Fullerenol Eye Drops Mitigate UVB-Induced Cataract Progression by Inhibiting Oxidative Stress and Cellular Senescence
Antioxidants (Basel). 2026 Jan 16;15(1):118. doi: 10.3390/antiox15010118. ABSTRACT Cataracts remain the leading cause of blindness worldwide, and surgery is currently the only effective clinical treatment, as no pharmacological therapy has yet been validated. Here, we explore Fullerenol, a hydroxylated fullerene derivative formulated as eye drops, as a potential nanomedicine for delaying cataract onset and progression. […]
NFS1 Plays a Critical Role in Regulating Ferroptosis Homeostasis
Biomolecules. 2025 Dec 24;16(1):32. doi: 10.3390/biom16010032. ABSTRACT Ferroptosis is an iron-dependent form of regulated cell death (RCD) characterized by intracellular iron homeostasis disruption and lipid peroxide accumulation. It is involved in many pathological processes, including malignant tumors, cardiovascular diseases, inflammatory diseases, and mitochondrial disorders. Cysteine desulfurase (NFS1), a key enzyme in mitochondrial iron-sulfur (Fe-S) cluster […]
Targeting Retinoic Acid Receptor-Related Orphan Receptor α to Prevent Cataracts: A New Pathway Through Nerve Growth Factor Activation
Antioxid Redox Signal. 2026 Jan 27:15230864261416452. doi: 10.1177/15230864261416452. Online ahead of print. ABSTRACT AIMS: Cataracts are the leading cause of blindness worldwide, and the mechanism underlying cataract formation is linked to the oxidative damage and the apoptosis of lens epithelial cells. Retinoic acid Receptor-related orphan receptor α (RORα), a transcription factor, prevents oxidative stress and […]
Astaxanthin Protects Retinal Müller Cells Against High Glucose-induced Oxidative Stress through the Sirtuin 1/AMPK/FOXO1 Pathway
Exp Eye Res. 2026 Jan 23:110887. doi: 10.1016/j.exer.2026.110887. Online ahead of print. ABSTRACT Diabetic retinopathy (DR) is characterized by microvascular damage in the retina due to hyperglycemia-induced oxidative stress. The pivotal role of Müller glial cells in DR pathogenesis has gained increasing recognition. Sirtuin 1 (SIRT1), a nicotinamide adenosine dinucleotide (NAD+)-dependent deacetylase, plays a crucial […]
LED lighting (350-650nm) undermines human visual performance unless supplemented by wider spectra (400-1500nm+) like daylight
Sci Rep. 2026 Jan 23;16(1):3061. doi: 10.1038/s41598-026-35389-6. ABSTRACT Life evolved under broad spectrum sunlight, from ultraviolet to infrared (300–2500 nm). This spectrally balanced light sculpted life’s physiology and metabolism. But modern lighting has recently become dominated by restricted spectrum light emitting diodes (350–650 nm LEDs). Absence of longer wavelengths in LEDs and their short wavelength […]
Chronic stress-induced steroids mediate mitochondrial fission and fibrosis in the trabecular meshwork via the MIEF1-MAOA complex
Free Radic Biol Med. 2026 Jan 22:S0891-5849(26)00055-9. doi: 10.1016/j.freeradbiomed.2026.01.037. Online ahead of print. ABSTRACT Glaucoma remains the leading cause of irreversible blindness worldwide. Trabecular meshwork (TM) dysfunction, particularly fibrosis, is a major driver of elevated intraocular pressure (IOP). Although steroid-induced glaucoma is well established, the impact of chronic stress-related endogenous steroids on TM pathology remains […]
Biosponge-armored polydopamine-modified conducting polypyrrole restores redox-iron homeostasis for enhanced neuroprotection in retinal ischemia-reperfusion injury
Biomaterials. 2026 Jan 17;330:124007. doi: 10.1016/j.biomaterials.2026.124007. Online ahead of print. ABSTRACT Retinal ischemia-reperfusion injury (RIRI) is a central pathological mechanism in vision-impairing disorders such as glaucoma and retinal vascular occlusion. Current treatment modalities are significantly constrained by their inability to simultaneously address the multifaceted injury cascades driven by lethal oxidative stress, ferroptosis, and neuroinflammation, which […]
MTFR1L is a cardiac antiaging factor for maintenance of mitochondrial homeostasis
Proc Natl Acad Sci U S A. 2026 Jan 27;123(4):e2527247123. doi: 10.1073/pnas.2527247123. Epub 2026 Jan 23. ABSTRACT Mitochondrial dysfunction is a hallmark of aging and a key contributor to age-related diseases including cardiovascular disease. However, molecular pathways that safeguard mitochondrial homeostasis in the aging heart remain poorly understood. Here, we identify MTFR1L as a regulator […]
A Case Report of Unilateral OPA3-Related Dominant Optic Atrophy
Case Rep Ophthalmol. 2025 Dec 11;17(1):81-86. doi: 10.1159/000550003. eCollection 2026 Jan-Dec. ABSTRACT INTRODUCTION: Autosomal dominant optic atrophy (DOA) is an inherited optic neuropathy characterized by progressive bilateral vision loss, cecocentral visual field (VF) defects, and retinal ganglion cell degeneration. Most cases are associated with OPA1 mutations, while OPA3-related DOA is rare and typically involves both […]
Leber Hereditary Optic Neuropathy-Associated Novel Mutation in MT-RNR2 Gene: A Case Report
Case Rep Ophthalmol. 2025 Dec 18;17(1):75-80. doi: 10.1159/000550116. eCollection 2026 Jan-Dec. ABSTRACT INTRODUCTION: Leber hereditary optic neuropathy (LHON) is a hereditary optic neuropathy mainly caused by mutations at 1,178, 14,484, and 3,460 in mitochondrial DNA. Patients with LHON have a higher risk of developing multiple sclerosis (MS), a coexistence also known as Harding’s syndrome. A […]