Cell-intrinsic vulnerability and immune activation cooperate to drive degeneration in a mitochondrial complex I deficiency model of optic neuropathy
J Neuroinflammation. 2026 Feb 6. doi: 10.1186/s12974-026-03707-4. Online ahead of print. NO ABSTRACT PMID:41645183 | DOI:10.1186/s12974-026-03707-4
A systematic review on age-related macular degeneration: New insights from multi-omics studies
Surv Ophthalmol. 2026 Feb 3:S0039-6257(26)00016-0. doi: 10.1016/j.survophthal.2026.02.001. Online ahead of print. ABSTRACT Age-related macular degeneration (AMD) is a leading cause of blindness in developed countries and a growing global health concern. The multifactorial nature of AMD calls for integrative multi-omics approaches. We summarize studies employing multi-omics in AMD. A comprehensive search in PubMed and Scopus […]
Taurochenodeoxycholic Acid Activates Calcium Signaling to Protect Against Fuchs’ Endothelial Corneal Dystrophy
Invest Ophthalmol Vis Sci. 2026 Feb 2;67(2):16. doi: 10.1167/iovs.67.2.16. ABSTRACT PURPOSE: Fuchs’ endothelial corneal dystrophy (FECD) is the leading cause of corneal endothelial dystrophy. This study aimed to investigate the protective effects and mechanism of taurochenodeoxycholic acid (TCDCA) in FECD. METHODS: TCDCA levels were quantified in aqueous humor from patients with FECD and ultraviolet A […]
An Apparently Isolated Optic Neuropathy Associated with Biallelic Variants in SLC25A46 Gene Encoding the Mitochondrial Ugo1-Like Protein
Neuroophthalmology. 2025 Nov 3;50(1):96-100. doi: 10.1080/01658107.2025.2581675. eCollection 2026. ABSTRACT Biallelic pathogenic variants in the SLC25A46 gene are responsible for various neurological syndromes, including Charcot-Marie-Tooth disease type 6B, pontocerebellar hypoplasia type 1E, Leigh syndrome, progressive myoclonic ataxia and Parkinson’s disease, most of them being associated with optic atrophy. We here report the case of a 26-year-old […]
NOP14 promotes proliferative diabetic retinopathy through ribosome biogenesis and endothelial dysfunction via Wnt/β-Catenin signaling activation
Exp Cell Res. 2026 Feb 2:114922. doi: 10.1016/j.yexcr.2026.114922. Online ahead of print. ABSTRACT Proliferative diabetic retinopathy (PDR) is characterized by pathological angiogenesis and endothelial dysfunction driven by hyperglycemia. Ribosome biogenesis plays a crucial role in endothelial proliferation, yet its involvement in PDR remains unexplored. This study investigates the role of NOP14, a key regulator of […]
Biomarking MELAS with neurofilament light chain and circulating cell free mitochondrial DNA
Mol Genet Metab. 2026 Jan 27;147(3):109753. doi: 10.1016/j.ymgme.2026.109753. Online ahead of print. ABSTRACT Mitochondrial diseases are genetic disorders caused either by nuclear or mitochondrial DNA (mtDNA) alterations and characterized by high genetic and phenotypic variability. The common mtDNA m.3243 A > G variant in the MT-TL1 gene leads to clinical manifestations ranging from the classical […]
Targeted Extracellular Vesicles Deliver Asiaticoside to Inhibit AURKB/DRP1-Mediated Mitochondrial Fission and Attenuate Hypertrophic Scar Formation
Adv Sci (Weinh). 2026 Feb 4:e17108. doi: 10.1002/advs.202517108. Online ahead of print. ABSTRACT Hypertrophic scars (HS) are fibroproliferative lesions arising from aberrant wound healing, their high incidence is countered by a lack of effective interventions owing to an incomplete understanding of pathogenesis. Here, we identify dysregulated mitochondrial dynamics as a key driver of HS and […]
Screening and identification of a novel PGAM5-specific inhibitor for attenuating multi-organ injury
J Adv Res. 2026 Feb 1:S2090-1232(26)00093-7. doi: 10.1016/j.jare.2026.01.075. Online ahead of print. ABSTRACT INTRODUCTION: The necroptosis regulator PGAM5 drives a pathological cycle of mitochondrial dysfunction and necroptotic signaling, contributing to multi-organ injury and representing a potential therapeutic target. Despite its clinical relevance, few PGAM5-specific small-molecule inhibitors have been developed. OBJECTIVES: We aimed to identify a […]
A novel prohibitin inhibitor acts as a dual inhibitor of angiogenesis and fibrosis
Biochem Biophys Res Commun. 2026 Jan 31;805:153386. doi: 10.1016/j.bbrc.2026.153386. Online ahead of print. ABSTRACT We previously showed that the benzoylphenylurea derivative BPU17 inhibits epithelial-mesenchymal transition and acts as an antifibrotic agent. This compound acts as a prohibitin (PHB) inhibitor by directly binding to PHB1. This binding disrupts the interaction between PHB1 and PHB2, leading to […]
TrkB Overexpression via Gene Therapy: Enhanced Optic Nerve Uptake With Associated Increases in Mitochondria and Axoplasmic Transport
Cureus. 2026 Jan 2;18(1):e100594. doi: 10.7759/cureus.100594. eCollection 2026 Jan. ABSTRACT INTRODUCTION: Glaucoma is a progressive neurodegenerative disease that affects retinal ganglion cells (RGCs), ultimately leading to vision loss. In this study, we investigated gene therapy-mediated transduction of RGCs and examined axonal transport changes in the optic nerve using a viral vector designed to upregulate tropomyosin […]