The Intracellular C5a-mtC5aR1 Axis Promotes Necroptosis in Dry Eye Through DRP1-Mediated Mitochondrial Dysfunction
Invest Ophthalmol Vis Sci. 2026 Feb 2;67(2):35. doi: 10.1167/iovs.67.2.35. ABSTRACT PURPOSE: As a multifactorial ocular surface pathology, dry eye (DE) is marked by inflammation and epithelial damage. While mitochondrial dysfunction and oxidative stress are implicated, the mechanisms driving cornea epithelial cell damage remain unclear. This study investigates the role of C5a-mitochondrial C5a receptor 1 (mtC5aR1) […]
Integrated tear proteomics define the molecular blueprint of corneal epithelial repair
Exp Biol Med (Maywood). 2026 Feb 2;250:10866. doi: 10.3389/ebm.2025.10866. eCollection 2025. ABSTRACT Tears are easy to collect, repeatable, and reflect the state of the corneal surface-attributes that make them attractive for bedside monitoring after surgery or injury. We performed a cross-species meta-analysis of tear proteomes from patients undergoing photorefractive keratectomy (PRK) and from mice after […]
Novel ocular feature in oculoskeletodental syndrome: high axial myopia and megalocornea in a child with a homozygous PIK3C2A variant
Ophthalmic Genet. 2026 Feb 17:1-4. doi: 10.1080/13816810.2026.2627545. Online ahead of print. ABSTRACT BACKGROUND: Oculoskeletodental syndrome (OCSKD) is a rare autosomal recessive ciliopathy caused by PIK3C2A loss-of-function variants, characterized by ocular, skeletal, and dental anomalies. Ocular findings most commonly include cataract and secondary glaucoma; however, high axial myopia and megalocornea have not been previously reported in […]
Identifying NDUFA12 mutation in a Saudi family: An unusual presentation of mitochondrial Complex I deficiency mimicking as idiopathic intracranial hypertension in a patient with papilledema and visual loss
J Family Community Med. 2026 Jan 19;33(1):47-52. doi: 10.4103/jfcm.jfcm_322_25. eCollection 2026 Jan-Mar. ABSTRACT Mitochondrial diseases are considered one of the most common groups of neurogenetic diseases. Complex I (CI) deficiency is the most encountered single enzyme deficiency of the mitochondrial diseases. The mutation of the NDUFA is linked to Leigh syndrome and CI defects. This […]
Dexamethasone Sensitizes Lens Epithelial Cells to Ferroptosis through the Glucocorticoid Receptor/Nuclear Factor Erythroid 2-Related Factor 2 Signaling Axis
Exp Eye Res. 2026 Feb 13:110908. doi: 10.1016/j.exer.2026.110908. Online ahead of print. ABSTRACT PURPOSE: The aim of this study was to investigate dexamethasone (Dex) involvement in lens epithelial cell (LEC) ferroptosis. METHODS: A Cell Counting Kit-8 was used to assess LEC viability. Ferroptosis-related indicators were evaluated by measuring the malondialdehyde (MDA) content, intracellular ferrous ion […]
Targeting translocator protein (TSPO) ameliorates inflammation and maintains mitochondrial homeostasis to protect against dry eye
Ocul Surf. 2026 Feb 13:S1542-0124(26)00022-4. doi: 10.1016/j.jtos.2026.02.005. Online ahead of print. ABSTRACT PURPOSE: To investigate the expression and role of translocator protein (TSPO) in dry eye disease (DED). METHODS: In vitro experiments were performed using immortalized human corneal epithelial cells (HCECs) cultured under hyperosmolar conditions (500 mOsM). Cell viability was analyzed by the Cell Counting […]
Mitochondrial energetic failure underlies FLVCR1-related sensory neuropathy
Commun Biol. 2026 Feb 14. doi: 10.1038/s42003-026-09691-y. Online ahead of print. ABSTRACT Genetic pain loss disorders represent a heterogeneous group of rare diseases mainly characterized by defective nociception. Understanding the underlying molecular mechanism is fundamental to improve the treatment of patients affected by these rare disorders. Feline Leukemia Virus Subgroup C Receptor 1 (FLVCR1) is […]
Author Response: OphthoACR (Ophthalmology Automated Chart Review): An AI-Powered Tool for Complete Automation of Ophthalmology Chart Reviews and Cohort Data Analysis
Transl Vis Sci Technol. 2026 Feb 2;15(2):17. doi: 10.1167/tvst.15.2.17. ABSTRACT PURPOSE: Prevalence of diabetic retinopathy closely depends on the duration of diabetes and severity of hyperglycemia. Experimental models have shown that high glucose initiates many metabolic, molecular and epigenetic changes in the retina before vascular histopathology is detectable. Several LncRNAs (RNAs with >200bp and no […]
Superoxide-responsive mitochondria-targeting peptide-persulfide donor conjugate for retinal ganglion cells protection in glaucoma
Biomaterials. 2026 Feb 9;330:124054. doi: 10.1016/j.biomaterials.2026.124054. Online ahead of print. ABSTRACT Glaucoma is a leading cause of irreversible blindness, primarily due to the progressive degeneration of retinal ganglion cells (RGCs). Despite available treatments targeting intraocular pressure (IOP), there remains an urgent need for effective strategies that directly protect RGCs by addressing mitochondrial dysfunction and oxidative […]
Chronic obstructive pulmonary disease reprograms the lung into an immune organ through trained immunity, cell death networks, and immune checkpoint dysregulation
Front Med (Lausanne). 2026 Jan 28;13:1721780. doi: 10.3389/fmed.2026.1721780. eCollection 2026. ABSTRACT INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is a heterogeneous inflammatory disorder characterized by persistent immune dysregulation and progressive structural deterioration of the lung. However, how COPD reshapes lung architecture, immune signaling, and cellular identity at a systems level remains incompletely understood. METHODS: We performed […]