Pharmacological Depletion of Retinal Mononuclear Phagocytes Is Neuroprotective in a Mouse Model of Mitochondrial Optic Neuropathy
Invest Ophthalmol Vis Sci. 2026 Feb 2;67(2):6. doi: 10.1167/iovs.67.2.6. ABSTRACT PURPOSE: The Vglut2-Cre;ndufs4loxP/loxP mouse strain with retinal ganglion cell (RGC)-specific mitochondrial complex I dysfunction develops severe RGC degeneration by postnatal day 90 (P90), with accompanying retinal mononuclear phagocyte (MNP) accumulation. We have reported that continuous exposure to hypoxia partially rescues RGC death in these mice, […]
Ferroptosis and retinal ganglion cell death in glaucoma: Mechanisms and therapeutic approaches
J Pharm Anal. 2026 Jan;16(1):101355. doi: 10.1016/j.jpha.2025.101355. Epub 2025 Jun 4. ABSTRACT Glaucoma represents a predominant worldwide etiology of permanent vision impairment; it is clinically manifested through progressive neuronal atrophy in retinal ganglion cells (RGCs) and is accompanied by axonal degeneration in the optic pathway. Given the limited efficacy of conventional intraocular pressure-lowering therapies in […]
A multifunctional mitochondria-targeted nanoparticle for the effective treatment of dry eye disease via reactive oxygen species scavenging
Mater Today Bio. 2026 Jan 16;37:102815. doi: 10.1016/j.mtbio.2026.102815. eCollection 2026 Apr. ABSTRACT Dry eye disease is a prevalent ocular surface disorder primarily driven by oxidative stress and inflammation, remains a therapeutic challenge due to the limitations of current treatments. In this study, we developed a multifunctional nanoparticle system, using a layer-by-layer self-assembly strategy to enhance […]
Recovery from apoptosis in photoreceptor cells: A role for mitophagy
Cell Death Dis. 2026 Jan 30. doi: 10.1038/s41419-026-08436-3. Online ahead of print. ABSTRACT Photoreceptors (PRs) are specialized light-sensitive cells responsible for vision, and their death is the primary cause of retinal degeneration and vision loss. Recent studies using cells such as HeLa and PC12 have demonstrated cellular recovery even from late stages of apoptosis. Here, […]
Resveratrol as a multitarget modulator in diabetic retinopathy: a systematic review of in vitro and in vivo studies
BMC Ophthalmol. 2026 Jan 29;26(1):55. doi: 10.1186/s12886-026-04623-0. ABSTRACT BACKGROUND: Resveratrol (RSV) has been extensively investigated for its antioxidant and anti-inflammatory properties across various disease settings; however, its upstream mechanisms in diabetic retinopathy (DR) remain insufficiently characterized. Given that early DR involves oxidative stress, mitochondrial disruption, and microglia-associated inflammatory amplification, this systematic review aims to synthesize […]
A type I interferon-mitochondrial axis regulates efferocytosis and interferon-stimulated gene induction in macrophages
Immunity. 2026 Jan 28:S1074-7613(25)00566-7. doi: 10.1016/j.immuni.2025.12.010. Online ahead of print. ABSTRACT Macrophage metabolism is intricately linked to cellular function. Contrasting with Toll-like receptor (TLR) stimulation, cytosolic nucleic acid sensing induced a decrease in mitochondrial membrane potential (MMP) while maintaining mitochondrial respiration. Interferon α/β (IFN-I) receptor (IFNAR) signaling was necessary and sufficient for this metabolic response. […]
Metabolism-Regulating Microspheres: Design Principles, Therapeutic Applications Across Multisystem Diseases, and Future Perspectives
Research (Wash D C). 2026 Jan 27;9:1106. doi: 10.34133/research.1106. eCollection 2026. ABSTRACT Metabolism-regulating microspheres have evolved from conventional drug carriers into active platforms capable of spatiotemporally reprogramming pathological metabolic networks. Chronic diseases are increasingly understood to be driven by metabolic dysregulation, highlighting the need for therapeutic strategies that enable localized and precise metabolic intervention. This […]
Fullerenol Eye Drops Mitigate UVB-Induced Cataract Progression by Inhibiting Oxidative Stress and Cellular Senescence
Antioxidants (Basel). 2026 Jan 16;15(1):118. doi: 10.3390/antiox15010118. ABSTRACT Cataracts remain the leading cause of blindness worldwide, and surgery is currently the only effective clinical treatment, as no pharmacological therapy has yet been validated. Here, we explore Fullerenol, a hydroxylated fullerene derivative formulated as eye drops, as a potential nanomedicine for delaying cataract onset and progression. […]
NFS1 Plays a Critical Role in Regulating Ferroptosis Homeostasis
Biomolecules. 2025 Dec 24;16(1):32. doi: 10.3390/biom16010032. ABSTRACT Ferroptosis is an iron-dependent form of regulated cell death (RCD) characterized by intracellular iron homeostasis disruption and lipid peroxide accumulation. It is involved in many pathological processes, including malignant tumors, cardiovascular diseases, inflammatory diseases, and mitochondrial disorders. Cysteine desulfurase (NFS1), a key enzyme in mitochondrial iron-sulfur (Fe-S) cluster […]
Socceromics: A Systematic Review of Omics Technologies to Optimize Performance and Health in Soccer
Int J Mol Sci. 2026 Jan 12;27(2):749. doi: 10.3390/ijms27020749. ABSTRACT The integration of omics technologies, including genomics, proteomics, metabolomics, and microbiomics, has transformed sports science, particularly soccer, by providing new opportunities to optimize player performance, reduce injury risk, and enhance recovery. This systematic literature review was conducted in accordance with PRISMA 2020 guidelines and structured […]