A preclinical candidate of cyclophilin D inhibition improves alcohol-associated liver injury
Cell Rep Med. 2026 Mar 17;7(3):102654. doi: 10.1016/j.xcrm.2026.102654. ABSTRACT Currently, no therapies are approved for alcohol-associated liver disease (ALD). Here, we identify cyclophilin D (CypD) as a critical mediator in the progression of ALD. We observe elevated expression of CypD in ALD patients and a corresponding mouse model. Hepatocyte-specific knockout of CypD mitigates hepatic mitochondrial […]
GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis
Adv Sci (Weinh). 2026 Mar 18:e22929. doi: 10.1002/advs.202522929. Online ahead of print. ABSTRACT Glaucoma is a leading cause of irreversible blindness worldwide. One hallmark of glaucoma is the degeneration of retinal ganglion cells (RGCs). In this study, a dual role for growth hormone-releasing hormone receptor (GHRHR) modulation under glaucoma-relevant conditions and complementary injury paradigms involving […]
A heterozygous pathogenic RPE65 variant phenocopies a mitochondrial retinopathy
Ophthalmic Genet. 2026 Mar 17:1-5. doi: 10.1080/13816810.2026.2631747. Online ahead of print. ABSTRACT The gene retinoid isomerohydrolase retinal pigment epithelium 65 (RPE65; OMIM# 180069), is abundantly expressed in the RPE and encodes an isomerohydrolase enzyme that catalyzes an essential step in the visual cycle by converting all-trans retinyl ester to 11-cis retinol. Most pathogenic variants in […]
A Case Report of Late-Onset Leber’s Hereditary Optic Neuropathy Diagnosed Following Vision Loss After Cataract Surgery
Neuroophthalmology. 2025 May 6;50(2):180-185. doi: 10.1080/01658107.2025.2495295. eCollection 2026. ABSTRACT Leber’s Hereditary Optic Neuropathy (LHON) is a rare mitochondrial disorder characterized by acute to subacute vision loss, predominantly affecting young males. We report a case of a 65-year-old male diagnosed with late-onset LHON after experiencing significant vision decline following cataract surgery. The patient initially presented with […]
Visual Loss from Leber’s Optic Neuropathy Presenting in a 76-Year-Old Man with the 14484 Mutations
Neuroophthalmology. 2025 May 19;50(2):159-166. doi: 10.1080/01658107.2025.2487842. eCollection 2026. ABSTRACT Leber’s Hereditary Optic Neuropathy (LHON) is an important hereditary optic neuropathy that typically causes bilateral visual loss, predominantly in male patients. While it usually manifests in young adults, it can uncommonly present in older individuals without a family history, potentially leading to diagnostic confusion. The mechanisms […]
Optic Atrophy Associated With a Mitochondrial G8363A Mutation in a Family
Clin Genet. 2026 Mar 18. doi: 10.1111/cge.70152. Online ahead of print. ABSTRACT We report a rare family of optic atrophy diseases associated with mitochondrial DNA G8363A transfer ribonucleic acid (RNA) cleavage mutations. This family does not exhibit the characteristic symptoms of myoclonic epilepsy or cutaneous lipomas, but instead presents with bilateral optic atrophy. The clinical […]
Knocking Down CDKN2A Enhances the Therapeutic Effects of Metformin and Resveratrol on Diabetic Retinopathy
Appl Biochem Biotechnol. 2026 Mar 17. doi: 10.1007/s12010-026-05664-3. Online ahead of print. NO ABSTRACT PMID:41843007 | DOI:10.1007/s12010-026-05664-3
Research Prospects for the Mitochondria in Glaucoma: A Bibliometric Analysis
Curr Med Chem. 2026 Mar 11. doi: 10.2174/0109298673417791251204121930. Online ahead of print. ABSTRACT BACKGROUND: Growing evidence implicates mitochondrial dysfunction as a pivotal contributor to glaucoma pathogenesis through oxidative stress, autophagy, and apoptotic pathways. However, systematic analyses of research collaboration patterns, key themes, and emerging trends in this field remain limited. METHODS: We retrieved relevant publications […]
1β,6α-Dihydroxyeudesm-4(15)-ene Protects Against MPP+-Induced Cytotoxicity in SH-SY5Y Cells: An In Vitro Model of Parkinson’s Disease
J Med Food. 2026 Feb;29(2):71-81. doi: 10.1177/1096620X261428649. Epub 2026 Mar 16. ABSTRACT Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the progressive degeneration of the nigrostriatal dopaminergic pathway, which regulates body movements. 1-Methyl-4-phenylpyridinium (MPP+) is a widely used neurotoxin for studying the neurodegenerative process in PD models. 1β,6α-Dihydroxyeudesm-4(15)-ene (DE) is a sesquiterpene isolated from […]
TAZ (Wwtr1) deficiency leads to ER stress and mitochondrial dysfunction in a mouse model of Fuchs’ endothelial corneal dystrophy
bioRxiv [Preprint]. 2026 Feb 19:2026.02.17.706456. doi: 10.64898/2026.02.17.706456. ABSTRACT Fuchs’ endothelial corneal dystrophy (FECD) impacts over 300 million individuals worldwide with corneal transplantation as the primary treatment. There is a dire need to establish non-surgical alternatives which are dependent on mouse models. Transcriptional co-activator with PDZ-binding motif (TAZ, encoded by Wwtr1) is a mechanotransducer implicated in […]