Zinc peroxide-copper bimetallic nanozyme with self-activated ROS and cuproptosis for superficial antifungal therapy
J Nanobiotechnology. 2026 Feb 8. doi: 10.1186/s12951-026-04088-9. Online ahead of print. ABSTRACT Fungal infections, particularly intractable cases such as fungal keratitis (FK) and skin wound infections, remain a pressing global health challenge, further exacerbated by rising antifungal resistance and treatment-associated cytotoxicity. Herein, we report a highly effective, non-antibiotic therapeutic strategy integrating reactive oxygen species (ROS) […]
Securinine bolsters anti-tumor immunity by promoting CD8⁺ T cell activation
Cancer Treat Res Commun. 2026 Jan 30;47:101120. doi: 10.1016/j.ctarc.2026.101120. Online ahead of print. ABSTRACT Securinine (SEC) is a natural alkaloid isolated from Flueggea suffruticosa, which can suppress tumor growth of some types. T cells play a critical role in anti-tumor function. However, whether SEC mediates T cell-mediated anti-tumor effects remains unknown. Here, we found that […]
Integrative Proteogenomic Analysis Identifies Genetically Supported Plasma Proteins, Metabolites, and Pathways in Glaucoma
Invest Ophthalmol Vis Sci. 2026 Feb 2;67(2):21. doi: 10.1167/iovs.67.2.21. ABSTRACT PURPOSE: Glaucoma is a leading cause of irreversible blindness, yet the circulating proteins and metabolic pathways that causally contribute to different glaucoma subtypes remain poorly defined. METHODS: We analyzed baseline plasma proteomics in 1485 glaucoma cases (447 primary open‑angle glaucoma [POAG], 177 primary angle-closure glaucoma […]
Cell-intrinsic vulnerability and immune activation cooperate to drive degeneration in a mitochondrial complex I deficiency model of optic neuropathy
J Neuroinflammation. 2026 Feb 6. doi: 10.1186/s12974-026-03707-4. Online ahead of print. NO ABSTRACT PMID:41645183 | DOI:10.1186/s12974-026-03707-4
A systematic review on age-related macular degeneration: New insights from multi-omics studies
Surv Ophthalmol. 2026 Feb 3:S0039-6257(26)00016-0. doi: 10.1016/j.survophthal.2026.02.001. Online ahead of print. ABSTRACT Age-related macular degeneration (AMD) is a leading cause of blindness in developed countries and a growing global health concern. The multifactorial nature of AMD calls for integrative multi-omics approaches. We summarize studies employing multi-omics in AMD. A comprehensive search in PubMed and Scopus […]
Taurochenodeoxycholic Acid Activates Calcium Signaling to Protect Against Fuchs’ Endothelial Corneal Dystrophy
Invest Ophthalmol Vis Sci. 2026 Feb 2;67(2):16. doi: 10.1167/iovs.67.2.16. ABSTRACT PURPOSE: Fuchs’ endothelial corneal dystrophy (FECD) is the leading cause of corneal endothelial dystrophy. This study aimed to investigate the protective effects and mechanism of taurochenodeoxycholic acid (TCDCA) in FECD. METHODS: TCDCA levels were quantified in aqueous humor from patients with FECD and ultraviolet A […]
An Apparently Isolated Optic Neuropathy Associated with Biallelic Variants in SLC25A46 Gene Encoding the Mitochondrial Ugo1-Like Protein
Neuroophthalmology. 2025 Nov 3;50(1):96-100. doi: 10.1080/01658107.2025.2581675. eCollection 2026. ABSTRACT Biallelic pathogenic variants in the SLC25A46 gene are responsible for various neurological syndromes, including Charcot-Marie-Tooth disease type 6B, pontocerebellar hypoplasia type 1E, Leigh syndrome, progressive myoclonic ataxia and Parkinson’s disease, most of them being associated with optic atrophy. We here report the case of a 26-year-old […]
NOP14 promotes proliferative diabetic retinopathy through ribosome biogenesis and endothelial dysfunction via Wnt/β-Catenin signaling activation
Exp Cell Res. 2026 Feb 2:114922. doi: 10.1016/j.yexcr.2026.114922. Online ahead of print. ABSTRACT Proliferative diabetic retinopathy (PDR) is characterized by pathological angiogenesis and endothelial dysfunction driven by hyperglycemia. Ribosome biogenesis plays a crucial role in endothelial proliferation, yet its involvement in PDR remains unexplored. This study investigates the role of NOP14, a key regulator of […]
Biomarking MELAS with neurofilament light chain and circulating cell free mitochondrial DNA
Mol Genet Metab. 2026 Jan 27;147(3):109753. doi: 10.1016/j.ymgme.2026.109753. Online ahead of print. ABSTRACT Mitochondrial diseases are genetic disorders caused either by nuclear or mitochondrial DNA (mtDNA) alterations and characterized by high genetic and phenotypic variability. The common mtDNA m.3243 A > G variant in the MT-TL1 gene leads to clinical manifestations ranging from the classical […]
Targeted Extracellular Vesicles Deliver Asiaticoside to Inhibit AURKB/DRP1-Mediated Mitochondrial Fission and Attenuate Hypertrophic Scar Formation
Adv Sci (Weinh). 2026 Feb 4:e17108. doi: 10.1002/advs.202517108. Online ahead of print. ABSTRACT Hypertrophic scars (HS) are fibroproliferative lesions arising from aberrant wound healing, their high incidence is countered by a lack of effective interventions owing to an incomplete understanding of pathogenesis. Here, we identify dysregulated mitochondrial dynamics as a key driver of HS and […]