Metabolic Alterations Induced by a Seizure-Causing Sodium Channel Mutation and their Partial Normalization by Dietary α-Linolenic Acid in Drosophila
Neurochem Res. 2026 Jan 20;51(1):51. doi: 10.1007/s11064-026-04673-2. ABSTRACT Epilepsy is increasingly recognized as a disorder with prominent metabolic disturbances, but how defined epilepsy-causing mutations reshape metabolism under controlled genetic and environmental conditions remains poorly understood. Here, we used the Drosophila melanogaster gain-of-function voltage-gated sodium channel (VGSC) mutant paraShu, a well-established model of neuronal and behavioral […]
Resveratrol alleviated diabetic retinal neuronal ferroptosis induced by high glucose through inhibiting HIF-1α and HMOX1 pathway
Exp Eye Res. 2026 Jan 17:110872. doi: 10.1016/j.exer.2026.110872. Online ahead of print. ABSTRACT Diabetic retinopathy (DR) is a common complication of diabetes mellitus that can cause blindness and affect the life quality of patients. Diabetic retinal neurodegeneration (DRN) caused by high glucose might be the earlier pathological change preceding vascular injury. Resveratrol has been showed […]
Targeting MFF succinylation: a novel therapeutic strategy for premature ovarian insufficiency by restoring mitochondrial dynamics in granulosa cells
J Ovarian Res. 2026 Jan 19. doi: 10.1186/s13048-026-01964-8. Online ahead of print. ABSTRACT Premature ovarian insufficiency (POI) is a significant clinical disorder characterized by the loss of ovarian function before the age of 40, and its global prevalence is rising. The development of effective therapies is hindered by an incomplete understanding of its pathogenesis. Growing […]
Baicalin attenuates HIF-1α-driven histone lactylation and neutrophil extracellular trap (NET) formation in autoimmune uveitis
Int J Biol Macromol. 2026 Jan 14:150264. doi: 10.1016/j.ijbiomac.2026.150264. Online ahead of print. ABSTRACT Uveitis is a group of vision-threatening intraocular inflammatory disorders that can affect the uveal tract, retina, optic nerve, and vitreous, leading to irreversible structural damage and vision loss. Neutrophil extracellular trap (NET) formation is a key driver of acute uveitis (AU) […]
Molecular underpinnings of induced degenerative heterogeneity in the retinal pigment epithelium
Proc Natl Acad Sci U S A. 2026 Jan 20;123(3):e2505412123. doi: 10.1073/pnas.2505412123. Epub 2026 Jan 16. ABSTRACT Cigarette smoking induces epigenetic changes that can cause degenerative heterogeneity with aging and disease. In disease such as age-related macular degeneration (AMD), the leading worldwide cause of blindness among the elderly, retinal pigment epithelial (RPE) cell heterogeneity is […]
Oxidative stress in diabetic retinopathy: Metabolic triggers, molecular pathways and emerging antioxidant therapies
Int J Biol Macromol. 2026 Jan 13:150272. doi: 10.1016/j.ijbiomac.2026.150272. Online ahead of print. ABSTRACT Diabetic retinopathy (DR) is a leading cause of blindness among adults worldwide, with hyperglycemia-induced oxidative stress lies at the core of its pathogenesis. This review synthesises evidence showing that elevated glucose, hypoxia and pro-inflammatory mediators act synergistically to impair the mitochondrial […]
Glutaredoxin 2 Protects Lens Epithelial Cells From Ferroptosis by Preventing HNRNPA2B1 S-Glutathionylation in Diabetes-Mediated Cataractogenesis
Invest Ophthalmol Vis Sci. 2025 Dec 1;66(15):58. doi: 10.1167/iovs.66.15.58. ABSTRACT PURPOSE: The purpose of this study was to investigate the role of glutaredoxin 2 (Grx2) in regulating ferroptosis under oxidative stress conditions induced by high glucose in lens epithelial cells (LECs) and its potential contribution to diabetes-mediated cataractogenesis. METHODS: Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was […]
Retinal Neurovascular and Mitochondrial Function Signatures in Response to a 24-Week Yoga Intervention in Healthy Adults
Invest Ophthalmol Vis Sci. 2025 Dec 1;66(15):62. doi: 10.1167/iovs.66.15.62. ABSTRACT PURPOSE: To evaluate changes in retinal neurovascular and mitochondrial function after a 24-week yoga intervention in healthy older adults. METHODS: Thirty participants (mean age 72 ± 6 years; 25 females, 5 males) were randomized to either a cue-based yoga program (n = 15) or traditional […]
Tumor-intrinsic redox programming drives an SPP1-CD44 axis of immune suppression in uveal melanoma
Redox Biol. 2026 Jan 6;90:104011. doi: 10.1016/j.redox.2026.104011. Online ahead of print. ABSTRACT Uveal melanoma (UM) is a rare yet aggressive malignancy with a high propensity for distant metastasis and poor response to systemic therapies, including immunotherapies. Although recent single-cell studies have uncovered pronounced intratumoral heterogeneity and an immunosuppressive tumor microenvironment, the tumor-intrinsic metabolic programs that […]
ercc6 deficient zebrafish exhibit UV and metronidazole sensitivity, increased oxygen consumption, and impaired hair cell mechanoelectrical transduction which can be restored by the superoxide dismutase mimetic MnTBAP
Hum Mol Genet. 2026 Jan 13:ddaf203. doi: 10.1093/hmg/ddaf203. Online ahead of print. ABSTRACT Cockayne Syndrome is an ultra-rare premature aging condition associated with UV sensitivity, neurocognitive decline, retinopathy, metronidazole-induced lethality, and sensorineural hearing loss. In 70% of affected patients, bi-allelic pathogenic variants in ERCC6 are identified. Although the role of ERCC6 in DNA damage repair […]