Human Umbilical Cord Mesenchymal Stem Cells Ameliorate Diabetic Neuropathic Pain via TRPV1-[Ca(2+)]i-AMPK Signaling-Mediated Mitochondrial Restoration in Schwann Cells
Stem Cells Int. 2025 Nov 26;2025:5533136. doi: 10.1155/sci/5533136. eCollection 2025. ABSTRACT BACKGROUND: The therapeutic potential of human umbilical cord mesenchymal stem cells (HUCMSCs) for diabetic peripheral neuropathy (DPN) and the underlying mechanisms involving transient receptor potential vanilloid 1 (TRPV1) signaling remain incompletely defined. OBJECTIVE: This study aimed to elucidate the role of the TRPV1-[Ca2+]i-AMPK signaling […]
FASTKD2-Related Combined Oxidative Phosphorylation Deficiency
2025 Dec 4. In: Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2025. ABSTRACT CLINICAL CHARACTERISTICS: FASTKD2-related combined oxidative phosphorylation deficiency (FASTKD2-COXPD) is a multisystem disorder that can present from infancy to adulthood with developmental delay with regression that is often triggered […]
Time Course of Structural, Functional, Complement Changes and Inflammatory Processes in a Sodium Iodate Rat Model of Geographic Atrophy
FASEB J. 2025 Dec 15;39(23):e71307. doi: 10.1096/fj.202502226R. ABSTRACT Geographic atrophy (GA) is characterized by the loss of choriocapillaris, retinal pigment epithelium (RPE) and photoreceptors and is an advanced form of age-related macular degeneration (AMD)-a leading cause of central vision loss in the elderly. The development of effective treatments has been hindered by the lack of […]
3-n-Butylphthalide exerts mitochondria-mediated retinal ganglion cell protection and modulates eye-brain axis-related emotional disturbances in glaucoma
Int J Surg. 2025 Dec 4. doi: 10.1097/JS9.0000000000004146. Online ahead of print. ABSTRACT BACKGROUND: Glaucoma is an irreversible blinding eye disease characterized by the progressive loss of retinal ganglion cells (RGCs). In addition to the conventional visual pathways, RGCs can also mediate emotional responses through non-image forming visual pathways. Emerging evidence indicates that oxidative stress […]
Decreased substrate stiffness leads to mitochondrial dysfunctions and Endothelial to Mesenchymal transition through Focal Adhesion Kinase activity in corneal endothelial cells
bioRxiv [Preprint]. 2025 Nov 8:2025.11.08.687366. doi: 10.1101/2025.11.08.687366. ABSTRACT PURPOSE: Fuchs’ Endothelial Corneal Dystrophy (FECD), a degenerative corneal disorder, is marked by the thickening of Descemet’s membrane and a progressive loss of corneal endothelial cells, ultimately leading to vision loss. A feature associated with the disease is the reduced stiffness of Descemet’s membrane. However, the effects […]
Blockade of mitochondrial components release by exosome pathway promotes the pathogenesis of Fuchs endothelial corneal dystrophy
Cell Death Discov. 2025 Dec 2. doi: 10.1038/s41420-025-02881-3. Online ahead of print. ABSTRACT Fuchs endothelial corneal dystrophy (FECD) is the leading indication of corneal transplantation worldwide and the focus of pathogenesis has been on the corneal endothelium. Instead of cellular analysis, we aimed to identify the protein changes of aqueous humor (AH) in patients with […]
Cell-penetrating peptide-functionalized biomimetic nanovesicles for efficient cataract treatment via enhanced corneal penetration and lens-mitochondria dual targeting
Bioact Mater. 2025 Nov 14;57:305-322. doi: 10.1016/j.bioactmat.2025.11.016. eCollection 2026 Mar. ABSTRACT Cataract is the leading cause of blindness worldwide. While the oxidative stress homeostasis unbalance of the lens is a key pathological mechanism underlying cataract formation. Due to the lens being deeply embedded behind multiple biological barriers, there is no effective drug treatment for cataract […]
Membrane-Targeting Poly(Amino Acids) with a Phage-Like Action Process for Antifungal Therapy
ACS Nano. 2025 Dec 1. doi: 10.1021/acsnano.5c13661. Online ahead of print. ABSTRACT Invasive fungal infections and the rising prevalence of drug resistance highlight the urgent need for alternative antifungal strategies. In this study, a guanidine-functionalized poly(amino acid) (PArg20) with a phage-like action process was synthesized, exhibiting superior antifungal activity and favorable biocompatibility. Emulating the three-step […]
Advanced therapies for inherited optic neuropathies
Eye (Lond). 2025 Nov 29. doi: 10.1038/s41433-025-04109-1. Online ahead of print. ABSTRACT Inherited optic neuropathies (IONs), such as Leber hereditary optic neuropathy (LHON) and autosomal dominant optic atrophy (ADOA), typically lead to irreversible severe vision loss due to mitochondrial dysfunction causing retinal ganglion cell degeneration. Although current treatment options are limited, substantial progress has been […]
From molecular mechanisms to translational applications: a parallel assessment of green and black tea modulation of oxidative stress
Nutr Metab (Lond). 2025 Nov 28;22(1):147. doi: 10.1186/s12986-025-01047-3. ABSTRACT Oxidative stress, driven by an imbalance between reactive oxygen species (ROS) and antioxidant defenses, is a key contributor to aging and chronic diseases such as cancer, cardiovascular disorders, and neurodegenerative conditions. Green and black tea contain polyphenolic compounds that exhibit potent antioxidant and anti-inflammatory activities. This […]