Sensing of DNA double-strand breaks by the NHEJ system stabilizes RORγt transcriptional activity and shapes Th17 pathogenicity in autoimmunity
Cell Res. 2026 Jan 7. doi: 10.1038/s41422-025-01204-6. Online ahead of print. ABSTRACT Robust mitochondrial ROS production induces extensive double-strand breaks (DSBs) in telomeric DNA of effector T cells, where the DNA repair machinery is rapidly hyper-evoked to sense and ligate DSBs during the respiratory burst. However, whether effector T cells can exploit the DNA repair […]
The Mitochondrial Protective Mechanisms Mediated by SGLT2i: From Molecular Basis to Clinical Implications
Xenobiotica. 2026 Jan 6:1-31. doi: 10.1080/00498254.2026.2613138. Online ahead of print. ABSTRACT 1. BACKGROUND: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are a novel class of oral hypoglycemic agents that selectively inhibit glucose reabsorption in the renal proximal tubules, thereby promoting urinary glucose excretion and reducing blood glucose levels. In recent years, accumulating evidence from large-scale clinical trials […]
A novel biomimetic nanozyme orchestrates ulcerative colitis resolution by targeting KEAP1-NRF2-ARE pathway: Redox balance restoration, colonic barrier repair, immune homeostasis regulation
Mater Today Bio. 2025 Dec 6;36:102627. doi: 10.1016/j.mtbio.2025.102627. eCollection 2026 Feb. ABSTRACT Ulcerative colitis (UC) leads to systemic complications with excessive oxidative stress, colonic barrier damage, and inflammation. Deuterohemin-AlaHisThrValGluLys (DhHP-6) is the biomimetic nanozyme rationally designed to mimic the peroxidase activity of Microperoxidase-11. It exhibits potent antioxidant properties, which might emerge as a promising therapeutic […]
cGAS knockout inhibited endotoxin-induced uveitis in mice
Genes Dis. 2025 Jul 29;13(2):101786. doi: 10.1016/j.gendis.2025.101786. eCollection 2026 Mar. ABSTRACT Our research focused on the impact of the cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) pathway on retinal inflammation and employed an endotoxin-induced uveitis (EIU) model. EIU was provoked in mice through the intravitreal administration of lipopolysaccharide. Transcriptome analysis was performed […]
Oxidative Stress in Glaucomatous Retinal Ganglion Cell Injury: Mechanisms and Neuroprotective Strategies
Exp Eye Res. 2026 Jan 2:110837. doi: 10.1016/j.exer.2025.110837. Online ahead of print. ABSTRACT Glaucoma is one of the major causes of irreversible blindness worldwide. The disease is characterized by the progressive loss of retinal ganglion cells (RGCs), and recent evidence supports a key role for oxidative stress in the pathogenesis. In this review, we systematically […]
A superoxide anion-responsive persulfide prodrug for remedying dry eye disease
J Control Release. 2026 Jan 2:114600. doi: 10.1016/j.jconrel.2026.114600. Online ahead of print. ABSTRACT Dry eye disease (DED) is a prevalent ocular surface disorder in which current therapies fail to achieve complete symptomatic relief. Given the pivotal role of excessive reactive oxygen species (ROS) in the vicious cycle of DED, effective strategies for ROS elimination remain […]
Atypical clinical and MRI features in Leber hereditary optic neuropathy: a case series of four patients
Neurol Sci. 2026 Jan 2;47(1):82. doi: 10.1007/s10072-025-08645-2. ABSTRACT BACKGROUND: Leber’s hereditary optic neuropathy (LHON) is a mitochondrial disorder typically presenting with subacute, painless, bilateral vision loss in young individuals. While often recognizable, atypical presentations can complicate diagnosis. Notably, optic nerve lesions on MRI are uncommon in LHON and are typically associated with inflammatory optic neuropathies, […]
Identification of prognostic genes associated with mitochondria and macrophage polarization in prostate adenocarcinoma based on transcriptome and Mendelian randomization analysis
Discov Oncol. 2025 Dec 31. doi: 10.1007/s12672-025-03858-5. Online ahead of print. ABSTRACT BACKGROUND: Prostate adenocarcinoma (PRAD) is a common malignancy in the male genitourinary system, with growing evidence linking its progression to mitochondrial function and macrophage polarization. This study identifies prognostic genes associated with these factors in PRAD through integrated transcriptomic data analysis and Mendelian […]
Comment on: “Identification of macrophage polarisation and mitochondrial-related biomarkers in diabetic retinopathy”
J Transl Med. 2025 Dec 30;23(1):1435. doi: 10.1186/s12967-025-07457-4. NO ABSTRACT PMID:41469915 | DOI:10.1186/s12967-025-07457-4
Thalidomide Synergistically Regulates Cell Cycle and Endoplasmic Reticulum Stress to Alleviate RPE Oxidative Damage Through the E2F2-FBXO5 Pathway
FASEB J. 2026 Jan 15;40(1):e71387. doi: 10.1096/fj.202502444R. ABSTRACT Thalidomide, a glutamate derivative with teratogenicity, possesses anti-inflammatory, immunomodulatory, and anti-angiogenic properties that enable its use in treating refractory diseases unresponsive to conventional therapies. Dry age-related macular degeneration (AMD), characterized by retinal pigment epithelium (RPE) degeneration and lacking effective therapies, represents a significant unmet medical need. Our […]