Mitochondrial complex I activity promotes antigen cross-presentation in dendritic cells
Sci Immunol. 2026 May 29;11(119):eaef0098. doi: 10.1126/sciimmunol.aef0098. Epub 2026 May 22. ABSTRACT Mitochondrial metabolism modulates immune cell signaling, yet how individual electron transport chain complexes fine-tune dendritic cell (DC) function remains unclear. Here, we identify mitochondrial complex I (CI) as a critical metabolic checkpoint controlling antigen cross-presentation by DCs in mice. Deficiency of the CI […]
Blue Light Induces Retinal Ganglion Cell Damage by Stimulating Drp1-Dependent Mitochondrial Fission and Activating NF-kappaB/NOX4 Axis
Invest Ophthalmol Vis Sci. 2026 May 1;67(5):62. doi: 10.1167/iovs.67.5.62. ABSTRACT PURPOSE: This study aimed to investigate the mechanisms of blue light-induced neurotoxicity in retinal ganglion cells (RGCs), focusing on the roles of mitochondrial dynamics and oxidative stress. METHODS: The impact of blue light exposure was assessed in vitro and in vivo. Key molecular changes were […]
Targeting metabolic dysregulation in postmenopausal breast cancer: Synergistic effects of nutrition-based interventions and exercise on molecular and cellular pathways
Cancer Cell Int. 2026 May 21. doi: 10.1186/s12935-026-04321-3. Online ahead of print. ABSTRACT Postmenopausal females diagnosed with breast cancer who are undergoing aromatase inhibitor (AI) therapy often exhibit metabolic disturbances, which may manifest as insulin resistance, dyslipidemia, increased adiposity, and an elevated risk of cardiovascular events. Such metabolic disruptions have the potential to undermine the […]
Mechanosensitive ion channel TRPV4 inhibition alleviates glaucomatous inflammation by regulating microglial ferroptosis
Int Immunopharmacol. 2026 May 20;183:116863. doi: 10.1016/j.intimp.2026.116863. Online ahead of print. ABSTRACT Glaucoma is a neurodegenerative disease characterized by the progressive and irreversible loss of retinal ganglion cells (RGCs). Elevated intraocular pressure (IOP) is a key factor in initiating pathological processes in acute glaucoma. This study aims to investigate the role of TRPV4 in mediating […]
SERAC1 Deficiency
2014 Apr 17 [updated 2026 May 21]. In: Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2026. ABSTRACT CLINICAL CHARACTERISTICS: The phenotypic spectrum of SERAC1 deficiency comprises infantile, severe MEGD(H)EL syndrome (3-methylglutaconic aciduria with deafness-dystonia, [hepatopathy], encephalopathy, and Leigh-like syndrome), juvenile-onset complicated […]
Myeloid Cell Protein Tyrosine Phosphatase 1B Drives Retinal Neurodegeneration in Diabetic Mice
Diabetes. 2026 May 21:db250904. doi: 10.2337/db25-0904. Online ahead of print. ABSTRACT Diabetic retinopathy (DR) is the leading cause of vision loss in the working-age population, with public health economic implications worldwide. Systemic inflammation and leukocyte activation are early events in diabetes, whereas microglial activation, neuroinflammation, and retinal neurodegeneration are early events in DR. Protein tyrosine […]
Artificial intelligence and neurodegeneration: state of the art and explainability
Int J Retina Vitreous. 2026 May 19. doi: 10.1186/s40942-026-00807-4. Online ahead of print. ABSTRACT BACKGROUND: Alzheimer disease (AD) and Parkinson disease (PD) are an increasing healthcare concern and growing cause of disability in our century. The advent of the artificial intelligence (AI) era and the early changes in retina and optic nerve morphology detected in […]
Organelle contact reorganization drives calcium-dependent autophagy under proteostatic stress
Autophagy. 2026 May 18. doi: 10.1080/15548627.2026.2677184. Online ahead of print. ABSTRACT Disruption of proteostasis is a defining feature of cancer and other chronic diseases. The AAA+ ATPase VCP/p97 (valosin containing protein) is a key regulator of proteostasis by disassembling ubiquitinated substrates for degradation. VCP overexpression supports cancer cell survival and correlates with poor prognosis, promoting […]
cGAS-STING Pathway Mediates Retinal Pigmental Epithelial Dysfunction in Diabetic Retinopathy
Diabetes. 2026 May 18:db250128. doi: 10.2337/db25-0128. Online ahead of print. ABSTRACT Diabetic retinopathy (DR) is a predominant cause of vision impairment among working-age individuals, with a subset of patients responding poorly to current treatments. This study investigated alterations in double-stranded DNA (dsDNA) levels in the aqueous humor and retinal pigment epithelium (RPE) dysfunction in DR […]
Transcriptomic Profiling of the Human Retina Reveals Inflammatory and Metabolic Signatures Associated With Clinical Severity After Retinal Detachment
Invest Ophthalmol Vis Sci. 2026 May 1;67(5):44. doi: 10.1167/iovs.67.5.44. ABSTRACT PURPOSE: Retinal detachment (RD) remains an ophthalmologic emergency with high anatomical success rates after surgery but often suboptimal visual outcomes. This study aimed to identify transcriptomic signatures linked with clinical severity in human RD to uncover the molecular basis of variability in functional recovery. METHODS: […]