Ophthalmotoxicology of Polyhalogenated Compounds
Toxicology. 2025 Nov 13:154337. doi: 10.1016/j.tox.2025.154337. Online ahead of print. ABSTRACT Polyhalogenated compounds (PHCs), including polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), polychlorinated dibenzodioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and per- and polyfluoroalkyl substances (PFAS), are persistent organic pollutants that bioaccumulate in tissues and are increasingly recognized as threats to human health. While their neurotoxic and […]
Advances in the genetics and pathology of Lewy body dementia
Lancet Neurol. 2025 Dec;24(12):1026-1037. doi: 10.1016/S1474-4422(25)00363-1. ABSTRACT Lewy body dementia is a heterogeneous disease that is underdiagnosed and poorly understood. Pathologically, Lewy body dementia is characterised by the accumulation of intraneuronal aggregates of misfolded α-synuclein, known as Lewy bodies and Lewy neurites. The genetic architecture of Lewy body dementia is complex, involving both common genetic […]
N-acetylcysteine amide alleviates pathological neovascularization through mitochondrial protection and energy metabolism reprogramming of vascular endothelial cells
Redox Biol. 2025 Nov 7;88:103907. doi: 10.1016/j.redox.2025.103907. Online ahead of print. ABSTRACT Hypoxia-induced pathological neovascularization is a major contributing factor to a variety of diseases across different age groups. Currently, the predominant therapeutic approach involves the repeated injection of anti-vascular endothelial growth factor (VEGF) agents, which are associated with several adverse effects that limit their […]
Clinicopathologic Correlation Between Lens Epithelial Cells and Capsular Bag Behavior in Intumescent White Cataracts
Am J Ophthalmol. 2025 Nov 13:S0002-9394(25)00600-2. doi: 10.1016/j.ajo.2025.11.014. Online ahead of print. ABSTRACT PURPOSE: To characterize the ultrastructural features of lens epithelial cells (LECs) in intumescent white cataracts and investigate their potential role in capsular bag behavior following cataract surgery. DESIGN: Pathological analysis and case-control study. METHODS: For pathological analysis, anterior lens capsules (including basement […]
The genotypic and phenotypic landscape of PDHA1-related pyruvate dehydrogenase complex deficiency
Brain. 2025 Nov 14:awaf430. doi: 10.1093/brain/awaf430. Online ahead of print. ABSTRACT This retrospective study on X-linked PDHA1-related pyruvate dehydrogenase complex (PDHc) deficiency combined a systematic literature review with a multicenter survey exploring genotypes, phenotypes, and survival. Data from 891 individuals (45% unpublished) were included. Of note, 53% of cases were females. Median age at last […]
Ultrasonic biomicroscope-guided radiofrequency ablation of the ciliary body in a rabbit glaucoma model
Sci Rep. 2025 Nov 14;15(1):40012. doi: 10.1038/s41598-025-23784-4. ABSTRACT Destruction of the ciliary body is regarded as a potential way to lower intraocular pressure (IOP) and treat glaucoma patients. This study evaluated the IOP-lowering capability of a novel device for ciliary body radiofrequency ablation (RFA) in a rabbit glaucoma model. The mechanism of RFA-induced IOP reduction […]
The Pedigree Study of Leber’s Hereditary Optic Neuropathy in Korean Population
Semin Ophthalmol. 2025 Nov 14:1-5. doi: 10.1080/08820538.2025.2588702. Online ahead of print. ABSTRACT PURPOSE: To investigate the pedigree-based penetrance analysis in Korean Leber hereditary optic neuropathy (LHON). METHODS: The pedigrees of 32 LHON patients’ families were thoroughly examined. Index patients were probands diagnosed by mitochondrial DNA (mtDNA) mutation at the position of 11,778 or 11,484, while […]
Effects of Benzalkonium Chloride, a Preservative in Topical Drugs, on the Barrier Function of Human Corneal Epithelial Cells
Transl Vis Sci Technol. 2025 Nov 3;14(11):16. doi: 10.1167/tvst.14.11.16. ABSTRACT PURPOSE: To assess the influence of varying concentrations of benzalkonium chloride (BAK), the predominant preservative utilized in ophthalmic formulations, on the barrier integrity and mitochondrial function of primary cultured human corneal epithelial cells (HCECs). METHODS: Primary HCEC monolayers were exposed to BAK at concentrations ranging […]
Mitogenomic architecture and phylogenetic placement of Ctenophthalmus yunnanus and Frontopsylla diqingensis: insights from comparative genomics
Front Vet Sci. 2025 Oct 29;12:1683581. doi: 10.3389/fvets.2025.1683581. eCollection 2025. ABSTRACT Fleas are among the most common hematophagous ectoparasites of mammals. In addition to causing allergic dermatitis and anemia, they can transmit various pathogens. Currently, molecular data on fleas remain relatively scarce. This study sequenced the complete mitochondrial genomes of Ctenophthalmus yunnanus (first mitogenome reported) […]
Identification and validation of key mitophagy-related biomarkers in the pathogenesis of proliferative diabetic retinopathy
Front Endocrinol (Lausanne). 2025 Oct 29;16:1652898. doi: 10.3389/fendo.2025.1652898. eCollection 2025. ABSTRACT INTRODUCTION: Diabetic retinopathy (DR) is one of the most common microvascular complications of diabetes mellitus, and proliferative diabetic retinopathy (PDR) represents its advanced stage. The etiology of PDR is complex. Mitophagy, the selective degradation of dysfunctional mitochondria, is crucial for cellular homeostasis and has […]