miR-223-3p improves macrophage polarization balance and mitochondrial metabolism to ameliorate uveitis by orchestrating P65(Lys310) acetylation through RBPJ/HDAC1 axis
Cell Mol Biol Lett. 2026 Mar 10. doi: 10.1186/s11658-026-00874-3. Online ahead of print. NO ABSTRACT PMID:41808024 | DOI:10.1186/s11658-026-00874-3
Long Noncoding RNAs as Blood-Based Biomarkers of Diabetic Retinopathy
Transl Vis Sci Technol. 2026 Jan 5;15(1):17. doi: 10.1167/tvst.15.1.17. ABSTRACT PURPOSE: Prevalence of diabetic retinopathy closely depends on the duration of diabetes and severity of hyperglycemia. Experimental models have shown that high glucose initiates many metabolic, molecular and epigenetic changes in the retina before vascular histopathology is detectable. Several LncRNAs (RNAs with >200bp and no […]
Ferroptosis mediates retinal damage caused by the combined effects of sleep deprivation and light damage
Free Radic Biol Med. 2026 Mar 7:S0891-5849(26)00193-0. doi: 10.1016/j.freeradbiomed.2026.03.015. Online ahead of print. ABSTRACT BACKGROUND: Sleep deprivation (SD) and excessive light exposure (LD) are increasingly prevalent stressors in modern life, yet their combined impact on retinal integrity remains unclear. This study investigates how SD amplifies LD-induced retinal injury and explores the mechanistic role of ferroptosis-a […]
Kenny is the adaptor protein for ubiquitin-dependent mitophagy in Drosophila melanogaster
Autophagy Rep. 2026 Mar 4;5(1):2638025. doi: 10.1080/27694127.2026.2638025. eCollection 2026. ABSTRACT Mitophagy is the selective degradation program for damaged and unnecessary mitochondria to maintain cellular mitostasis and survival. Specific mutations in the mediators for the canonical ubiquitin (ub)-dependent mitophagy pathway have been identified with unique neurological diseases like Parkinson disease and ALS (amyotrophic lateral sclerosis), metabolic […]
Stem cells ameliorate neurotrauma-induced visual disturbances and retinal degeneration via broad normalization of β-catenin-related signaling
Int J Med Sci. 2026 Jan 23;23(3):758-779. doi: 10.7150/ijms.123975. eCollection 2026. ABSTRACT BACKGROUND: Traumatic brain injury (TBI) is associated with visual dysfunction and retinal degeneration, but the underlying mechanisms and therapeutic options remain limited. Mesenchymal stem cells (MSCs) have shown neuroprotective effects in various central nervous system injuries, including optic neuropathies. OBJECTIVE: To investigate the […]
Mitochondria transplantation reduces intraocular pressure by improving mitochondrial function and remodeling trabecular meshwork
J Transl Med. 2026 Mar 7. doi: 10.1186/s12967-026-07964-y. Online ahead of print. NO ABSTRACT PMID:41794792 | DOI:10.1186/s12967-026-07964-y
Single-cell and multi-omics analysis identifies mitophagy-related biomarkers and therapeutic targets in ischemic stroke
Sci Rep. 2026 Mar 6. doi: 10.1038/s41598-026-43377-z. Online ahead of print. ABSTRACT Ischemic stroke (IS) remains a leading cause of death and disability, with limited effective treatments in the acute phase. Mitophagy, the selective degradation of damaged mitochondria, plays a crucial role in cellular homeostasis and survival during IS. However, its exact mechanisms in stroke […]
SIRT3 mediates mitochondrial protection and attenuates mtROS-TXNIP-NLRP3 signaling activation in dry eye disease
Exp Eye Res. 2026 Mar 4:110960. doi: 10.1016/j.exer.2026.110960. Online ahead of print. ABSTRACT BACKGROUND/AIM: Dry eye disease (DED) is a chronic inflammatory disorder of the ocular surface in which mitochondrial dysfunction and oxidative stress have been increasingly implicated, yet the molecular mechanisms linking mitochondrial redox imbalance to inflammatory signaling remain unclear. This study aimed to […]
Long-term Efficacy and Safety of Photobiomodulation in Dry Age-Related Macular Degeneration (LIGHTSITE III: 24-Month Analysis)
Retina. 2026 Mar 3. doi: 10.1097/IAE.0000000000004822. Online ahead of print. ABSTRACT PURPOSE: To evaluate the safety and efficacy of multiwavelength photobiomodulation (PBM) in nonexudative (dry) age-related macular degeneration (AMD). METHODS: LIGHTSITE III employed a double-masked, randomized, sham-controlled, parallel-group, prospective study design. Subjects were enrolled with a diagnosis of dry AMD and treated with multiwavelength PBM […]
Neuropilin-2 Deficiency Promotes Mitochondrial Dysfunction and NAD+-Dependent Cellular Senescence in Retinal Degeneration
Invest Ophthalmol Vis Sci. 2026 Mar 2;67(3):11. doi: 10.1167/iovs.67.3.11. ABSTRACT PURPOSE: Retinal pigment epithelial (RPE) dysfunction is a central pathological feature of retinal degenerative diseases, leading to irreversible vision loss. RPE dysfunction is substantially driven by mitochondrial impairment and senescence. However, the upstream regulators of these processes remain largely undefined. This study investigated the role […]