Omics in hereditary optic neuropathies:A systematic review of clinical studies with an integrated point of view
Surv Ophthalmol. 2026 Apr 28:S0039-6257(26)00059-7. doi: 10.1016/j.survophthal.2026.04.006. Online ahead of print. ABSTRACT Hereditary optic neuropathies are characterized by bilateral visual loss due to the degeneration of retinal ganglion cells, resulting in optic nerve degeneration and atrophy. Although the genetic origin of the main isolated and syndromic hereditary optic neuropathies have been characterized, the clinical phenotypes […]
Local inhibition of glaucomatous mitochondrial dysfunction using an engineered annular sector microneedle
Biomaterials. 2026 Apr 27;334:124252. doi: 10.1016/j.biomaterials.2026.124252. Online ahead of print. ABSTRACT Mitochondrial dysfunction plays a critical role in glaucomatous trabecular meshwork (TM) degeneration, whereas increasing intracellular nicotinamide adenine dinucleotide (NAD+) levels can restore mitochondrial homeostasis, offering therapeutic benefits for glaucoma. We propose that intracellular NAD+ can be boosted by promoting NAD+ biosynthesis through the co-delivery […]
Mitochondrial metabolic dysfunction drives PANoptosis in retinal pigment epithelium during fungal endophthalmitis: emerging roles of the MITF-FBXW7 axis
Front Immunol. 2026 Apr 13;17:1826337. doi: 10.3389/fimmu.2026.1826337. eCollection 2026. ABSTRACT Fungal endophthalmitis (FE), although less common than bacterial endophthalmitis, carries a disproportionately high risk of irreversible blindness. Clinical observations show that some patients continue to experience progressive visual loss even after successful microbiological clearance, suggesting that disease outcomes are strongly influenced by excessive host immune-inflammatory […]
Ten-year natural history of visual function in Japanese patients with Leber hereditary optic neuropathy: A retrospective cohort study
PLoS One. 2026 Apr 28;21(4):e0348093. doi: 10.1371/journal.pone.0348093. eCollection 2026. ABSTRACT Leber hereditary optic neuropathy (LHON) is a mitochondrial optic neuropathy that typically causes severe bilateral central vision loss. Although several natural-history studies have reported visual outcomes, long-term trajectories beyond 5 years remain incompletely quantified, particularly in Asian cohorts. We performed a single-center retrospective cohort study […]
Retinal Pigment Epithelium Ageing: Cellular and Molecular Mechanisms of Long-Term Homeostasis and Age-Related Dysfunction
Cells. 2026 Apr 19;15(8):725. doi: 10.3390/cells15080725. ABSTRACT The retinal pigment epithelium (RPE) is a long-lived, highly polarised epithelial monolayer that performs essential functions in retinal homeostasis, including outer blood-retina barrier maintenance, visual cycle activity, metabolic exchange, phagocytic clearance of photoreceptor outer segments, and regulation of oxidative and immune balance. Because RPE cells persist for decades […]
Intermittent fasting ameliorates diabetes-induced meibomian gland dysfunction in mice
Int J Ophthalmol. 2026 May 18;19(5):846-857. doi: 10.18240/ijo.2026.05.02. eCollection 2026. ABSTRACT AIM: To investigate the effect of intermittent fasting (IF) on diabetes-induced meibomian gland dysfunction (MGD) in a mice model. METHODS: The diabetic mice underwent an 8-week dietary intervention of ad libitum (AL) and IF diet. Meibomian gland (MG) proliferative potential, apoptosis, and ductal hyperkeratinization […]
Astrocytopathy in Wernicke Encephalopathy and Neuromyelitis Optica Spectrum Disorder. Pathogenic Differences With Occasional Clinical and Neuroimaging Overlap. A Review
Curr Neurol Neurosci Rep. 2026 Apr 25;26(1):27. doi: 10.1007/s11910-026-01497-z. ABSTRACT PURPOSE OF THE REVIEW: There is an increasing number of single case reports describing patients with findings compatible with thiamine deficiency, in whom rapid replacement of thiamine fails to induce improvement. Further work-up identifies positive aquaporin-4 antibodies (AQP-4) leading to a final diagnosis of neuromyelitis […]
The impact of near-infrared photobiomodulation therapy on human oocyte rescue in vitro maturation
J Photochem Photobiol B. 2026 Apr 21;279:113452. doi: 10.1016/j.jphotobiol.2026.113452. Online ahead of print. ABSTRACT This prospective study investigated the effects of photobiomodulation therapy (PBMT) at 810 nm on rescue in vitro maturation (rescue-IVM) of human immature oocytes following controlled ovarian stimulation (COS). A total of 260 immature oocytes (germinal vesicles (GV): 143; metaphase I (MI): […]
Nr2e3-Deficient Mice Show Evidence for Elevated Photoreceptor Bioenergetics and Retinal Visual Cycle Activity Based on OCT Metabolic Biomarkers
Invest Ophthalmol Vis Sci. 2026 Apr 1;67(4):57. doi: 10.1167/iovs.67.4.57. ABSTRACT PURPOSE: Ex vivo studies show that photoreceptors of Nr2e3-deficient (rd7) mice display (1) cone-like juxtanuclear mitochondria suggesting higher bioenergetics than in wild-type (WT) mice, and (2) reliance on a cone-only “retinal” visual cycle-two hypotheses examined in vivo herein. METHODS: We measured two optical coherence tomography […]
TARGETING DRP1 ATTENUATES FERROPTOSIS AND DELAYS THE PROGRESSION OF DIABETIC RETINOPATHY
Exp Eye Res. 2026 Apr 21:111035. doi: 10.1016/j.exer.2026.111035. Online ahead of print. ABSTRACT Diabetic retinopathy (DR), the leading cause of blindness among working-age adults, is driven by largely undefined modes of retinal microvascular cell death. We asked whether the mitochondrial fission GTPase dynamin-related protein 1 (DRP1) governs ferroptotic injury in this setting. In cultured human […]