Screening and identification of a novel PGAM5-specific inhibitor for attenuating multi-organ injury
J Adv Res. 2026 Feb 1:S2090-1232(26)00093-7. doi: 10.1016/j.jare.2026.01.075. Online ahead of print. ABSTRACT INTRODUCTION: The necroptosis regulator PGAM5 drives a pathological cycle of mitochondrial dysfunction and necroptotic signaling, contributing to multi-organ injury and representing a potential therapeutic target. Despite its clinical relevance, few PGAM5-specific small-molecule inhibitors have been developed. OBJECTIVES: We aimed to identify a […]
A novel prohibitin inhibitor acts as a dual inhibitor of angiogenesis and fibrosis
Biochem Biophys Res Commun. 2026 Jan 31;805:153386. doi: 10.1016/j.bbrc.2026.153386. Online ahead of print. ABSTRACT We previously showed that the benzoylphenylurea derivative BPU17 inhibits epithelial-mesenchymal transition and acts as an antifibrotic agent. This compound acts as a prohibitin (PHB) inhibitor by directly binding to PHB1. This binding disrupts the interaction between PHB1 and PHB2, leading to […]
TrkB Overexpression via Gene Therapy: Enhanced Optic Nerve Uptake With Associated Increases in Mitochondria and Axoplasmic Transport
Cureus. 2026 Jan 2;18(1):e100594. doi: 10.7759/cureus.100594. eCollection 2026 Jan. ABSTRACT INTRODUCTION: Glaucoma is a progressive neurodegenerative disease that affects retinal ganglion cells (RGCs), ultimately leading to vision loss. In this study, we investigated gene therapy-mediated transduction of RGCs and examined axonal transport changes in the optic nerve using a viral vector designed to upregulate tropomyosin […]
Molecular landscape connecting complications of dry eye disease: mechanisms, therapeutic targets, biomarkers, and future innovations
Int Ophthalmol. 2026 Feb 2;46(1):97. doi: 10.1007/s10792-026-03940-z. ABSTRACT PURPOSE: This review paper is a sightseeing on the molecular pathways of the DED, which culminate in the cascades of inflammatory cytokines, apoptosis, oxidative stress, as well as the breakdown of homeostasis of the ocular surface. The article also discusses complications, and it explains the connection between […]
Pharmacological Depletion of Retinal Mononuclear Phagocytes Is Neuroprotective in a Mouse Model of Mitochondrial Optic Neuropathy
Invest Ophthalmol Vis Sci. 2026 Feb 2;67(2):6. doi: 10.1167/iovs.67.2.6. ABSTRACT PURPOSE: The Vglut2-Cre;ndufs4loxP/loxP mouse strain with retinal ganglion cell (RGC)-specific mitochondrial complex I dysfunction develops severe RGC degeneration by postnatal day 90 (P90), with accompanying retinal mononuclear phagocyte (MNP) accumulation. We have reported that continuous exposure to hypoxia partially rescues RGC death in these mice, […]
Ferroptosis and retinal ganglion cell death in glaucoma: Mechanisms and therapeutic approaches
J Pharm Anal. 2026 Jan;16(1):101355. doi: 10.1016/j.jpha.2025.101355. Epub 2025 Jun 4. ABSTRACT Glaucoma represents a predominant worldwide etiology of permanent vision impairment; it is clinically manifested through progressive neuronal atrophy in retinal ganglion cells (RGCs) and is accompanied by axonal degeneration in the optic pathway. Given the limited efficacy of conventional intraocular pressure-lowering therapies in […]
A multifunctional mitochondria-targeted nanoparticle for the effective treatment of dry eye disease via reactive oxygen species scavenging
Mater Today Bio. 2026 Jan 16;37:102815. doi: 10.1016/j.mtbio.2026.102815. eCollection 2026 Apr. ABSTRACT Dry eye disease is a prevalent ocular surface disorder primarily driven by oxidative stress and inflammation, remains a therapeutic challenge due to the limitations of current treatments. In this study, we developed a multifunctional nanoparticle system, using a layer-by-layer self-assembly strategy to enhance […]
Recovery from apoptosis in photoreceptor cells: A role for mitophagy
Cell Death Dis. 2026 Jan 30. doi: 10.1038/s41419-026-08436-3. Online ahead of print. ABSTRACT Photoreceptors (PRs) are specialized light-sensitive cells responsible for vision, and their death is the primary cause of retinal degeneration and vision loss. Recent studies using cells such as HeLa and PC12 have demonstrated cellular recovery even from late stages of apoptosis. Here, […]
Resveratrol as a multitarget modulator in diabetic retinopathy: a systematic review of in vitro and in vivo studies
BMC Ophthalmol. 2026 Jan 29;26(1):55. doi: 10.1186/s12886-026-04623-0. ABSTRACT BACKGROUND: Resveratrol (RSV) has been extensively investigated for its antioxidant and anti-inflammatory properties across various disease settings; however, its upstream mechanisms in diabetic retinopathy (DR) remain insufficiently characterized. Given that early DR involves oxidative stress, mitochondrial disruption, and microglia-associated inflammatory amplification, this systematic review aims to synthesize […]
A type I interferon-mitochondrial axis regulates efferocytosis and interferon-stimulated gene induction in macrophages
Immunity. 2026 Jan 28:S1074-7613(25)00566-7. doi: 10.1016/j.immuni.2025.12.010. Online ahead of print. ABSTRACT Macrophage metabolism is intricately linked to cellular function. Contrasting with Toll-like receptor (TLR) stimulation, cytosolic nucleic acid sensing induced a decrease in mitochondrial membrane potential (MMP) while maintaining mitochondrial respiration. Interferon α/β (IFN-I) receptor (IFNAR) signaling was necessary and sufficient for this metabolic response. […]