Lactate-Lactylation Axis as an Emerging Metabolic-Epigenetic Pathway in Diabetic Microvascular Complications
Ageing Res Rev. 2026 Mar 12:103100. doi: 10.1016/j.arr.2026.103100. Online ahead of print. ABSTRACT Lactate, once viewed merely as a glycolytic byproduct, is now recognized as a key signaling molecule and epigenetic regulator through the recently identified post-translational modification known as lactylation. In diabetic microvascular complications, including diabetic retinopathy (DR), diabetic kidney disease (DKD), and diabetic […]
Characterization of the Effects of a Humanin Fragment Peptide (HNF14) in Age-Related Macular Degeneration
J Clin Med. 2026 Feb 24;15(5):1686. doi: 10.3390/jcm15051686. ABSTRACT Background: Age-related macular degeneration (AMD) is a leading cause of vision loss and is strongly associated with mitochondrial dysfunction in retinal pigment epithelial cells. Mitochondrial-derived peptides, including Humanin and its analogs, have demonstrated cytoprotective effects in AMD-related cellular models. However, the effects of shorter Humanin-derived fragments […]
COG5 deficiency disrupts cellular copper homeostasis and underlies the impaired mitochondrial OXPHOS function
PLoS Genet. 2026 Mar 13;22(3):e1012076. doi: 10.1371/journal.pgen.1012076. eCollection 2026 Mar. ABSTRACT COG5, a subunit of the conserved oligomeric Golgi (COG) complex, plays a critical role in retrograde trafficking within the Golgi apparatus. Dysfunction of COG5 is associated with various human disorders, yet the underlying pathogenic mechanisms remain poorly understood. To investigate the mechanisms, we conducted […]
Leber Hereditary Optic Neuropathy Caused by the Rare MT-ND1 m.3394T>C Mutation: A Case With Favorable Visual Prognosis and a Literature Review
Cureus. 2026 Feb 9;18(2):e103261. doi: 10.7759/cureus.103261. eCollection 2026 Feb. ABSTRACT Leber hereditary optic neuropathy (LHON) is an inherited mitochondrial optic neuropathy characterized by acute or subacute painless central visual loss. Most cases are associated with three primary mitochondrial DNA mutations; however, rare variants remain incompletely characterized. Early diagnosis is essential for appropriate management and genetic […]
Reversing Mitochondrial Dysfunction in Optineurin E50K Glaucoma: A Metabolic Approach to Neuroprotection
Res Sq [Preprint]. 2026 Feb 19:rs.3.rs-8380062. doi: 10.21203/rs.3.rs-8380062/v1. ABSTRACT Mutations in optineurin (OPTN) are linked to neurodegenerative diseases such as normal tension glaucoma (NTG) and amyotrophic lateral sclerosis. The E50K-OPTN mutation is the most common genetic cause of NTG, where it disrupts mitophagy and leads to the accumulation of dysfunctional mitochondria. To understand how cellular […]
Mitochondrial Short-Chain Enoyl-CoA Hydratase Deficiency
2019 Jun 20 [updated 2026 Mar 12]. In: Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2026. ABSTRACT CLINICAL CHARACTERISTICS: Mitochondrial short-chain enoyl-CoA hydratase deficiency (ECHS1D) represents a clinical spectrum in which several phenotypes have been described. Individuals with ECHS1D can present […]
A coenzyme-based “interface-welding” hydrogel coating for titanium implants promotes diabetic osseointegration by regulating mitochondrial dynamics
Biomaterials. 2026 Mar 5;331:124115. doi: 10.1016/j.biomaterials.2026.124115. Online ahead of print. ABSTRACT The impaired bone healing and osseointegration in diabetes are largely driven by hyperglycemia-induced mitochondrial dysfunction in bone marrow mesenchymal stem cells (BMSCs). To rescue this cellular deficit and enhance bone repair, this study aimed to develop an adhesive, self-healing, mitochondrial coenzyme-based hydrogel coating for […]
miR-223-3p improves macrophage polarization balance and mitochondrial metabolism to ameliorate uveitis by orchestrating P65(Lys310) acetylation through RBPJ/HDAC1 axis
Cell Mol Biol Lett. 2026 Mar 10. doi: 10.1186/s11658-026-00874-3. Online ahead of print. NO ABSTRACT PMID:41808024 | DOI:10.1186/s11658-026-00874-3
Long Noncoding RNAs as Blood-Based Biomarkers of Diabetic Retinopathy
Transl Vis Sci Technol. 2026 Jan 5;15(1):17. doi: 10.1167/tvst.15.1.17. ABSTRACT PURPOSE: Prevalence of diabetic retinopathy closely depends on the duration of diabetes and severity of hyperglycemia. Experimental models have shown that high glucose initiates many metabolic, molecular and epigenetic changes in the retina before vascular histopathology is detectable. Several LncRNAs (RNAs with >200bp and no […]
Ferroptosis mediates retinal damage caused by the combined effects of sleep deprivation and light damage
Free Radic Biol Med. 2026 Mar 7:S0891-5849(26)00193-0. doi: 10.1016/j.freeradbiomed.2026.03.015. Online ahead of print. ABSTRACT BACKGROUND: Sleep deprivation (SD) and excessive light exposure (LD) are increasingly prevalent stressors in modern life, yet their combined impact on retinal integrity remains unclear. This study investigates how SD amplifies LD-induced retinal injury and explores the mechanistic role of ferroptosis-a […]