investigating disease mechanisms. iPSC-derived organoids, including retinal organoids, offer patient-specific models that closely replicate in vivo cellular environments, making them […]
Taurine mechanism in preventing retinal cell damage from acute ocular hypertension through GTPBP3 regulation
Exp Eye Res. 2024 Dec 20:110222. doi: 10.1016/j.exer.2024.110222. Online ahead of print. ABSTRACT We aimed to explore the protective effects and underlying mechanisms of taurine on retinal cells during acute ocular hypertension (AOH)-induced damage. Retinal morphology, apoptosis, mitochondrial structure, electroretinography, expression of GTP binding protein 3 (GTPBP3), and molecules in the unfolded protein response (UPR) […]
PRDX4 mitigates diabetic retinopathy by inhibiting reactive gliosis, apoptosis, ER stress, oxidative stress, and mitochondrial dysfunction in Muller cells
J Biol Chem. 2024 Dec 18:108111. doi: 10.1016/j.jbc.2024.108111. Online ahead of print. ABSTRACT Diabetic retinopathy (DR) is a neurovascular complication of diabetes. As a crucial player in the retinal physiology, Müller cells are affected in DR, impairments of Müller cell function lead to retinal malfunctions. Therefore, searching for approaches to mitigate diabetes-induced injury in Müller […]