Recovery from apoptosis in photoreceptor cells: A role for mitophagy
Cell Death Dis. 2026 Jan 30. doi: 10.1038/s41419-026-08436-3. Online ahead of print. ABSTRACT Photoreceptors (PRs) are specialized light-sensitive cells responsible for vision, and their death is the primary cause of retinal degeneration and vision loss. Recent studies using cells such as HeLa and PC12 have demonstrated cellular recovery even from late stages of apoptosis. Here, […]
Resveratrol as a multitarget modulator in diabetic retinopathy: a systematic review of in vitro and in vivo studies
BMC Ophthalmol. 2026 Jan 29;26(1):55. doi: 10.1186/s12886-026-04623-0. ABSTRACT BACKGROUND: Resveratrol (RSV) has been extensively investigated for its antioxidant and anti-inflammatory properties across various disease settings; however, its upstream mechanisms in diabetic retinopathy (DR) remain insufficiently characterized. Given that early DR involves oxidative stress, mitochondrial disruption, and microglia-associated inflammatory amplification, this systematic review aims to synthesize […]
A type I interferon-mitochondrial axis regulates efferocytosis and interferon-stimulated gene induction in macrophages
Immunity. 2026 Jan 28:S1074-7613(25)00566-7. doi: 10.1016/j.immuni.2025.12.010. Online ahead of print. ABSTRACT Macrophage metabolism is intricately linked to cellular function. Contrasting with Toll-like receptor (TLR) stimulation, cytosolic nucleic acid sensing induced a decrease in mitochondrial membrane potential (MMP) while maintaining mitochondrial respiration. Interferon α/β (IFN-I) receptor (IFNAR) signaling was necessary and sufficient for this metabolic response. […]
Metabolism-Regulating Microspheres: Design Principles, Therapeutic Applications Across Multisystem Diseases, and Future Perspectives
Research (Wash D C). 2026 Jan 27;9:1106. doi: 10.34133/research.1106. eCollection 2026. ABSTRACT Metabolism-regulating microspheres have evolved from conventional drug carriers into active platforms capable of spatiotemporally reprogramming pathological metabolic networks. Chronic diseases are increasingly understood to be driven by metabolic dysregulation, highlighting the need for therapeutic strategies that enable localized and precise metabolic intervention. This […]
Socceromics: A Systematic Review of Omics Technologies to Optimize Performance and Health in Soccer
Int J Mol Sci. 2026 Jan 12;27(2):749. doi: 10.3390/ijms27020749. ABSTRACT The integration of omics technologies, including genomics, proteomics, metabolomics, and microbiomics, has transformed sports science, particularly soccer, by providing new opportunities to optimize player performance, reduce injury risk, and enhance recovery. This systematic literature review was conducted in accordance with PRISMA 2020 guidelines and structured […]
The Protonic Brain: Nanoscale pH Dynamics, Proton Wires, and Acid-Base Information Coding in Neural Tissue
Int J Mol Sci. 2026 Jan 6;27(2):560. doi: 10.3390/ijms27020560. ABSTRACT Emerging research indicates that neuronal activity is maintained by an architectural system of protons in a multi-scale fashion. Proton architecture is formed when organelles (such as mitochondria, endoplasmic reticulum, lysosomes, synaptic vesicles, etc.) are coupled together to produce dynamic energy domains. Techniques have been developed […]
Fullerenol Eye Drops Mitigate UVB-Induced Cataract Progression by Inhibiting Oxidative Stress and Cellular Senescence
Antioxidants (Basel). 2026 Jan 16;15(1):118. doi: 10.3390/antiox15010118. ABSTRACT Cataracts remain the leading cause of blindness worldwide, and surgery is currently the only effective clinical treatment, as no pharmacological therapy has yet been validated. Here, we explore Fullerenol, a hydroxylated fullerene derivative formulated as eye drops, as a potential nanomedicine for delaying cataract onset and progression. […]
NFS1 Plays a Critical Role in Regulating Ferroptosis Homeostasis
Biomolecules. 2025 Dec 24;16(1):32. doi: 10.3390/biom16010032. ABSTRACT Ferroptosis is an iron-dependent form of regulated cell death (RCD) characterized by intracellular iron homeostasis disruption and lipid peroxide accumulation. It is involved in many pathological processes, including malignant tumors, cardiovascular diseases, inflammatory diseases, and mitochondrial disorders. Cysteine desulfurase (NFS1), a key enzyme in mitochondrial iron-sulfur (Fe-S) cluster […]
Targeting Retinoic Acid Receptor-Related Orphan Receptor α to Prevent Cataracts: A New Pathway Through Nerve Growth Factor Activation
Antioxid Redox Signal. 2026 Jan 27:15230864261416452. doi: 10.1177/15230864261416452. Online ahead of print. ABSTRACT AIMS: Cataracts are the leading cause of blindness worldwide, and the mechanism underlying cataract formation is linked to the oxidative damage and the apoptosis of lens epithelial cells. Retinoic acid Receptor-related orphan receptor α (RORα), a transcription factor, prevents oxidative stress and […]
Astaxanthin Protects Retinal Müller Cells Against High Glucose-induced Oxidative Stress through the Sirtuin 1/AMPK/FOXO1 Pathway
Exp Eye Res. 2026 Jan 23:110887. doi: 10.1016/j.exer.2026.110887. Online ahead of print. ABSTRACT Diabetic retinopathy (DR) is characterized by microvascular damage in the retina due to hyperglycemia-induced oxidative stress. The pivotal role of Müller glial cells in DR pathogenesis has gained increasing recognition. Sirtuin 1 (SIRT1), a nicotinamide adenosine dinucleotide (NAD+)-dependent deacetylase, plays a crucial […]