The N6-methyladenosine (m6A) reader YTHDF3 increases PINK1/Parkin-mediated mitophagy by facilitating prohibitin 2 (PHB2) translation to promote retinal ganglion cell damage in diabetic retinopathy
J Neuropathol Exp Neurol. 2026 Apr 23:nlag027. doi: 10.1093/jnen/nlag027. Online ahead of print. ABSTRACT Retinal ganglion cells (RGCs) are particularly vulnerable to damage during the early stages of diabetic retinopathy (DR). Emerging evidence indicates that dysregulated expression of N6-methyladenosine (m6A) methylation regulators contributes to DR pathogenesis. In particular, the m6A reader protein YTHDF3 has been […]
Exploring the mechanism of baicalein on choroid melanoma based on network pharmacology, transcriptomics and experimental verification
Front Pharmacol. 2026 Apr 8;17:1787798. doi: 10.3389/fphar.2026.1787798. eCollection 2026. ABSTRACT OBJECTIVE: Baicalein (BAI), a flavonoid from Scutellaria baicalensis, exhibits therapeutic potential across inflammation, viral infections, and cancers. Yet, its role in choroidal melanoma (CM), the most common intraocular malignancy, remains poorly understood. The aim of this study was to investigate BAI’s anti-CM effects and underlying […]
Nanobacterial detection in aqueous humor and its effect on postphacoemulsification visual acuity among highly myopic patients
Mol Vis. 2026 Feb 17;32:84-100. eCollection 2026. ABSTRACT This study aimed to investigate factors affecting visual outcomes after phacoemulsification in highly myopic patients with cataracts, based on the detection of nanobacteria (NB) in aqueous humor. Fifty highly myopic patients with cataracts who underwent phacoemulsification surgery at The First People’s Hospital of Ziyang from December 2022 […]
Efficacy of lenadogene nolparvovec gene therapy versus idebenone in Leber hereditary optic neuropathy due to the m.11778G>A MT-ND4 variant: two matching adjusted indirect comparisons
Br J Ophthalmol. 2026 Apr 22:bjo-2025-329206. doi: 10.1136/bjo-2025-329206. Online ahead of print. ABSTRACT BACKGROUND: Lenadogene nolparvovec is an intravitreal gene therapy for patients with Leber hereditary optic neuropathy (LHON) carrying the m.11778G>A MT-ND4 variant. Idebenone, a synthetic coenzyme Q10 analogue, is the only approved treatment for LHON. To estimate the relative effects of both treatments, […]
Amino Acid Metabolism in Retinal Diseases: Mechanisms, Diagnostics, and Therapeutic Opportunities
Exp Eye Res. 2026 Apr 20:111033. doi: 10.1016/j.exer.2026.111033. Online ahead of print. ABSTRACT Amino acid metabolism serves as a central hub linking retinal energy supply, neurotransmission, and cell signaling, which is critical for maintaining retinal structure and function. This review summarizes the molecular mechanisms by which abnormal amino acid metabolism contributes to retinal diseases. The […]
Molecular mechanisms of mitochondrial dysfunction mediated by the MAPK axis in diabetic cataract
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2026 Apr;42(4):316-324. ABSTRACT Objective To explore molecular mechanisms of mitochondrial dysfunction mediated by p38 mitogen-activated protein kinase (p38 MAPK) in diabetic cataract (DC). Methods Lens epithelial cells (LECs) from cell line SRA01/04 were divided into the following six treatment groups: blank group (Con), osmotic control […]
Branch retinal vein occlusion in Leber hereditary optic neuropathy with onset at age 50 years or older: frequency and clinical characteristics
Jpn J Ophthalmol. 2026 Apr 22. doi: 10.1007/s10384-026-01364-x. Online ahead of print. ABSTRACT PURPOSE: To describe branch retinal vein occlusion (BRVO) observed in patients with Leber hereditary optic neuropathy (LHON) with onset at age ≥50 years and to explore whether BRVO prevalence may be higher than age- and sex-matched general population estimates. STUDY DESIGN: Retrospective […]
Lipid stress evolved, microbiome-based probiotics reduce lipid uptake in mice
Bioeng Transl Med. 2026 Feb 1;11(2):e70122. doi: 10.1002/btm2.70122. eCollection 2026 Mar. ABSTRACT Controlling the molecular transport of nutrients through the gut is an attractive strategy to modulate host metabolism. Herein, a technique of stress-based evolution of an individual’s own microbiota to enhance lipid metabolism is presented, which is based on sequential culture of these bacteria […]
CIDEC impairs mitochondrial fitness and blocks protective autophagy via the inhibition of cGMP/PKG pathway to exert tumor-suppressive effects in breast cancer
Cell Oncol (Dordr). 2026 Apr 20;49(3):78. doi: 10.1007/s13402-026-01211-8. NO ABSTRACT PMID:42010152 | DOI:10.1007/s13402-026-01211-8
Submandibular gland oncocytoma: Imaging features and histopathological correlation of a rare benign salivary gland tumor
Radiol Case Rep. 2026 Apr 8;21(7):2680-2684. doi: 10.1016/j.radcr.2026.02.014. eCollection 2026 Jul. ABSTRACT Submandibular gland oncocytoma is a rare benign epithelial tumor accounting for less than 1% of all salivary gland neoplasms. It is composed of oncocytes-large polygonal epithelial cells with abundant eosinophilic granular cytoplasm resulting from mitochondrial accumulation-and typically affects adults between the fifth and […]