Glutaredoxin 2 Protects Lens Epithelial Cells From Ferroptosis by Preventing HNRNPA2B1 S-Glutathionylation in Diabetes-Mediated Cataractogenesis
Invest Ophthalmol Vis Sci. 2025 Dec 1;66(15):58. doi: 10.1167/iovs.66.15.58. ABSTRACT PURPOSE: The purpose of this study was to investigate the role of glutaredoxin 2 (Grx2) in regulating ferroptosis under oxidative stress conditions induced by high glucose in lens epithelial cells (LECs) and its potential contribution to diabetes-mediated cataractogenesis. METHODS: Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was […]
Tumor-intrinsic redox programming drives an SPP1-CD44 axis of immune suppression in uveal melanoma
Redox Biol. 2026 Jan 6;90:104011. doi: 10.1016/j.redox.2026.104011. Online ahead of print. ABSTRACT Uveal melanoma (UM) is a rare yet aggressive malignancy with a high propensity for distant metastasis and poor response to systemic therapies, including immunotherapies. Although recent single-cell studies have uncovered pronounced intratumoral heterogeneity and an immunosuppressive tumor microenvironment, the tumor-intrinsic metabolic programs that […]
ercc6 deficient zebrafish exhibit UV and metronidazole sensitivity, increased oxygen consumption, and impaired hair cell mechanoelectrical transduction which can be restored by the superoxide dismutase mimetic MnTBAP
Hum Mol Genet. 2026 Jan 13:ddaf203. doi: 10.1093/hmg/ddaf203. Online ahead of print. ABSTRACT Cockayne Syndrome is an ultra-rare premature aging condition associated with UV sensitivity, neurocognitive decline, retinopathy, metronidazole-induced lethality, and sensorineural hearing loss. In 70% of affected patients, bi-allelic pathogenic variants in ERCC6 are identified. Although the role of ERCC6 in DNA damage repair […]
Glutathione redox system as a therapeutic target for Plasmodium: Opportunities, Challenges, and future perspectives
Folia Microbiol (Praha). 2026 Jan 13. doi: 10.1007/s12223-025-01410-0. Online ahead of print. ABSTRACT Glutathione (GSH) serves as an essential guardian for parasites, protecting them from the onslaught of oxidative stress. As hemoglobin breaks down and energy is harvested through the intricate mitochondrial respiratory pathway, GSH meticulously creates a reducing environment, akin to a fortress against […]
Quercetin ameliorates SIRT1-mediated oxidative stress and inflammation to attenuate ciliary muscle remodeling in experimental myopia
Biochem Pharmacol. 2026 Jan 8:117698. doi: 10.1016/j.bcp.2026.117698. Online ahead of print. ABSTRACT This study aimed to investigate the role of quercetin in myopic ciliary muscle remodeling through the regulation of SIRT1 expression. To this end, a randomized controlled trial was conducted using negative lens-induced myopic (LIM) guinea pig models for durations of 4 weeks and […]
Multi-omics integration uncovers key molecular mechanisms and therapeutic targets in myopia and pathological myopia
Asia Pac J Ophthalmol (Phila). 2026 Jan 8:100277. doi: 10.1016/j.apjo.2026.100277. Online ahead of print. ABSTRACT PURPOSE: Myopia, particularly pathological myopia (PM), poses a significant global health burden due to its increasing prevalence and associated vision-threatening complications. Despite extensive genetic research, the molecular mechanisms underlying myopia progression remain unclear. This study aims to identify key causal […]
Ferroptosis dysregulation, mitochondrial dysfunction, and iron metabolism alterations are correlated with aggressiveness in uveal melanoma
Apoptosis. 2026 Jan 10;31(1):13. doi: 10.1007/s10495-025-02205-x. ABSTRACT To elucidate the dysregulation of ferroptosis in uveal melanoma (UM), a comprehensive understanding is required of the expression patterns of ferroptosis-related genes, their association with key driver mutations and clinicopathological features, and their prognostic significance in UM patients. We analyzed tumor tissues from 56 UM enucleated eyeballs using […]
Mitochondrial Health Through Nicotinamide Riboside and Berberine: Shared Pathways and Therapeutic Potential
Int J Mol Sci. 2026 Jan 2;27(1):485. doi: 10.3390/ijms27010485. ABSTRACT Mitochondrial dysfunction represents a central hallmark of aging and a broad spectrum of chronic diseases, ranging from metabolic to neurodegenerative and ocular disorders. Nicotinamide riboside (NR), a vitamin B3 derivative and efficient precursor of NAD+ (nicotinamide adenine dinucleotide), and berberine (BBR), an isoquinoline alkaloid widely […]
Comprehensive Multimodal and Multiscale Analysis of Alzheimer’s Disease in 5xFAD Mice: Optical Spectroscopies, TEM, Neuropathological, and Behavioral Investigations
Int J Mol Sci. 2025 Dec 24;27(1):198. doi: 10.3390/ijms27010198. ABSTRACT Alzheimer’s disease (AD) is considered one of the leading causes of death in the United States, and there is no effective cure for it. Understanding the neuropathological mechanisms underlying AD is essential for identifying early, reliable biomarkers and developing effective therapies. In this paper, we […]
Neurovascular Signaling at the Gliovascular Interface: From Flow Regulation to Cognitive Energy Coupling
Int J Mol Sci. 2025 Dec 21;27(1):69. doi: 10.3390/ijms27010069. ABSTRACT Thought processes in the brain occur as it continually modifies its use of energy. This review integrates research findings from molecular neurology, vascular physiology and non-equilibrium thermodynamics to create a comprehensive perspective on thinking as a coordinated energy process. Data shows that there is a […]