Transcriptomic Profiling of the Human Retina Reveals Inflammatory and Metabolic Signatures Associated With Clinical Severity After Retinal Detachment
Invest Ophthalmol Vis Sci. 2026 May 1;67(5):44. doi: 10.1167/iovs.67.5.44. ABSTRACT PURPOSE: Retinal detachment (RD) remains an ophthalmologic emergency with high anatomical success rates after surgery but often suboptimal visual outcomes. This study aimed to identify transcriptomic signatures linked with clinical severity in human RD to uncover the molecular basis of variability in functional recovery. METHODS: […]
Crosstalk between endoplasmic reticulum stress and mitochondrial homeostasis: A new perspective on ophthalmic disease treatment
J Cell Commun Signal. 2026 May 16;20:e70080. doi: 10.1002/ccs3.70080. eCollection 2026 Jun. ABSTRACT Endoplasmic reticulum (ER) stress and mitochondrial dysfunction are hallmarks of many ophthalmic diseases; however, they have traditionally been examined as isolated pathological processes. Recent evidence indicates that these organelles are inextricably coupled through mitochondria-endoplasmic reticulum contact sites, also known as mitochondria-associated membranes […]
Pharmacological restoration of impaired autophagy in retinal ganglion cells prevents abnormal mitochondrial accumulation and glaucomatous neurodegeneration
Mol Neurodegener. 2026 May 16. doi: 10.1186/s13024-026-00950-4. Online ahead of print. ABSTRACT BACKGROUND: Progressive loss of retinal ganglion cells (RGCs) and degeneration of optic nerve (ON) axons are the key pathological hallmarks of glaucoma, the leading cause of irreversible blindness. Elevated intraocular pressure (IOP), primarily due to dysfunction of the trabecular meshwork (TM), remains the […]
Anesthesia-Related Neurologic Risk in Patients of Venezuelan Descent: Implications for Ophthalmology
Am J Ophthalmol. 2026 May 15:S0002-9394(26)00237-0. doi: 10.1016/j.ajo.2026.05.004. Online ahead of print. ABSTRACT PURPOSE: To alert ophthalmologists to an emerging pattern of catastrophic neurologic injury following general anesthesia in patients of maternal Venezuelan descent, to describe the proposed genetic mechanism, and to provide practical guidance for ophthalmologists regarding this high-risk population. DESIGN: Perspective SUBJECTS: Patients […]
Long-term safety and efficacy of triheptanoin in Korean patients with long-chain fatty acid oxidation disorders: a prospective, open-label, single-center, phase II clinical study
BMC Med Genomics. 2026 May 16. doi: 10.1186/s12920-026-02390-x. Online ahead of print. ABSTRACT BACKGROUND: Long-chain fatty acid oxidation disorders (LC-FAOD) are inherited metabolic conditions caused by impaired mitochondrial β-oxidation of long-chain fatty acids, leading to rhabdomyolysis, cardiomyopathy, and hypoglycemia. Triheptanoin, a medium odd-chain triglyceride, provides anaplerotic substrates that replenish tricarboxylic acid cycle intermediates, offering alternative […]
A Theoretical Model for the Influence of Age, Race and Ethnicity on Retinal Mitochondria Dysfunction
J Theor Biol. 2026 May 14:112502. doi: 10.1016/j.jtbi.2026.112502. Online ahead of print. ABSTRACT Glaucoma is a group of diseases characterized by a degeneration of retinal ganglion cells (RGC) and is the second major cause of blindness worldwide. RGC vulnerability is thought to be the result of the interaction among mechanical, vascular, metabolic and neurodegenerative processes […]
Atomoxetine Hydrochloride impairs human sperm quality and function via disruption of calcium homeostasis and PKC signaling: A combined network pharmacology and in vitro study
Reprod Toxicol. 2026 May 14:109263. doi: 10.1016/j.reprotox.2026.109263. Online ahead of print. ABSTRACT Atomoxetine Hydrochloride (ATX) is a widely prescribed first-line pharmacotherapy for adult attention deficit hyperactivity disorder (ADHD). Despite its chronic use among men of reproductive age, the potential impact of ATX on male fertility remains largely unknown. This study aimed to elucidate the toxicological […]
KEAP1-mediated mitochondrial remodeling on stiffness-graded collagen substrates drives hepatocellular carcinoma adaptation
Biomaterials. 2026 May 12;334:124302. doi: 10.1016/j.biomaterials.2026.124302. Online ahead of print. ABSTRACT Mechanical and structural cues of the extracellular matrix (ECM) regulate tumor cell metabolism and drug response, yet the molecular mediators that link these biophysical signals are unclear. We present an elastically supported surface platform bioengineered with varying stiffness and collagen fiber anisotropy to replicate […]
Single-Cell Sequencing Analysis Reveals Dysregulated Energy Metabolism and Altered Synaptic Connectivity in the Mouse Retina Following Dark Rearing
Invest Ophthalmol Vis Sci. 2026 May 1;67(5):35. doi: 10.1167/iovs.67.5.35. ABSTRACT PURPOSE: In this study, single-cell RNA sequencing (scRNA-seq) was applied to retinas from dark-reared and normally reared mice to resolve how each cell type contributes to retinal alterations under visual deprivation. METHODS: C57BL/6J mice were reared in complete darkness from birth to postnatal day 36 […]
Disrupting VE-cadherin Y685 phosphorylation inhibits development of experimental diabetic and prediabetic retinopathy
J Clin Invest. 2026 May 15;136(10):e195048. doi: 10.1172/JCI195048. eCollection 2026 May 15. ABSTRACT Diabetic retinopathy involves early retinal vascular barrier breakdown and pericyte loss, yet the initiating molecular events remain poorly defined. Vascular endothelial cadherin (VE-cadherin), a key regulator of endothelial integrity, is notably reduced in diabetic and prediabetic nucleoside diphosphate kinase B-deficient (NDPKB-deficient) mouse […]