Anti-Apoptotic and Neurite-Protective Nanomedicine Augments Embryonic Stem Cells-Derived Retinal Ganglion Cell Transplantation in Glaucoma Recovery
Adv Sci (Weinh). 2026 Feb 21:e13499. doi: 10.1002/advs.202513499. Online ahead of print. ABSTRACT Retinal ganglion cell (RGC) degeneration represents a cardinal etiology of irreversible vision loss in glaucoma, where efficacious regenerative therapies remain scarce. RGC replacement therapy holds promise for visual function restoration, yet its therapeutic efficacy is constrained by the hostile glaucomatous microenvironment, dominated […]
From Regeneration Failure to Functional Restoration: Unlocking the Neuronal-Intrinsic Regenerative Capacity as a Therapeutic Frontier for Optic Neuropathy and Glaucoma
CNS Neurosci Ther. 2026 Feb;32(2):e70800. doi: 10.1002/cns.70800. ABSTRACT BACKGROUND: Optic neuropathy encompasses ocular conditions arising from traumatic or nontraumatic damage to optic nerves, causing permanent visual impairment due to retinal ganglion cell (RGC) loss and disrupted axonal connections. Glaucomatous optic neuropathy represents the most prevalent form, affecting over 70 million individuals worldwide and causing blindness […]
Skeletal muscle in spinal muscular atrophy: Critical insights from pathogenesis to therapeutic strategies
Neurobiol Dis. 2026 Feb 18:107324. doi: 10.1016/j.nbd.2026.107324. Online ahead of print. ABSTRACT Spinal muscular atrophy (SMA) is a genetic neuromuscular disorder caused by loss of the survival motor neuron (SMN) protein. While SMA was originally viewed as a pure motor neuron disease, it is currently considered a multi-system disorder in which skeletal muscle plays a […]
Stereopsis and Vision-Related Quality of Life After Pars Plana Vitrectomy for Rhegmatogenous Retinal Detachment: A Prospective Cohort Study
Ophthalmol Ther. 2026 Feb 19. doi: 10.1007/s40123-026-01337-w. Online ahead of print. ABSTRACT INTRODUCTION: To determine whether macular involvement (on or off) at the time of rhegmatogenous retinal detachment (RRD) influences postoperative stereopsis and to explore factors associated with vision-related quality of life (VR-QoL). METHODS: In this prospective, single-centre observational cohort study conducted at the University […]
Altered Carnitine Homeostasis Modulates Hyperosmolarity-Induced Mitochondrial Dysfunction and Lipotoxicity in Human Corneal Epithelial Cells
Invest Ophthalmol Vis Sci. 2026 Feb 2;67(2):39. doi: 10.1167/iovs.67.2.39. ABSTRACT PURPOSE: Tear hyperosmolarity, a hallmark of dry eye disease (DED), contributes to corneal epithelial injury, inflammation, and mitochondrial dysfunction. This study examined the effects of hyperosmolar stress on mitochondrial carnitine metabolism in human telomerase-immortalized corneal epithelial (hTCEpi) cells and evaluated the osmoprotective potential of L-carnitine […]
Disrupted energy metabolism is associated with retinal ganglion cell degeneration in autosomal dominant optic atrophy
Sci Adv. 2026 Feb 20;12(8):eadx7815. doi: 10.1126/sciadv.adx7815. Epub 2026 Feb 18. ABSTRACT Autosomal dominant optic atrophy (ADOA) is a hereditary optic neuropathy caused by OPA1 variants, leading to retinal ganglion cell (RGC) degeneration and vision loss. The mechanisms behind RGC vulnerability to mitochondrial dysfunction remain unclear. We developed a patient-specific Opa1V291D/+ knock-in mouse model to […]
The Intracellular C5a-mtC5aR1 Axis Promotes Necroptosis in Dry Eye Through DRP1-Mediated Mitochondrial Dysfunction
Invest Ophthalmol Vis Sci. 2026 Feb 2;67(2):35. doi: 10.1167/iovs.67.2.35. ABSTRACT PURPOSE: As a multifactorial ocular surface pathology, dry eye (DE) is marked by inflammation and epithelial damage. While mitochondrial dysfunction and oxidative stress are implicated, the mechanisms driving cornea epithelial cell damage remain unclear. This study investigates the role of C5a-mitochondrial C5a receptor 1 (mtC5aR1) […]
Integrated tear proteomics define the molecular blueprint of corneal epithelial repair
Exp Biol Med (Maywood). 2026 Feb 2;250:10866. doi: 10.3389/ebm.2025.10866. eCollection 2025. ABSTRACT Tears are easy to collect, repeatable, and reflect the state of the corneal surface-attributes that make them attractive for bedside monitoring after surgery or injury. We performed a cross-species meta-analysis of tear proteomes from patients undergoing photorefractive keratectomy (PRK) and from mice after […]
Novel ocular feature in oculoskeletodental syndrome: high axial myopia and megalocornea in a child with a homozygous PIK3C2A variant
Ophthalmic Genet. 2026 Feb 17:1-4. doi: 10.1080/13816810.2026.2627545. Online ahead of print. ABSTRACT BACKGROUND: Oculoskeletodental syndrome (OCSKD) is a rare autosomal recessive ciliopathy caused by PIK3C2A loss-of-function variants, characterized by ocular, skeletal, and dental anomalies. Ocular findings most commonly include cataract and secondary glaucoma; however, high axial myopia and megalocornea have not been previously reported in […]
Identifying NDUFA12 mutation in a Saudi family: An unusual presentation of mitochondrial Complex I deficiency mimicking as idiopathic intracranial hypertension in a patient with papilledema and visual loss
J Family Community Med. 2026 Jan 19;33(1):47-52. doi: 10.4103/jfcm.jfcm_322_25. eCollection 2026 Jan-Mar. ABSTRACT Mitochondrial diseases are considered one of the most common groups of neurogenetic diseases. Complex I (CI) deficiency is the most encountered single enzyme deficiency of the mitochondrial diseases. The mutation of the NDUFA is linked to Leigh syndrome and CI defects. This […]