Vitamin abnormalities in neuropathic corneal pain
Eye Vis (Lond). 2025 Oct 12;12(1):39. doi: 10.1186/s40662-025-00457-x. ABSTRACT Neuropathic corneal pain (NCP) refers to spontaneous corneal pain in the absence of stimuli arising from corneal nerve dysfunction with no clinically observable ocular surface abnormalities. It is debilitating with difficult-to-manage symptoms-burning pain, photophobia, and irritation being profound. However, evidence-based clinical recommendations for the management of […]
Drug loaded cerium oxide nanozymes prevent radiation-Induced cataracts via suppressing the cGAS-STING pathway
J Nanobiotechnology. 2025 Oct 10;23(1):657. doi: 10.1186/s12951-025-03706-2. ABSTRACT Radiation-induced cataracts (RIC), a significant cause of blindness, arise from oxidative damage and inflammation in the lens epithelium, and there has been a lack of effective targeted therapeutic drugs in clinic. Here, we proposed and developed a novel approach for prevention and treatment of RIC via multifunctional […]
KIF11-related MCLMR presenting with FEVR-like retinopathy: first report in an Indian child
Ophthalmic Genet. 2025 Oct 9:1-4. doi: 10.1080/13816810.2025.2572708. Online ahead of print. ABSTRACT INTRODUCTION: KIF11 gene mutations can result in a rare autosomal dominant inheritable disease called microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR/MLCRD). Recently, such mutations were also found to be associated with familial exudative vitreoretinopathy (FEVR). METHODS: Retrospective case report. RESULTS: […]
Prosapogenin CP4 exacerbates mitophagy to induce apoptosis via AMPK-mTOR and PINK1/Parkin pathways in A549 cells
Phytomedicine. 2025 Sep 28;148:157333. doi: 10.1016/j.phymed.2025.157333. Online ahead of print. ABSTRACT BACKGROUND: Non-small cell lung cancer (NSCLC) remains a major cause of cancer-related mortality worldwide. While mitophagy, a process that selectively removes damaged mitochondria, typically promotes cell survival, its excessive activation can trigger apoptosis, offering a novel therapeutic avenue. In this study, we report for […]
Visual Recovery in Leber’s Hereditary Optic Neuropathy Plus: A Case Report and Literature Insight
Case Rep Ophthalmol. 2025 Aug 28;16(1):686-692. doi: 10.1159/000547946. eCollection 2025 Jan-Dec. ABSTRACT INTRODUCTION: Leber’s hereditary optic neuropathy (LHON) is a maternally inherited mitochondrial disorder that primarily affects young men, leading to subacute, painless, bilateral loss of central vision. It is caused by point mutations in mitochondrial DNA, especially those involving the MT-ND1, MT-ND4, and MT-ND6 […]
Polydatin’s neuroprotective mechanism in optic nerve injury: targeting mitochondrial function and glial cell activation
Exp Eye Res. 2025 Oct 6:110685. doi: 10.1016/j.exer.2025.110685. Online ahead of print. ABSTRACT Optic nerve injury (ONI) frequently causes irreversible visual impairment, making it a significant clinical challenge. This study evaluated the neuroprotective effects of polydatin (PD), focusing on its ability to preserve mitochondrial function and inhibit glial cell activation. We utilized an in vitro […]
Beyond Ornithine Metabolism in Gyrate Atrophy: Tissue-Specific Proteomic Insights into Neonatal and Adult OAT Deficiency
bioRxiv [Preprint]. 2025 Sep 16:2025.09.10.675383. doi: 10.1101/2025.09.10.675383. ABSTRACT Ornithine aminotransferase (OAT) links the urea and TCA cycles by interconverting ornithine to pyrroline-5-carboxylate. Despite its abundance in the liver, OAT mutations primarily cause gyrate atrophy (GA) and blindness. Paradoxically, adult GA patients have hyperornithinemia that is managed by arginine-restricted diet, while neonates experience hypoornithinemia and require […]
Transferrin is a drug candidate for the treatment of dry age-related macular degeneration (AMD)
Cell Death Dis. 2025 Oct 6;16(1):692. doi: 10.1038/s41419-025-07950-0. ABSTRACT Dysregulation of iron homeostasis plays a crucial role in retinal diseases, contributing to oxidative stress, inflammation, and ferroptosis, key processes that drive the degeneration of the retinal pigment epithelium (RPE) and photoreceptors in age-related macular degeneration (AMD). Previous studies, though limited in patient numbers, have reported […]
ZFP36 promotes ferroptosis and mitochondrial dysfunction and inhibits malignant progression in osteosarcoma by regulating the E2F1/ATF4 axis
J Pharm Anal. 2025 Sep;15(9):101228. doi: 10.1016/j.jpha.2025.101228. Epub 2025 Feb 12. ABSTRACT Zinc finger protein 36 (ZFP36) was found to be downregulated in osteosarcoma (OS) tumor tissues. We aimed to investigate the roles and mechanisms of ZFP36 in ferroptosis regulation during OS development. Two Gene Expression Omnibus (GEO) datasets showed that ZFP36 was a differentially […]
Association between Disorders of Lipid Metabolism and Oculopathy: An Overview
Int J Med Sci. 2025 Aug 22;22(15):3878-3894. doi: 10.7150/ijms.116512. eCollection 2025. ABSTRACT Lipid metabolism disorders, which lead to lipid deposition or changes in blood lipid composition, play a significant role in inducing or exacerbating the pathogenesis of diseases such as hypercholesterolemia and diabetes. Moreover, these disorders are closely associated with the development and progression of […]