Ethanol and Cyanide: A Case Report on Toxic and Nutritional Optic Neuropathy Associated With Alcohol and Tobacco
Cureus. 2025 Nov 17;17(11):e97067. doi: 10.7759/cureus.97067. eCollection 2025 Nov. ABSTRACT Tobacco-alcohol amblyopia, an acquired optic neuropathy, is now classified as toxic and nutritional optic neuropathy (TNON). A 40-year-old man presented with gradual, painless, symmetrical visual loss and central scotomas. Pupillary reactions were normal, with no relative afferent pupillary defect (RAPD), though colour vision was markedly […]
AKAP1 regulates mitochondrial and synaptic homeostasis to enable neuroprotection and repair in retinal ganglion cell degeneration
bioRxiv [Preprint]. 2025 Nov 27:2025.11.24.689866. doi: 10.1101/2025.11.24.689866. ABSTRACT Glaucoma is a leading cause of irreversible blindness, characterized by progressive retinal ganglion cell (RGC) loss and optic nerve degeneration. Mitochondrial dysfunction plays a central role in this neurodegeneration, yet effective targeted therapies remain limited. Here, we identify the mitochondrial scaffold A-kinase anchoring protein 1 (AKAP1) as […]
DCLRE1 downregulated by SYVN1-mediated ubiquitination and degradation, weakening mitochondrial homeostasis protection in ARC formation
Exp Eye Res. 2025 Dec 18:110811. doi: 10.1016/j.exer.2025.110811. Online ahead of print. ABSTRACT DNA oxidative damage of lens epithelium cells (LECs) has been proved to be significantly related to age-related cataract (ARC). DCLRE1A, as a member of the DNA interstrand cross-links pathway, can repair damaged DNA. However, DCLRE1A has not been addressed in maintaining mitochondrial […]
Transcriptome-wide isoform and promoter remodeling in DM1 fibroblasts uncovered by long-read RNA sequencing
Genomics. 2025 Dec 16:111175. doi: 10.1016/j.ygeno.2025.111175. Online ahead of print. ABSTRACT Myotonic dystrophy type 1 (DM1) is characterized by sequestration of RNA-binding proteins and widespread transcriptomic dysregulation, yet isoform-level transcriptomic landscapes remain incompletely defined. Here, we performed integrated long-read (PacBio Iso-Seq) and short-read (Illumina RNA-seq) profiling of primary fibroblasts from DM1 patients and healthy controls. […]
Short-term high-dose nicotinamide treatment across glaucoma subtypes reveals increased mtDNA content and minimal metabolomic change in blood
Exp Eye Res. 2025 Dec 16:110807. doi: 10.1016/j.exer.2025.110807. Online ahead of print. ABSTRACT In glaucoma, retinal ganglion cell degeneration has been linked to declining mitochondrial metabolic capacity. Nicotinamide (NAM) supplementation has emerged as a potential treatment for this. We assessed the effects of a 2-week NAM supplementation on blood buffy coat mitochondrial content (qPCR to […]
Ezetimibe attenuates diabetic retinopathy via NRF2-mediated suppression of inflammation and oxidative stress
J Diabetes Complications. 2025 Dec 13;40(2):109250. doi: 10.1016/j.jdiacomp.2025.109250. Online ahead of print. ABSTRACT BACKGROUND: Diabetic retinopathy (DR) is a leading cause of blindness in working-age adults, driven by chronic inflammation and oxidative stress. Ezetimibe (EZE), a lipid-lowering agent, has been shown to activate the NRF2 pathway, but its role in DR remains unexplored. Our study […]
Long-acting fenofibrate-loaded microparticles for treating retinal disorders
Int J Pharm. 2025 Dec 15:126503. doi: 10.1016/j.ijpharm.2025.126503. Online ahead of print. ABSTRACT Age-related macular degeneration (AMD) and Diabetic retinopathy (DR) are the most common forms of retinal disorders and are the leading causes of vision loss. Traditional treatments such as anti-VEGF therapies often require repeated intravitreal injections. Up to 40 % DR/AMD patients do […]
Association between serum carotenoid concentrations and risk of major age-related eye diseases among middle-aged and older adults
Front Med (Lausanne). 2025 Dec 1;12:1596799. doi: 10.3389/fmed.2025.1596799. eCollection 2025. ABSTRACT BACKGROUND: Age-related eye diseases are the main causes of progressive and irreversible vision loss in aging populations worldwide. Carotenoids, as a group of common natural antioxidants, can suppress free radicals produced by complex physiological reactions, thereby protecting the eyes from the effects of oxidative […]
Single Cell RNAseq Analysis of Thyroid Hormone Effects on Retinal Glial Cells
Aging Dis. 2025 Dec 15. doi: 10.14336/AD.2025.1221. Online ahead of print. ABSTRACT Thyroid hormone (TH) signaling regulates cellular metabolism and stress response in the retina. Increased TH levels in circulation are associated with a higher incidence of age-related macular degeneration. Furthermore, stimulation of TH signaling induces retinal degeneration in mice, which is accompanied by the […]
Full recovery of vision following early and intensive hemodialysis in an 18-year-old woman with methylmalonic acidemia-related optic neuropathy
Mol Genet Metab Rep. 2025 Nov 27;45:101279. doi: 10.1016/j.ymgmr.2025.101279. eCollection 2025 Dec. ABSTRACT BACKGROUND: Methylmalonic acidemia (MMA) caused by complete or partial deficiency of the mitochondrial enzyme methylmalonyl-CoA mutase (mut0 or mut- enzymatic subtype, respectively) leads to the accumulation of toxic organic acids, causing severe organ dysfunction and life-threatening complications. Despite appropriate treatment, optic neuropathy […]