Quercetin Enhances Topotecan Cytotoxicity in Retinoblastoma Cells Through ROS-Associated Stress and Apoptotic Signaling
Biomolecules. 2026 Apr 17;16(4):597. doi: 10.3390/biom16040597. ABSTRACT Quercetin, a naturally occurring flavonoid, exhibits antiproliferative and pro-apoptotic effects across various cancer models. Topotecan, a topoisomerase I inhibitor, is used in the treatment of retinoblastoma; however, its clinical utility is limited by dose-dependent toxicity. This study aimed to investigate whether quercetin is associated with enhanced topotecan-induced cytotoxicity […]
From Genetic Diagnosis to Therapeutic Implementation in Retinal Diseases: Translational Advances and Persistent Bottlenecks
Biomedicines. 2026 Mar 30;14(4):782. doi: 10.3390/biomedicines14040782. ABSTRACT Background: Retinal and optic nerve disorders are a leading cause of irreversible visual impairment worldwide. Advances in molecular genetics-including next-generation sequencing, genome-wide association studies, and gene-based therapeutic technologies-have reshaped understanding of both inherited and complex retinal diseases. However, translating genetic discovery into sustained clinical benefit remains biologically and […]
Cellular Senescence of Lens Epithelial Cells and Age-Related Cataract: A Systematic Review
Bioengineering (Basel). 2026 Apr 7;13(4):433. doi: 10.3390/bioengineering13040433. ABSTRACT Recent evidence links lens epithelial cell (LEC) dysfunction and cellular senescence-an irreversible cell cycle arrest with a pro-inflammatory secretory phenotype-to age-related cataract (ARC) progression. This systematic review synthesizes current knowledge on LEC senescence, its molecular features, and laboratory methods for senescence assessment in the ARC. Following PRISMA […]
Review of Therapeutic Potential of Coenzyme Q10 in Ophthalmology: Focus on Age-Related Macular Degeneration, Glaucoma, and Retinitis Pigmentosa
Antioxidants (Basel). 2026 Apr 19;15(4):506. doi: 10.3390/antiox15040506. ABSTRACT Coenzyme Q10 (CoQ10), a natural antioxidant produced by the human body, has strong anti-inflammatory properties, reduces oxidative stress, and improves mitochondrial function. It is also known for its strong neuroprotective effects. With age, endogenously produced CoQ10 levels decline, contributing to the development of chronic diseases, including eye […]
Protective Role of Adenosine Triphosphate Against Tamoxifen-Induced Retinal Toxicity in a Rat Model
Medicina (Kaunas). 2026 Apr 19;62(4):787. doi: 10.3390/medicina62040787. ABSTRACT Background and Objectives: Tamoxifen, a cornerstone selective estrogen receptor modulator in breast cancer therapy, is increasingly recognized to be associated with retinal toxicity characterized by mitochondrial dysfunction, oxidative stress, lipid peroxidation, and oxidative DNA injury. By targeting mitochondrial bioenergetic dysfunction and redox disequilibrium, adenosine triphosphate (ATP) emerges […]
Synergistic Anticancer Effects of Resveratrol and Carboplatin in Y79 Retinoblastoma Cells: Mechanistic Insights into Apoptosis, G2/M Arrest, and ROS-Dependent Mitochondrial Dysfunction
Int J Mol Sci. 2026 Apr 13;27(8):3473. doi: 10.3390/ijms27083473. ABSTRACT This study aimed to investigate the effects of resveratrol (RES) and carboplatin (CPT), alone and in combination, on cell viability, apoptosis, cell cycle progression, mitochondrial function, and oxidative stress in Y79 retinoblastoma (RB) cells. Particular emphasis was placed on evaluating the synergistic potential of the […]
A Viscous DES-AAV-Foxo1 Delivery System With High Transfection Efficiency for the Treatment of Corneal Endothelial Dysfunction by Restoring Mitochondria-ER Contacts
Adv Sci (Weinh). 2026 May 3:e75464. doi: 10.1002/advs.75464. Online ahead of print. ABSTRACT Corneal endothelial dysfunction is a major cause of global blindness, with an estimated 12.7 million patients awaiting corneal transplantation, and the severe shortage of donor grafts underscores the urgent need for non-surgical therapies. Gene therapy offers a promising alternative, but is hindered […]
Acarbose modulates microglial Pkm2 acetylation to reshape immunometabolism and preserve retinal neurons after ischemia-reperfusion
J Neuroinflammation. 2026 May 2. doi: 10.1186/s12974-026-03838-8. Online ahead of print. ABSTRACT Retinal ischemia-reperfusion (IR) elicits microglia-driven neuroinflammation and mitochondrial failure that led to retinal ganglion cell (RGCs) loss, yet effective disease-modifying therapies remain limited. Acarbose (ACA), an α-glucosidase inhibitor widely used for diabetes, has recently been recognized for its dual regulatory potential on immune […]
METTL14 Ameliorates Mitochondrial Dysfunction and Autophagy in Lens Epithelial Cells of Diabetic Cataracts via m6A Modification of RPL3
Kaohsiung J Med Sci. 2026 May 1:e70194. doi: 10.1002/kjm2.70194. Online ahead of print. ABSTRACT Diabetic cataracts are a leading cause of blindness, with lens epithelial cells (LECs) exhibiting mitochondrial dysfunction and autophagy inhibition under high glucose (HG) conditions. Methyltransferase-like 14 (METTL14), an RNA methyltransferase, regulates N6-methyladenosine (m6A) RNA modification; however, its role in modulating mitochondrial […]
Redox imbalance dictates dependence on GOT1 versus GOT2 for rod photoreceptor health during aging and stress
bioRxiv [Preprint]. 2026 Apr 7:2026.04.05.716322. doi: 10.64898/2026.04.05.716322. ABSTRACT Photoreceptor (PR) loss causes vision loss in many blinding diseases, and effective therapies to prevent this cell loss are lacking. Aspartate aminotransferases (GOTs), located in the cytosol (GOT1) and mitochondria (GOT2), are key components of the malate-aspartate shuttle, which transfers reducing equivalents from cytosol to mitochondria. Previous […]