Comparison of thickness changes in retinal nerve fibre layer in Leber’s hereditary optic neuropathy patients with 11778, 14484 and 3460 mutations
Transl Pediatr. 2025 Dec 31;14(12):3420-3428. doi: 10.21037/tp-2025-589. Epub 2025 Dec 25. ABSTRACT BACKGROUND: There was limited research comparing retinal nerve fibre layer (RNFL) involvement among different mitochondrial DNA (mtDNA) mutations associated with varying visual prognoses. This study aimed to observe and compare the thickness changes of RNFL among Leber’s hereditary optic neuropathy (LHON) patients with […]
Müller Glial Kir4.1 Channel Dysfunction in APOE4-KI Model of Alzheimer’s Disease
Glia. 2026 Mar;74(3):e70119. doi: 10.1002/glia.70119. ABSTRACT Alzheimer’s disease (AD), particularly late-onset AD (LOAD), affects millions worldwide, with the apolipoprotein ε4 (APOE4) allele being a significant genetic risk factor. Retinal abnormalities are a hallmark of LOAD, and our recent study demonstrated significant age-related retinal impairments in APOE4-knock-in (KI) mice, highlighting that retinal impairments occur before the […]
BDH1-Dependent Ketone Body Metabolism Maintains Müller Cell Homeostasis and Retinal Function
bioRxiv [Preprint]. 2025 Dec 27:2025.12.27.696636. doi: 10.64898/2025.12.27.696636. ABSTRACT Ketone body metabolism serves as an auxiliary regulator of cellular energetics and redox balance, particularly during prolonged fasting and carbohydrate restriction, yet its role in retinal homeostasis under physiological conditions remains poorly defined. β-hydroxybutyrate dehydrogenase 1 (BDH1) is a mitochondrial enzyme that interconverts acetoacetate and β-hydroxybutyrate, and […]
SPG7-Related Neurologic Disorder
2006 Aug 24 [updated 2026 Jan 8]. In: Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2026. ABSTRACT CLINICAL CHARACTERISTICS: The phenotypic spectrum of SPG7-related neurologic disorder includes uncomplicated spastic ataxia, complicated spastic ataxia, spinocerebellar ataxia, and isolated optic nerve atrophy. Although […]
Polystyrene and polyvinyl chloride microplastics exposure induces ocular surface inflammation by causing mitochondrial damage and lipid metabolic disruption
J Hazard Mater. 2025 Dec 30;502:140995. doi: 10.1016/j.jhazmat.2025.140995. Online ahead of print. ABSTRACT Microplastics (MPs), particularly polystyrene (PS) and polyvinyl chloride (PVC), are pervasive environmental pollutants implicated in ocular surface damage through poorly understood molecular mechanisms. Here, we elucidate the pathways underlying PS/PVC-induced ocular surface inflammation. In vitro, PS and PVC particles were internalized by […]
Generation of a PLIN2-GFP2-P2A-Puro human induced pluripotent stem cell line (SEUi001-A) via CRISPR/Cas9-mediated gene editing technology
Stem Cell Res. 2025 Dec 23;90:103896. doi: 10.1016/j.scr.2025.103896. Online ahead of print. ABSTRACT Perilipin 2 (PLIN2) dysregulation drives metabolic pathologies including non-alcoholic fatty liver disease (NAFLD). To enable real-time tracking of PLIN2 dynamics, we established a human induced pluripotent stem cell (hiPSC) line with endogenous GFP2 knock-in at the PLIN2 locus via CRISPR/Cas9-mediated non-homologous end […]
Sensing of DNA double-strand breaks by the NHEJ system stabilizes RORγt transcriptional activity and shapes Th17 pathogenicity in autoimmunity
Cell Res. 2026 Jan 7. doi: 10.1038/s41422-025-01204-6. Online ahead of print. ABSTRACT Robust mitochondrial ROS production induces extensive double-strand breaks (DSBs) in telomeric DNA of effector T cells, where the DNA repair machinery is rapidly hyper-evoked to sense and ligate DSBs during the respiratory burst. However, whether effector T cells can exploit the DNA repair […]
The Mitochondrial Protective Mechanisms Mediated by SGLT2i: From Molecular Basis to Clinical Implications
Xenobiotica. 2026 Jan 6:1-31. doi: 10.1080/00498254.2026.2613138. Online ahead of print. ABSTRACT 1. BACKGROUND: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are a novel class of oral hypoglycemic agents that selectively inhibit glucose reabsorption in the renal proximal tubules, thereby promoting urinary glucose excretion and reducing blood glucose levels. In recent years, accumulating evidence from large-scale clinical trials […]
A novel biomimetic nanozyme orchestrates ulcerative colitis resolution by targeting KEAP1-NRF2-ARE pathway: Redox balance restoration, colonic barrier repair, immune homeostasis regulation
Mater Today Bio. 2025 Dec 6;36:102627. doi: 10.1016/j.mtbio.2025.102627. eCollection 2026 Feb. ABSTRACT Ulcerative colitis (UC) leads to systemic complications with excessive oxidative stress, colonic barrier damage, and inflammation. Deuterohemin-AlaHisThrValGluLys (DhHP-6) is the biomimetic nanozyme rationally designed to mimic the peroxidase activity of Microperoxidase-11. It exhibits potent antioxidant properties, which might emerge as a promising therapeutic […]
cGAS knockout inhibited endotoxin-induced uveitis in mice
Genes Dis. 2025 Jul 29;13(2):101786. doi: 10.1016/j.gendis.2025.101786. eCollection 2026 Mar. ABSTRACT Our research focused on the impact of the cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) pathway on retinal inflammation and employed an endotoxin-induced uveitis (EIU) model. EIU was provoked in mice through the intravitreal administration of lipopolysaccharide. Transcriptome analysis was performed […]