Imaging of the retinal hypoxia: A journey from oxygen microelectrode to the first hypoxia imaging in the living retina
Prog Retin Eye Res. 2025 Oct 28:101411. doi: 10.1016/j.preteyeres.2025.101411. Online ahead of print. ABSTRACT Oxygen is the major element for metabolism in the retina. Reduced oxygen supply causes significant changes in cellular metabolism and gene expression in the retina initiating inflammasome activation, apoptosis of retinal cells, mitochondrial damage, oxidative stress and neurodegeneration. Physiologically, retinal hypoxia […]
R405W Desmin Knock-In Mice Highlight Alterations of Mitochondria, Protein Quality Control and Myofibrils in Myofibrillar Myopathy
J Cachexia Sarcopenia Muscle. 2025 Dec;16(6):e70094. doi: 10.1002/jcsm.70094. ABSTRACT BACKGROUND: Mutations in the desmin gene cause skeletal myopathies and cardiomyopathies. The objective of this study was to elucidate the molecular pathology induced by the expression of R405W mutant desmin in murine skeletal muscle. METHODS: A comprehensive characterization of the skeletal muscle pathology in hetero- and […]
Mechanistic analysis of luteolin in mitigating dry age-related macular degeneration through network pharmacology and experimental validation
Sci Rep. 2025 Oct 29;15(1):37862. doi: 10.1038/s41598-025-21730-y. ABSTRACT Dry age-related macular degeneration (AMD) ranks among the primary causes of irreversible vision loss in the elderly. Luteolin, with its diverse biological activities, has attracted significant attention as a promising candidate for intervening in dry AMD. Explore the protective effect of luteolin on dry AMD to address […]
Multimodal imaging of RCBTB1-associated retinal dystrophy
Ophthalmic Genet. 2025 Oct 29:1-4. doi: 10.1080/13816810.2025.2578382. Online ahead of print. ABSTRACT INTRODUCTION: Variants in the RCBTB1 gene have recently been described in patients with inherited retinal disease; so far, there is limited knowledge about this entity, differential diagnoses, and disease progression. Here, we report a novel splice variant in RCBTB1 and describe the associated […]
Title Oxidative Stress in Age-Related Macular Degeneration: From Molecular Mechanisms to Emerging Therapeutic Targets
Antioxidants (Basel). 2025 Oct 18;14(10):1251. doi: 10.3390/antiox14101251. ABSTRACT Age-related macular degeneration (AMD) is a leading cause of irreversible visual impairment in the elderly, and oxidative stress, primarily mediated by reactive oxygen species (ROS), is widely recognized as a central driver of its onset and progression. The retina is highly susceptible to oxidative damage due to […]
Oxidative Stress in Diabetic Retinopathy: A Comprehensive Review of Mechanisms, Biomarkers, and Therapeutic Perspectives
Antioxidants (Basel). 2025 Oct 4;14(10):1204. doi: 10.3390/antiox14101204. ABSTRACT Diabetic retinopathy (DR) is a leading cause of vision loss globally and represents one of the most common microvascular complications of diabetes. In addition to metabolic disturbances associated with hyperglycemia, oxidative stress has emerged as a critical contributor to the onset and progression of DR. Oxidative stress, […]
An intraocular lens coated with polycaprolactone and methotrexate as a slow-release system for prophylaxis of posterior capsule opacification in-vitro
Biomed Pharmacother. 2025 Oct 27;192:118693. doi: 10.1016/j.biopha.2025.118693. Online ahead of print. ABSTRACT PURPOSE: Posterior capsule opacification (PCO) is the most common postoperative complication after cataract surgery. As a pharmacological prophylaxis, we designed a drug-carrying slow-release intraocular lens (IOL) implant coated with polycaprolactone and methotrexate and characterized the release kinetics and the in-vitro effect. METHODS: Electron […]
The Neuro-Ophthalmologic Manifestations of SPG7-Associated Disease
J Pers Med. 2025 Oct 16;15(10):495. doi: 10.3390/jpm15100495. ABSTRACT The gene SPG7 codes for the protein paraplegin, a subunit of the m-AAA protease in the inner mitochondrial membrane involved in protein quality control. SPG7 was initially identified as causing autosomal recessive hereditary spastic paraplegia (HSP), with a pure (insidiously progressive bilateral leg weakness and spasticity) […]
Deficiency of 2-Oxoglutarate Carrier (Slc25a11) Drives RPE Epithelial-to-Mesenchymal Transition and Exacerbates Subretinal Fibrosis in Neovascular Age-Related Macular Degeneration
Aging Cell. 2025 Oct 28:e70271. doi: 10.1111/acel.70271. Online ahead of print. ABSTRACT Subretinal fibrosis significantly contributes to vision loss in neovascular age-related macular degeneration (nAMD). Epithelial-to-mesenchymal transition (EMT) in RPE cells is a key early step in subretinal fibrosis. While mitochondrial dysfunction in RPE is involved, the metabolic and molecular connections between EMT and mitochondria […]
Light-evoked activity and BDNF regulate mitochondrial dynamics and mitochondrial localized translation in CNS axons
iScience. 2025 Sep 15;28(10):113563. doi: 10.1016/j.isci.2025.113563. eCollection 2025 Oct 17. ABSTRACT Mitochondria coordinate well-described maintenance functions within neuronal axons and dendrites. However, less is known about how mitochondria are regulated during axon development and maturation. Here, we demonstrate that within the developing visual system, retinal ganglion cell (RGC) axons in the retina and optic nerve […]