Early detection of visual impairment in young children using a smartphone-based deep learning system
Nat Med. 2023 Feb;29(2):493-503. doi: 10.1038/s41591-022-02180-9. Epub 2023 Jan 26. ABSTRACT Early detection of visual impairment is crucial but is frequently missed in young children, who are capable of only limited cooperation with standard vision tests. Although certain features of visually impaired children, such as facial appearance and ocular movements, can assist ophthalmic practice, applying […]
PK2/PKRs pathway is involved in the protective effect of artemisinin against trimethyltin chloride-induced hippocampal injury
Toxicology. 2023 Mar 1;486:153432. doi: 10.1016/j.tox.2023.153432. Epub 2023 Jan 22. ABSTRACT Neuroinflammation is one of the important mechanisms of trimethyltin chloride (TMT) central neurotoxicity. Artemisinin (ARS) is a well-known antimalarial drug that also has significant anti-inflammatory effects. Prokineticin 2 (PK2) is a small molecule secreted protein that is widely expressed in the nervous system and […]
Inhibition of mitochondrial VDAC1 oligomerization alleviates apoptosis and necroptosis of retinal neurons following OGD/R injury
Ann Anat. 2023 Jan 20;247:152049. doi: 10.1016/j.aanat.2023.152049. Online ahead of print. ABSTRACT Ischemia-reperfusion (I/R) injury is a common pathological mechanism in many retinal diseases, which can lead to cell death via mitochondrial dysfunction. Voltage-dependent anion channel 1 (VDAC1), which is mainly located in the outer mitochondrial membrane, is the gatekeeper of mitochondria. The permeability of […]
Autophagy Requirements for Eye Lens Differentiation and Transparency
Cells. 2023 Feb 1;12(3):475. doi: 10.3390/cells12030475. ABSTRACT Recent evidence points to autophagy as an essential cellular requirement for achieving the mature structure, homeostasis, and transparency of the lens. Collective evidence from multiple laboratories using chick, mouse, primate, and human model systems provides evidence that classic autophagy structures, ranging from double-membrane autophagosomes to single-membrane autolysosomes, are […]
Characterization of Oxygen Nanobubbles and In Vitro Evaluation of Retinal Cells in Hypoxia
Transl Vis Sci Technol. 2023 Feb 1;12(2):16. doi: 10.1167/tvst.12.2.16. ABSTRACT PURPOSE: Vein or artery occlusion causes a hypoxic environment by preventing oxygen delivery and diffusion to tissues. Diseases such as retinal vein occlusion, central retinal artery occlusion, or diabetic retinopathy create a stroke-type condition that leads to functional blindness in the effected eye. We aim […]
PINK1/Parkin-mediated mitophagy inhibits osteoblast apoptosis induced by advanced oxidation protein products
Cell Death Dis. 2023 Feb 7;14(2):88. doi: 10.1038/s41419-023-05595-5. ABSTRACT Osteoblast apoptosis plays an important role in age-related bone loss and osteoporosis. Our previous study revealed that advanced oxidation protein products (AOPPs) could induce nicotinamide adenine dinucleotide phosphate oxidase (NOX)-derived reactive oxygen species (ROS) production, cause mitochondrial membrane potential (ΔΨm) depolarization, trigger the mitochondria-dependent intrinsic apoptosis […]
The outcome of boosting mitochondrial activity in alcoholic liver disease (ALD) is organ-dependent
Hepatology. 2023 Feb 9. doi: 10.1097/HEP.0000000000000303. Online ahead of print. ABSTRACT OBJECTIVE: Alcoholic liver disease (ALD) accounts for 70% of liver-related deaths in Europe, with no effective approved therapies. Although mitochondrial dysfunction is one of the earliest manifestations of alcohol-induced injury, restoring mitochondrial activity remains a problematic strategy due to oxidative stress. Here, we identify […]
Cone photoreceptors transfer damaged mitochondria to Müller glia
Cell Rep. 2023 Feb 15;42(2):112115. doi: 10.1016/j.celrep.2023.112115. Online ahead of print. ABSTRACT Mitochondria are vital organelles that require sophisticated homeostatic mechanisms for maintenance. Intercellular transfer of damaged mitochondria is a recently identified strategy broadly used to improve cellular health and viability. Here, we investigate mitochondrial homeostasis in the vertebrate cone photoreceptor, the specialized neuron that […]
N-Acetylcysteine and cysteamine bitartrate prevent azide-induced neuromuscular decompensation by restoring glutathione balance in two novel surf1-/- zebrafish deletion models of Leigh syndrome
Hum Mol Genet. 2023 Feb 16:ddad031. doi: 10.1093/hmg/ddad031. Online ahead of print. ABSTRACT SURF1 deficiency (OMIM # 220110) causes Leigh syndrome (LS, OMIM # 256000), a mitochondrial disorder typified by stress-induced metabolic strokes, neurodevelopmental regression, and progressive multisystem dysfunction. Here, we describe two novel surf1-/- zebrafish knockout models generated by CRISPR/Cas9 technology. While gross larval […]
Mitochondrial Genome Alterations, Cytochrome C Oxidase Activity, and Oxidative Stress: Implications in Primary Open-angle Glaucoma
J Curr Glaucoma Pract. 2022 Sep-Dec;16(3):158-165. doi: 10.5005/jp-journals-10078-1376. ABSTRACT AIM: To evaluate mitochondrial genome alterations, cytochrome c oxidase (COX) activity, and oxidative stress in primary open-angle glaucoma (POAG). METHODOLOGY: Whole mitochondrial genome was screened in 75 POAG cases and 105 controls by polymerase chain reaction (PCR) sequencing. COX activity was measured from peripheral blood mononuclear […]