Identification and functional characterization of a novel CRYBB1 deletion mutation causing autosomal dominant congenital cataract in a Chinese family
BMC Ophthalmol. 2026 Jan 20. doi: 10.1186/s12886-026-04624-z. Online ahead of print. NO ABSTRACT PMID:41559635 | DOI:10.1186/s12886-026-04624-z
Loss of the CoA-degrading enzyme NUDT19 exacerbates albuminuria and disrupts renal lipid homeostasis in high fat diet-fed mice
Sci Rep. 2026 Jan 20. doi: 10.1038/s41598-026-36136-7. Online ahead of print. ABSTRACT Nudix hydrolase 19 (NUDT19) is a peroxisomal enzyme that hydrolyzes CoA species at the phosphodiester bond and has been linked to peroxisomal dysfunction in the context of diabetic kidney disease. Despite its predominant expression in mouse kidneys, the physiological role of NUDT19 remains […]
Single-cell profiling of trabecular meshwork identifies mitochondrial dysfunction in a glaucoma model that is protected by vitamin B3 treatment
Elife. 2026 Jan 20;14:RP107161. doi: 10.7554/eLife.107161. ABSTRACT Since the trabecular meshwork (TM) is central to intraocular pressure (IOP) regulation and glaucoma, a deeper understanding of its genomic landscape is needed. We present a multimodal, single-cell resolution analysis of mouse limbal cells (includes TM). In total, we sequenced 9,394 wild-type TM cell transcriptomes. We discovered three […]
Metabolic Alterations Induced by a Seizure-Causing Sodium Channel Mutation and their Partial Normalization by Dietary α-Linolenic Acid in Drosophila
Neurochem Res. 2026 Jan 20;51(1):51. doi: 10.1007/s11064-026-04673-2. ABSTRACT Epilepsy is increasingly recognized as a disorder with prominent metabolic disturbances, but how defined epilepsy-causing mutations reshape metabolism under controlled genetic and environmental conditions remains poorly understood. Here, we used the Drosophila melanogaster gain-of-function voltage-gated sodium channel (VGSC) mutant paraShu, a well-established model of neuronal and behavioral […]
Resveratrol alleviated diabetic retinal neuronal ferroptosis induced by high glucose through inhibiting HIF-1α and HMOX1 pathway
Exp Eye Res. 2026 Jan 17:110872. doi: 10.1016/j.exer.2026.110872. Online ahead of print. ABSTRACT Diabetic retinopathy (DR) is a common complication of diabetes mellitus that can cause blindness and affect the life quality of patients. Diabetic retinal neurodegeneration (DRN) caused by high glucose might be the earlier pathological change preceding vascular injury. Resveratrol has been showed […]
Targeting MFF succinylation: a novel therapeutic strategy for premature ovarian insufficiency by restoring mitochondrial dynamics in granulosa cells
J Ovarian Res. 2026 Jan 19. doi: 10.1186/s13048-026-01964-8. Online ahead of print. ABSTRACT Premature ovarian insufficiency (POI) is a significant clinical disorder characterized by the loss of ovarian function before the age of 40, and its global prevalence is rising. The development of effective therapies is hindered by an incomplete understanding of its pathogenesis. Growing […]
Baicalin attenuates HIF-1α-driven histone lactylation and neutrophil extracellular trap (NET) formation in autoimmune uveitis
Int J Biol Macromol. 2026 Jan 14:150264. doi: 10.1016/j.ijbiomac.2026.150264. Online ahead of print. ABSTRACT Uveitis is a group of vision-threatening intraocular inflammatory disorders that can affect the uveal tract, retina, optic nerve, and vitreous, leading to irreversible structural damage and vision loss. Neutrophil extracellular trap (NET) formation is a key driver of acute uveitis (AU) […]
Molecular underpinnings of induced degenerative heterogeneity in the retinal pigment epithelium
Proc Natl Acad Sci U S A. 2026 Jan 20;123(3):e2505412123. doi: 10.1073/pnas.2505412123. Epub 2026 Jan 16. ABSTRACT Cigarette smoking induces epigenetic changes that can cause degenerative heterogeneity with aging and disease. In disease such as age-related macular degeneration (AMD), the leading worldwide cause of blindness among the elderly, retinal pigment epithelial (RPE) cell heterogeneity is […]
Oxidative stress in diabetic retinopathy: Metabolic triggers, molecular pathways and emerging antioxidant therapies
Int J Biol Macromol. 2026 Jan 13:150272. doi: 10.1016/j.ijbiomac.2026.150272. Online ahead of print. ABSTRACT Diabetic retinopathy (DR) is a leading cause of blindness among adults worldwide, with hyperglycemia-induced oxidative stress lies at the core of its pathogenesis. This review synthesises evidence showing that elevated glucose, hypoxia and pro-inflammatory mediators act synergistically to impair the mitochondrial […]
Retinal Neurovascular and Mitochondrial Function Signatures in Response to a 24-Week Yoga Intervention in Healthy Adults
Invest Ophthalmol Vis Sci. 2025 Dec 1;66(15):62. doi: 10.1167/iovs.66.15.62. ABSTRACT PURPOSE: To evaluate changes in retinal neurovascular and mitochondrial function after a 24-week yoga intervention in healthy older adults. METHODS: Thirty participants (mean age 72 ± 6 years; 25 females, 5 males) were randomized to either a cue-based yoga program (n = 15) or traditional […]