Grx2 maintains GSH/GSSG homeostasis to enhance GPX4-mediated ferroptosis defense in UVB irradiation induced cataract
Exp Eye Res. 2025 May 12:110421. doi: 10.1016/j.exer.2025.110421. Online ahead of print. ABSTRACT PURPOSE: Ultraviolet B (UVB) irradiation induces cataract pathogenesis, and Glutaredoxin 2 (Grx2) deficiency causes the early onset of UVB-induced cataracts. Several researchers have shown that, apart from apoptosis and pyroptosis, UVB irradiation also can induce cell ferroptosis. We explored the role of […]
Oral 7,8-Dihydroxyflavone Protects Retinal Ganglion Cells by Modulating the Gut-Retina Axis and Inhibiting Ferroptosis via the Indoleacrylic Acid-AhR-ALDH1A3-FSP1 Pathway
CNS Neurosci Ther. 2025 May;31(5):e70442. doi: 10.1111/cns.70442. ABSTRACT OBJECTIVES: 7,8-Dihydroxyflavone (7,8-DHF) activates the TrkB receptor, offering neuroprotection, yet its pharmacological limitations restrict its safe and effective delivery to the eye and brain, impeding clinical translation. This study explores the protective effects of oral 7,8-DHF on retinal ganglion cells (RGCs) by inhibiting ferroptosis and investigates the […]
Association of mitochondrial RNA expression levels in saliva and plasma with interferon signature gene expression and disease activity in patients with Sjogren disease
RMD Open. 2025 May 13;11(2):e005166. doi: 10.1136/rmdopen-2024-005166. ABSTRACT OBJECTIVE: To unveil the clinical implications of mitochondrial RNAs (mt-RNAs) in Sjögren disease (SjD), this study evaluated mt-RNA expression levels in the plasma and saliva of patients with SS and their association with SjD-related features. METHODS: Plasma, saliva and/or peripheral blood mononuclear cells (PBMCs) were collected from […]
Baicalin prevents experimental autoimmune uveitis by promoting macrophage polarization balance through inhibiting the HIF-1α signaling pathway
Sci Rep. 2025 May 12;15(1):16424. doi: 10.1038/s41598-025-01286-7. ABSTRACT Uveitis is a series of autoimmune eye diseases that can seriously damage people’s eyesight. This study aimed to explore the therapeutic potential of baicalin in treating uveitis, focusing on its modulation of HIF-1α expression and macrophage polarization. Using an experimental autoimmune uveitis (EAU) rat model, we found […]
Restoring AIBP expression in the retina provides neuroprotection in glaucoma
Mol Ther. 2025 May 9:S1525-0016(25)00379-X. doi: 10.1016/j.ymthe.2025.05.009. Online ahead of print. ABSTRACT Glaucoma is a neurodegenerative disease manifested by retinal ganglion cell (RGC) death and irreversible blindness. We have identified apolipoprotein A-I binding protein (AIBP) that controls excessive cholesterol accumulation and neuroinflammation in the retina by upregulating the cholesterol transporter ABCA1 and reducing TLR4 signaling […]
Microwave-Responsive AlEu-MOFs Potentiate NLRP3-Mediated Pyroptosis via a “Triple Initiating” Tactic for Breast Cancer Microwave-Immunotherapy
Small. 2025 May 9:e2501157. doi: 10.1002/smll.202501157. Online ahead of print. ABSTRACT Microwave thermotherapy is favored in clinical practice for breast cancer conservation strategies due to its minimally invasive characteristic. Nevertheless, the immunosuppressive tumor microenvironment (TME) significantly attenuates the therapeutic efficacy of anti-tumor immune response, posing challenges in effectively preventing tumor recurrence and metastasis. Pyroptosis, a […]
Recurrent Optic Neuritis as a Misleading Presentation of Leber Hereditary Optic Neuropathy: The Need for High Clinical Suspicion in Young Men
Cureus. 2025 Apr 8;17(4):e81863. doi: 10.7759/cureus.81863. eCollection 2025 Apr. ABSTRACT A 29-year-old Chinese gentleman presented with acute-onset right eye (RE) central scotoma and blurring of vision. Upon presentation, RE visual acuity (VA) was 6/30. The RE optic disc (OD) was mildly swollen, but other findings were unremarkable. A computed tomography (CT) imaging study showed no […]
MiR-125a-5p in MSC-derived small extracellular vesicles alleviates Müller cells injury in diabetic retinopathy by modulating mitophagy via PTP1B pathway
Cell Death Discov. 2025 May 8;11(1):226. doi: 10.1038/s41420-025-02439-3. ABSTRACT Diabetic retinopathy (DR) ranks among the primary causes of adult blindness globally. Oxidative stress and mitochondrial dysfunction play a critical role in the progression of DR. Mounting data indicated that small extracellular vesicles (sEVs) of mesenchymal stem cell (MSC) have the ability to transport bioactive chemicals […]
Corrigendum to “In vitro studies in VCP-associated multisystem proteinopathy suggest altered mitochondrial bioenergetics” [Mitochondrion 22 (2015) 1-8]
Mitochondrion. 2025 May 7:102044. doi: 10.1016/j.mito.2025.102044. Online ahead of print. NO ABSTRACT PMID:40340170 | DOI:10.1016/j.mito.2025.102044
Fenofibrate inhibits activation of cGAS-STING pathway by alleviating mitochondrial damage to attenuate inflammatory response in diabetic dry eye
Free Radic Biol Med. 2025 May 6:S0891-5849(25)00658-6. doi: 10.1016/j.freeradbiomed.2025.05.383. Online ahead of print. ABSTRACT The cyclic GMP-AMP synthase (cGAS) and Stimulator of Interferon Genes (STING) signaling pathway are critical regulators of inflammation. This study aims to investigate the role of the cGAS-STING signaling pathway in diabetic dry eye disease (DDE) and further explore the therapeutic […]