Comparative mitogenomic and phylogenetic insights from four newly sequenced tick mitochondrial genomes
Front Vet Sci. 2026 Jan 22;12:1678349. doi: 10.3389/fvets.2025.1678349. eCollection 2025. ABSTRACT Ticks, recognized as the second most significant vector of pathogens after mosquitoes, are of considerable interest in medical research. Although mitochondrial genomes are commonly employed in the phylogenetic studies of insects and arthropods, investigations into tick mitochondrial genomes are relatively scarce. The evolutionary and […]
Microtubule dynamics in adult retinal ganglion cells and dorsal root ganglion neurons
Front Mol Neurosci. 2026 Jan 23;19:1739387. doi: 10.3389/fnmol.2026.1739387. eCollection 2026. ABSTRACT INTRODUCTION: While axon regeneration is very limited in the adult central nervous system (CNS) in vivo, this is not the case in the peripheral nervous system (PNS). Indeed, both CNS and PNS neurons can regenerate in vitro although to varying degrees. Given the role […]
Endothelial TET2 deficiency exacerbates diabetic coronary microvascular dysfunction via CMPK2-mediated mitochondrial impairment
Clin Sci (Lond). 2026 Feb 2:CS20256842. doi: 10.1042/CS20256842. Online ahead of print. ABSTRACT Coronary microvascular dysfunction (CMD) is prevalent in diabetes. Ten-Eleven Translocation-2 (TET2) as the major demethylase in endothelial cells (ECs) is decreased in diabetic CMD, and the role warrants further exploration. In this study, a multi-modality imaging, consist of transthoracic Doppler echocardiography and […]
Zinc peroxide-copper bimetallic nanozyme with self-activated ROS and cuproptosis for superficial antifungal therapy
J Nanobiotechnology. 2026 Feb 8. doi: 10.1186/s12951-026-04088-9. Online ahead of print. ABSTRACT Fungal infections, particularly intractable cases such as fungal keratitis (FK) and skin wound infections, remain a pressing global health challenge, further exacerbated by rising antifungal resistance and treatment-associated cytotoxicity. Herein, we report a highly effective, non-antibiotic therapeutic strategy integrating reactive oxygen species (ROS) […]
Securinine bolsters anti-tumor immunity by promoting CD8⁺ T cell activation
Cancer Treat Res Commun. 2026 Jan 30;47:101120. doi: 10.1016/j.ctarc.2026.101120. Online ahead of print. ABSTRACT Securinine (SEC) is a natural alkaloid isolated from Flueggea suffruticosa, which can suppress tumor growth of some types. T cells play a critical role in anti-tumor function. However, whether SEC mediates T cell-mediated anti-tumor effects remains unknown. Here, we found that […]
Integrative Proteogenomic Analysis Identifies Genetically Supported Plasma Proteins, Metabolites, and Pathways in Glaucoma
Invest Ophthalmol Vis Sci. 2026 Feb 2;67(2):21. doi: 10.1167/iovs.67.2.21. ABSTRACT PURPOSE: Glaucoma is a leading cause of irreversible blindness, yet the circulating proteins and metabolic pathways that causally contribute to different glaucoma subtypes remain poorly defined. METHODS: We analyzed baseline plasma proteomics in 1485 glaucoma cases (447 primary open‑angle glaucoma [POAG], 177 primary angle-closure glaucoma […]
Cell-intrinsic vulnerability and immune activation cooperate to drive degeneration in a mitochondrial complex I deficiency model of optic neuropathy
J Neuroinflammation. 2026 Feb 6. doi: 10.1186/s12974-026-03707-4. Online ahead of print. NO ABSTRACT PMID:41645183 | DOI:10.1186/s12974-026-03707-4
A systematic review on age-related macular degeneration: New insights from multi-omics studies
Surv Ophthalmol. 2026 Feb 3:S0039-6257(26)00016-0. doi: 10.1016/j.survophthal.2026.02.001. Online ahead of print. ABSTRACT Age-related macular degeneration (AMD) is a leading cause of blindness in developed countries and a growing global health concern. The multifactorial nature of AMD calls for integrative multi-omics approaches. We summarize studies employing multi-omics in AMD. A comprehensive search in PubMed and Scopus […]
Taurochenodeoxycholic Acid Activates Calcium Signaling to Protect Against Fuchs’ Endothelial Corneal Dystrophy
Invest Ophthalmol Vis Sci. 2026 Feb 2;67(2):16. doi: 10.1167/iovs.67.2.16. ABSTRACT PURPOSE: Fuchs’ endothelial corneal dystrophy (FECD) is the leading cause of corneal endothelial dystrophy. This study aimed to investigate the protective effects and mechanism of taurochenodeoxycholic acid (TCDCA) in FECD. METHODS: TCDCA levels were quantified in aqueous humor from patients with FECD and ultraviolet A […]
An Apparently Isolated Optic Neuropathy Associated with Biallelic Variants in SLC25A46 Gene Encoding the Mitochondrial Ugo1-Like Protein
Neuroophthalmology. 2025 Nov 3;50(1):96-100. doi: 10.1080/01658107.2025.2581675. eCollection 2026. ABSTRACT Biallelic pathogenic variants in the SLC25A46 gene are responsible for various neurological syndromes, including Charcot-Marie-Tooth disease type 6B, pontocerebellar hypoplasia type 1E, Leigh syndrome, progressive myoclonic ataxia and Parkinson’s disease, most of them being associated with optic atrophy. We here report the case of a 26-year-old […]