The use of Nicotinamide and Nicotinamide riboside as an adjunct therapy in the treatment of glaucoma
Eur J Ophthalmol. 2023 Mar 14:11206721231161101. doi: 10.1177/11206721231161101. Online ahead of print. ABSTRACT Glaucoma is an optic neuropathy characterized by death of retinal ganglion cells (RGCs), which leads to progressive visual field loss and may result in blindness. Currently, the only available treatment to avoid or delay progression in glaucoma patients is to decrease intraocular […]
Optic Nerve Injury Enhanced Mitochondrial Fission and Increased Mitochondrial Density without Altering the Uniform Mitochondrial Distribution in the Unmyelinated Axons of Retinal Ganglion Cells in a Mouse Model
Int J Mol Sci. 2023 Feb 22;24(5):4356. doi: 10.3390/ijms24054356. ABSTRACT Glaucomatous optic neuropathy (GON), a major cause of blindness, is characterized by the loss of retinal ganglion cells (RGCs) and the degeneration of their axons. Mitochondria are deeply involved in maintaining the health of RGCs and their axons. Therefore, lots of attempts have been made […]
Lacrimal Gland Epithelial Cells Shape Immune Responses through the Modulation of Inflammasomes and Lipid Metabolism
Int J Mol Sci. 2023 Feb 21;24(5):4309. doi: 10.3390/ijms24054309. ABSTRACT Lacrimal gland inflammation triggers dry eye disease through impaired tear secretion by the epithelium. As aberrant inflammasome activation occurs in autoimmune disorders including Sjögren’s syndrome, we analyzed the inflammasome pathway during acute and chronic inflammation and investigated its potential regulators. Bacterial infection was mimicked by […]
Antioxidative and Mitochondrial Protection in Retinal Pigment Epithelium: New Light Source in Action
Int J Mol Sci. 2023 Mar 1;24(5):4794. doi: 10.3390/ijms24054794. ABSTRACT Low-color-temperature light-emitting diodes (LEDs) (called 1900 K LEDs for short) have the potential to become a healthy light source due to their blue-free property. Our previous research demonstrated that these LEDs posed no harm to retinal cells and even protected the ocular surface. Treatment targeting […]
Deficits in mitochondrial TCA cycle and OXPHOS precede rod photoreceptor degeneration during chronic HIF activation
Mol Neurodegener. 2023 Mar 7;18(1):15. doi: 10.1186/s13024-023-00602-x. ABSTRACT BACKGROUND: Major retinal degenerative diseases, including age-related macular degeneration, diabetic retinopathy and retinal detachment, are associated with a local decrease in oxygen availability causing the formation of hypoxic areas affecting the photoreceptor (PR) cells. Here, we addressed the underlying pathological mechanisms of PR degeneration by focusing on […]
Hypoxia-induced transcriptional differences in African and Asian versus European diabetic cybrids
Sci Rep. 2023 Mar 7;13(1):3818. doi: 10.1038/s41598-023-30518-x. ABSTRACT Diabetic retinopathy (DR) is the most common diabetic microvascular complication and cause of blindness in adults under the age of 65. Our results suggest that, when comparing transcriptomes of cultures grown in hypoxic conditions versus room-air, cybrids containing mitochondria from African and Asian diabetic subjects ([Afr + […]
Autonomic instability, arrhythmia and visual impairment in a new presentation of MTFMT-related mitochondrial disease
JIMD Rep. 2022 Dec 8;64(2):150-155. doi: 10.1002/jmd2.12355. eCollection 2023 Mar. ABSTRACT Mitochondrial methionyl-tRNA formyltransferase (MTFMT) is required for the initiation of translation in mitochondria. Pathogenic variants in MTFMT have been described in association with clinical presentations with Leigh syndrome, as well with as multisystem involvement (particularly cardiac and ocular involvement). There is a spectrum of […]
Benzyl isothiocyanate improves the prognosis of Aspergillus fumigatus keratitis by reducing fungal load and inhibiting Mincle signal pathway
Front Microbiol. 2023 Feb 16;14:1119568. doi: 10.3389/fmicb.2023.1119568. eCollection 2023. ABSTRACT Aspergillus fumigatus keratitis is a potential blinding disease associated with A. fumigatus invasion and excessive inflammatory response. Benzyl isothiocyanate (BITC) is a secondary metabolite with broad antibacterial and anti-inflammatory activity extracted from cruciferous species. However, the role of BITC in A. fumigatus keratitis has not […]
Curcumin Alleviates Oxidative stress, Neuroinflammation, and Promotes Behavioral Recovery after Traumatic Brain Injury
Curr Neurovasc Res. 2023 Mar 3. doi: 10.2174/1567202620666230303144323. Online ahead of print. ABSTRACT BACKGROUND: Neuroinflammation and oxidative stress after traumatic brain injury (TBI) can further lead to neuronal apoptosis, which plays a crucial role in the process of neuron death. Curcumin, which is derived from the rhizome of the Curcuma longa plant, has multiple pharmacological […]
Cigarette smoke induces the ROS accumulation and iNOS activation through deactivation of Nrf-2/SIRT3 axis to mediate the human bronchial epithelium ferroptosis
Free Radic Biol Med. 2023 Mar 3:S0891-5849(23)00100-4. doi: 10.1016/j.freeradbiomed.2023.03.002. Online ahead of print. ABSTRACT Cigarette smoke (CS)-induced oxidative stress drives the pathogenesis of respiratory diseases, in which the activation and accumulation of reactive oxygen species (ROS) play an important role. Ferroptosis, a regulated cell death induced by Fe2+-dependent, lipid peroxidation, and ROS, is closely related […]