Idebenone Protects Photoreceptors Impaired by Oxidative Phosphorylation Disorder in Retinal Detachment
Invest Ophthalmol Vis Sci. 2025 Jan 2;66(1):17. doi: 10.1167/iovs.66.1.17. ABSTRACT PURPOSE: Oxidative phosphorylation (OXPHOS) is an aerobic metabolic mechanism, and its dysfunction plays an important role in the pathological changes of ischemic diseases. However, systematic studies on the occurrence of retinal detachment (RD) are lacking. METHODS: Single-cell RNA sequencing (scRNA-seq) of the human retina was […]
A Cerium Oxide Loaded Hyaluronic Acid Nanosystem Remits Glucose Oxidative Stress-Induced Odontoblasts Mitochondrial Apoptosis through Regulation of PGAM5 Pathway
ACS Appl Mater Interfaces. 2025 Jan 8. doi: 10.1021/acsami.4c13484. Online ahead of print. ABSTRACT Diabetes mellitus (DM) induced mitochondrial oxidative stress (OS) can lead to severe injury of dental pulp. The cerium oxide nanoparticles (CNP) have been proven to have excellent antioxidative activity. However, whether CNP can relieve dental pulp damage caused by DM and […]
Insights on the Genetic and Phenotypic Complexities of Optic Neuropathies
Genes (Basel). 2024 Nov 29;15(12):1559. doi: 10.3390/genes15121559. ABSTRACT Background/Objectives: Optic neuropathies are a category of illnesses that ultimately cause damage to the optic nerve, leading to vision impairment and possible blindness. Disorders such as dominant optic atrophy (DOA), Leber hereditary optic neuropathy (LHON), and glaucoma demonstrate intricate genetic foundations and varied phenotypic manifestations. This narrative […]
Ferroptosis and PANoptosis Under Hypoxia Pivoting on the Crosstalk between DHODH and GPX4 in Corneal Epithelium
Free Radic Biol Med. 2025 Jan 4:S0891-5849(24)01159-6. doi: 10.1016/j.freeradbiomed.2024.12.050. Online ahead of print. ABSTRACT Cell death under stress conditions like hypoxia, involves multiple interconnected pathways. In this study, a stable dihydroorotate dehydrogenase (DHODH) knockdown human corneal epithelial cell line was established to explore the regulation of hypoxic cell death, which was mitigated by various cell […]
Identification of macrophage polarisation and mitochondria-related biomarkers in diabetic retinopathy
J Transl Med. 2025 Jan 6;23(1):23. doi: 10.1186/s12967-024-06038-1. ABSTRACT BACKGROUND: The activation of macrophages or microglia in patients’ whole body or local eyes play significant roles in diabetic retinopathy (DR). Mitochondrial function regulates the inflammatory polarization of macrophages. Therefore, the common mechanism of mitochondrial related genes (MRGs) and macrophage polarisation related genes (MPRGs) in DR […]
G6PD protects against cerebral ischemia-reperfusion injury by inhibiting excessive mitophagy
Life Sci. 2025 Jan 3:123367. doi: 10.1016/j.lfs.2024.123367. Online ahead of print. ABSTRACT AIMS: Cerebral ischemia-reperfusion injury (CIRI) exacerbates post-stroke brain damage. We aimed to understand the role of glucose-6-phosphate dehydrogenase (G6PD) in CIRI and mitophagy. MATERIALS AND METHODS: Lentivirus and small interfering RNA were utilized to suppress G6PD in tissues and cells, leading to the […]
Non-canonical roles of CFH in retinal pigment epithelial cells revealed by dysfunctional rare CFH variants
Stem Cell Reports. 2024 Dec 17:102385. doi: 10.1016/j.stemcr.2024.11.015. Online ahead of print. ABSTRACT Complement factor H (CFH) common genetic variants have been associated with age-related macular degeneration (AMD). While most previous in vitro RPE studies focused on the common p.His402Tyr CFH variant, we characterized rare CFH variants that are highly penetrant for AMD using induced […]
Blue light-induced phototoxicity in retinal cells: implications in age-related macular degeneration
Front Aging Neurosci. 2024 Dec 17;16:1509434. doi: 10.3389/fnagi.2024.1509434. eCollection 2024. ABSTRACT Sunlight exposure is recognized as a risk factor for the development of age-related macular degeneration (AMD), a common neurodegenerative retinal disease in the elderly. Specifically, the blue light wavelengths within sunlight can negatively impact the physiology of light-sensitive retinal cells, including retinal pigmented epithelium […]
FADS1 inhibition protects retinal pigment epithelium cells from ferroptosis in age related macular degeneration
Eur J Pharmacol. 2024 Dec 28:177227. doi: 10.1016/j.ejphar.2024.177227. Online ahead of print. ABSTRACT PURPOSE: Age-related macular degeneration (AMD) is the leading cause of vision loss among the elderly individuals. Retinal pigment epithelium (RPE) ferroptosis is a significant pathogenetic component in AMD. This study aims to elucidate the role and mechanisms of fatty acid desaturase 1 […]
Oxidative stress mediates retinal damage after corneal alkali burn through the activation of the cGAS/STING pathway
Exp Eye Res. 2024 Dec 28:110228. doi: 10.1016/j.exer.2024.110228. Online ahead of print. ABSTRACT Retinal damage accounts for irreversible vision loss following ocular alkali burn (OAB), but the underlying mechanisms remain largely unexplored. Herein, using an OAB mouse model, we examined the impact of oxidative stress (OS) in retinal damage and its molecular mechanism. Results revealed […]