Category: Ophthalmology AND mitochondrial

LED lighting (350-650nm) undermines human visual performance unless supplemented by wider spectra (400-1500nm+) like daylight

Sci Rep. 2026 Jan 23;16(1):3061. doi: 10.1038/s41598-026-35389-6. ABSTRACT Life evolved under broad spectrum sunlight, from ultraviolet to infrared (300–2500 nm). This spectrally balanced light sculpted life’s physiology and metabolism. But modern lighting has recently become dominated by restricted spectrum light emitting diodes (350–650 nm LEDs). Absence of longer wavelengths in LEDs and their short wavelength […]

Chronic stress-induced steroids mediate mitochondrial fission and fibrosis in the trabecular meshwork via the MIEF1-MAOA complex

Free Radic Biol Med. 2026 Jan 22:S0891-5849(26)00055-9. doi: 10.1016/j.freeradbiomed.2026.01.037. Online ahead of print. ABSTRACT Glaucoma remains the leading cause of irreversible blindness worldwide. Trabecular meshwork (TM) dysfunction, particularly fibrosis, is a major driver of elevated intraocular pressure (IOP). Although steroid-induced glaucoma is well established, the impact of chronic stress-related endogenous steroids on TM pathology remains […]

Biosponge-armored polydopamine-modified conducting polypyrrole restores redox-iron homeostasis for enhanced neuroprotection​ in retinal ischemia-reperfusion injury

Biomaterials. 2026 Jan 17;330:124007. doi: 10.1016/j.biomaterials.2026.124007. Online ahead of print. ABSTRACT Retinal ischemia-reperfusion injury (RIRI) is a central pathological mechanism in vision-impairing disorders such as glaucoma and retinal vascular occlusion. Current treatment modalities are significantly constrained by their inability to simultaneously address the multifaceted injury cascades driven by lethal oxidative stress, ferroptosis, and neuroinflammation, which […]

MTFR1L is a cardiac antiaging factor for maintenance of mitochondrial homeostasis

Proc Natl Acad Sci U S A. 2026 Jan 27;123(4):e2527247123. doi: 10.1073/pnas.2527247123. Epub 2026 Jan 23. ABSTRACT Mitochondrial dysfunction is a hallmark of aging and a key contributor to age-related diseases including cardiovascular disease. However, molecular pathways that safeguard mitochondrial homeostasis in the aging heart remain poorly understood. Here, we identify MTFR1L as a regulator […]

A Case Report of Unilateral OPA3-Related Dominant Optic Atrophy

Case Rep Ophthalmol. 2025 Dec 11;17(1):81-86. doi: 10.1159/000550003. eCollection 2026 Jan-Dec. ABSTRACT INTRODUCTION: Autosomal dominant optic atrophy (DOA) is an inherited optic neuropathy characterized by progressive bilateral vision loss, cecocentral visual field (VF) defects, and retinal ganglion cell degeneration. Most cases are associated with OPA1 mutations, while OPA3-related DOA is rare and typically involves both […]

Leber Hereditary Optic Neuropathy-Associated Novel Mutation in MT-RNR2 Gene: A Case Report

Case Rep Ophthalmol. 2025 Dec 18;17(1):75-80. doi: 10.1159/000550116. eCollection 2026 Jan-Dec. ABSTRACT INTRODUCTION: Leber hereditary optic neuropathy (LHON) is a hereditary optic neuropathy mainly caused by mutations at 1,178, 14,484, and 3,460 in mitochondrial DNA. Patients with LHON have a higher risk of developing multiple sclerosis (MS), a coexistence also known as Harding’s syndrome. A […]

ABCA4-associated retinopathy complicated by didanosine-associated retinal toxicity

Am J Ophthalmol Case Rep. 2025 Dec 29;41:102509. doi: 10.1016/j.ajoc.2025.102509. eCollection 2026 Mar. ABSTRACT PURPOSE: To describe a rare case of severe central and peripheral chorioretinal atrophy in a patient with ABCA4-associated retinopathy and prior didanosine exposure. OBSERVATIONS: A 66-year-old man with a 20-year history of Stargardt disease and HIV/AIDS treated with didanosine for almost […]

Volumetric brain analysis and associated retinal thinning in autosomal dominant optic atrophy patients

Neuroimage Rep. 2026 Jan 6;6(1):100314. doi: 10.1016/j.ynirp.2025.100314. eCollection 2026 Mar. ABSTRACT INTRODUCTION: Dominant optic atrophy (DOA) is an inherited mitochondrial disorder characterized by retinal thinning and progressive visual loss. When accompanied by additional neurological or systemic features, such as progressive external ophthalmoplegia, myopathy, or deafness, it is classified as DOA-plus (DOA+). Although central nervous system […]