NSUN4-mediated m5C RNA methylation protects retinal cells against excitotoxic injury via the SHH signaling pathway
PLoS One. 2026 Apr 15;21(4):e0347414. doi: 10.1371/journal.pone.0347414. eCollection 2026. ABSTRACT Glaucoma, a leading global cause of blindness, is characterized by progressive retinal neuronal loss. NOP2/Sun RNA methyltransferase 4 (NSUN4), a writer of 5-methylcytosine (m5C) RNA modifications, has established roles in methylation and mitoribosome assembly, yet its function in retinal cell survival remains unexplored. In this […]
Rhesus macaques with an OPA1 mutation demonstrate features of autosomal dominant optic atrophy
Proc Natl Acad Sci U S A. 2026 Apr 21;123(16):e2509165123. doi: 10.1073/pnas.2509165123. Epub 2026 Apr 15. ABSTRACT Autosomal dominant optic atrophy (ADOA) is an inherited optic neuropathy primarily caused by mutations in OPA1. We identified and defined a spontaneous nonhuman primate (NHP) model of ADOA using rhesus macaques heterozygous for a missense mutation (OPA1A8S). With […]
Comparative Proteomic Profiling of Microdissected Spindle and Epithelioid Uveal Melanoma Subtypes
Invest Ophthalmol Vis Sci. 2026 Apr 1;67(4):32. doi: 10.1167/iovs.67.4.32. ABSTRACT PURPOSE: Uveal melanoma (UM), the most prevalent primary intraocular cancer in adults, is defined by salient histopathological diversity. Spindle and epithelioid cells constitute its two dominant pathological lineages, yet the latter foreshadows aggressive behavior and shortened survival. This study aimed to explore the molecular and […]
Quercetin improves retinal glycolysis to slow myopia progression through orchestrating the AKT/FOXO/HK2 axis
Redox Biol. 2026 Mar 31;93:104139. doi: 10.1016/j.redox.2026.104139. Online ahead of print. ABSTRACT OBJECTIVES: Myopia is a major global public health issue. The retina relies on glycolysis to maintain its normal physiological functions and is vulnerable to oxidative damage. However, the effects of altered glycolysis on myopia progression remain poorly understood. This study aimed to explore […]
Modulation of Iron-Induced Glucose Metabolic Reprogramming Alleviates Retinal Pigment Epithelial Cell Senescence
Invest Ophthalmol Vis Sci. 2026 Apr 1;67(4):30. doi: 10.1167/iovs.67.4.30. ABSTRACT PURPOSE: This study aimed to investigate whether iron overload induces retinal pigment epithelial (RPE) cell senescence through glucose metabolic reprogramming and to evaluate the therapeutic potential of targeting this metabolic pathway. METHODS: We utilized human-induced pluripotent stem cell-derived RPE cells and induced RPE cells, along […]
Dihydroartemisinin Induces Ferroptosis in Uveal Melanoma Cells Through the HO-1 and xCT/GPX4 Signaling Pathways
Int J Mol Sci. 2026 Mar 26;27(7):3027. doi: 10.3390/ijms27073027. ABSTRACT Uveal melanoma (UM) represents an uncommon intraocular malignancy with high aggressiveness. Dysregulation of ferroptosis has been associated with UM progression. Dihydroartemisinin (DHA), a natural derivative of Artemisia annua, exhibits potent antitumor activity with a favorable safety profile, yet its role in ferroptosis regulation in UM […]
Spleen Tyrosine Kinase (SYK) is Necessary for cGAS-STING Signaling in Müller Glia and Visual Function Deficits in Diabetic Mice
Glia. 2026 Jun;74(6):e70155. doi: 10.1002/glia.70155. ABSTRACT It is well established that inflammation contributes to the ocular complications caused by diabetes; however, the specific molecular events that drive diabetes-induced pro-inflammatory signaling in the retina remain to be fully elucidated. This study investigated the role of Müller glial spleen tyrosine kinase (SYK) in diabetes-induced retinal complications. Hyperglycemic […]
Chronic psychological stress disrupts liver homeostasis by dysregulating oxidative phosphorylation via the PI3K/AKT/FoxO3a axis
iScience. 2026 Mar 18;29(4):115389. doi: 10.1016/j.isci.2026.115389. eCollection 2026 Apr 17. ABSTRACT Epidemiological evidence indicates that chronic psychological stress correlates with the morbidity and mortality of chronic liver disease. However, the underlying mechanisms remain unclear. We established a chronic restraint stress (CRS) mouse model to simulate emotional stress. Histological and biochemical analyses showed marked hepatocyte vacuolization, […]
Multi-omics liquid biopsy identifies mitochondrial dysfunction in geographic atrophy and supports the longevity-associated metabolite alpha-ketoglutarate as a therapeutic strategy
medRxiv [Preprint]. 2026 Mar 19:2026.03.12.26347263. doi: 10.64898/2026.03.12.26347263. ABSTRACT BACKGROUND: Mitochondrial dysfunction is an emerging metabolic hallmark of age-related diseases, yet tools to directly profile mitochondrial pathways and test metabolic interventions in the living human eye remain limited. Multi-omics ocular liquid biopsy enables real-time proteomic and metabolomic profiling of the intraocular microenvironment, complementing systemic biomarkers and […]
The human cytomegalovirus vMIA protein inhibits apoptosis and innate immune signaling in human Mueller cells
Exp Eye Res. 2026 Apr 10:111009. doi: 10.1016/j.exer.2026.111009. Online ahead of print. ABSTRACT Human cytomegalovirus (HCMV) encodes the viral mitochondria-localized inhibitor of apoptosis (vMIA) protein which blocks host cell apoptosis. vMIA also inhibits innate immune signaling through the DNA sensing cGAS-STING pathway and the RNA sensing RLR pathway which interacts with the mitochondrial adapter protein […]