Repeated low-level red light modulates retinal metabolic alterations in lens-induced myopic chicks
J Photochem Photobiol B. 2026 Mar 21;278:113432. doi: 10.1016/j.jphotobiol.2026.113432. Online ahead of print. ABSTRACT BACKGROUND: Repeated low-level red-light (RLRL) therapy effectively controls myopia, yet its retinal metabolic mechanisms remain elusive. This study aimed to elucidate RLRL-induced metabolic alterations in a lens-induced myopia (LIM) chick model. METHODS: Seven-day-old chicks were randomized into three groups (n = […]
Clinical and Genetic Spectrum of ACO2-Linked Dominant Optic Atrophy
JAMA Ophthalmol. 2026 Apr 9. doi: 10.1001/jamaophthalmol.2026.0634. Online ahead of print. ABSTRACT IMPORTANCE: Aconitase 2 (ACO2) gene variants are one of the most frequent causes of dominant optic atrophy (DOA). However, the associated phenotypes and genotypes still lack proper characterization. OBJECTIVE: To characterize the clinical and genetic spectrum of ACO2-related DOA and evaluate genotype-phenotype correlations. […]
Targeting of ibrutinib resistance-driving pathways by miR-28 in ABC-DLBCL
Leukemia. 2026 Apr 8. doi: 10.1038/s41375-026-02948-9. Online ahead of print. ABSTRACT Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive B-cell lymphoma. Although many patients respond well to R-CHOP immunochemotherapy, those with the activated B-cell (ABC) subtype are often refractory or relapse. Bruton tyrosine kinase (BTK) inhibitors such as ibrutinib have improved outcomes, but […]
Hypoxia-Induced Ferroptosis Resistance Drives Orbital Fibrosis in Thyroid Eye Disease
Invest Ophthalmol Vis Sci. 2026 Apr 1;67(4):15. doi: 10.1167/iovs.67.4.15. ABSTRACT PURPOSE: To determine whether hypoxia promotes a ferroptosis-resistant phenotype in patient-derived thyroid eye disease (TED) orbital fibroblasts (OFs), and whether hypoxia-associated metabolic changes (lactate) relate to profibrotic activation readouts, as well as to test whether modulating ferroptosis alters these readouts. METHODS: Primary OFs from TED […]
Histologic Photoreceptor and Retinal Pigment Epithelium Degeneration in an Eye With Clinically Documented Geographic Atrophy of AMD
Invest Ophthalmol Vis Sci. 2026 Apr 1;67(4):12. doi: 10.1167/iovs.67.4.12. ABSTRACT PURPOSE: In geographic atrophy (GA) of AMD, comparing photoreceptor disintegrity and RPE loss in optical coherence tomography (OCT) and microscopy may elucidate atrophy expansion and suggest imaging biomarkers. METHODS: One eye of a 93-year-old woman with bilateral drusen-driven GA of AMD was analyzed. RPE loss […]
FTO mediated m6A demethylation of LncRNA RMRP drives mitochondrial dysfunction in diabetic cataract
Exp Eye Res. 2026 Apr 4:110991. doi: 10.1016/j.exer.2026.110991. Online ahead of print. ABSTRACT Diabetic cataract is characterized by early lens opacification. This study identifies a pathogenic axis that involves the N6-methyladenosine (m6A) demethylase fat mass and obesity-associated protein (FTO) and the mitochondria-enriched long non-coding RNA (lncRNA) RMRP. Transcriptomic analysis of lens epithelial cells (LECs) under […]
Synergistic Anticancer Effects of Lenvatinib Combined with N-butylidenephthalide in Human Colorectal Cancer Cells
Int J Med Sci. 2026 Mar 4;23(4):1356-1368. doi: 10.7150/ijms.122381. eCollection 2026. ABSTRACT BACKGROUND: Colorectal cancer (CRC) is one of the most prevalent and deadly gastrointestinal malignancies worldwide. Lenvatinib, a multi-tyrosine kinase inhibitor, has shown limited clinical benefit as a monotherapy for CRC. Therefore, combining lenvatinib with N-butylidenephthalide (BP), a known anticancer and adjuvant agent, has […]
A dual-responsive CO-releasing nanogel ameliorates retinal ischemia-reperfusion injury by restoring mitochondrial homeostasis and attenuating cGAS-STING pathway activation
Mater Today Bio. 2026 Mar 5;38:102974. doi: 10.1016/j.mtbio.2026.102974. eCollection 2026 Jun. ABSTRACT Retinal ischemia-reperfusion injury (RIRI) represents a central pathological mechanism underlying neurodegeneration in multiple blinding ocular diseases, including glaucoma, diabetic retinopathy, and retinal vein occlusion. Ischemic stress triggers a surge of reactive oxygen species (ROS) within retinal ganglion cells, leading to mitochondrial dysfunction and […]
Using image classifiers to predict CMT2A disease-relevant mitochondrial motility phenotypes in iPSC motor neurons
bioRxiv [Preprint]. 2026 Mar 17:2026.03.16.712192. doi: 10.64898/2026.03.16.712192. ABSTRACT Charcot-Marie-Tooth disease type 2A (CMT2A) is a genetic disease characterized by autosomal dominant MFN2 mutations and dysregulated mitochondrial trafficking. While there is currently no FDA-approved CMT2A therapy, the recent development of iPSC motor neuron model systems, high-throughput imaging platforms, and CRISPR-based gene editing technologies holds promise for […]
Leber Hereditary Optic Neuropathy in the Elderly: A Case Report
Case Rep Ophthalmol. 2026 Feb 20;17(1):305-311. doi: 10.1159/000551146. eCollection 2026 Jan-Dec. ABSTRACT INTRODUCTION: Leber hereditary optic neuropathy (LHON) is a mitochondrial disorder typically affecting young males, with rare reports of late-onset disease. Among the three primary LHON mutations, m.14484T>C is generally associated with a relatively favorable visual prognosis. However, the disease in elderly patients carrying […]