Necrotic cell death through sodium overload provides a potential mechanism against neurodegenerative diseases
Environ Pollut. 2025 Oct 23:127308. doi: 10.1016/j.envpol.2025.127308. Online ahead of print. NO ABSTRACT PMID:41138844 | DOI:10.1016/j.envpol.2025.127308
Development of an AAV-Based Gene Therapy for the Ocular Phenotype of Friedreich’s Ataxia
Mol Ther. 2025 Oct 23:S1525-0016(25)00869-X. doi: 10.1016/j.ymthe.2025.10.048. Online ahead of print. ABSTRACT Friedreich’s Ataxia (FA) is a leading form of hereditary ataxia caused by autosomal recessive mutations in frataxin (FXN). GAA triplet repeat expansions lead to lower levels of FXN expression, abnormal influx of iron into mitochondria and damage to the nervous system. Patients typically […]
Advances in eye-brain axis: anatomy, immunity, and association with visual dysfunction
Ageing Res Rev. 2025 Oct 22:102925. doi: 10.1016/j.arr.2025.102925. Online ahead of print. ABSTRACT The “eye-brain axis” refers to the dynamic system of interactions between the eyes and the brain, collectively encompassing the visual signal transmission and integration pathways. The eyes and the brain exhibit structural and functional synergy, and visual dysfunction not only impairs information […]
Sappanone A alleviates high glucose-induced retinal oxidative injury and mitochondrial dysfunction via SIRT7/NRF2 pathway
J Ethnopharmacol. 2025 Oct 22:120774. doi: 10.1016/j.jep.2025.120774. Online ahead of print. ABSTRACT ETHNOPHARMACOLOGICAL RELEVANCE: Diabetic retinopathy (DR) is a major microvascular complication of diabetes characterized by oxidative stress, mitochondrial dysfunction, and inflammation. Sappanone A (SA), a natural flavonoid derived from Caesalpinia sappan, is known for its antioxidant activity, but its ocular pharmacological potential and underlying […]
Transcriptomic profiling reveals neural-immune-stromal dysregulation and risk-associated gene signatures in advanced keratoconus
Sci Rep. 2025 Oct 24;15(1):37262. doi: 10.1038/s41598-025-21254-5. ABSTRACT This study aimed to characterize transcriptomic alterations and the effects of demographic and behavioral risk factors on disease-associated gene expression patterns in late-stage keratoconus (KC). Corneal stromal tissues from 31 KC patients and four normal donors underwent bulk RNA sequencing. Differentially expressed genes (DEGs) and weighted gene […]
Development of Two In Vitro ND1-LHON Models for Evaluating Gene Therapy Efficacy
Invest Ophthalmol Vis Sci. 2025 Oct 1;66(13):34. doi: 10.1167/iovs.66.13.34. ABSTRACT PURPOSE: The purpose of this study was to address the lack of effective treatments for NADH-ubiquinone oxidoreductase chain 1 (ND1)-related Leber hereditary optic neuropathy (LHON), this study aimed to (1) establish in vitro models mimicking mitochondrial dysfunction in LHON and (2) evaluate the therapeutic potential […]
FLIM-guided self-reporting of PDT efficacy using a mitochondria-targeted, viscosity-sensitive quinolinium probe
J Mater Chem B. 2025 Oct 22. doi: 10.1039/d5tb01668a. Online ahead of print. ABSTRACT Mitochondrial viscosity plays a pivotal role in the microenvironment of mitochondria and is closely associated with pathological conditions. As a light-activated treatment for cancer and infections, photodynamic therapy (PDT) relies on reactive oxygen species (ROS) generation by photosensitizers to induce cell […]
Proliferative diabetic retinopathy subtypes defined by immune defense and endothelial mitochondrial dysfunction
Signal Transduct Target Ther. 2025 Oct 22;10(1):350. doi: 10.1038/s41392-025-02448-9. ABSTRACT Proliferative diabetic retinopathy (PDR) is a major complication of diabetes characterized by pathological angiogenesis in the retina. Standard treatment includes vitrectomy to remove these abnormal vessels, and the resulting clinical specimens provide an opportunity to define drivers of PDR. Here, we profiled endothelial and immune […]
The Emerging Role of Metabolic Interventions in Uveal Melanoma
Semin Cancer Biol. 2025 Oct 17:S1044-579X(25)00126-9. doi: 10.1016/j.semcancer.2025.10.002. Online ahead of print. ABSTRACT Uveal Melanoma (UM) is the most common primary intraocular malignancy in adults, presenting significant clinical challenges due to its aggressive nature and metastatic potential, which results in poor prognosis in some patients. Despite recent therapeutic advances, the survival rate for metastatic UM […]
Lights-on for Cardiovascular Disease: Can Red and Near Infrared Light Treatment Help the Recovery Process?
Ann Biomed Eng. 2025 Oct 17. doi: 10.1007/s10439-025-03884-y. Online ahead of print. ABSTRACT Two of the most common, often fatal, forms of cardiovascular disease are acute myocardial infarction and stroke. Both conditions involve compromised blood flow to target organs, resulting in dysfunction and subsequent death of cardiac and brain cells. Unfortunately, treatment options aiding the […]