Optic atrophy in a patient with axonal Charcot-Marie-Tooth disease 2A2A due to MFN2 gene mutations
Zhonghua Yan Ke Za Zhi. 2023 May 11;59(5):408-410. doi: 10.3760/cma.j.cn112142-20220611-00289. ABSTRACT A 27-year-old male patient had progressive vision loss in both eyes, which was mainly manifested by impaired ganglion cells in the macular area, accompanied by systemic muscle atrophy in limbs. A complete mitochondrial exon gene detection was performed. The final diagnosis was bilateral optic […]
Protective effects of Scoparia dulcis L. extract on high glucose-induced injury in human retinal pigment epithelial cells
Front Nutr. 2023 Mar 30;10:1085248. doi: 10.3389/fnut.2023.1085248. eCollection 2023. ABSTRACT Diabetic retinopathy (DR) is a major cause of vision loss in diabetic patients. Hyperglycemia-induced oxidative stress and the accumulation of inflammatory factors result in blood-retinal barrier dysfunction and the pathogenesis of DR. Scoparia dulcis L. extract (SDE), a traditional Chinese medicine, has been recently recognized […]
Mitochondrial decline in the ageing old world primate retina: Little evidence for difference between the centre and periphery
PLoS One. 2023 May 2;18(5):e0273882. doi: 10.1371/journal.pone.0273882. eCollection 2023. ABSTRACT Mitochondrial decline is a key feature of ageing. The retina has more mitochondria than any other tissue and ages rapidly. To understand human retinal ageing it is critical to examine old world primates that have similar visual systems to humans, and do so across central […]
The Interplay Between Metabolites and MicroRNAs in Aqueous Humor to Coordinate Corneal Endothelium Integrity
Ophthalmol Sci. 2023 Mar 16;3(3):100299. doi: 10.1016/j.xops.2023.100299. eCollection 2023 Sep. ABSTRACT PURPOSE: The purpose of the study was to clarify the interplay between metabolites and microRNAs (miRs) in the aqueous humor (AqH) of bullous keratopathy (BK) patients to retain human corneal endothelium (HCE) integrity. DESIGN: Prospective, comparative, observational study. PARTICIPANTS: A total of 55 patients […]
iPSC-derived retinal pigmented epithelial cells from patients with macular telangiectasia show decreased mitochondrial function
J Clin Invest. 2023 May 1;133(9):e163771. doi: 10.1172/JCI163771. ABSTRACT Patient-derived induced pluripotent stem cells (iPSCs) provide a powerful tool for identifying cellular and molecular mechanisms of disease. Macular telangiectasia type 2 (MacTel) is a rare, late-onset degenerative retinal disease with an extremely heterogeneous genetic architecture, lending itself to the use of iPSCs. Whole-exome sequencing screens […]
Nordalbergin Exerts Anti-Neuroinflammatory Effects by Attenuating MAPK Signaling Pathway, NLRP3 Inflammasome Activation and ROS Production in LPS-Stimulated BV2 Microglia
Int J Mol Sci. 2023 Apr 14;24(8):7300. doi: 10.3390/ijms24087300. ABSTRACT Microglia-associated neuroinflammation is recognized as a critical factor in the pathogenesis of neurodegenerative diseases; however, there is no effective treatment for the blockage of neurodegenerative disease progression. In this study, the effect of nordalbergin, a coumarin isolated from the wood bark of Dalbergia sissoo, on […]
Curcumin attenuates hydroxychloroquine-mediated apoptosis and oxidative stress via the inhibition of TRPM2 channel signalling pathways in a retinal pigment epithelium cell line
Graefes Arch Clin Exp Ophthalmol. 2023 Apr 26. doi: 10.1007/s00417-023-06082-5. Online ahead of print. ABSTRACT PURPOSE: Hydroxychloroquine (HCQ) is used in the treatment of several diseases, such as malaria, Sjögren’s disease, Covid-19, and rheumatoid arthritis. However, HCQ induces retinal pigment epithelium death via the excessive increase of cytosolic (cROS) and mitochondrial (mROS) free oxygen radical […]
Fucoxanthin protects retinal ganglion cells and promotes parkin-mediated mitophagy against glutamate excitotoxicity
Neuroreport. 2023 May 3;34(7):385-394. doi: 10.1097/WNR.0000000000001902. Epub 2023 Apr 1. ABSTRACT OBJECTIVE: To clarify whether fucoxanthin plays a protective role and regulates parkin-mediated mitophagy on retinal ganglion cells (RGCs) against glutamate excitotoxicity. METHODS: The excitotoxicity model of primary RGCs was carried out with glutamate. Mitochondrial membrane potential was measured by JC-1 kit (Abcam, USA). The […]
Fucoxanthin protects retinal ganglion cells and promotes parkin-mediated mitophagy against glutamate excitotoxicity
Neuroreport. 2023 Apr 3. doi: 10.1097/WNR.0000000000001902. Online ahead of print. ABSTRACT OBJECTIVE: To clarify whether fucoxanthin plays a protective role and regulates parkin-mediated mitophagy on retinal ganglion cells (RGCs) against glutamate excitotoxicity. METHODS: The excitotoxicity model of primary RGCs was carried out with glutamate. Mitochondrial membrane potential was measured by JC-1 kit (Abcam, USA). The […]
Metabolic Intervention Liposome Boosted Lung Cancer Radio-Immunotherapy via Hypoxia Amelioration and PD-L1 Restraint
Adv Sci (Weinh). 2023 Apr 24:e2207608. doi: 10.1002/advs.202207608. Online ahead of print. ABSTRACT At present, radiotherapy (RT) still acquires limited success in clinical due to the lessened DNA damage under hypoxia and acquired immune tolerance owing to the amplified programmed death ligand-1 (PD-L1) expression. Incredibly, intracellular PD-L1 expression depression is proven to better sensitize RT […]