Kenny is the adaptor protein for ubiquitin-dependent mitophagy in Drosophila melanogaster
Autophagy Rep. 2026 Mar 4;5(1):2638025. doi: 10.1080/27694127.2026.2638025. eCollection 2026. ABSTRACT Mitophagy is the selective degradation program for damaged and unnecessary mitochondria to maintain cellular mitostasis and survival. Specific mutations in the mediators for the canonical ubiquitin (ub)-dependent mitophagy pathway have been identified with unique neurological diseases like Parkinson disease and ALS (amyotrophic lateral sclerosis), metabolic […]
Stem cells ameliorate neurotrauma-induced visual disturbances and retinal degeneration via broad normalization of β-catenin-related signaling
Int J Med Sci. 2026 Jan 23;23(3):758-779. doi: 10.7150/ijms.123975. eCollection 2026. ABSTRACT BACKGROUND: Traumatic brain injury (TBI) is associated with visual dysfunction and retinal degeneration, but the underlying mechanisms and therapeutic options remain limited. Mesenchymal stem cells (MSCs) have shown neuroprotective effects in various central nervous system injuries, including optic neuropathies. OBJECTIVE: To investigate the […]
Mitochondria transplantation reduces intraocular pressure by improving mitochondrial function and remodeling trabecular meshwork
J Transl Med. 2026 Mar 7. doi: 10.1186/s12967-026-07964-y. Online ahead of print. NO ABSTRACT PMID:41794792 | DOI:10.1186/s12967-026-07964-y
Single-cell and multi-omics analysis identifies mitophagy-related biomarkers and therapeutic targets in ischemic stroke
Sci Rep. 2026 Mar 6. doi: 10.1038/s41598-026-43377-z. Online ahead of print. ABSTRACT Ischemic stroke (IS) remains a leading cause of death and disability, with limited effective treatments in the acute phase. Mitophagy, the selective degradation of damaged mitochondria, plays a crucial role in cellular homeostasis and survival during IS. However, its exact mechanisms in stroke […]
SIRT3 mediates mitochondrial protection and attenuates mtROS-TXNIP-NLRP3 signaling activation in dry eye disease
Exp Eye Res. 2026 Mar 4:110960. doi: 10.1016/j.exer.2026.110960. Online ahead of print. ABSTRACT BACKGROUND/AIM: Dry eye disease (DED) is a chronic inflammatory disorder of the ocular surface in which mitochondrial dysfunction and oxidative stress have been increasingly implicated, yet the molecular mechanisms linking mitochondrial redox imbalance to inflammatory signaling remain unclear. This study aimed to […]
Long-term Efficacy and Safety of Photobiomodulation in Dry Age-Related Macular Degeneration (LIGHTSITE III: 24-Month Analysis)
Retina. 2026 Mar 3. doi: 10.1097/IAE.0000000000004822. Online ahead of print. ABSTRACT PURPOSE: To evaluate the safety and efficacy of multiwavelength photobiomodulation (PBM) in nonexudative (dry) age-related macular degeneration (AMD). METHODS: LIGHTSITE III employed a double-masked, randomized, sham-controlled, parallel-group, prospective study design. Subjects were enrolled with a diagnosis of dry AMD and treated with multiwavelength PBM […]
Neuropilin-2 Deficiency Promotes Mitochondrial Dysfunction and NAD+-Dependent Cellular Senescence in Retinal Degeneration
Invest Ophthalmol Vis Sci. 2026 Mar 2;67(3):11. doi: 10.1167/iovs.67.3.11. ABSTRACT PURPOSE: Retinal pigment epithelial (RPE) dysfunction is a central pathological feature of retinal degenerative diseases, leading to irreversible vision loss. RPE dysfunction is substantially driven by mitochondrial impairment and senescence. However, the upstream regulators of these processes remain largely undefined. This study investigated the role […]
Bilateral optic neuropathy following prolonged linezolid use: A case report
IDCases. 2026 Feb 19;43:e02524. doi: 10.1016/j.idcr.2026.e02524. eCollection 2026. ABSTRACT This report describes a case of bilateral linezolid-associated optic neuropathy in a 65-year-old woman treated for Mycobacterium abscessus infection and highlights the importance of early recognition and intervention. The patient developed progressive, painless bilateral visual decline after more than six months of linezolid therapy. Ophthalmic examination […]
Physical exercise modulates T cell activity and mitigates synaptic dysfunction in multiple sclerosis through vagus nerve engagement
Brain Behav Immun. 2026 Mar 2:106523. doi: 10.1016/j.bbi.2026.106523. Online ahead of print. ABSTRACT Physical exercise (PE) exerts beneficial effects in people with multiple sclerosis (pwMS). Preclinical studies in mice with experimental autoimmune encephalomyelitis (EAE), an animal model of MS, indicate that PE may attenuate key pathological features of the disease-including immune dysregulation and inflammation-driven synaptotoxicity-although […]
Photoreceptor deletion of pyruvate dehydrogenase E1 subunit α1 induces retinal degeneration and reprograms retinal metabolism
Mol Metab. 2026 Mar 2:102343. doi: 10.1016/j.molmet.2026.102343. Online ahead of print. ABSTRACT Rod and cone photoreceptors are among the most energy-demanding cells in the body, exhibiting a high rate of ATP consumption. Their primary energy source is glucose, which is metabolized through both glycolysis and mitochondrial pyruvate oxidative phosphorylation. The pyruvate dehydrogenase E1 subunit α1 […]