Activation of GSDME by all-trans-retinal increases sensitivity to photoreceptor ferroptosis
Int J Biol Sci. 2025 Oct 27;21(15):7029-7042. doi: 10.7150/ijbs.114187. eCollection 2025. ABSTRACT Impaired clearance of all-trans-retinal (atRAL) due to visual cycle dysfunction contributes to photoreceptor atrophy, a key pathological hallmark of Stargardt disease type 1 (STGD1) and dry age-related macular degeneration (AMD). Prior studies have shown that light-induced atRAL accumulation promotes ferroptosis and activates gasdermin […]
In vivo mitochondrial base editing restores genotype and visual function in a mouse model of LHON
Nat Commun. 2025 Nov 23. doi: 10.1038/s41467-025-66600-3. Online ahead of print. ABSTRACT Leber hereditary optic neuropathy (LHON), a maternally inherited mitochondrial disorder, results from point mutations in mitochondrial DNA (mtDNA), primarily affecting the MT-ND4 gene. To date, no animal model harboring authentic LHON mutations has been available, limiting therapeutic development. However, when we attempted to […]
Acute High Intraocular Pressure Induced by Vitreous Cavity Infusion: an animal model to evaluate corneal endothelial injuries
Exp Eye Res. 2025 Nov 20:110765. doi: 10.1016/j.exer.2025.110765. Online ahead of print. ABSTRACT Elevated intraocular pressure (IOP) is a critical factor in corneal endothelial cells (CECs) injury, yet the precise mechanisms remain poorly understood due to confounding variables in clinical studies. This study developed an acute high IOP model in New Zealand rabbits by vitreous […]
First record of Argulus japonicus infestation on Cyprinus carpio in Hungary, and the first description of Argulus japonicus europaeus subsp. nov. Keve, 2025
Parasit Vectors. 2025 Nov 21;18(1):480. doi: 10.1186/s13071-025-07106-1. ABSTRACT BACKGROUND: Species belonging to the genus Argulus are globally distributed fish parasites. Their veterinary significance primarily lies in their disruptive presence and their role as mechanical vectors. Although Argulus japonicus Thiele, 1900 is a widely distributed representative of this genus that feeds on freshwater fish, only Argulus […]
Amniotic membrane transplantation promotes retinal hole closure in a rabbit model
Sci Rep. 2025 Nov 21;15(1):41253. doi: 10.1038/s41598-025-25162-6. ABSTRACT Amniotic membrane transplantation (AMT) is an effective treatment for refractory macular hole closure, yet the underlying mechanism supporting that effectiveness remains unclear. Here, we investigated the role of retinal regeneration in this process using an in vivo rabbit retinal-hole (RH) model in which AMT was performed on […]
RAB3GAP2 silencing alleviates oxidative stress in cataracts by enhancing Mfn2-mediated mitochondrial autophagy by activating JNK/STAT3
Int J Biol Macromol. 2025 Nov 19:149102. doi: 10.1016/j.ijbiomac.2025.149102. Online ahead of print. ABSTRACT Cataracts seriously affect the vision of patients and can even lead to blindness. RAB3GAP2 is associated with cataracts, but its regulatory effects on cataracts need to be determined. We established a mouse model of cataracts and cell models of cataracts induced […]
IT TAKES TWO TO TANGO: potential novel therapies for autosomal dominant optic atrophy
Front Ophthalmol (Lausanne). 2025 Nov 5;5:1688232. doi: 10.3389/fopht.2025.1688232. eCollection 2025. ABSTRACT Autosomal dominant optic atrophy (ADOA) is among the most prevalent inherited optic neuropathies with hallmark symptoms of bilateral, painless, progressive, and typically permanent vision loss over time. ADOA can affect patients’ quality of life with debilitating visual symptoms, and there is a pressing need […]
3-Hydroxyisobutyryl-CoA Hydrolase Deficiency
2025 Nov 20. In: Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2025. ABSTRACT CLINICAL CHARACTERISTICS: 3-Hydroxyisobutyryl-CoA hydrolase (HIBCH) deficiency can be categorized into three subtypes based on age of presentation. Neonatal onset, the least frequent phenotype, is characterized by hypotonia, seizures, […]
Kenny mediates the recruitment of the phagophore for ubiquitin-dependent mitophagy in Drosophila neurons
Mol Biol Cell. 2025 Nov 19:mbcE25050235. doi: 10.1091/mbc.E25-05-0235. Online ahead of print. ABSTRACT The maintenance of healthy mitochondria is essential to neuronal homeostasis. Mitophagy is a critical mechanism that degrades damaged mitochondria, and disruption of this process is associated with neurodegenerative disease. Previous work has shown that mammalian optineurin (OPTN), a gene mutated in familial […]
Protective effects of luteolin on high glucose-induced ferroptosis in müller cells
Int Ophthalmol. 2025 Nov 19;45(1):494. doi: 10.1007/s10792-025-03850-6. ABSTRACT PURPOSE: This study aims to investigate the protective effects of luteolin on Müller cells under high glucose conditions and to elucidate its potential mechanisms of action. METHODS: Firstly, Primary rat retinal Müller cells were divided into three groups: a control group (Control), a high glucose group (HG), […]