Environmental Stress-Induced Mitochondrial Metabolic Reprogramming as a Central Driver of Endocrine Dysfunction: A Food and Chemical Toxicology Perspective
Food Chem Toxicol. 2026 May 13:116154. doi: 10.1016/j.fct.2026.116154. Online ahead of print. ABSTRACT Dietary and environmental chemical exposures including food contact materials, pesticide residues, heavy metals, mycotoxins, and synthetic food additives are increasingly recognized as contributors to endocrine and metabolic disease via mitochondrial mechanisms not captured by classical receptor-based screening. Mitochondria function as central integrators […]
Maternal-Derived Polystyrene Nanoplastics Impair Early Retinal Development in Zebrafish (Danio rerio)
ACS Nano. 2026 May 14. doi: 10.1021/acsnano.6c00114. Online ahead of print. ABSTRACT The ubiquitous presence of nanoplastics (NPs) has drawn widespread attention for their accumulation in reproductive tissues, posing latent threats to the delicate retina. Nevertheless, the transgenerational effects of maternally transferred NPs on embryonic retinal morphogenesis and functional development remain largely uncharacterized. Here, we […]
Reply To: Comments on “Age-Associated Differences in Optic Disc Findings of Leber’s Hereditary Optic Neuropathy”
Neuroophthalmology. 2026 Mar 9;50(3):294-295. doi: 10.1080/01658107.2026.2642123. eCollection 2026. NO ABSTRACT PMID:42131162 | PMC:PMC13166215 | DOI:10.1080/01658107.2026.2642123
Gene Therapy for Leber Hereditary Optic Neuropathy (LHON): A Systematic Review and Meta-Analysis
Neuroophthalmology. 2026 Feb 17;50(3):215-221. doi: 10.1080/01658107.2026.2624440. eCollection 2026. ABSTRACT BACKGROUND: LHON is a rare mitochondrial disease causing bilateral vision loss, most commonly due to the m.11778G>A mutation. rAAV2/2-ND4 gene therapy is a potential disease-modifying treatment. METHODS: Systematic review and meta-analysis of three RCTs (RESCUE, REVERSE, REFLECT) including 175 patients. RESULTS: Gene therapy significantly improved best-corrected […]
An X-linked long non-coding RNA, PTCHD1-AS, and the core features of autism
Nature. 2026 May 13. doi: 10.1038/s41586-026-10515-6. Online ahead of print. ABSTRACT There are around 100 genes or copy-number variations used in genetic testing for autism spectrum disorder (ASD)1,2. The established genes are protein coding, and the associated phenotypes usually extend beyond sociobehavioural traits seen in autism, including cognitive/medical complexities and attention deficit hyperactivity disorder (ADHD)3,4. […]
Strabismus as a primary presentation of combined OXPHOS deficiency: a case of GTPBP3 mutations
Strabismus. 2026 Jun;34(2):234-237. doi: 10.1080/09273972.2025.2571777. Epub 2026 May 13. NO ABSTRACT PMID:42126113 | DOI:10.1080/09273972.2025.2571777
Targeting Neuroinflammation and Oxidative Stress to Slow Neurodegeneration in the Visual System
J Clin Med. 2026 Apr 24;15(9):3254. doi: 10.3390/jcm15093254. ABSTRACT PURPOSE: Neuroinflammation and oxidative stress are increasingly recognized as central, interconnected drivers of neurodegeneration in the visual system. This review examines the pathogenic mechanisms shared across glaucoma, age-related macular degeneration (AMD), diabetic retinopathy (DR), and Alzheimer’s disease (AD), and evaluates the therapeutic rationale for targeting both […]
Therapeutic Effects of Glycyrrhizic Acid on Dry Eye Disease: Targeting Pyroptosis, Oxidative Stress, and Epithelial Barrier Dysfunction
Int J Mol Sci. 2026 May 6;27(9):4153. doi: 10.3390/ijms27094153. ABSTRACT Dry eye disease (DED) is a common ocular surface disorder characterized by instability of the tear film, inflammatory responses, and epithelial damage, and therapeutic interventions directed at these fundamental pathogenetic processes are still insufficient. This research aimed to evaluate the medicinal efficacy of glycyrrhizic acid […]
Emerin is necessary for microtubule-organizing center translocation to the nuclear envelope of muscle cells
Cell Death Dis. 2026 May 12. doi: 10.1038/s41419-026-08819-6. Online ahead of print. ABSTRACT During myogenic differentiation, the Microtubule-Organizing Center (MTOC) is relocated to the nuclear envelope by a molecular platform including Linker of Nucleoskeleton and Cytoskeleton (LINC) complex proteins, A Kinase Anchoring Proteins (AKAP9 and AKAP6) and Pericentriolar Material 1 (PCM-1). Here, we show that […]
Metformin Attenuates Ciliary Muscle Aging by Downregulating GSK-3β to Modulate Cell-Cycle Progression and Autophagy
FASEB J. 2026 May 31;40(10):e71835. doi: 10.1096/fj.202600364R. ABSTRACT Presbyopia is linked to age-related decline in ciliary muscle (CM) function, yet pharmacologic strategies that target CM senescence remain limited. We investigated whether metformin (MET) mitigates CM aging in guinea pigs and explored the underlying mechanism. A D-galactose-induced CM aging model was established in vivo in guinea […]