Ophthalmic manifestations of mitochondrial disorders
Prog Retin Eye Res. 2026 Apr 3:101466. doi: 10.1016/j.preteyeres.2026.101466. Online ahead of print. ABSTRACT Mitochondrial diseases are the most common group of inherited neurometabolic disorders and frequently involve multiple organ systems with high energy demands. Ophthalmic manifestations are a common occurrence in affected individuals and may be the earliest or predominant clinical feature. However, the […]
Mitochondrial dynamics and their role in the pathogenesis of age-related macular degeneration: A comprehensive review
Redox Biol. 2025 Dec 20;93:103976. doi: 10.1016/j.redox.2025.103976. Online ahead of print. ABSTRACT Age-related macular degeneration (AMD) is a leading cause of irreversible blindness in the elderly and has a multifactorial etiology involving advanced age, genetic susceptibility, and environmental risk factors. Accumulating evidence suggests that mitochondrial dysfunction is a central pathogenic mechanism in AMD, particularly in […]
Metabolic and redox adaptations of the corneal endothelium: From metabolic plasticity to therapeutic opportunities
Redox Biol. 2026 Mar 30;93:104148. doi: 10.1016/j.redox.2026.104148. Online ahead of print. ABSTRACT The corneal endothelium, a monolayer of nonregenerating cells on the posterior cornea, maintains corneal transparency through active fluid pumping. This review examines how corneal endothelial cells (CEnCs) meet high energy demands and adapt metabolically from quiescence to stress, with particular emphasis on their […]
Leber hereditary optic neuropathy triggered by the AstraZeneca coronavirus disease 2019 vaccination
Oman J Ophthalmol. 2026 Feb 27;19(1):137-139. doi: 10.4103/ojo.ojo_431_24. eCollection 2026 Jan-Apr. ABSTRACT Leber hereditary optic neuropathy (LHON) is a rare mitochondrial disorder primarily affecting young males, characterized by progressive vision loss due to retinal ganglion cell degeneration. LHON is typically associated with specific mitochondrial mutations with potential triggers such as environmental factors and, more recently, […]
The 5-HT1A receptor antagonist WAY-100635 maleate promotes retinal ganglion cell differentiation and protects the retino-visual circuits
Commun Med (Lond). 2026 Apr 2. doi: 10.1038/s43856-026-01528-3. Online ahead of print. ABSTRACT BACKGROUND: Growing evidence implicates early metabolic dysfunctions in retinal ganglion cells (RGCs) as a contributor to both high- and normal-tension glaucoma, yet no approved therapy directly protects RGCs to preserve vision. We aimed at identifying a safe, druggable neuroprotective strategy that restores […]
Neuron-derived mitochondrial DNA (mtDNA) activates microglia via the Z-DNA binding protein 1 (ZBP1)-mediated pathway in mild traumatic brain injury
Proc Natl Acad Sci U S A. 2026 Apr 7;123(14):e2527009123. doi: 10.1073/pnas.2527009123. Epub 2026 Apr 2. ABSTRACT Traumatic brain injury (TBI) is a leading cause of morbidity and mortality, with closed-head mild TBI (mTBI) accounting for nearly 90% of all cases. Early pathological events include microglial activation and neuronal mitochondrial dysfunction; however, their interconnection in […]
Mitochondrial hyperoxidation contributes to warm ischemia-reperfusion injury in rat and pig livers
Commun Med (Lond). 2026 Apr 1. doi: 10.1038/s43856-026-01551-4. Online ahead of print. ABSTRACT BACKGROUND: Mitochondrial dysfunction is a critical factor in several diseases, but current in situ assessment methods are severely limited. Non-invasive monitoring of mitochondrial redox state using resonance Raman Spectroscopy (RRS) offers a promising solution. This study aims to demonstrate RRS utility with […]
Hepatocyte Growth Factor Confers Trabecular Meshwork Stem Cell Resilience and Paracrine Protection of Trabecular Meshwork Cells in Glaucoma
Invest Ophthalmol Vis Sci. 2026 Apr 1;67(4):1. doi: 10.1167/iovs.67.4.1. ABSTRACT PURPOSE: We have reported that trabecular meshwork stem cells (TMSCs) are effective for trabecular meshwork (TM) regeneration. This study aims to investigate different responses of TMSCs and TM cells to TGF-β2 and protective factors in TMSCs. METHODS: Human TMSCs and TM cells were exposed to […]
Mitochondrial kinase CMPK2 in immune homeostasis and disease: from metabolic regulation to inflammatory signaling
Int Immunopharmacol. 2026 Mar 30;178:116582. doi: 10.1016/j.intimp.2026.116582. Online ahead of print. ABSTRACT Cytidine monophosphate kinase 2 (CMPK2) is a pivotal mitochondrial enzyme that plays a multifaceted role in cellular nucleotide metabolism, immune regulation, and disease pathogenesis. This review comprehensively examines the structural characteristics, enzymatic functions, and regulatory mechanisms of CMPK2, emphasizing its significance in maintaining […]
NAD+ subcellular partitioning mediated by miR-183 and miR-96 regulates muscle stem cell differentiation
J Mol Cell Biol. 2026 Mar 31:mjag015. doi: 10.1093/jmcb/mjag015. Online ahead of print. ABSTRACT The intracellular abundance of NAD+, a vital metabolic cofactor, critically influences muscle stem cell (MuSC) function. However, the spatial regulation of NAD+ and its impact on MuSC function remain unclear. In this study, we demonstrated that the loss of miR-183 and […]