Endothelial mitochondrial-derived vesicles (EMDVs) with retinal targeted homing properties dynamically modulate the eIF2alpha-ATF4-CHOP signaling pathway and efficiently restore mitochondrial homeostasis in diabetic retina
J Nanobiotechnology. 2025 Dec 14. doi: 10.1186/s12951-025-03929-3. Online ahead of print. NO ABSTRACT PMID:41392137 | DOI:10.1186/s12951-025-03929-3
Melatonin alleviates atherosclerosis by inhibiting pro-inflammatory differentiation of macrophages via regulating Sirt3-Drp1 mediated mitochondrial fission
Int Immunopharmacol. 2025 Dec 12;169:116019. doi: 10.1016/j.intimp.2025.116019. Online ahead of print. ABSTRACT BACKGROUND: Pro-inflammatory macrophage function is linked to an increase in mitochondrial fission. Melatonin has a positive impact on atherosclerosis and has a significant effect on the control of mitochondrial fission and fusion. Nevertheless, it is still unclear how melatonin contributes to slowing the […]
Retinal Ganglion Cell Diversity in Disease: Clinical Implications and Type-Specific Evaluation
J Neuroophthalmol. 2025 Sep 1;45(3):350-361. doi: 10.1097/WNO.0000000000002381. ABSTRACT BACKGROUND: Retinal ganglion cells (RGCs) are diverse. Various types play specialized roles in vision, and they may be differentially susceptible in optic nerve disease where their death causes vision loss. RGCs are accordingly compelling targets for novel therapeutic strategies, and so it is clinically imperative to be […]
Targeting endothelial mitochondrial dynamics in glaucoma: A novel therapeutic opportunity
Mol Ther. 2025 Dec 10:S1525-0016(25)01022-6. doi: 10.1016/j.ymthe.2025.11.036. Online ahead of print. NO ABSTRACT PMID:41380675 | DOI:10.1016/j.ymthe.2025.11.036
Combination of YAP inhibition and photodynamic therapy induces dual DNA damage and activates STING pathway to enhance immunotherapy in uveal melanoma
Redox Biol. 2025 Dec 6;89:103965. doi: 10.1016/j.redox.2025.103965. Online ahead of print. ABSTRACT Uveal melanoma (UM) is the most common primary intraocular malignancy in adults and is highly aggressive, with no therapies shown to improve overall survival. Although immunotherapy achieves response rates of 33-40 % in advanced cutaneous melanoma, its efficacy in UM is disappointingly low, […]
Honokiol (HNK) accelerates corneal epithelial wound healing by promoting HMGCS2-mediated mitochondrial metabolic homeostasis
Exp Eye Res. 2025 Dec 9:110805. doi: 10.1016/j.exer.2025.110805. Online ahead of print. ABSTRACT Corneal epithelial regeneration is critical for restoring ocular surface function after injury. This study investigated the therapeutic potential and molecular mechanism of honokiol (HNK) in promoting corneal epithelial repair. Using a murine corneal epithelial debridement model, we observed that HNK accelerated wound […]
Autophagy and Mitophagy in Diabetic Retinopathy: The Effects and Mechanism of Action on the Neurovascular Unit
Exp Eye Res. 2025 Dec 9:110802. doi: 10.1016/j.exer.2025.110802. Online ahead of print. ABSTRACT While diabetic retinopathy (DR) is the primary cause of vision impairment and blindness in people with diabetes, current treatments fail to target early pathogenic mechanisms to halt disease progression. The development of DR involves complex cellular stress responses associated with metabolic dysregulation. […]
Dietary restriction-responsive genes define prognostic subtypes and predict metastasis in colorectal cancer
Transl Cancer Res. 2025 Nov 30;14(11):7790-7809. doi: 10.21037/tcr-2025-1329. Epub 2025 Nov 26. ABSTRACT BACKGROUND: Colorectal cancer (CRC) is a major cause of cancer-related death, with a poor prognosis often due to metastasis and recurrence. Dietary restriction (DR) is known to delay tumor progression and extend lifespan, but the roles of dietary restriction-responsive genes (DRRGs) in […]
Ocular Toxicity and Mechanistic Investigation for Berberine and Its Metabolite Berberrubine on Zebrafish
Molecules. 2025 Nov 30;30(23):4602. doi: 10.3390/molecules30234602. ABSTRACT Berberine (BBR) has seen growing application in ophthalmology, yet the ocular toxicity of BBR and its metabolites remains poorly understood. This study aimed to evaluate the ocular toxicity of BBR and its major metabolite M1 and unravel their underlying mechanisms. Ocular toxicity was evaluated in human corneal epithelial […]
Multi-Target Neuroprotective Effects of Flavonoid-Rich Ficus benjamina L. Leaf Extracts: Mitochondrial Modulation, Antioxidant Defense, and Retinal Ganglion Cell Survival In Vivo
Int J Mol Sci. 2025 Dec 4;26(23):11746. doi: 10.3390/ijms262311746. ABSTRACT Oxidative-stress-induced neuronal injury is a major contributor to neurodegenerative diseases, underscoring the need for novel neuroprotective strategies. Natural products with antioxidant and mitochondrial-stabilizing properties are increasingly recognized as promising multi-target therapeutics. Ficus benjamina L., a member of the Moraceae family, is rich in flavonoids and […]