Complement, Inflammasome, and Microglial Crosstalk in Glaucoma: From Neurodegeneration to Immune-Based Precision Therapy
Life (Basel). 2026 Feb 24;16(3):368. doi: 10.3390/life16030368. ABSTRACT Glaucoma is no longer viewed solely as a pressure-mediated optic neuropathy but as a chronic neurodegenerative disease with a strong immune component. Across experimental models and patient samples, convergent inflammatory circuitry complement activation, NLRP3 inflammasome signaling, and microglial reactivity emerge as a central driver of retinal ganglion […]
Mapping the Hypoxic Fitness Landscape of Retinal Pigment Epithelial Cells
Int J Mol Sci. 2026 Mar 21;27(6):2857. doi: 10.3390/ijms27062857. ABSTRACT Chronic hypoxia is a hallmark of aging and retinal diseases such as age-related macular degeneration (AMD), yet the molecular mechanisms that enable retinal pigment epithelium (RPE) cells to survive under sustained low-oxygen conditions remain poorly understood. To address this, we conducted transcriptomic profiling and a […]
Peripheral Blood Mononuclear Cell Oxygen Consumption and Systemic Bioenergetics in Glaucoma Management
Int J Mol Sci. 2026 Mar 16;27(6):2704. doi: 10.3390/ijms27062704. ABSTRACT Glaucoma is a multifaceted optic neuropathy, characterized by the progressive loss of retinal ganglion cells. This damage frequently continues even after intraocular pressure (IOP) has been effectively lowered. This resistance to conventional IOP-lowering therapy underscores the critical role of interacting IOP-independent mechanisms; specifically metabolic failure […]
Synergistic Antitumor Effects of Rosmarinic Acid and Cisplatin in Retinoblastoma: Evidence from 2D and 3D Tumor Models
Biomedicines. 2026 Mar 8;14(3):602. doi: 10.3390/biomedicines14030602. ABSTRACT Background/Objectives: Retinoblastoma (RB) is the most common primary intraocular malignancy in children, with treatment limited by chemoresistance and therapy-related toxicity. Enhancing the efficacy of conventional chemotherapeutics while reducing dose-related adverse effects is crucial. This study investigates the chemosensitizing potential of rosmarinic acid (RA), a natural polyphenolic compound, in […]
Bi-allelic ATG12 variants impair autophagy and cause a neurodevelopmental disorder
Am J Hum Genet. 2026 Mar 26:S0002-9297(26)00112-6. doi: 10.1016/j.ajhg.2026.03.002. Online ahead of print. ABSTRACT Autophagy is an essential developmental and homeostatic process, defined by the endolysosomal degradation of intracellular components and pathogens. Dysfunctional autophagy is implicated in complex human disease, yet reports of congenital autophagy disorders were considered exceedingly rare until the recent report of […]
Dual-Targeting Cuproptosis and Mitophagy via a Flavopiridol-Copper Nanoplatform Potentiates Immunotherapy Against Uveal Melanoma
Adv Sci (Weinh). 2026 Mar 27:e21183. doi: 10.1002/advs.202521183. Online ahead of print. ABSTRACT Uveal melanoma (UM) is a highly therapy-resistant ocular malignancy with an immunosuppressive tumor microenvironment (TME) and low tumor mutational burden. Here, we developed NP@Fla-Cu, a glutathione (GSH)-responsive nanoparticle designed to co-induce cuproptosis and mitophagy dysregulation. Cuproptosis, a copper-dependent mitochondrial cell death pathway, […]
Myeloid cell Nuclear Differentiation Antigen (MNDA) is an interferon-inducible regulator of myelopoiesis. Potential role in the myeloid-biased aging process
Ageing Res Rev. 2026 Mar 24:103112. doi: 10.1016/j.arr.2026.103112. Online ahead of print. ABSTRACT Aging is a myeloid-biased process, i.e., the differentiation of myeloid cells increases, while the lymphoid lineage declines. Cellular senescence increases the secretion of inflammatory mediators which skew hematopoiesis toward myeloid cell generation. Myeloid cell nuclear differentiation antigen (MNDA) is a type-1 interferon […]
Inhalable PD-L1-engineered hybrid cellular vesicles suppress excessive neutrophil activation and restore mitochondrial homeostasis to alleviate ischemia-reperfusion lung injury and pneumonia
Bioact Mater. 2026 Mar 16;62:319-341. doi: 10.1016/j.bioactmat.2026.03.024. eCollection 2026 Aug. ABSTRACT Lung ischemia-reperfusion injury and severe pneumonia represent major clinical challenges with high mortality rates and a lack of effective targeted therapies after lung transplant. Their pathogenesis involves multiple factors, including immune dysregulation, oxidative stress, and mitochondrial dysfunction, which limit the efficacy of single-target treatment […]
An Engineered Triple-Functional Nanoplatform for Effective Sepsis Therapy via Macrophage-Targeted Polo-like Kinase 1 Inhibition
ACS Nano. 2026 Mar 23. doi: 10.1021/acsnano.5c20947. Online ahead of print. ABSTRACT Sepsis accounts for 20% of global mortality, largely driven by dysregulated hyperactivation of macrophages that disrupts immune homeostasis. Current anti-inflammatory strategies often compromise pathogen clearance and exacerbate immunosuppression. Precisely targeting hyperactivated macrophages while preserving antimicrobial function represents a promising therapeutic approach. Through high-throughput […]
Spatial transcriptomic profiling identifies lacrimal-gland-epithelial cell-driven mechanisms underlying autoimmunity in Sjögren’s disease
Front Immunol. 2026 Mar 5;17:1759347. doi: 10.3389/fimmu.2026.1759347. eCollection 2026. ABSTRACT INTRODUCTION: Sjögren’s disease (SjD) is the second most prevalent rheumatic disease and is characterized by autoimmune pathology targeting the tear-producing lacrimal glands, leading to chronic ocular surface disease. Despite important advances, lacrimal gland pathology in SjD remains incompletely understood, limiting both diagnosis and treatment. METHODS: […]