Baicalin attenuates HIF-1α-driven histone lactylation and neutrophil extracellular trap (NET) formation in autoimmune uveitis
Int J Biol Macromol. 2026 Jan 14:150264. doi: 10.1016/j.ijbiomac.2026.150264. Online ahead of print. ABSTRACT Uveitis is a group of vision-threatening intraocular inflammatory disorders that can affect the uveal tract, retina, optic nerve, and vitreous, leading to irreversible structural damage and vision loss. Neutrophil extracellular trap (NET) formation is a key driver of acute uveitis (AU) […]
Molecular underpinnings of induced degenerative heterogeneity in the retinal pigment epithelium
Proc Natl Acad Sci U S A. 2026 Jan 20;123(3):e2505412123. doi: 10.1073/pnas.2505412123. Epub 2026 Jan 16. ABSTRACT Cigarette smoking induces epigenetic changes that can cause degenerative heterogeneity with aging and disease. In disease such as age-related macular degeneration (AMD), the leading worldwide cause of blindness among the elderly, retinal pigment epithelial (RPE) cell heterogeneity is […]
Oxidative stress in diabetic retinopathy: Metabolic triggers, molecular pathways and emerging antioxidant therapies
Int J Biol Macromol. 2026 Jan 13:150272. doi: 10.1016/j.ijbiomac.2026.150272. Online ahead of print. ABSTRACT Diabetic retinopathy (DR) is a leading cause of blindness among adults worldwide, with hyperglycemia-induced oxidative stress lies at the core of its pathogenesis. This review synthesises evidence showing that elevated glucose, hypoxia and pro-inflammatory mediators act synergistically to impair the mitochondrial […]
Retinal Neurovascular and Mitochondrial Function Signatures in Response to a 24-Week Yoga Intervention in Healthy Adults
Invest Ophthalmol Vis Sci. 2025 Dec 1;66(15):62. doi: 10.1167/iovs.66.15.62. ABSTRACT PURPOSE: To evaluate changes in retinal neurovascular and mitochondrial function after a 24-week yoga intervention in healthy older adults. METHODS: Thirty participants (mean age 72 ± 6 years; 25 females, 5 males) were randomized to either a cue-based yoga program (n = 15) or traditional […]
Glutaredoxin 2 Protects Lens Epithelial Cells From Ferroptosis by Preventing HNRNPA2B1 S-Glutathionylation in Diabetes-Mediated Cataractogenesis
Invest Ophthalmol Vis Sci. 2025 Dec 1;66(15):58. doi: 10.1167/iovs.66.15.58. ABSTRACT PURPOSE: The purpose of this study was to investigate the role of glutaredoxin 2 (Grx2) in regulating ferroptosis under oxidative stress conditions induced by high glucose in lens epithelial cells (LECs) and its potential contribution to diabetes-mediated cataractogenesis. METHODS: Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was […]
Tumor-intrinsic redox programming drives an SPP1-CD44 axis of immune suppression in uveal melanoma
Redox Biol. 2026 Jan 6;90:104011. doi: 10.1016/j.redox.2026.104011. Online ahead of print. ABSTRACT Uveal melanoma (UM) is a rare yet aggressive malignancy with a high propensity for distant metastasis and poor response to systemic therapies, including immunotherapies. Although recent single-cell studies have uncovered pronounced intratumoral heterogeneity and an immunosuppressive tumor microenvironment, the tumor-intrinsic metabolic programs that […]
ercc6 deficient zebrafish exhibit UV and metronidazole sensitivity, increased oxygen consumption, and impaired hair cell mechanoelectrical transduction which can be restored by the superoxide dismutase mimetic MnTBAP
Hum Mol Genet. 2026 Jan 13:ddaf203. doi: 10.1093/hmg/ddaf203. Online ahead of print. ABSTRACT Cockayne Syndrome is an ultra-rare premature aging condition associated with UV sensitivity, neurocognitive decline, retinopathy, metronidazole-induced lethality, and sensorineural hearing loss. In 70% of affected patients, bi-allelic pathogenic variants in ERCC6 are identified. Although the role of ERCC6 in DNA damage repair […]
Glutathione redox system as a therapeutic target for Plasmodium: Opportunities, Challenges, and future perspectives
Folia Microbiol (Praha). 2026 Jan 13. doi: 10.1007/s12223-025-01410-0. Online ahead of print. ABSTRACT Glutathione (GSH) serves as an essential guardian for parasites, protecting them from the onslaught of oxidative stress. As hemoglobin breaks down and energy is harvested through the intricate mitochondrial respiratory pathway, GSH meticulously creates a reducing environment, akin to a fortress against […]
Quercetin ameliorates SIRT1-mediated oxidative stress and inflammation to attenuate ciliary muscle remodeling in experimental myopia
Biochem Pharmacol. 2026 Jan 8:117698. doi: 10.1016/j.bcp.2026.117698. Online ahead of print. ABSTRACT This study aimed to investigate the role of quercetin in myopic ciliary muscle remodeling through the regulation of SIRT1 expression. To this end, a randomized controlled trial was conducted using negative lens-induced myopic (LIM) guinea pig models for durations of 4 weeks and […]
Multi-omics integration uncovers key molecular mechanisms and therapeutic targets in myopia and pathological myopia
Asia Pac J Ophthalmol (Phila). 2026 Jan 8:100277. doi: 10.1016/j.apjo.2026.100277. Online ahead of print. ABSTRACT PURPOSE: Myopia, particularly pathological myopia (PM), poses a significant global health burden due to its increasing prevalence and associated vision-threatening complications. Despite extensive genetic research, the molecular mechanisms underlying myopia progression remain unclear. This study aims to identify key causal […]